SedAting with Volatile Anesthetics Critically Ill COVID-19 Patients in ICU: Effects on Ventilatory Parameters and Survival (SAVE-ICU)

SAVE-ICU is a pragmatic multi-centre RCT comparing the effect of sedation with inhaled anesthetics versus intravenous sedatives in mechanically ventilated patients with acute hypoxic respiratory failure on patient (mortality, quality of life) and health system (ICU- and ventilator-free days) outcomes. SAVE-ICU has two prospective cohort studies assessing neurocogntive outcomes (Neuro-SAVE-ICU) and biomarkers (Biomarkers-SAVE-ICU) in patients enrolled in the main RCT.

This work is part of a broader program of research on the use of inhaled anesthetics in the ICU.

For more information, visit the SAVE-ICU website: www.saveicu.com

View trial on ClinicalTrials.gov