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SedAting with Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects on Ventilatory Parameters and Survival (SAVE-ICU)

Status: Enrolling

SAVE-ICU is a pragmatic multi-centre RCT comparing the effect of sedation with inhaled anesthetics versus intravenous sedatives in mechanically ventilated patients with acute hypoxic respiratory failure on patient (mortality, quality of life) and health system (ICU- and ventilator-free days) outcomes. SAVE-ICU has two prospective cohort studies assessing neurocogntive outcomes (Neuro-SAVE-ICU) and biomarkers (Biomarkers-SAVE-ICU) in patients enrolled in the main RCT.

This work is part of a broader program of research on the use of inhaled anesthetics in the ICU.

For more information, visit the SAVE-ICU website: www.saveicu.com

Participating Centres:

LHSC-Victoria Hospital
LHSC-University Hospital
CHUS de Sherbrooke
Toronto General Hospital
IUCPQ (Laval) 
Toronto Western Hospital
Hôpital Sacré-Coeur de Montréal
University of Alberta Hospital
Massachusetts General Hospital
MUHC – Royal Victoria Hospital
MUHC – Montreal General Hospital
The Ottawa Hospital – Civic Campus
The Ottawa Hospital – General Campus