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Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial

First Author:

Rynne J

Journal:

Intensive Care Med

Year:

2025

Group:

Rynne J, Mosavie M, Masse MH, Ménard J, Battista MC, Maslove DM, Del Sorbo L, St-Arnaud C, DAragon F, Fox-Robichaud A, Charbonney E, Adhikari NKJ, Lamontagne F, Shankar-Hari M; LOVIT Investigators, the Canadian Critical Care Trials Group. Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial. Intensive Care Med. 2025 Jan 7. doi: 10.1007/s00134-024-07733-9. Epub ahead of print. PMID: 39774855.

Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity

First Author:

Banoei MM

Journal:

Crit Care

Year:

2025

Group:

Banoei MM, Hutchison J, Panenka W, Wong A, Wishart DS, Winston BW; Canadian Biobank and Database for Traumatic Brain Injury (CanTBI) study investigators; Canadian Critical Care Translational Biology Group (CCCTBG); Canadian Traumatic Brain Injury Research Consortium (CTRC). Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity. Crit Care. 2025 Jan 15;29(1):26. doi: 10.1186/s13054-025-05258-1. PMID: 39815318.

Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine

First Author:

Heirali A

Journal:

JAMA Netw Open

Year:

2025

Group:

Heirali A, Heybati K, Sereeyotin J, Khan F, Yarnell C, Krewulak K, Murthy S, Burns KEA, Fowler R, Fiest K, Mehta S; Canadian Critical Care Trials Group. Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine. JAMA Netw Open. 2025 Jan 2;8(1):e2454944. doi: 10.1001/jamanetworkopen.2024.54944. PMID: 39821399.

Investigator-initiated randomized clinical trials in infectious diseases: the BALANCE experience

First Author:

Daneman N

Journal:

Clin Microbiol Infect

Year:

2025

Group:

Daneman N, Rishu AH, Pinto R, Arabi YM, Cook DJ, Hall R, Muscedere J, Parke R, Reynolds S, Rogers B, Shehabi Y, Fowler RA; BALANCE Investigators for the Canadian Critical Care Trials Group (CCCTG); Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network (AMMI CRN); Australian and New Zealand Intensive Care Society (ANZICS); Clinical Trials Group and the Australasian Society of Infectious Diseases (ASID) Clinical Research Network. Investigator-initiated randomized clinical trials in infectious diseases: the BALANCE experience. Clin Microbiol Infect. 2025 Feb 28:S1198-743X(25)00094-1. doi: 10.1016/j.cmi.2025.02.033. Epub ahead of print. PMID: 40024529.

Defining Priorities for Canadian PICU Family Presence Policies Under Changing Contexts: A Qualitative Focus Group Study.

First Author:

Krewulak KD

Journal:

J Pediatr Health Care

Year:

2025

Group:

, ,

Krewulak KD, Foster JR, Lee LA, Ryan MJ, Rhyno D, Reznikov V, Garros D, Seabrook JA, Curran J, Slumkoski C, Walls M, Fiest KM; Canadian Critical Care Trials Group RFP-PICU research collaboration. Defining Priorities for Canadian PICU Family Presence Policies Under Changing Contexts: A Qualitative Focus Group Study. J Pediatr Health Care. 2025 Apr 1:S0891-5245(25)00065-3. doi: 10.1016/j.pedhc.2025.03.002. Epub ahead of print. PMID: 40167417.

Impact of PAD4 deficiency in a fecal-induced peritonitis model of sepsis

First Author:

Cani E

Journal:

J Thromb Haemost

Year:

2025

Group:

,

Cani E, Dwivedi D, Carlin S, Sharma N, Chen A, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG). Impact of PAD4 deficiency in a fecal-induced peritonitis model of sepsis. J Thromb Haemost. 2025 Apr 6:S1538-7836(25)00205-3. doi: 10.1016/j.jtha.2025.03.025. Epub ahead of print. PMID: 40199446.

Early Rehabilitation in Critically ill Children: A Two Center Implementation Study

First Author:

Choong K

Journal:

Pediatr Crit Care Med.

Year:

2024

Group:

,

Choong K, Fraser DD, Al-Farsi A, Awlad Thani S, Cameron S, Clark H, Cuello C, Debigaré S, Ewusie J, Kennedy K, Kho ME, Krasevich K, Martin CM, Thabane L, Nanji J, Watts C, Simpson A, Todt A, Wong J, Xie F, Vu M, Cupido C; Canadian Critical Care Trials Group. Early Rehabilitation in Critically ill Children: A Two Center Implementation Study. Pediatr Crit Care Med. 2024 Feb 1;25(2):92-105. doi: 10.1097/PCC.0000000000003343. Epub 2024 Jan 19. PMID: 38240534.

Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study

First Author:

Choong K

Journal:

Pediatr Crit Care Med

Year:

2024

Group:

,

Choong K, Fraser DD, Cameron S, Cuello C, Debigaré S, Ewusie J, Kho ME, Krasevich K, Martin CM, Thabane L, Todt A, Cupido C; Canadian Critical Care Trials Group. Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study. Pediatr Crit Care Med. 2024 Feb 2. doi: 10.1097/PCC.0000000000003467. Epub ahead of print. PMID: 38305699.

Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis

First Author:

Hum C

Journal:

Stem Cells Transl Med

Year:

2024

Group:

Hum C, Tahir U, Mei SHJ, Champagne J, Fergusson DA, Lalu M, Stewart DJ, Walley K, Marshall J, Dos Santos CC, Winston BW, Mendelson AA, Dave C, McIntyre L; Canadian Critical Care Translational Biology Group. Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl Med. 2024 Feb 21:szae003. doi: 10.1093/stcltm/szae003. Epub ahead of print. PMID: 38381583.

Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives

First Author:

Vanstone MG

Journal:

J Crit Care

Year:

2024

Group:

Vanstone MG, Krewulak K, Taneja S, Swinton M, Fiest K, Burns KEA, Debigare S, Dionne JC, Guyatt G, Marshall JC, Muscedere JG, Deane AM, Finfer S, Myburgh JA, Gouskos A, Rochwerg B, Ball I, Mele T, Niven DJ, English SW, Verhovsek M, Cook DJ; Canadian Critical Care Trials Group. Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives. J Crit Care. 2024 Mar 5;81:154761. doi: 10.1016/j.jcrc.2024.154761. Epub ahead of print. PMID: 38447306.

Administrative data ICD-10 diagnostic codes identifies most lab-confirmed SARS-CoV-2 admissions but misses many discharged from the Emergency Department

First Author:

Moura CS

Journal:

Sci Rep

Year:

2024

Group:

Moura CS, Morrison LJ, Hohl CM, Grant L, Pilote L, Neville A, Hau JP, Bernatsky S; and the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Administrative data ICD-10 diagnostic codes identifies most lab-confirmed SARS-CoV-2 admissions but misses many discharged from the Emergency Department. Sci Rep. 2024 Mar 12;14(1):6008. doi: 10.1038/s41598-023-49501-7. PMID: 38472258.

Adjudication of a primary trial outcome: Results of a calibration exercise and protocol for a large international trial

First Author:

Cook D

Journal:

Contemp Clin Trials Commun

Year:

2024

Group:

Cook D, Deane A, Dionne JC, Lauzier F, Marshall JC, Arabi YM, Wilcox ME, Ostermann M, Al-Fares A, Heels-Ansdell D, Zytaruk N, Thabane L, Finfer S; REVISE Investigators and the Canadian Critical Care Trials Group. Adjudication of a primary trial outcome: Results of a calibration exercise and protocol for a large international trial. Contemp Clin Trials Commun. 2024 Mar 5;39:101284. doi: 10.1016/j.conctc.2024.101284. PMID: 38559746; PMCID: PMC10979133.

Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study

First Author:

Muscedere J

Journal:

Intensive Care Med

Year:

2024

Group:

Muscedere J, Bagshaw SM, Kho M, Mehta S, Cook DJ, Boyd JG, Sibley S, Wang HT, Archambault PM, Albert M, Rewa OG, Ball I, Norman PA, Day AG, Hunt M, Loubani O, Mele T, Sarti AJ, Shahin J; Canadian Critical Care Trials Group. Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study. Intensive Care Med. 2024 May 15. doi: 10.1007/s00134-024-07404-9. Epub ahead of print. PMID: 38748266.

Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers

First Author:

Cani E

Journal:

PLoS One

Year:

2024

Group:

,

Cani E, Tsang JLY, Binnie A, Dos Santos CC, Fowler R, Lamontagne F, Mehta S, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG), and the Canadian Critical Care Trials Group (CCCTG). Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers. PLoS One. 2024 May 17;19(5):e0303304. doi: 10.1371/journal.pone.0303304. PMID: 38758919; PMCID: PMC11101101.

Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial

First Author:

D'Aragon F

Journal:

BMJ Open

Year:

2024

Group:

D'Aragon F, Selzner M, Breau R, Masse MH, Lamontagne F, Masse M, Chassé M, Carrier FM, Cardinal H, Chaudhury P, Weiss M, Lauzier F, Turgeon AF, Frenette AJ, Bolduc B, Ducharme A, Lamarche C, Couture E, Holdsworth S, Bertholz L, Talbot H, Slessarev M, Luke P, Boyd JG, Shamseddin MK, Burns KEA, Zaltzman J, English S, Knoll G, Dhanani S, Healey A, Hanna S, Rochwerg B, Oczkowski SJW, Treleaven D, Meade M; Canadian Critical Care Trials Group and the Canadian Donation and Transplant Research Program. Calcineurin Inhibitor in NEuRoloGically deceased donors to decrease kidney delayed graft function study: study protocol of the CINERGY Pilot randomised controlled trial. BMJ Open. 2024 Jun 13;14(6):e086777. doi: 10.1136/bmjopen-2024-086777. PMID: 38871657.

Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury

First Author:

Turgeon AF

Journal:

N Engl J Med

Year:

2024

Group:

Turgeon AF, Fergusson DA, Clayton L, Patton MP, Neveu X, Walsh TS, Docherty A, Malbouisson LM, Pili-Floury S, English SW, Zarychanski R, Moore L, Bonaventure PL, Laroche V, Verret M, Scales DC, Adhikari NKJ, Greenbaum J, Kramer A, Rey VG, Ball I, Khwaja K, Wise M, Harvey D, Lamontagne F, Chabanne R, Algird A, Krueper S, Pottecher J, Zeiler F, Rhodes J, Rigamonti A, Burns KEA, Marshall J, Griesdale DE, Sisconetto LS, Kutsogiannis DJ, Roger C, Green R, Boyd JG, Wright J, Charbonney E, Nair P, Astles T, Sy E, Hébert PC, Chassé M, Gomez A, Ramsay T, Taljaard M, Fox-Robichaud A, Tinmouth A, St-Onge M, Costerousse O, Lauzier F; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain Injury Research Consortium. Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med. 2024 Jun 13. doi: 10.1056/NEJMoa2404360. Epub ahead of print. PMID: 38869931. New England Journal of Medicine/NEJM

Leveraging a clinical emergency department dataset to estimate two-dose COVID-19 vaccine effectiveness and duration of protection in Canada

First Author:

Ting DK

Journal:

Vaccine

Year:

2024

Group:

Ting DK, Rosychuk RJ, Hau JP, Righolt CH, Kwong JC, Skowronski DM, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Leveraging a clinical emergency department dataset to estimate two-dose COVID-19 vaccine effectiveness and duration of protection in Canada. Vaccine. 2024 Jun 14:S0264-410X(24)00699-6. doi: 10.1016/j.vaccine.2024.06.025. Epub ahead of print. PMID: 38879407.

The response of Canada’s clinical health research ecosystem to the COVID-19 pandemic

First Author:

Lamontagne F

Journal:

CMAJ

Year:

2024

Group:

Lamontagne F, Masse MH, Yarnell C, Camirand-Lemyre F, Lévesque S, Domingue MP, O'Hearn K, Watpool I, Hoogenes J, Sprague S, Ménard J, Lemaire-Paquette S, Hébert-Dufresne L, Cook D, Hébert P, Rowan K, Yada N, Menon K, Fowler R, Fox-Robichaud A, Boutin D, Marshall J, Kho ME; Canadian Clinical Research Network (CCRN), the Canadian Critical Care Trials Group (CCCTG) and Sepsis Canada. The response of Canada's clinical health research ecosystem to the COVID-19 pandemic. CMAJ. 2024 Jun 16;196(23):E779-E788. doi: 10.1503/cmaj.230760. PMID: 38885975.

Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy

First Author:

Mirsajadi A

Journal:

Crit Care Explor

Year:

2024

Group:

Mirsajadi A, Erickson D, Alias S, Froese L, Singh Sainbhi A, Gomez A, Majumdar R, Herath I, Wilson M, Zarychanski R, Zeiler FA, Mendelson AA; Microvasclar Monitoring in Circulatory Shock and Sepsis (MiMICSS) Investigators and the Canadian Critical Care Translational Biology Group. Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy. Crit Care Explor. 2024 Jun 21;6(7):e1111. doi: 10.1097/CCE.0000000000001111. PMID: 38904977.

The Diversity of Research Participants in Randomized Controlled Trials and Observational Studies Conducted by the Canadian Critical Care Trials Group

First Author:

Mehta S

Journal:

Ann Am Thorac Soc

Year:

2024

Group:

Mehta S, Ahluwalia A, Ahluwalia A, Burns KEA, O'Hearn K, Maratta C, Menon K, Rochwerg B, Murthy S, Fowler R, Fiest KM. The Diversity of Research Participants in Randomized Controlled Trials and Observational Studies Conducted by the Canadian Critical Care Trials Group. Ann Am Thorac Soc. 2024 Sep;21(9):1309-1315. doi: 10.1513/AnnalsATS.202312-1074OC PMID: 38889344.

Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic

First Author:

Cook D

Journal:

JAMA Netw Open

Year:

2024

Group:

Cook D, Taneja S, Krewulak K, Zytaruk N, Menon K, Fowler R, Lamontagne F, Kho ME, Rochwerg B, Masse MH, Lauzier F, O'Hearn K, Adhikari NKJ, Burns KEA, Bosma KJ, English S, McNally D, Turgeon AF, Brochard L, Parker M, Clayton L, Rishu A, Tuttle A, Daneman N, Fergusson D, McIntyre L, Kelly L, Orr S, Austin P, Mulligan S, Fiest K; Canadian Critical Care Trials Group and Canadian Clinical Research Network. Barriers, Solutions, and Opportunities for Adapting Critical Care Clinical Trials in the COVID-19 Pandemic. JAMA Netw Open. 2024 Jul 1;7(7):e2420458. doi: 10.1001/jamanetworkopen.2024.20458. PMID: 38995645; PMCID: PMC11245722.

What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey

First Author:

Andersen CR

Journal:

Transl Stroke Res

Year:

2024

Group:

Andersen CR, Presseau J, Shea B, Marti ML, McCoy M, Fernie G, McIntyre L, Delaney A, Chassé M, Saigle V, Marshall S, Fergusson DA, Graham I, Brehaut J, Turgeon AF, Lauzier F, Tugwell P, Zha X, Talbot P, Muscedere J, Marshall JC, Thavorn K, Griesdale D; Canadian Critical Care Trials Group; English SW. What to Measure in Aneurysmal Subarachnoid Haemorrhage Research-An International Delphi Survey. Transl Stroke Res. 2024 Jul 13. doi: 10.1007/s12975-024-01271-8. Epub ahead of print. PMID: 38997598.

Pediatric critical care capacity in Canada

First Author:

Ganesan SL

Journal:

Paediatrics & Child Health

Year:

2024

Group:

,

Ganesan SL, Garros D, Foster J, Di Genova T, Fontela PS, Murthy S, for the Canadian Pediatric Intensive Care Consortium (CanPICC) of the Canadian Critical Care Trials Group (CCCTG)., Pediatric critical care capacity in Canada, Paediatrics & Child Health, 2024;, pxae024, https://doi.org/10.1093/pch/pxae024

Statistical analysis plan for the SQUEEZE trial: A trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy vs. usual care (SQUEEZE)

First Author:

Parker MJ

Journal:

Crit Care Resusc

Year:

2024

Group:

, ,

Parker MJ, Foster G, Fox-Robichaud A, Choong K, Mbuagbaw L, Thabane L; With the SQUEEZE Trial Steering Committee and on behalf of the SQUEEZE Trial Investigators, the Canadian Critical Care Trials Group, Pediatric Emergency Research Canada, and the Canadian Critical Care Translational Biology Group. Statistical analysis plan for the SQUEEZE trial: A trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy vs. usual care (SQUEEZE). Crit Care Resusc. 2024 Jun 22;26(2):123-134. doi: 10.1016/j.ccrj.2024.02.002. PMID: 39072232; PMCID: PMC11282343.

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