Publications

Rynne J, Mosavie M, Masse MH, Ménard J, Battista MC, Maslove DM, Del Sorbo L, St-Arnaud C, DAragon F, Fox-Robichaud A, Charbonney E, Adhikari NKJ, Lamontagne F, Shankar-Hari M; LOVIT Investigators, the Canadian Critical Care Trials Group. Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial. Intensive Care Med. 2025 Jan 7. doi: 10.1007/s00134-024-07733-9. Epub ahead of print. PMID: 39774855.

Heirali A, Heybati K, Sereeyotin J, Khan F, Yarnell C, Krewulak K, Murthy S, Burns KEA, Fowler R, Fiest K, Mehta S; Canadian Critical Care Trials Group. Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine. JAMA Netw Open. 2025 Jan 2;8(1):e2454944. doi: 10.1001/jamanetworkopen.2024.54944. PMID: 39821399.

Daneman N, Rishu AH, Pinto R, Arabi YM, Cook DJ, Hall R, Muscedere J, Parke R, Reynolds S, Rogers B, Shehabi Y, Fowler RA; BALANCE Investigators for the Canadian Critical Care Trials Group (CCCTG); Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network (AMMI CRN); Australian and New Zealand Intensive Care Society (ANZICS); Clinical Trials Group and the Australasian Society of Infectious Diseases (ASID) Clinical Research Network. Investigator-initiated randomized clinical trials in infectious diseases: the BALANCE experience. Clin Microbiol Infect. 2025 Feb 28:S1198-743X(25)00094-1. doi: 10.1016/j.cmi.2025.02.033. Epub ahead of print. PMID: 40024529.

Krewulak KD, Foster JR, Lee LA, Ryan MJ, Rhyno D, Reznikov V, Garros D, Seabrook JA, Curran J, Slumkoski C, Walls M, Fiest KM; Canadian Critical Care Trials Group RFP-PICU research collaboration. Defining Priorities for Canadian PICU Family Presence Policies Under Changing Contexts: A Qualitative Focus Group Study. J Pediatr Health Care. 2025 Apr 1:S0891-5245(25)00065-3. doi: 10.1016/j.pedhc.2025.03.002. Epub ahead of print. PMID: 40167417.

O’Grady, H.K., Smith, K., Dalziel, S. et al. Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed methods study within a trial (SWAT). Res Involv Engagem 11, 37 (2025). PMID: 40281565 PMCID: PMC12032667 DOI: 10.1186/s40900-025-00705-3

Choong K, Fraser DD, Al-Farsi A, Awlad Thani S, Cameron S, Clark H, Cuello C, Debigaré S, Ewusie J, Kennedy K, Kho ME, Krasevich K, Martin CM, Thabane L, Nanji J, Watts C, Simpson A, Todt A, Wong J, Xie F, Vu M, Cupido C; Canadian Critical Care Trials Group. Early Rehabilitation in Critically ill Children: A Two Center Implementation Study. Pediatr Crit Care Med. 2024 Feb 1;25(2):92-105. doi: 10.1097/PCC.0000000000003343. Epub 2024 Jan 19. PMID: 38240534.

Choong K, Fraser DD, Cameron S, Cuello C, Debigaré S, Ewusie J, Kho ME, Krasevich K, Martin CM, Thabane L, Todt A, Cupido C; Canadian Critical Care Trials Group. Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study. Pediatr Crit Care Med. 2024 Feb 2. doi: 10.1097/PCC.0000000000003467. Epub ahead of print. PMID: 38305699.

Vanstone MG, Krewulak K, Taneja S, Swinton M, Fiest K, Burns KEA, Debigare S, Dionne JC, Guyatt G, Marshall JC, Muscedere JG, Deane AM, Finfer S, Myburgh JA, Gouskos A, Rochwerg B, Ball I, Mele T, Niven DJ, English SW, Verhovsek M, Cook DJ; Canadian Critical Care Trials Group. Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives. J Crit Care. 2024 Mar 5;81:154761. doi: 10.1016/j.jcrc.2024.154761. Epub ahead of print. PMID: 38447306.

Cook D, Deane A, Dionne JC, Lauzier F, Marshall JC, Arabi YM, Wilcox ME, Ostermann M, Al-Fares A, Heels-Ansdell D, Zytaruk N, Thabane L, Finfer S; REVISE Investigators and the Canadian Critical Care Trials Group. Adjudication of a primary trial outcome: Results of a calibration exercise and protocol for a large international trial. Contemp Clin Trials Commun. 2024 Mar 5;39:101284. doi: 10.1016/j.conctc.2024.101284. PMID: 38559746; PMCID: PMC10979133.

Muscedere J, Bagshaw SM, Kho M, Mehta S, Cook DJ, Boyd JG, Sibley S, Wang HT, Archambault PM, Albert M, Rewa OG, Ball I, Norman PA, Day AG, Hunt M, Loubani O, Mele T, Sarti AJ, Shahin J; Canadian Critical Care Trials Group. Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study. Intensive Care Med. 2024 May 15. doi: 10.1007/s00134-024-07404-9. Epub ahead of print. PMID: 38748266.

Cani E, Tsang JLY, Binnie A, Dos Santos CC, Fowler R, Lamontagne F, Mehta S, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG), and the Canadian Critical Care Trials Group (CCCTG). Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers. PLoS One. 2024 May 17;19(5):e0303304. doi: 10.1371/journal.pone.0303304. PMID: 38758919; PMCID: PMC11101101.

Turgeon AF, Fergusson DA, Clayton L, Patton MP, Neveu X, Walsh TS, Docherty A, Malbouisson LM, Pili-Floury S, English SW, Zarychanski R, Moore L, Bonaventure PL, Laroche V, Verret M, Scales DC, Adhikari NKJ, Greenbaum J, Kramer A, Rey VG, Ball I, Khwaja K, Wise M, Harvey D, Lamontagne F, Chabanne R, Algird A, Krueper S, Pottecher J, Zeiler F, Rhodes J, Rigamonti A, Burns KEA, Marshall J, Griesdale DE, Sisconetto LS, Kutsogiannis DJ, Roger C, Green R, Boyd JG, Wright J, Charbonney E, Nair P, Astles T, Sy E, Hébert PC, Chassé M, Gomez A, Ramsay T, Taljaard M, Fox-Robichaud A, Tinmouth A, St-Onge M, Costerousse O, Lauzier F; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain Injury Research Consortium. Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med. 2024 Jun 13. doi: 10.1056/NEJMoa2404360. Epub ahead of print. PMID: 38869931. New England Journal of Medicine/NEJM

Ting DK, Rosychuk RJ, Hau JP, Righolt CH, Kwong JC, Skowronski DM, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Leveraging a clinical emergency department dataset to estimate two-dose COVID-19 vaccine effectiveness and duration of protection in Canada. Vaccine. 2024 Jun 14:S0264-410X(24)00699-6. doi: 10.1016/j.vaccine.2024.06.025. Epub ahead of print. PMID: 38879407.

Cook D, Taneja S, Krewulak K, Zytaruk N, Menon K, Fowler R, Lamontagne F, Kho ME, Rochwerg B, Masse MH, Lauzier F, O'Hearn K, Adhikari NKJ, Burns KEA, Bosma KJ, English S, McNally D, Turgeon AF, Brochard L, Parker M, Clayton L, Rishu A, Tuttle A, Daneman N, Fergusson D, McIntyre L, Kelly L, Orr S, Austin P, Mulligan S, Fiest K; Canadian Critical Care Trials Group and Canadian Clinical Research Network. Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic. JAMA Netw Open. 2024 Jul 1;7(7):e2420458. doi: 10.1001/jamanetworkopen.2024.20458. PMID: 38995645; PMCID: PMC11245722.

Andersen CR, Presseau J, Shea B, Marti ML, McCoy M, Fernie G, McIntyre L, Delaney A, Chassé M, Saigle V, Marshall S, Fergusson DA, Graham I, Brehaut J, Turgeon AF, Lauzier F, Tugwell P, Zha X, Talbot P, Muscedere J, Marshall JC, Thavorn K, Griesdale D; Canadian Critical Care Trials Group; English SW. What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey. Transl Stroke Res. 2024 Jul 13. doi: 10.1007/s12975-024-01271-8. Epub ahead of print. PMID: 38997598.

Ganesan SL, Garros D, Foster J, Di Genova T, Fontela PS, Murthy S, for the Canadian Pediatric Intensive Care Consortium (CanPICC) of the Canadian Critical Care Trials Group (CCCTG)., Pediatric critical care capacity in Canada, Paediatrics & Child Health, 2024;, pxae024, https://doi.org/10.1093/pch/pxae024

Parker MJ, Foster G, Fox-Robichaud A, Choong K, Mbuagbaw L, Thabane L; With the SQUEEZE Trial Steering Committee and on behalf of the SQUEEZE Trial Investigators, the Canadian Critical Care Trials Group, Pediatric Emergency Research Canada, and the Canadian Critical Care Translational Biology Group. Statistical analysis plan for the SQUEEZE trial: A trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy vs. usual care (SQUEEZE). Crit Care Resusc. 2024 Jun 22;26(2):123-134. doi: 10.1016/j.ccrj.2024.02.002. PMID: 39072232; PMCID: PMC11282343.

Panchuk J, Hobson S, Dahl J, Moulson A, Jaworsky D; SPRINT-SARI Canada Investigators and the Canadian Critical Care Trials Group. COVID-19 in a rural intensive care unit in Northern British Columbia: Descriptive analysis of outcomes and demands on rural resources. Can J Rural Med. 2024 Jul 1;29(3):109-116. English, French. doi: 10.4103/cjrm.cjrm_42_23. Epub 2024 Aug 20. PMID: 39155633. Full Article Link.

Heirali A, Mehta S, Li Y, Rochwerg B, Maratta C, Charbonney E, Burns KEA, O'Hearn K, Menon K, Fowler R, Mohsen S, Murthy S, Fiest KM; Canadian Critical Care Trials Group. An Equity, Diversity, and Inclusion glossary for sociodemographic determinants of health within critical care medicine. Can J Anaesth. 2024 Sep 6. English. doi: 10.1007/s12630-024-02824-z. Epub ahead of print. PMID: 39242476.

O'Hearn K, Menon K, Albrecht L, Amrein K, Britz-McKibbin P, Cayouette F, Choong K, Foster JR, Fergusson DA, Floh A, Fontela P, Geier P, Gilfoyle E, Guerra GG, Gunz A, Helmeczi E, Khamessan A, Joffe AR, Lee L, McIntyre L, Murthy S, Parsons SJ, Ramsay T, Ryerson L, Tucci M, McNally D; Canadian Critical Care Trials Group. Rapid normalization of vitamin D deficiency in PICU (VITdALIZE-KIDS): study protocol for a phase III, multicenter randomized controlled trial. Trials. 2024 Sep 19;25(1):619. doi: 10.1186/s13063-024-08461-7. PMID: 39300483.