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Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation.

First Author:

Weiss MJ

Journal:

Can J Anaesth.

Year:

2020

Group:

,

Weiss MJ, English SW, D'Aragon F, Lauzier F, Turgeon AF, Dhanani S, McIntyre L, Shemie SD, Knoll G, Fergusson DA, Anthony SJ, Haj-Moustafa A, Hartell D, Mohr J, Chassé M; Canadian Critical Care Trials Group. Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation. Can J Anaesth. 2019, 67(3):313-323. PMID: 31768789

Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial

First Author:

Masse MH

Journal:

BMJ Open

Year:

2020

Group:

,

Masse MH, Battista MC, Wilcox ME, Pinto R, Marinoff N, D'Aragon F, St-Arnaud C, Mayette M, Leclair MA, Quiroz Martinez H, Grondin-Beaudoin B, Poulin Y, Carbonneau É, Seely AJE, Watpool I, Porteous R, Chassé M, Lebrasseur M, Lauzier F, Turgeon AF, Bellemare D, Mehta S, Charbonney E, Belley-Côté É, Botton É, Cohen D, Lamontagne F, Adhikari NKJ; OVATION-65 team members; Canadian Critical Care Trials Group. Optimal VAsopressor TitraTION in patients 65 years and older (OVATION-65): protocol and statistical analysis plan for a randomised clinical trial. BMJ Open. 2020 Nov 14;10(11):e037947

Near-Infrared Spectroscopy to Assess Cerebral Autoregulation and Optimal Mean Arterial Pressure in Patients With Hypoxic-Ischemic Brain Injury: A Prospective Multicenter Feasibility Study

First Author:

Griesdale DE

Journal:

Crit Care Explor

Year:

2020

Group:

,

Griesdale DEG, Sekhon MS, Wood MD, Cardim D, Brasher PMA, McCredie V, Sirounis D, Foster D, Krasnogolova Y, Smielewski P, Scales DC, Ainslie PN, Menon DK, Boyd JG, Field TS, Dorian P; Cerebral Oximetry to Assess Cerebral Autoregulation in Hypoxic-Ischemic Brain Injury (CONCEPT) Research Group, on behalf of the Canadian Critical Care Trials Group. Near-Infrared Spectroscopy to Assess Cerebral Autoregulation and Optimal Mean Arterial Pressure in Patients With Hypoxic-Ischemic Brain Injury: A Prospective Multicenter Feasibility Study. Crit Care Explor. 2020 Sep 25;2(10):e0217. doi: 10.1097/CCE.0000000000000217. PMID: 33063026; PMCID: PMC7523861

Volume-dependent effect of stored red blood cells: A secondary analysis of the Age of Blood Evaluation trial

First Author:

Mack J

Journal:

Transfusion

Year:

2020

Group:

,

Mack J, Kahn SR, Tinmouth A, Fergusson D, Hébert PC, Lacroix J; Canadian Critical Care Trials Group.Volume-dependent effect of stored red blood cells: A secondary analysis of the Age of Blood Evaluation trial. Transfusion. 2020 Sep;60(9):1929-1939. doi: 10.1111/trf.15933. Epub 2020 Aug 28. PMID: 32856734 Clinical Trial.

Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study

First Author:

D'Aragon F

Journal:

Can J Anaesth

Year:

2020

Group:

,

D'Aragon F, Lamontagne F, Cook D, Dhanani S, Keenan S, Chassé M, English S, Burns KEA, Frenette AJ, Ball I, Boyd JG, Masse M, Breau R, Akhtar A, Kramer A, Rochwerg B, Lauzier F, Kutsogiannis DJ, Ibrahim Q, Hand L, Zhou Q, Meade MO, Canadian Critical Care Trials Group and the Canadian Donation and Transplant Research Program. Variability in deceased donor care in Canada: a report of the Canada-DONATE cohort study. Can J Anaesth. 2020 Aug;67(8):992-1004.  doi: 10.1007/s12630-020-01692-7

Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients

First Author:

Kho ME

Journal:

BMJ Open Resp Res

Year:

2019

Group:

Kho ME, Molloy AJ, Clarke FJ, et al. Multicentre pilot randomised clinical trial of early in-bed cycle ergometry with ventilated patients. BMJ Open Resp Res 2019;6:e000383. doi:10.1136/bmjresp-2018-000383.

Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients

First Author:

Schlosser K

Journal:

Crit Care Med

Year:

2019

Group:

,

Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients. Crit Care Med. 2019 Feb 1. doi: 10.1097/CCM.0000000000003657. [Epub ahead of print] PMID: 30720538

Development of a multinational registry of pediatric deceased organ donation activity

First Author:

Weiss MJ

Journal:

Pediatr Transplant

Year:

2019

Group:

,

Weiss MJ, Domínguez-Gil B, Lahaie N, Nakagawa TA, Scales A, Hornby L, Green M, Gelbart B, Hawkins K, Dhanani S, Dipchand AI, Shemie SD; Canadian Critical Care Trials Group. Development of a multinational registry of pediatric deceased organ donation activity. Pediatr Transplant. 2019 Feb 5:e13345. doi: 10.1111/petr.13345. [Epub ahead of print] PMID: 30724003

Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI

First Author:

Bagshaw SM

Journal:

Clin J Am Soc Nephrol

Year:

2019

Group:

Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R; Canadian Critical Care Trials Group.Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI. Clin J Am Soc Nephrol. 2019 Apr 5;14(4):496-505. PMID: 30898872

Effect of age of transfused red blood cells on neurologic outcome following traumatic brain injury (ABLE-tbi Study): a nested study of the Age of Blood Evaluation (ABLE) trial

First Author:

Ruel-Laliberté J

Journal:

Can J Anaesth.

Year:

2019

Group:

,

Ruel-Laliberté J, Lessard Bonaventure P, Fergusson D, Lacroix J, Zarychanski R, Lauzier F, Tinmouth A, Hébert PC, Green R, Griesdale D, Fowler R, Kramer A, McIntyre LA, Zygun D, Walsh T, Stanworth S, Capellier G, Pili-Floury S, Samain E, Clayton L, Marshall J, Pagliarello G, Sabri E, Neveu X, Léger C, Turgeon AF; Canadian Critical Care Trials Group.Effect of age of transfused red blood cells on neurologic outcome following traumatic brain injury (ABLE-tbi Study): a nested study of the Age of Blood Evaluation (ABLE) trial. Can J Anaesth. 2019 Feb 26. doi: 10.1007/s12630-019-01326-7. [Epub ahead of print] PMID: 30809776

Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials

First Author:

Burns KEA

Journal:

Crit Care Med.

Year:

2019

Group:

Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group. Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials. Crit Care Med. 2019 Jun;47(6):817-825. PMID: 30920411

Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes

First Author:

Lessard Bonaventure P

Journal:

Can J Anaesth.

Year:

2019

Group:

Lessard Bonaventure P, Lauzier F, Zarychanski R, Boutin A, Shemilt M, Saxena M, Zolfagari P, Griesdale D, Menon DK, Stanworth S, English S, Chassé M, Fergusson DA, Moore L, Kramer A, Robitaille A, Myburgh J, Cooper J, Hutchinson P, Turgeon AF; Canadian Critical Care Trials Group and the Canadian Traumatic Brain Injury Research Consortium. Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes. Can J Anaesth. 2019 Sep;66(9):1038-1048. PMID: 31012052

Determinants of Depressive Symptoms at One Year after Intensive Care Unit Discharge in Survivors of ≥7 Days of Mechanical Ventilation: Results from the RECOVER Program - a Secondary Analysis of a Prospective Multi-Centre Cohort Study

First Author:

Hamilton M

Journal:

Chest

Year:

2019

Group:

Hamilton M, Tomlinson G, Chu L, Robles P, Matte A, Burns S, Thomas C, Lamontagne F, Adhikari NK, Ferguson N, Friedrich JO, Rudkowski JC, Skrobik Y, Meggison H, Cameron J, Herridge M; RECOVER Program Investigators and the Canadian Critical Care Trials Group. Determinants of Depressive Symptoms at One Year after Intensive Care Unit Discharge in Survivors of ≥7 Days of Mechanical Ventilation: Results from the RECOVER Program - a Secondary Analysis of a Prospective Multi-Centre Cohort Study. Chest. 2019 May 15. pii: S0012-3692(19)31046-3. doi: 10.1016/j.chest.2019.04.104. [Epub ahead of print]. PMID: 31102611

Body Mass Index and Mortality in Subjects With ARDS: Post-hoc Analysis of the OSCILLATE Trial

First Author:

Tlayjeh H

Journal:

Respir Care

Year:

2019

Group:

Tlayjeh H, Arabi YM, Ferguson ND, Zhou Q, Lamontagne F, Arroliga A, Danesh V, Dominguez-Cherit G, Jimenez E, Mullaly A, Staub B, Meade MO; Canadian Critical Care Trials Group.Body Mass Index and Mortality in Subjects With ARDS: Post-hoc Analysis of the OSCILLATE Trial. Respir Care. 2019 May 28. pii: respcare.06675. doi: 10.4187/respcare.06675. [Epub ahead of print]. PMID: 31138733

Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials.

First Author:

Garcia Guerra G

Journal:

J Crit Care

Year:

2019

Group:

,

Garcia Guerra G, Almeida L, Zorzela L, King-Jones S, Joffe AR, Hartling L, Jou H, Vohra S; Canadian Critical Care Trials Group. Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials. J Crit Care. 2019 Jun 4;53:75-80. PMID: 31202161

Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury

First Author:

Turgeon AF

Journal:

CMAJ

Year:

2019

Group:

Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group. Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury. CMAJ. 2019 Jun 17;191(24):E652-E663. PMID: 31209132 

Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT.

First Author:

Johnstone J

Journal:

BMJ Open

Year:

2019

Group:

,

Johnstone J, Heels-Ansdell D, Thabane L, Meade M, Marshall J, Lauzier F, Duan EH, Zytaruk N, Lamarche D, Surette M, Cook DJ; PROSPECT Investigators and the Canadian Critical Care Trials Group.Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT. BMJ Open. 2019 Jun 20;9(6):e025228. PMID: 31227528

Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group.

First Author:

Wood MD

Journal:

BMJ Open

Year:

2019

Group:

,

Wood MD, Khan J, Lee KFH, Maslove DM, Muscedere J, Hunt M, Scott SH, Day A, Jacobson JA, Ball I, Slessarev M, O'Regan N, English SW, McCredie V, Chasse M, Griesdale D, Boyd JG. Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group. BMJ Open. 2019 Jun 25;9(6):e029189. PMID: 31243036

Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study.

First Author:

Burns KEA

Journal:

BMJ Open

Year:

2019

Group:

Burns KEA, Rizvi L, Cook DJ, Dodek P, Slutsky AS, Jones A, Villar J, Kapadia FN, Gattas DJ, Epstein SK, Meade MO; Canadian Critical Care Trials Group. Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study. BMJ Open. 2019 Sep 8;9(9):e031775. PMID: 31501132

Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.

First Author:

Burns KEA

Journal:

Trials

Year:

2019

Group:

Burns KEA, Rizvi L, Cook DJ, Seely AJE, Rochwerg B, Lamontagne F, Devlin JW, Dodek P, Mayette M, Tanios M, Gouskos A, Kay P, Mitchell S, Kiedrowski KC, Hill NS; Canadian Critical Care Trials Group. Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial Trials. 2019 Oct 11;20(1):587. PMID: 31604480

Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

First Author:

Spinella PC

Journal:

JAMA

Year:

2019

Group:

,

Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF; ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10;322(22):2179-2190. PMID: 31821429

Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol.

First Author:

Crawshaw J

Journal:

BMJ Open

Year:

2019

Group:

Crawshaw J, Presseau J, van Allen Z, Pinheiro Carvalho L, Jordison K, English S, Fergusson DA, Lauzier F, Turgeon AF, Sarti AJ, Martin C, D'Aragon F, Li AH, Knoll G, Ball I, Brehaut J, Burns KEA, Fortin MC, Weiss M, Meade M, Marsolais P, Shemie S, Zaabat S, Dhanani S, Kitto SC, Chassé M; Canadian Donation and Transplantation Research Program and the Canadian Critical Care Trials Group. Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol. BMJ Open. 2019 Dec 23;9(12):e034594. PMID: 31874899

Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial.

First Author:

McIntyre LA

Journal:

Am J Respir Crit Care Med.

Year:

2018

Group:

, ,

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347. PMID: 28960096

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery.

First Author:

Ball IM

Journal:

Can J Anaesth.

Year:

2018

Group:

, ,

Ball IM, Burry L, Dodek P, Hutchison JS, Leigh JP, McCredie V, Murthy S, Rochwerg B, Cook D; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery. Can J Anaesth. 2018 Mar;65(3):239-245. PMID: 29150787