Publications

Rynne J, Mosavie M, Masse MH, Ménard J, Battista MC, Maslove DM, Del Sorbo L, St-Arnaud C, DAragon F, Fox-Robichaud A, Charbonney E, Adhikari NKJ, Lamontagne F, Shankar-Hari M; LOVIT Investigators, the Canadian Critical Care Trials Group. Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial. Intensive Care Med. 2025 Jan 7. doi: 10.1007/s00134-024-07733-9. Epub ahead of print. PMID: 39774855.

Banoei MM, Hutchison J, Panenka W, Wong A, Wishart DS, Winston BW; Canadian Biobank and Database for Traumatic Brain Injury (CanTBI) study investigators; Canadian Critical Care Translational Biology Group (CCCTBG); Canadian Traumatic Brain Injury Research Consortium (CTRC). Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity. Crit Care. 2025 Jan 15;29(1):26. doi: 10.1186/s13054-025-05258-1. PMID: 39815318.

Heirali A, Heybati K, Sereeyotin J, Khan F, Yarnell C, Krewulak K, Murthy S, Burns KEA, Fowler R, Fiest K, Mehta S; Canadian Critical Care Trials Group. Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine. JAMA Netw Open. 2025 Jan 2;8(1):e2454944. doi: 10.1001/jamanetworkopen.2024.54944. PMID: 39821399.

Daneman N, Rishu AH, Pinto R, Arabi YM, Cook DJ, Hall R, Muscedere J, Parke R, Reynolds S, Rogers B, Shehabi Y, Fowler RA; BALANCE Investigators for the Canadian Critical Care Trials Group (CCCTG); Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network (AMMI CRN); Australian and New Zealand Intensive Care Society (ANZICS); Clinical Trials Group and the Australasian Society of Infectious Diseases (ASID) Clinical Research Network. Investigator-initiated randomized clinical trials in infectious diseases: the BALANCE experience. Clin Microbiol Infect. 2025 Feb 28:S1198-743X(25)00094-1. doi: 10.1016/j.cmi.2025.02.033. Epub ahead of print. PMID: 40024529.

Krewulak KD, Foster JR, Lee LA, Ryan MJ, Rhyno D, Reznikov V, Garros D, Seabrook JA, Curran J, Slumkoski C, Walls M, Fiest KM; Canadian Critical Care Trials Group RFP-PICU research collaboration. Defining Priorities for Canadian PICU Family Presence Policies Under Changing Contexts: A Qualitative Focus Group Study. J Pediatr Health Care. 2025 Apr 1:S0891-5245(25)00065-3. doi: 10.1016/j.pedhc.2025.03.002. Epub ahead of print. PMID: 40167417.

Cani E, Dwivedi D, Carlin S, Sharma N, Chen A, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG). Impact of PAD4 deficiency in a fecal-induced peritonitis model of sepsis. J Thromb Haemost. 2025 Apr 6:S1538-7836(25)00205-3. doi: 10.1016/j.jtha.2025.03.025. Epub ahead of print. PMID: 40199446.

O’Grady, H.K., Smith, K., Dalziel, S. et al. Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed methods study within a trial (SWAT). Res Involv Engagem 11, 37 (2025). PMID: 40281565 PMCID: PMC12032667 DOI: 10.1186/s40900-025-00705-3

Dionne JC, Johnstone J, Heels-Ansdell D, Tahvildar Khazaneh P, Zytaruk N, Clarke F, Hand L, Millen T, Dechert W, Porteous R, Auld F, Hunt M, Campbell E, Bentall T, Campbell T, Smith O, Rose L, Arabi YM, Duan E, Wilcox ME, McIntyre L, Rochwerg B, Karachi T, Adhikari NK, Charbonney E, St-Arnaud C, Kristof A, Khwaja K, Marquis F, Zarychanski R, Golan E, Cook D; PROSPECT Research Coordinators Group, the PROSPECT Investigators and the Canadian Critical Care Trials Group. Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy. Crit Care Med. 2025 Jun 1;53(6):e1247-e1256. doi: 10.1097/CCM.0000000000006667. Epub 2025 Apr 3. PMID: 40459385.

McIntyre L, Fergusson D, McArdle T, English S, Cook DJ, Fox-Robichaud AE, Martin C, Marshall J, Pugliese M, Menon K, Thavorn K, Graham ID, Hawken S, Iyengar A, Kyeremanteng K, Saginur R, Seely AJE, Stiell IG, Bainbridge D, Weijer C, Taljaard M; Canadian Critical Care Trials Group. A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline. N Engl J Med. 2025 Jun 12. doi: 10.1056/NEJMoa2416761. Epub ahead of print. PMID: 40503714.

Bosma K, Burns KEA, Martin CM, Skrobik Y, Mancebo Cortés J, Mulligan S, Lafreniere-Roula M, +40 ,for the PROMIZING Study Investigators, the Canadian Critical Care Trials Group, and the REVA Network. Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N Engl J Med. 2025 Jun 13. DOI: 10.1056/NEJMoa2505708. Epub ahead of print. PMID:

Chassé M, Shankar JJS, Fergusson DA, et al. Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria. JAMA Neurol. Published online June 13, 2025. doi:10.1001/jamaneurol.2025.2375

Sarti AJ, Sutherland S, Meade M, Weiss MJ, Dhanani S, Lotherington KM, Landriault A, Vanderspank-Wright B, Valiani S, Keenan S, Kramer AH, Beed S, Brennan J, Cardinal P, Chassé M, Nickerson P, Shemie SD; Canadian Critical Care Trials Group (CCCTG). Organ donation after death determination by circulatory criteria: family members' experiences with withdrawal of life-sustaining measures in Canadian intensive care units. Can J Anaesth. 2025 Jun 26. English. doi: 10.1007/s12630-025-02978-4. Epub ahead of print. PMID: 40571891.

Carlin S, Dwivedi DJ, Cani E, Sharma N, Venegas-Pino DE, Lalu M, Mendelson AA, McDonald B, Werstuck GH, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG). Impact of streptozotocin (STZ)-induced hyperglycemia on the host response to sepsis. J Thromb Haemost. 2025 Jul 16:S1538-7836(25)00427-1. doi: 10.1016/j.jtha.2025.07.004. Epub ahead of print. PMID: 40680936.

Tarride JE, Blackhouse G, Rochwerg B, Fox-Robichaud AE, Ball IM, Burns KEA, Seely AJE, Muscedere J, Berney S, Pastva AM, D'Aragon F, Archambault PM, Tsang JL, Verceles AC, Serri K, Reeve BK, English SW, Lamontagne F, Karachi T, Duan EH, Strong G, Kelly L, Reid JC, Rudkowski JC, O'Grady HK, Herridge MS, Thabane L, Heels-Ansdell D, Cook DJ, Kho ME; Canadian Critical Care Trials Group. Cost-Effectiveness of In-Bed Cycling and Routine Physiotherapy for Patients Receiving Mechanical Ventilation. JAMA Netw Open. 2025 Sep 2;8(9):e2529399. doi: 10.1001/jamanetworkopen.2025.29399. PMID: 40920382; PMCID: PMC12418132.

Longstaff H, Lucas B, Schichter B, Murthy S, Flamenbaum J; Canadian Critical Care Trials Group. Core elements of consent documentation for clinical research in Canada: guidance for policy. CMAJ. 2025 Sep 14;197(30):E941-E952. doi: 10.1503/cmaj.250500. PMID: 40953890.

Ménard J, Cohen D, Masse MH, Adhikari NKJ, Cook D, Heels-Ansdell D, Sprague S, D'Aragon F, Kho M, Lamontagne F, Cumyn A. Communicating Results of a Critical Care Trial - A Survey of Participants and Family Members. NEJM Evid. 2025 Sep 17:EVIDoa2500056. doi: 10.1056/EVIDoa2500056. Epub ahead of print. PMID: 40960889.

Suleman S, O'Brien JM, McIlduff C, Benson B, Labine N, Khan S, Tse T, Kawchuk J, Kapur P, Abramyk C, Reimche E, Gondal T, Valiani S; Canadian Critical Care Trials Group. Opportunities and threats to communication and relationships with patients and patients' loved ones along an intensive care unit journey: a qualitative journey mapping study. Can J Anaesth. 2025 Sep 18. English. doi: 10.1007/s12630-025-03037-8. Epub ahead of print. PMID: 40968261.

Thabane A, Heels-Ansdell D, Zytaruk N, Johnstone J, Lauzier F, Arabi YM, Muscedere J, Clarke F, Hand L, Watpool I, Porteous R, Sandu G, Santos M, Tassy D, Marshall J, McIntyre L, Ball I, Rochwerg B, Karachi T, Zarychanski R, Marquis F, Friedrich JO, Lysecki P, Cook D; PROSPECT Investigators and the Canadian Critical Care Trials Group. Coenrollment of critically ill patients in PROSPECT: characteristics and association with treatment efficacy and safety. Trials. 2025 Sep 26;26(1):370. doi: 10.1186/s13063-025-09028-w. PMID: 41013603; PMCID: PMC12465574.

Jerath A, Slessarev M, Martin C, D'Aragon F, Carrier FM, Senaratne J, Meggison H, Hooper J, Alexandros Cavayas Y, Goligher EC, Couture EJ, Randall I, Hatzakorzian R, Jacka M, Wiener-Kronish J, Xie Z, Pinto RL, Cuthbertson B; SAVE-ICU Investigators and the Canadian Critical Care Trials Group. Sedating with volatile anaesthetics for COVID-19 and non-COVID-19 acute hypoxaemic respiratory failure patients in ICU (SAVE-ICU): protocol for a randomised clinical trial. BMJ Open. 2025 Oct 13;15(10):e108441. doi: 10.1136/bmjopen-2025-108441. PMID: 41083292.

Lee LA, Krewulak KD, Gilfoyle E, Choong K, O'Hearn K, Todd M, Foster JR, Birnie KA, Doig CJ, Letourneau N, Fiest KM; Canadian Critical Care Trials Group. Identifying barriers and facilitators to therapeutic cuddling in the paediatric intensive care unit: A survey guided by the theoretical domains framework. Aust Crit Care. 2025 Oct 1;38(6):101440. doi: 10.1016/j.aucc.2025.101440. Epub ahead of print. PMID: 41037838.

Angriman F, Ferreyro BL, Rochwerg B, Sklar M, Adhikari N, Bagshaw SM, Brochard L, Cuthbertson B, Del Sorbo L, Fowler R, Geagea A, Granton JT, Mehta S, Munshi L, Muscedere J, Nardi J, Parhar K, Pinto RL, Piquette D, Seely A, Slessarev M, Tobin S, Scales DC, Ferguson ND; HONOUR Investigators and the Canadian Critical Care Trials Group. High-flow nasal Oxygen with or without alternating helmet Non-invasive ventilation for Oxygenation sUpport in acute Respiratory failure (HONOUR): a protocol for a pilot randomised controlled trial. BMJ Open. 2025 Oct 27;15(10):e111526. doi: 10.1136/bmjopen-2025-111526. PMID: 41145249.

SuDDICU Investigators for the Australia and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group; Cuthbertson BH, Billot L, Campbell MK, Daneman N, Davis JS, Delaney A, Devaux A, Ferguson ND, Finfer SR, Fowler R, Gordon AC, Hammond NE, Klein G, Li Q, Marshall J, Micallef S, Murthy S, Mysore J, Naik C, Patel C, Pinto R, Rose L, Seppelt IM, Venkatesh B, Young PJ, Myburgh JA. Selective Decontamination of the Digestive Tract during Ventilation in the ICU. N Engl J Med. 2025 Oct 29. doi: 10.1056/NEJMoa2506398. Epub ahead of print. PMID: 41159880.

Choong K, Fraser DD, Al-Farsi A, Awlad Thani S, Cameron S, Clark H, Cuello C, Debigaré S, Ewusie J, Kennedy K, Kho ME, Krasevich K, Martin CM, Thabane L, Nanji J, Watts C, Simpson A, Todt A, Wong J, Xie F, Vu M, Cupido C; Canadian Critical Care Trials Group. Early Rehabilitation in Critically ill Children: A Two Center Implementation Study. Pediatr Crit Care Med. 2024 Feb 1;25(2):92-105. doi: 10.1097/PCC.0000000000003343. Epub 2024 Jan 19. PMID: 38240534.

Choong K, Fraser DD, Cameron S, Cuello C, Debigaré S, Ewusie J, Kho ME, Krasevich K, Martin CM, Thabane L, Todt A, Cupido C; Canadian Critical Care Trials Group. Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study. Pediatr Crit Care Med. 2024 Feb 2. doi: 10.1097/PCC.0000000000003467. Epub ahead of print. PMID: 38305699.