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MicroRNA regulatory networks associated with abnormal muscle repair in survivors of critical illness

First Author:

Walsh, CJ

Journal:

J Cachexia Sarcopenia Muscle

Year:

2022

Group:

Walsh CJ, Escudero King C, Gupta M, Plant PJ, Herridge MJ, Mathur S, Hu P, Correa J, Ahmed S, Bigot A, Dos Santos CC, Batt J; Submitted on behalf of the MusclE and Nerve Dysfunction (MEND)-ICU Group and Canadian Critical Care Translational Biology Group (CCCTBG). J Cachexia Sarcopenia Muscle. 2022 Jan 28. doi: 10.1002/jcsm.12903.PMID: 35092190

Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians

First Author:

McGinn, R

Journal:

Crit Care Med

Year:

2021

Group:

McGinn R, Fergusson DA, Stewart DJ, Kristof AS, Barron CC, Thebaud B, McIntyre L, Stacey D, Liepmann M, Dodelet-Devillers A, Zhang H, Renlund R, Lilley E, Downey GP, Brown EG, Côté L, Dos Santos CC, Fox-Robichaud AE, Hussain SNA, Laffey JG, Liu M, MacNeil J, Orlando H, Qureshi ST, Turner PV, Winston BW, Lalu MM; Canadian Critical Care Translational Biology Group.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021 Feb 1;49(2):311-323. PMID: 33332817

Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study

First Author:

Mendelson AA

Journal:

J Clin Monit Comput

Year:

2021

Group:

Mendelson AA, Rajaram A, Bainbridge D, Lawrence KS, Bentall T, Sharpe M, Diop M, Ellis CG; Canadian Critical Care Translational Biology Group. Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study. J Clin Monit Comput. 2021 Dec;35(6):1453-1465. PMID: 33104968

Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review

First Author:

Chornenki JN

Journal:

Can J Anaesth.

Year:

2020

Chornenki JN, Liaw P, Bagshaw S, Burns K, Dodek P, English S, Fan E, Ferrari N, Fowler R, Fox-Robichaud A, Garland A, Green R, Hebert P, Kho M, Martin C, Maslove D, McDonald E, Menon K, Murthy S, Muscedere J, Scales D, Stelfox HT, Wang HT, Weiss M; Canadian Critical Care Trials Group (CCCTG) and Canadian Critical Care Translational Biology Group (CCCTBG). Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Can J Anaesth. 2020 Apr;67(4):475-484.

Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients

First Author:

Schlosser K

Journal:

Crit Care Med

Year:

2019

Group:

,

Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients. Crit Care Med. 2019 Feb 1. doi: 10.1097/CCM.0000000000003657. [Epub ahead of print] PMID: 30720538

Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial.

First Author:

McIntyre LA

Journal:

Am J Respir Crit Care Med.

Year:

2018

Group:

, ,

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347. PMID: 28960096

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery.

First Author:

Ball IM

Journal:

Can J Anaesth.

Year:

2018

Group:

, ,

Ball IM, Burry L, Dodek P, Hutchison JS, Leigh JP, McCredie V, Murthy S, Rochwerg B, Cook D; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery. Can J Anaesth. 2018 Mar;65(3):239-245. PMID: 29150787

Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study.

First Author:

Lamarche D

Journal:

Respir Res.

Year:

2018

Group:

, ,

Lamarche D, Johnstone J, Zytaruk N, Clarke F, Hand L, Loukov D, Szamosi JC, Rossi L, Schenck LP, Verschoor CP, McDonald E, Meade MO, Marshall JC, Bowdish DME, Karachi T, Heels-Ansdell D, Cook DJ, Surette MG; PROSPECT Investigators; Canadian Critical Care Trials Group; Canadian Critical Care Translational Biology Group. Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respir Res. 2018 Dec 7;19(1):245. PMID: 30526610

Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury.

First Author:

Wilkinson AA

Journal:

BMC Pediatr

Year:

2017

Group:

, ,

Wilkinson AA, Dennis M, Simic N, Taylor MJ, Morgan BR, Frndova H, Choong K, Campbell C, Fraser D, Anderson V, Guerguerian AM, Schachar R, Hutchison J; Canadian Critical Care Trials Group (CCCTG); Canadian Critical Care Translational Biology Group (CCCTBG). Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury. BMC Pediatr. 2017 Jul 24;17(1):173. PMID: 28738850

Serum Biomarkers Help Predict Attention Problems in Critically Ill Children With Traumatic Brain Injury.

First Author:

Wilkinson AA

Journal:

Pediatr Crit Care Med.

Year:

2016

Group:

,

Wilkinson AA, Simic N, Frndova H, Taylor MJ, Choong K, Fraser D, Campbell C, Dhanani S, Kuehn S, Beauchamp MH, Farrell C, Anderson V, Guerguerian AM, Dennis M, Schachar R, Hutchison JS; Attention and Traumatic Brain Injury Investigators, the Canadian Critical Care Trials Group, and the Canadian Critical Care Translational Biology Group. Serum Biomarkers Help Predict Attention Problems in Critically Ill Children With Traumatic Brain Injury. Pediatr Crit Care Med. 2016 Jul;17(7):638-48. PMID: 27167007

A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial.

First Author:

Parker MJ

Journal:

Trials

Year:

2016

Group:

, ,

Parker MJ, Thabane L, Fox-Robichaud A, Liaw P, Choong K; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Trials. 2016 Nov 22;17(1):556. PMID: 27876084

Prognostic utility and characterization of cell-free DNA in patients with severe sepsis

First Author:

Dwivedi DJ

Journal:

Journal of Critical Care

Year:

2012

Group:

Dwivedi DJ, Toltl LJ, Swystun LL, Pogue J, Liaw KL, Weitz JI, Cook DJ, Fox-Robichaud AE, Liaw PC and Canadian Critical Care Translational Biology Group. Prognostic utility and characterization of cell-free DNA in patients with severe sepsis. Critical Care 2012, 16:R151.

Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum

First Author:

Fraser DD

Journal:

Pediatr Crit Care Med

Year:

2011

Group:

Fraser DD, Close TE, Rose KL, Ward R, Mehl M, Farrell C, Lacroix J, Creery D, Kesselman M, Stanimirovic D, Hutchison JS, for the Canadian Critical Care Translational Biology Group. Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med 2011;12:319-24. PMID: 20625342

Activated protein C up-regulates IL-10 and inhibits tissue factor in bloodmonocytes

First Author:

Beaudin S

Journal:

Journal of Immunology

Year:

2008

Group:

Toltl LJ, Beaudin S, Liaw PC; Canadian Critical Care Translational Biology Group. Activated protein C up-regulates IL-10 and inhibits tissue factor in bloodmonocytes. J Immunol. 2008 Aug 1;181(3):2165-73.

Protein biomarkers in sera of paediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS

First Author:

Haqqani AS

Journal:

Journal of Neurotrauma

Year:

2007

Group:

Arsalan S. Haqqani, JS Hutchison, R Ward, DB Stanimirovic for the Canadian Critical Care Translational Biology Group. Biomarkers and diagnosis; Protein biomarkers in sera of paediatric patients with severe traumatic brain injury identified by ICAT-LC-MS/MS. Journal of Neurotrauma, 2007, 24:54-74.