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Early Rehabilitation in Critically ill Children: A Two Center Implementation Study

First Author:

Choong K

Journal:

Pediatr Crit Care Med.

Year:

2024

Group:

,

Choong K, Fraser DD, Al-Farsi A, Awlad Thani S, Cameron S, Clark H, Cuello C, Debigaré S, Ewusie J, Kennedy K, Kho ME, Krasevich K, Martin CM, Thabane L, Nanji J, Watts C, Simpson A, Todt A, Wong J, Xie F, Vu M, Cupido C; Canadian Critical Care Trials Group. Early Rehabilitation in Critically ill Children: A Two Center Implementation Study. Pediatr Crit Care Med. 2024 Feb 1;25(2):92-105. doi: 10.1097/PCC.0000000000003343. Epub 2024 Jan 19. PMID: 38240534.

Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study

First Author:

Choong K

Journal:

Pediatr Crit Care Med

Year:

2024

Group:

,

Choong K, Fraser DD, Cameron S, Cuello C, Debigaré S, Ewusie J, Kho ME, Krasevich K, Martin CM, Thabane L, Todt A, Cupido C; Canadian Critical Care Trials Group. Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study. Pediatr Crit Care Med. 2024 Feb 2. doi: 10.1097/PCC.0000000000003467. Epub ahead of print. PMID: 38305699.

Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis

First Author:

Hum C

Journal:

Stem Cells Transl Med

Year:

2024

Group:

,

Hum C, Tahir U, Mei SHJ, Champagne J, Fergusson DA, Lalu M, Stewart DJ, Walley K, Marshall J, Dos Santos CC, Winston BW, Mendelson AA, Dave C, McIntyre L; Canadian Critical Care Translational Biology Group. Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl Med. 2024 Feb 21:szae003. doi: 10.1093/stcltm/szae003. Epub ahead of print. PMID: 38381583.

Prognostic association between d-dimer thresholds and 30-day pulmonary embolism diagnosis among emergency department patients with suspected SARS-CoV-2 infection: a Canadian COVID-19 Emergency Department Rapid Response Network study

First Author:

Lin K

Journal:

CJEM

Year:

2023

Group:

Lin K, Xu K, Daoust R, Taylor J, Rosychuk RJ, Hau JP, Davis P, Clark G, McRae AD, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, the Canadian Critical Care Trials Group. Prognostic association between d-dimer thresholds and 30-day pulmonary embolism diagnosis among emergency department patients with suspected SARS-CoV-2 infection: a Canadian COVID-19 Emergency Department Rapid Response Network study. CJEM. 2023 Jan 10. doi: 10.1007/s43678-022-00440-8. Epub ahead of print. PMID: 36624252.

FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate

First Author:

McIntyre LA

Journal:

BMJ Open

Year:

2023

Group:

McIntyre LA, Fergusson DA, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Cook DJ, Graham ID, Hawken S, McCartney C, Menon K, Saginur R, Seely A, Stiell I, Thavorn K, Weijer C, Iyengar A, Muscedere J, Forster AJ, Taljaard M; Canadian Critical Care Trials Group. FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate. BMJ Open. 2023 Feb 3;13(2):e067142. doi: 10.1136/bmjopen-2022-067142. PMID: 36737087; PMCID: PMC9900065.

A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies

First Author:

Hunniford VT

Journal:

eLIFE

Year:

2023

Group:

Hunniford VT, Grudniewicz A, Fergusson DA, Montroy J, Grigor E, Lansdell C, Lalu MM; Canadian Critical Care Translational Biology Group. A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies. Elife. 2023 Mar 9;12:e76300. doi: 10.7554/eLife.76300. Epub ahead of print. PMID: 36892457.

Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study

First Author:

Bosma, KA

Journal:

Trials

Year:

2023

Group:

Bosma KJ, Martin CM, Burns KEA, Mancebo Cortes J, Suárez Montero JC, Skrobik Y, Thorpe KE, Amaral ACK, Arabi Y, Basmaji J, Beduneau G, Beloncle F, Carteaux G, Charbonney E, Demoule A, Dres M, Fanelli V, Geagea A, Goligher E, Lellouche F, Maraffi T, Mercat A, Rodriguez PO, Shahin J, Sibley S, Spadaro S, Vaporidi K, Wilcox ME, Brochard L; Canadian Critical Care Trials Group and; REVA Network. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials. 2023 Mar 27;24(1):232. doi: 10.1186/s13063-023-07163-w. PMID: 36973743

Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocolSyst Rev

First Author:

Zhang M

Journal:

Syst Rev

Year:

2023

Group:

Zhang M, Fergusson DA, Sharma R, Khoo C, Mendelson AA, McDonald B, Macala KF, Sharma N, Gill SE, Fiest KM, Lehmann C, Shorr R, Jahandideh F, Bourque SL, Liaw PC, Fox-Robichaud A, Lalu MM; Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform. Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol. Syst Rev. 2023 Mar 21;12(1):50. doi: 10.1186/s13643-023-02189-2. PMID: 36945012; PMCID: PMC10029211

Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study

First Author:

Johnstone J

Journal:

J Crit Care

Year:

2023

Group:

Johnstone J, Muscedere J, Dionne J, Duan E, Rochwerg B, Centofanti J, Oczkowski S, Lauzier F, Marshall J, Heels-Ansdell D, Daneman N, Mehta S, Arabi Y, Zytaruk N, Dodek P, Adhikari NK, Karachi T, Charbonney E, Stelfox HT, Kristof AS, Ball I, Hand L, Fowler R, Zarychanski R, Arnaud CS, Takaoka A, Kutsogiannis J, Khwaja K, Sligl W, Loubani O, Tsang J, Lamarche D, Bowdish D, Surette M, Cook D; Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study. J Crit Care. 2023 Mar 2:154284. doi: 10.1016/j.jcrc.2023.154284. Epub ahead of print. PMID: 36870801

Sensitivity and Diagnostic Yield of the First SARS-CoV-2 Nucleic Acid Amplification Test Performed for Patients Presenting to the Hospital

First Author:

Hohl CM

Journal:

JAMA Netw Open

Year:

2023

Group:

Hohl CM, Hau JP, Vaillancourt S, Grant J, Brooks SC, Morrison LJ, Perry JJ, Rosychuk RJ; CCEDRRN investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Sensitivity and Diagnostic Yield of the First SARS-CoV-2 Nucleic Acid Amplification Test Performed for Patients Presenting to the Hospital. JAMA Netw Open. 2022 Oct 3;5(10):e2236288. doi: 10.1001/jamanetworkopen.2022.36288. PMID: 36223119; PMCID: PMC9557877

Addressing health care inequities in Canadian critical care through inclusive science: a pilot tool for standardized data collection

First Author:

Li, Y

Journal:

Can J Anaesth

Year:

2023

Group:

Li Y, Fiest K, Burns KEA, O'Hearn K, Maratta C, Menon K, Rochwerg B, Murthy S, Fowler R, Mehta S; Canadian Critical Care Trials Group. Addressing health care inequities in Canadian critical care through inclusive science: a pilot tool for standardized data collection. Can J Anaesth. 2023 May 10. English. doi: 10.1007/s12630-023-02450-1. Epub ahead of print. PMID: 37165123.

Death determination by neurologic criteria-what do families understand?

First Author:

Sarti AJ

Journal:

Can J Anaesth

Year:

2023

Group:

Sarti AJ, Sutherland S, Meade M, Hornby L, Wilson LC, Landriault A, Vanderspank-Wright B, Valiani S, Keenan S, Weiss MJ, Werestiuk K, Beed S, Kramer AH, Kawchuk J, Cardinal P, Dhanani S, Lotherington K, Pagliarello G, Chassé M, Gatien M, Parsons K, Chandler JA, Nickerson P, Shemie SD; Canadian Critical Care Trials Group (CCCTG). Death determination by neurologic criteria-what do families understand? Can J Anaesth. 2023 Apr;70(4):637-650. doi: 10.1007/s12630-023-02416-3. Epub 2023 May 2. Erratum in: Can J Anaesth. 2023 May 30;: PMID: 37131029; PMCID: PMC10203015.

Full article: https://pubmed.ncbi.nlm.nih.gov/37131029/

Correction: https://pubmed.ncbi.nlm.nih.gov/37253861/

Effect of red blood cell storage time in pediatric cardiac surgical patients: a subgroup analysis of a randomized controlled trial

First Author:

Martin SM

Journal:

JTCVS Open

Year:

2023

Group:

Martin SM, Tucci M, Spinella PC, Ducruet T, Fergusson DA, Freed DH,
Lacroix J, Poirier N, Ben Sivarajan V, Steiner ME, Willems A, Guerra GG, on behalf of the ABC-PICU
Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis
Investigators (PALISI) Network, the BloodNet Pediatric Critical Care Blood Research Network, and the
Groupe Francophone de Réanimation et Urgences Pédiatriques, Effect of red blood cell storage time in
pediatric cardiac surgical patients: a subgroup analysis of a randomized controlled trial, JTCVS Open
(2023), doi: https://doi.org/10.1016/j.xjon.2023.04.022.

Sex differences in thromboprophylaxis of the critically ill: a secondary analysis of a randomized trial.

First Author:

Burns KEA

Journal:

Can J Anaesth

Year:

2023

Group:

Burns KEA, Heels-Ansdell D, Thabane L, Kahn SR, Lauzier F, Mehta S, Ostermann M, Bhuptani P, Crowther MA, Finfer S, Cook DJ; PROTECT Investigators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Sex differences in thromboprophylaxis of the critically ill: a secondary analysis of a randomized trial. Can J Anaesth. 2023 Jun 13. English. doi: 10.1007/s12630-023-02457-8. Epub ahead of print. PMID: 37310606.

Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients.

First Author:

Kho ME

Journal:

BMJ Open

Year:

2023

Group:

Kho ME, Reid J, Molloy AJ, Herridge MS, Seely AJ, Rudkowski JC, Buckingham L, Heels-Ansdell D, Karachi T, Fox-Robichaud A, Ball IM, Burns KEA, Pellizzari JR, Farley C, Berney S, Pastva AM, Rochwerg B, D'Aragon F, Lamontagne F, Duan EH, Tsang JLY, Archambault P, English SW, Muscedere J, Serri K, Tarride JE, Mehta S, Verceles AC, Reeve B, O'Grady H, Kelly L, Strong G, Hurd AH, Thabane L, Cook DJ; CYCLE Investigators and the Canadian Critical Care Trials Group. Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients. BMJ Open. 2023 Jun 23;13(6):e075685. doi: 10.1136/bmjopen-2023-075685. PMID: 37355270.

Accuracy of Self-Reported COVID-19 Vaccination Status Compared With a Public Health Vaccination Registry in Qu├ębec: Observational Diagnostic Study

First Author:

Archambault PM

Journal:

JMIR Public Health Surveill

Year:

2023

Group:

Archambault PM, Rosychuk RJ, Audet M, Bola R, Vatanpour S, Brooks SC, Daoust R, Clark G, Grant L, Vaillancourt S, Welsford M, Morrison LJ, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Accuracy of Self-Reported COVID-19 Vaccination Status Compared With a Public Health Vaccination Registry in Québec: Observational Diagnostic Study. JMIR Public Health Surveill. 2023 Jun 16;9:e44465. doi: 10.2196/44465. PMID: 37327046; PMCID: PMC10278735.

Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study

First Author:

Teo K

Journal:

CMAJ Open

Year:

2023

Group:

Teo K, Fowler RA, Adhikari NKJ, Rishu A, Tsang JLY, Binnie A, Murthy S; Canadian Critical Care Trials Group. Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study. CMAJ Open. 2023 Jul 4;11(4):E615-E620. doi: 10.9778/cmajo.20220129. PMID: 37402556.

Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months.

First Author:

Banoei MM

Journal:

Crit Care

Year:

2023

Group:

Banoei MM, Lee CH, Hutchison J, Panenka W, Wellington C, Wishart DS, Winston BW; Canadian biobank, database for Traumatic Brain Injury (CanTBI) investigators, the Canadian Critical Care Translational Biology Group (CCCTBG), the Canadian Traumatic Brain Injury Research, Clinical Network (CTRC). Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months. Crit Care. 2023 Jul 22;27(1):295. doi: 10.1186/s13054-023-04573-9. PMID: 37481590; PMCID: PMC10363297.

A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)

First Author:

O'Hearn K

Journal:

BMC Pediatr

Year:

2023

Group:

O'Hearn K, Menon K, Weiler HA, Amrein K, Fergusson D, Gunz A, Bustos R, Campos R, Catalan V, Roedl S, Tsampalieros A, Barrowman N, Geier P, Henderson M, Khamessan A, Lawson ML, McIntyre L, Redpath S, Jones G, Kaufmann M, McNally D; Canadian Critical Care Trials Group. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study). BMC Pediatr. 2023 Aug 14;23(1):397. doi: 10.1186/s12887-023-04205-9. PMID: 37580663; PMCID: PMC10424361.

A survey of pediatric intensive care unit clinician experience with restricted family presence during COVID-19

First Author:

Foster JR

Journal:

Can J Anaesth

Year:

2023

Group:

Foster JR, Lee LA, Seabrook JA, Ryan M, Slumkoski C, Walls M, Betts LJ, Burgess SA, Moghadam N, Garros D; Canadian Critical Care Trials Group. A survey of pediatric intensive care unit clinician experience with restricted family presence during COVID-19. Can J Anaesth. 2023 Aug 23. English. doi: 10.1007/s12630-023-02547-7. Epub ahead of print. PMID: 37610552.

Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial

First Author:

Dennis BB

Journal:

Trials

Year:

2023

Group:

Dennis BB, Thabane L, Heels-Ansdell D, Dionne JC, Binnie A, Tsang J, Guyatt G, Ahmed A, Lauzier F, Deane A, Arabi Y, Marshall J, Zytaruk N, Saunders L, Finfer S, Myburgh J, Muscedere J, English S, Ostermann M, Hardie M, Knowles S, Cook D; REVISE Investigators the Canadian Critical Care Trials Group. Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial. Trials. 2023 Aug 30;24(1):561. doi: 10.1186/s13063-023-07589-2. PMID: 37644556; PMCID: PMC10466724.

Differences in directives to limit treatment and discontinue mechanical ventilation between elderly and very elderly patients: a substudy of a multinational observational study

First Author:

Burns KEA

Journal:

Intensive Care Med

Year:

2023

Group:

Burns KEA, Cook DJ, Xu K, Dodek P, Villar J, Jones A, Kapadia FN, Gattas DJ, Epstein SK, Pelosi P, Kefala K, Meade MO, Rizvi L; Canadian Critical Care Trials Group. Differences in directives to limit treatment and discontinue mechanical ventilation between elderly and very elderly patients: a substudy of a multinational observational study. Intensive Care Med. 2023 Sep 22. doi: 10.1007/s00134-023-07188-4. Epub ahead of print. PMID: 37736783.

Comparing methods to classify admitted patients with SARS-CoV-2 as admitted for COVID-19 versus with incidental SARS-CoV-2: A cohort study

First Author:

Hohl CM

Journal:

PLoS One

Year:

2023

Group:

Hohl CM, Cragg A, Purssel E, McAlister FA, Ting DK, Scheuermeyer F, Stachura M, Grant L, Taylor J, Kanu J, Hau JP, Cheng I, Atzema CL, Bola R, Morrison LJ, Landes M, Perry JJ, Rosychuk RJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Comparing methods to classify admitted patients with SARS-CoV-2 as admitted for COVID-19 versus with incidental SARS-CoV-2: A cohort study. PLoS One. 2023 Sep 26;18(9):e0291580. doi: 10.1371/journal.pone.0291580. PMID: 37751455; PMCID: PMC10522023.

Frequency of screening and SBT Technique Trial-North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan

First Author:

Burns KEA

Journal:

Trials

Year:

2023

Group:

Burns KEA, Lafrienier-Roula M, Hill NS, Cook DJ, Seely AJE, Rochwerg B, Mayette M, D'Aragon F, Devlin JW, Dodek P, Tanios M, Gouskos A, Turgeon AF, Aslanian P, Sia YT, Beitler JR, Hyzy R, Criner GJ, Kassis EB, Tsang JLY, Meade MO, Liebler JM, Wong JTY, Thorpe KE; Canadian Critical Care Trials Group. Frequency of screening and SBT Technique Trial-North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan. Trials. 2023 Oct 2;24(1):626. doi: 10.1186/s13063-023-07079-5. PMID: 37784109; PMCID: PMC10544476.

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