Curriculum

Rynne J, Mosavie M, Masse MH, Ménard J, Battista MC, Maslove DM, Del Sorbo L, St-Arnaud C, DAragon F, Fox-Robichaud A, Charbonney E, Adhikari NKJ, Lamontagne F, Shankar-Hari M; LOVIT Investigators, the Canadian Critical Care Trials Group. Sepsis subtypes and differential treatment response to vitamin C: biological sub-study of the LOVIT trial. Intensive Care Med. 2025 Jan 7. doi: 10.1007/s00134-024-07733-9. Epub ahead of print. PMID: 39774855.

Banoei MM, Hutchison J, Panenka W, Wong A, Wishart DS, Winston BW; Canadian Biobank and Database for Traumatic Brain Injury (CanTBI) study investigators; Canadian Critical Care Translational Biology Group (CCCTBG); Canadian Traumatic Brain Injury Research Consortium (CTRC). Metabolomic in severe traumatic brain injury: exploring primary, secondary injuries, diagnosis, and severity. Crit Care. 2025 Jan 15;29(1):26. doi: 10.1186/s13054-025-05258-1. PMID: 39815318.

Heirali A, Heybati K, Sereeyotin J, Khan F, Yarnell C, Krewulak K, Murthy S, Burns KEA, Fowler R, Fiest K, Mehta S; Canadian Critical Care Trials Group. Eligibility Criteria of Randomized Clinical Trials in Critical Care Medicine. JAMA Netw Open. 2025 Jan 2;8(1):e2454944. doi: 10.1001/jamanetworkopen.2024.54944. PMID: 39821399.

Daneman N, Rishu AH, Pinto R, Arabi YM, Cook DJ, Hall R, Muscedere J, Parke R, Reynolds S, Rogers B, Shehabi Y, Fowler RA; BALANCE Investigators for the Canadian Critical Care Trials Group (CCCTG); Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network (AMMI CRN); Australian and New Zealand Intensive Care Society (ANZICS); Clinical Trials Group and the Australasian Society of Infectious Diseases (ASID) Clinical Research Network. Investigator-initiated randomized clinical trials in infectious diseases: the BALANCE experience. Clin Microbiol Infect. 2025 Feb 28:S1198-743X(25)00094-1. doi: 10.1016/j.cmi.2025.02.033. Epub ahead of print. PMID: 40024529.

Krewulak KD, Foster JR, Lee LA, Ryan MJ, Rhyno D, Reznikov V, Garros D, Seabrook JA, Curran J, Slumkoski C, Walls M, Fiest KM; Canadian Critical Care Trials Group RFP-PICU research collaboration. Defining Priorities for Canadian PICU Family Presence Policies Under Changing Contexts: A Qualitative Focus Group Study. J Pediatr Health Care. 2025 Apr 1:S0891-5245(25)00065-3. doi: 10.1016/j.pedhc.2025.03.002. Epub ahead of print. PMID: 40167417.

Cani E, Dwivedi D, Carlin S, Sharma N, Chen A, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG). Impact of PAD4 deficiency in a fecal-induced peritonitis model of sepsis. J Thromb Haemost. 2025 Apr 6:S1538-7836(25)00205-3. doi: 10.1016/j.jtha.2025.03.025. Epub ahead of print. PMID: 40199446.

O’Grady, H.K., Smith, K., Dalziel, S. et al. Co-designing and pilot-testing an infographic to support the consent process in an adaptive platform trial for adults in ICU with community-acquired pneumonia or COVID-19: a mixed methods study within a trial (SWAT). Res Involv Engagem 11, 37 (2025). PMID: 40281565 PMCID: PMC12032667 DOI: 10.1186/s40900-025-00705-3

Dionne JC, Johnstone J, Heels-Ansdell D, Tahvildar Khazaneh P, Zytaruk N, Clarke F, Hand L, Millen T, Dechert W, Porteous R, Auld F, Hunt M, Campbell E, Bentall T, Campbell T, Smith O, Rose L, Arabi YM, Duan E, Wilcox ME, McIntyre L, Rochwerg B, Karachi T, Adhikari NK, Charbonney E, St-Arnaud C, Kristof A, Khwaja K, Marquis F, Zarychanski R, Golan E, Cook D; PROSPECT Research Coordinators Group, the PROSPECT Investigators and the Canadian Critical Care Trials Group. Diarrhea in Mechanically Ventilated Patients: A Nested Multicenter Substudy. Crit Care Med. 2025 Jun 1;53(6):e1247-e1256. doi: 10.1097/CCM.0000000000006667. Epub 2025 Apr 3. PMID: 40459385.

McIntyre L, Fergusson D, McArdle T, English S, Cook DJ, Fox-Robichaud AE, Martin C, Marshall J, Pugliese M, Menon K, Thavorn K, Graham ID, Hawken S, Iyengar A, Kyeremanteng K, Saginur R, Seely AJE, Stiell IG, Bainbridge D, Weijer C, Taljaard M; Canadian Critical Care Trials Group. A Crossover Trial of Hospital-Wide Lactated Ringer's Solution versus Normal Saline. N Engl J Med. 2025 Jun 12. doi: 10.1056/NEJMoa2416761. Epub ahead of print. PMID: 40503714.

Bosma K, Burns KEA, Martin CM, Skrobik Y, Mancebo Cortés J, Mulligan S, Lafreniere-Roula M, +40 ,for the PROMIZING Study Investigators, the Canadian Critical Care Trials Group, and the REVA Network. Proportional-Assist Ventilation for Minimizing the Duration of Mechanical Ventilation. N Engl J Med. 2025 Jun 13. DOI: 10.1056/NEJMoa2505708. Epub ahead of print. PMID:

Chassé M, Shankar JJS, Fergusson DA, et al. Computed Tomography Perfusion and Angiography for Death by Neurologic Criteria. JAMA Neurol. Published online June 13, 2025. doi:10.1001/jamaneurol.2025.2375

Choong K, Fraser DD, Al-Farsi A, Awlad Thani S, Cameron S, Clark H, Cuello C, Debigaré S, Ewusie J, Kennedy K, Kho ME, Krasevich K, Martin CM, Thabane L, Nanji J, Watts C, Simpson A, Todt A, Wong J, Xie F, Vu M, Cupido C; Canadian Critical Care Trials Group. Early Rehabilitation in Critically ill Children: A Two Center Implementation Study. Pediatr Crit Care Med. 2024 Feb 1;25(2):92-105. doi: 10.1097/PCC.0000000000003343. Epub 2024 Jan 19. PMID: 38240534.

Choong K, Fraser DD, Cameron S, Cuello C, Debigaré S, Ewusie J, Kho ME, Krasevich K, Martin CM, Thabane L, Todt A, Cupido C; Canadian Critical Care Trials Group. Post-Intensive Care Sequelae in Pediatrics-Results of an Early Rehabilitation Implementation Study. Pediatr Crit Care Med. 2024 Feb 2. doi: 10.1097/PCC.0000000000003467. Epub ahead of print. PMID: 38305699.

Hum C, Tahir U, Mei SHJ, Champagne J, Fergusson DA, Lalu M, Stewart DJ, Walley K, Marshall J, Dos Santos CC, Winston BW, Mendelson AA, Dave C, McIntyre L; Canadian Critical Care Translational Biology Group. Efficacy and Safety of Umbilical Cord-Derived Mesenchymal Stromal Cell Therapy in Preclinical Models of Sepsis: A Systematic Review and Meta-analysis. Stem Cells Transl Med. 2024 Feb 21:szae003. doi: 10.1093/stcltm/szae003. Epub ahead of print. PMID: 38381583.

Vanstone MG, Krewulak K, Taneja S, Swinton M, Fiest K, Burns KEA, Debigare S, Dionne JC, Guyatt G, Marshall JC, Muscedere JG, Deane AM, Finfer S, Myburgh JA, Gouskos A, Rochwerg B, Ball I, Mele T, Niven DJ, English SW, Verhovsek M, Cook DJ; Canadian Critical Care Trials Group. Patient-important upper gastrointestinal bleeding in the ICU: A mixed-methods study of patient and family perspectives. J Crit Care. 2024 Mar 5;81:154761. doi: 10.1016/j.jcrc.2024.154761. Epub ahead of print. PMID: 38447306.

Cook D, Deane A, Dionne JC, Lauzier F, Marshall JC, Arabi YM, Wilcox ME, Ostermann M, Al-Fares A, Heels-Ansdell D, Zytaruk N, Thabane L, Finfer S; REVISE Investigators and the Canadian Critical Care Trials Group. Adjudication of a primary trial outcome: Results of a calibration exercise and protocol for a large international trial. Contemp Clin Trials Commun. 2024 Mar 5;39:101284. doi: 10.1016/j.conctc.2024.101284. PMID: 38559746; PMCID: PMC10979133.

Muscedere J, Bagshaw SM, Kho M, Mehta S, Cook DJ, Boyd JG, Sibley S, Wang HT, Archambault PM, Albert M, Rewa OG, Ball I, Norman PA, Day AG, Hunt M, Loubani O, Mele T, Sarti AJ, Shahin J; Canadian Critical Care Trials Group. Frailty, Outcomes, Recovery and Care Steps of Critically Ill Patients (FORECAST): a prospective, multi-centre, cohort study. Intensive Care Med. 2024 May 15. doi: 10.1007/s00134-024-07404-9. Epub ahead of print. PMID: 38748266.

Cani E, Tsang JLY, Binnie A, Dos Santos CC, Fowler R, Lamontagne F, Mehta S, Liaw PC; Canadian Critical Care Translational Biology Group (CCCTBG), and the Canadian Critical Care Trials Group (CCCTG). Barriers to participation in biosampling-based translational research: A cross-sectional survey of Canadian critical care researchers. PLoS One. 2024 May 17;19(5):e0303304. doi: 10.1371/journal.pone.0303304. PMID: 38758919; PMCID: PMC11101101.

Turgeon AF, Fergusson DA, Clayton L, Patton MP, Neveu X, Walsh TS, Docherty A, Malbouisson LM, Pili-Floury S, English SW, Zarychanski R, Moore L, Bonaventure PL, Laroche V, Verret M, Scales DC, Adhikari NKJ, Greenbaum J, Kramer A, Rey VG, Ball I, Khwaja K, Wise M, Harvey D, Lamontagne F, Chabanne R, Algird A, Krueper S, Pottecher J, Zeiler F, Rhodes J, Rigamonti A, Burns KEA, Marshall J, Griesdale DE, Sisconetto LS, Kutsogiannis DJ, Roger C, Green R, Boyd JG, Wright J, Charbonney E, Nair P, Astles T, Sy E, Hébert PC, Chassé M, Gomez A, Ramsay T, Taljaard M, Fox-Robichaud A, Tinmouth A, St-Onge M, Costerousse O, Lauzier F; HEMOTION Trial Investigators on behalf of the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group, and the Canadian Traumatic Brain Injury Research Consortium. Liberal or Restrictive Transfusion Strategy in Patients with Traumatic Brain Injury. N Engl J Med. 2024 Jun 13. doi: 10.1056/NEJMoa2404360. Epub ahead of print. PMID: 38869931. New England Journal of Medicine/NEJM

Ting DK, Rosychuk RJ, Hau JP, Righolt CH, Kwong JC, Skowronski DM, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Leveraging a clinical emergency department dataset to estimate two-dose COVID-19 vaccine effectiveness and duration of protection in Canada. Vaccine. 2024 Jun 14:S0264-410X(24)00699-6. doi: 10.1016/j.vaccine.2024.06.025. Epub ahead of print. PMID: 38879407.

Mirsajadi A, Erickson D, Alias S, Froese L, Singh Sainbhi A, Gomez A, Majumdar R, Herath I, Wilson M, Zarychanski R, Zeiler FA, Mendelson AA; Microvasclar Monitoring in Circulatory Shock and Sepsis (MiMICSS) Investigators and the Canadian Critical Care Translational Biology Group. Microvascular Autoregulation in Skeletal Muscle Using Near-Infrared Spectroscopy and Derivation of Optimal Mean Arterial Pressure in the ICU: Pilot Study and Comparison With Cerebral Near-Infrared Spectroscopy. Crit Care Explor. 2024 Jun 21;6(7):e1111. doi: 10.1097/CCE.0000000000001111. PMID: 38904977.