Publications

Banoei MM, Hutchison J, Panenka W, Wong A, Wishart DS, Winston BW; Canadian Biobank and Database for Traumatic Brain Injury (CanTBI) study investigators; Canadian Critical Care Translational Biology Group (CCCTBG); Canadian Traumatic Brain Injury Research Consortium (CTRC). Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity. Crit Care. 2025 Jan 15;29(1):26. doi: 10.1186/s13054-025-05258-1. PMID: 39815318.

Cani E, Dwivedi D, Carlin S, Sharma N, Chen A, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG). Impact of PAD4 deficiency in a fecal-induced peritonitis model of sepsis. J Thromb Haemost. 2025 Apr 6:S1538-7836(25)00205-3. doi: 10.1016/j.jtha.2025.03.025. Epub ahead of print. PMID: 40199446.

Carlin S, Dwivedi DJ, Cani E, Sharma N, Venegas-Pino DE, Lalu M, Mendelson AA, McDonald B, Werstuck GH, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG). Impact of streptozotocin (STZ)-induced hyperglycemia on the host response to sepsis. J Thromb Haemost. 2025 Jul 16:S1538-7836(25)00427-1. doi: 10.1016/j.jtha.2025.07.004. Epub ahead of print. PMID: 40680936.

Hum C, Tahir U, Mei SHJ, Champagne J, Fergusson DA, Lalu M, Stewart DJ, Walley K, Marshall J, Dos Santos CC, Winston BW, Mendelson AA, Dave C, McIntyre L; Canadian Critical Care Translational Biology Group. Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl Med. 2024 Feb 21:szae003. doi: 10.1093/stcltm/szae003. Epub ahead of print. PMID: 38381583.

Cani E, Tsang JLY, Binnie A, Dos Santos CC, Fowler R, Lamontagne F, Mehta S, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG), and the Canadian Critical Care Trials Group (CCCTG). Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers. PLoS One. 2024 May 17;19(5):e0303304. doi: 10.1371/journal.pone.0303304. PMID: 38758919; PMCID: PMC11101101.

Mirsajadi A, Erickson D, Alias S, Froese L, Singh Sainbhi A, Gomez A, Majumdar R, Herath I, Wilson M, Zarychanski R, Zeiler FA, Mendelson AA; Microvasclar Monitoring in Circulatory Shock and Sepsis (MiMICSS) Investigators and the Canadian Critical Care Translational Biology Group. Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy. Crit Care Explor. 2024 Jun 21;6(7):e1111. doi: 10.1097/CCE.0000000000001111. PMID: 38904977.

Parker MJ, Foster G, Fox-Robichaud A, Choong K, Mbuagbaw L, Thabane L; With the SQUEEZE Trial Steering Committee and on behalf of the SQUEEZE Trial Investigators, the Canadian Critical Care Trials Group, Pediatric Emergency Research Canada, and the Canadian Critical Care Translational Biology Group. Statistical analysis plan for the SQUEEZE trial: A trial to determine whether septic shock reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy vs. usual care (SQUEEZE). Crit Care Resusc. 2024 Jun 22;26(2):123-134. doi: 10.1016/j.ccrj.2024.02.002. PMID: 39072232; PMCID: PMC11282343.

Soussi S, Ahmadiankalati M, Jentzer JC, Marshall JC, Lawler PR, Herridge M, Mebazaa A, Gayat E, Lu Z, Dos Santos CC; French and European Outcome Registry in Intensive Care Units (FROG‐ICU) and CCCTBG trans‐trial group study for InFACT – the International Forum for Acute Care Trialists. Clinical phenotypes of cardiogenic shock survivors: insights into late host responses and long-term outcomes. ESC Heart Fail. 2024 Apr;11(2):1242-1248. doi: 10.1002/ehf2.14596. Epub 2023 Dec 4. PMID: 38050658; PMCID: PMC10966268.

Sharma N, Chen A, Heinen L, Liu R, Dwivedi DJ, Zhou J, Lalu MM, Mendelson AA, McDonald B, Kretz CA, Fox-Robichaud AE, Liaw PC. Impact of age on the host response to sepsis in a murine model of fecal-induced peritonitis. Intensive Care Med Exp. 2024 Mar 8;12(1):28. doi: 10.1186/s40635-024-00609-8. PMID: 38457063; PMCID: PMC10923763.

Hunniford VT, Grudniewicz A, Fergusson DA, Montroy J, Grigor E, Lansdell C, Lalu MM; Canadian Critical Care Translational Biology Group. A systematic assessment of preclinical multilaboratory studies and a comparison to single laboratory studies. Elife. 2023 Mar 9;12:e76300. doi: 10.7554/eLife.76300. Epub ahead of print. PMID: 36892457.

Zhang M, Fergusson DA, Sharma R, Khoo C, Mendelson AA, McDonald B, Macala KF, Sharma N, Gill SE, Fiest KM, Lehmann C, Shorr R, Jahandideh F, Bourque SL, Liaw PC, Fox-Robichaud A, Lalu MM; Canadian Critical Care Translational Biology Group, the Sepsis Canada National Preclinical Sepsis Platform. Sex-based analysis of treatment responses in animal models of sepsis: a preclinical systematic review protocol. Syst Rev. 2023 Mar 21;12(1):50. doi: 10.1186/s13643-023-02189-2. PMID: 36945012; PMCID: PMC10029211

Banoei MM, Lee CH, Hutchison J, Panenka W, Wellington C, Wishart DS, Winston BW; Canadian biobank, database for Traumatic Brain Injury (CanTBI) investigators, the Canadian Critical Care Translational Biology Group (CCCTBG), the Canadian Traumatic Brain Injury Research, Clinical Network (CTRC). Using metabolomics to predict severe traumatic brain injury outcome (GOSE) at 3 and 12 months. Crit Care. 2023 Jul 22;27(1):295. doi: 10.1186/s13054-023-04573-9. PMID: 37481590; PMCID: PMC10363297.

Sharma N, Chwastek D, Dwivedi DJ, Schlechte J, Yu IL, McDonald B, Arora J, Cani E, Eng M, Engelberts D, Kuhar E, Medeiros SK, Bourque SL, Cepinskas G, Gill SE, Jahandideh F, Macala KF, Panahi S, Pape C, Sontag D, Sunohara-Neilson J, Fergusson DA, Fox-Robichaud AE, Liaw PC, Lalu MM, Mendelson AA; National Preclinical Sepsis Platform, Sepsis Canada. Development and characterization of a fecal-induced peritonitis model of murine sepsis: results from a multi-laboratory study and iterative modification of experimental conditions. Intensive Care Med Exp. 2023 Jul 17;11(1):45. doi: 10.1186/s40635-023-00533-3. PMID: 37460911; PMCID: PMC10352196.

Walsh CJ, Escudero King C, Gupta M, Plant PJ, Herridge MJ, Mathur S, Hu P, Correa J, Ahmed S, Bigot A, Dos Santos CC, Batt J; Submitted on behalf of the MusclE and Nerve Dysfunction (MEND)-ICU Group and Canadian Critical Care Translational Biology Group (CCCTBG). J Cachexia Sarcopenia Muscle. 2022 Jan 28. doi: 10.1002/jcsm.12903.PMID: 35092190

Soussi S, Sharma D, Jüni P, Lebovic G, Brochard L, Marshall JC, Lawler PR, Herridge M, Ferguson N, Del Sorbo L, Feliot E, Mebazaa A, Acton E, Kennedy JN, Xu W, Gayat E, Dos Santos CC; FROG-ICU; CCCTBG trans-trial group study for InFACT - the International Forum for Acute Care Trialists. Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort. Crit Care. 2022 Apr 21;26(1):114. doi: 10.1186/s13054-022-03972-8. PMID: 35449071; PMCID: PMC9022336.

McGinn R, Fergusson DA, Stewart DJ, Kristof AS, Barron CC, Thebaud B, McIntyre L, Stacey D, Liepmann M, Dodelet-Devillers A, Zhang H, Renlund R, Lilley E, Downey GP, Brown EG, Côté L, Dos Santos CC, Fox-Robichaud AE, Hussain SNA, Laffey JG, Liu M, MacNeil J, Orlando H, Qureshi ST, Turner PV, Winston BW, Lalu MM; Canadian Critical Care Translational Biology Group.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021 Feb 1;49(2):311-323. PMID: 33332817

Mendelson AA, Rajaram A, Bainbridge D, Lawrence KS, Bentall T, Sharpe M, Diop M, Ellis CG; Canadian Critical Care Translational Biology Group. Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study. J Clin Monit Comput. 2021 Dec;35(6):1453-1465. PMID: 33104968

Chornenki JN, Liaw P, Bagshaw S, Burns K, Dodek P, English S, Fan E, Ferrari N, Fowler R, Fox-Robichaud A, Garland A, Green R, Hebert P, Kho M, Martin C, Maslove D, McDonald E, Menon K, Murthy S, Muscedere J, Scales D, Stelfox HT, Wang HT, Weiss M; Canadian Critical Care Trials Group (CCCTG) and Canadian Critical Care Translational Biology Group (CCCTBG). Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Can J Anaesth. 2020 Apr;67(4):475-484.

Binnie A, Walsh CJ, Hu P, Dwivedi DJ, Fox-Robichaud A, Liaw PC, Tsang JLY, Batt J, Carrasqueiro G, Gupta S, Marshall JC, Castelo-Branco P, Dos Santos CC; Epigenetic Profiling in Severe Sepsis (EPSIS) Study of the Canadian Critical Care Translational Biology Group (CCCTBG). Epigenetic Profiling in Severe Sepsis: A Pilot Study of DNA Methylation Profiles in Critical Illness. Crit Care Med. 2020 Feb;48(2):142-150. doi: 10.1097/CCM.0000000000004097. PMID: 31939781.

Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients. Crit Care Med. 2019 Feb 1. doi: 10.1097/CCM.0000000000003657. [Epub ahead of print] PMID: 30720538

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347. PMID: 28960096

Ball IM, Burry L, Dodek P, Hutchison JS, Leigh JP, McCredie V, Murthy S, Rochwerg B, Cook D; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery. Can J Anaesth. 2018 Mar;65(3):239-245. PMID: 29150787

Lamarche D, Johnstone J, Zytaruk N, Clarke F, Hand L, Loukov D, Szamosi JC, Rossi L, Schenck LP, Verschoor CP, McDonald E, Meade MO, Marshall JC, Bowdish DME, Karachi T, Heels-Ansdell D, Cook DJ, Surette MG; PROSPECT Investigators; Canadian Critical Care Trials Group; Canadian Critical Care Translational Biology Group. Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study. Respir Res. 2018 Dec 7;19(1):245. PMID: 30526610

Wilkinson AA, Dennis M, Simic N, Taylor MJ, Morgan BR, Frndova H, Choong K, Campbell C, Fraser D, Anderson V, Guerguerian AM, Schachar R, Hutchison J; Canadian Critical Care Trials Group (CCCTG); Canadian Critical Care Translational Biology Group (CCCTBG). Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury. BMC Pediatr. 2017 Jul 24;17(1):173. PMID: 28738850