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Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

First Author:

Spinella PC

Journal:

JAMA

Year:

2019

Group:

,

Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF; ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10;322(22):2179-2190. PMID: 31821429

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery.

First Author:

Ball IM

Journal:

Can J Anaesth.

Year:

2018

Group:

, ,

Ball IM, Burry L, Dodek P, Hutchison JS, Leigh JP, McCredie V, Murthy S, Rochwerg B, Cook D; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery. Can J Anaesth. 2018 Mar;65(3):239-245. PMID: 29150787

Prospective cohort study on noise levels in a pediatric cardiac intensive care unit.

First Author:

Garcia Guerra G

Journal:

J Crit Care

Year:

2018

Group:

, ,

Garcia Guerra G, Joffe AR, Sheppard C, Pugh J, Moez EK, Dinu IA, Jou H, Hartling L, Vohra S; Sedation Withdrawal and Analgesia Team (SWAT); Canadian Critical Care Trials Group (CCCTG). Prospective cohort study on noise levels in a pediatric cardiac intensive care unit.  J Crit Care. 2018 Apr;44:318-322. PMID: 29274594

Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial.

First Author:

Parshuram CS

Journal:

JAMA

Year:

2018

Group:

,

Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt EA, Joffe AR, Lacroix J, Moga MA, Nadkarni V, Ninis N, Parkin PC, Wensley D, Willan AR, Tomlinson GA; Canadian Critical Care Trials Group and the EPOCH Investigators. Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial. JAMA. 2018 Mar 13;319(10):1002-1012. PMID: 29486493

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial.

First Author:

Green RS

Journal:

Transfusion

Year:

2018

Group:

,

Green RS, Erdogan M, Lacroix J, Hébert PC, Tinmouth AT, Sabri E, Zhang T, Fergusson DA, Turgeon AF; ABLE Investigators and the Canadian Critical Care Trials Group. Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial. Transfusion. 2018 Aug;58(8):1846-1854. PMID: 29672869

Random serum free cortisol and total cortisol measurements in pediatric septic shock.

First Author:

Menon K

Journal:

J Pediatr Endocrinol Metab

Year:

2018

Group:

,

Menon K, McNally D, Acharya A, O'Hearn K, Choong K, Wong HR, McIntyre L, Lawson M; Canadian Critical Care Trials Group. Random serum free cortisol and total cortisol measurements in pediatric septic shock. J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):757-762. doi: 10.1515/jpem-2018-0027. PMID: 29953408

The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial.

First Author:

Tucci M

Journal:

Trials.

Year:

2018

Group:

,

Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial. Trials. 2018 Jul 28;19(1):404. PMID: 30055634

The Canadian Traumatic Brain Injury Research Consortium: Epitomizing Collaborative Research in Canada.

First Author:

Hutchison JS

Journal:

J Neurotrauma.

Year:

2018

Group:

,

Hutchison JS, Emery C, Gagnon I, Léger C, Riopelle R, Wellington C, Wilson E, Turgeon AF. The Canadian Traumatic Brain Injury Research Consortium: Epitomizing Collaborative Research in Canada. J Neurotrauma. 2018 Aug 15;35(16):1858-1863. PMID: 30074867

Improved Clinical Performance and Teamwork of Pediatric Interprofessional Resuscitation Teams With a Simulation-Based Educational Intervention.

First Author:

Gilfoyle E

Journal:

Pediatr Crit Care Med

Year:

2017

Group:

,

Gilfoyle E, Koot DA, Annear JC, Bhanji F, Cheng A, Duff JP, Grant VJ, St George-Hyslop CE, Delaloye NJ, Kotsakis A, McCoy CD, Ramsay CE, Weiss MJ, Gottesman RD; Teams4Kids Investigators and the Canadian Critical Care Trials Group. Improved Clinical Performance and Teamwork of Pediatric Interprofessional Resuscitation Teams With a Simulation-Based Educational Intervention. Pediatr Crit Care Med. 2017 Feb;18(2):e62-e69. PMID: 28157808

The intensive care medicine clinical research agenda in paediatrics.

First Author:

Peters MJ

Journal:

Intensive Care Med

Year:

2017

Group:

Peters MJ, Argent A, Festa M, Leteurtre S, Piva J, Thompson A, Willson D, Tissières P, Tucci M, Lacroix J. The intensive care medicine clinical research agenda in paediatrics. Intensive Care Med. 2017 Sep;43(9):1210-1224. PMID: 28315043

High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators.

First Author:

Duffett M

Journal:

Pediatr Crit Care Med.

Year:

2017

Group:

,

Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, Cook DJ; Canadian Critical Care Trials Group. High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators. Pediatr Crit Care Med. 2017 May;18(5):405-413. PMID: 28328786

A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study

First Author:

Menon K

Journal:

Pediatr Crit Care Med.

Year:

2017

Group:

,

Menon K, McNally D, O'Hearn K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K; Canadian Critical Care Trials Group. A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study. Pediatr Crit Care Med. 2017 Jun;18(6):505-512. PMID: 28406862

Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial.

First Author:

Duffett M

Journal:

Pilot Feasibility Stud

Year:

2017

Group:

,

Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group. Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial. Pilot Feasibility Stud. 2017 May 19;3:26. PMID: 28533916

Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey.

First Author:

Fontela PS

Journal:

Pediatr Crit Care Med.

Year:

2017

Group:

,

Fontela PS, Quach C, Karim ME, Willson DF, Gilfoyle E, McNally JD, Gonzales M, Papenburg J, Reynolds S, Lacroix J; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network; on behalf of the Canadian Critical Care Trials Group. Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey. Pediatr Crit Care Med. 2017 Sep;18(9):e395-e405. PMID: 28661973

Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury.

First Author:

Wilkinson AA

Journal:

BMC Pediatr

Year:

2017

Group:

, ,

Wilkinson AA, Dennis M, Simic N, Taylor MJ, Morgan BR, Frndova H, Choong K, Campbell C, Fraser D, Anderson V, Guerguerian AM, Schachar R, Hutchison J; Canadian Critical Care Trials Group (CCCTG); Canadian Critical Care Translational Biology Group (CCCTBG). Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury. BMC Pediatr. 2017 Jul 24;17(1):173. PMID: 28738850

Early Exercise in Critically Ill Youth and Children, a Preliminary Evaluation: The wEECYCLE Pilot Trial.

First Author:

Choong K

Journal:

Pediatr Crit Care Med

Year:

2017

Group:

,

Choong K, Awladthani S, Khawaji A, Clark H, Borhan A, Cheng J, Laskey S, Neu C, Sarti A, Thabane L, Timmons BW, Zheng K, Al-Harbi S; Canadian Critical Care Trials Group. Early Exercise in Critically Ill Youth and Children, a Preliminary Evaluation: The wEECYCLE Pilot Trial. Pediatr Crit Care Med. 2017 Nov;18(11):e546-e554. PMID: 28922268

Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors.

First Author:

D'Aragon F

Journal:

BMJ Open

Year:

2017

Group:

,

D'Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chassé M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program. Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors. BMJ Open. 2017 Sep 28;7(9). PMID: 28963316

Performance Monitoring in Children Following Traumatic Brain Injury Compared to Typically Developing Children.

First Author:

Wilkinson AA

Journal:

Child Neurol Open.

Year:

2017

Group:

,

Wilkinson AA, Dennis M, Taylor MJ, Guerguerian AM, Boutis K, Choong K, Campbell C, Fraser D, Hutchison J, Schachar R; Canadian Critical Care Trials Group (CCCTG). Performance Monitoring in Children Following Traumatic Brain Injury Compared to Typically Developing Children. Child Neurol Open. 2017 Oct 12;4. eCollection 2017 Jan-Dec. PMID: 29051909

2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians.

First Author:

Jung JJ

Journal:

PLoS One.

Year:

2017

Group:

, ,

Jung JJ, Pinto R, Zarychanski R, Cook DJ, Jouvet P, Marshall JC, Kumar A, Long J, Rodin R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. 2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians. PLoS One. 2017 Oct 19;12(10):e0184013. eCollection 2017. PMID: 29049285

Study protocol for a phase II dose evaluation randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study).

First Author:

McNally D

Journal:

Pilot Feasibility Stud

Year:

2017

Group:

, ,

McNally D, Amrein K, O'Hearn K, Fergusson D, Geier P, Henderson M, Khamessan A, Lawson ML, McIntyre L, Redpath S, Weiler HA, Menon K; Canadian Critical Care Trials Group.. Study protocol for a phase II dose evaluation randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study). Pilot Feasibility Stud. 2017 Dec 8;3:70. PMID: 29234503

Comparison of Consent Models in a Randomized Trial of Corticosteroids in Pediatric Septic Shock

First Author:

Menon K

Journal:

Pediatr Crit Care Med

Year:

2017

Group:

, ,

Menon K, O'Hearn K, McNally JD, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K. Comparison of Consent Models in a Randomized Trial of Corticosteroids in Pediatric Septic Shock. Pediatr Crit Care Med. 2017 Nov;18(11):1009-1018. PMID: 28817507.

Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial.

First Author:

Lamontagne F

Journal:

Intensive Care Med

Year:

2016

Group:

,

Lamontagne F, Meade MO, Hébert PC, Asfar P, Lauzier F, Seely AJ, Day AG, Mehta S, Muscedere J, Bagshaw SM, Ferguson ND, Cook DJ, Kanji S, Turgeon AF, Herridge MS, Subramanian S, Lacroix J, Adhikari NK, Scales DC, Fox-Robichaud A, Skrobik Y, Whitlock RP, Green RS, Koo KK, Tanguay T, Magder S, Heyland DK; Canadian Critical Care Trials Group. Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial. Intensive Care Med. 2016 Feb 18. [Epub ahead of print] PMID: 26891677

The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness

First Author:

Delaney JW

Journal:

Crit Care

Year:

2016

Group:

, ,

Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care. 2016 Mar 30;20(1):75. PMID: 27036638

Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial.

First Author:

O'Hearn K

Journal:

Trials

Year:

2016

Group:

, ,

O'Hearn K, McNally D, Choong K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Menon K; Canadian Critical Care Trials Group. Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial. Trials. 2016 May 6;17(1):238. PMID: 27153945