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Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients

First Author:

Schlosser K

Journal:

Crit Care Med

Year:

2019

Group:

,

Schlosser K, Wang JP, Dos Santos C, Walley KR, Marshall J, Fergusson DA, Winston BW, Granton J, Watpool I, Stewart DJ, McIntyre LA, Mei SHJ; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.Effects of Mesenchymal Stem Cell Treatment on Systemic Cytokine Levels in a Phase 1 Dose Escalation Safety Trial of Septic Shock Patients. Crit Care Med. 2019 Feb 1. doi: 10.1097/CCM.0000000000003657. [Epub ahead of print] PMID: 30720538

Development of a multinational registry of pediatric deceased organ donation activity

First Author:

Weiss MJ

Journal:

Pediatr Transplant

Year:

2019

Group:

,

Weiss MJ, Domínguez-Gil B, Lahaie N, Nakagawa TA, Scales A, Hornby L, Green M, Gelbart B, Hawkins K, Dhanani S, Dipchand AI, Shemie SD; Canadian Critical Care Trials Group. Development of a multinational registry of pediatric deceased organ donation activity. Pediatr Transplant. 2019 Feb 5:e13345. doi: 10.1111/petr.13345. [Epub ahead of print] PMID: 30724003

Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI

First Author:

Bagshaw SM

Journal:

Clin J Am Soc Nephrol

Year:

2019

Group:

Bagshaw SM, Adhikari NKJ, Burns KEA, Friedrich JO, Bouchard J, Lamontagne F, McIntrye LA, Cailhier JF, Dodek P, Stelfox HT, Herridge M, Lapinsky S, Muscedere J, Barton J, Griesdale D, Soth M, Ambosta A, Lebovic G, Wald R; Canadian Critical Care Trials Group.Selection and Receipt of Kidney Replacement in Critically Ill Older Patients with AKI. Clin J Am Soc Nephrol. 2019 Apr 5;14(4):496-505. PMID: 30898872

Effect of age of transfused red blood cells on neurologic outcome following traumatic brain injury (ABLE-tbi Study): a nested study of the Age of Blood Evaluation (ABLE) trial

First Author:

Ruel-Laliberté J

Journal:

Can J Anaesth.

Year:

2019

Group:

,

Ruel-Laliberté J, Lessard Bonaventure P, Fergusson D, Lacroix J, Zarychanski R, Lauzier F, Tinmouth A, Hébert PC, Green R, Griesdale D, Fowler R, Kramer A, McIntyre LA, Zygun D, Walsh T, Stanworth S, Capellier G, Pili-Floury S, Samain E, Clayton L, Marshall J, Pagliarello G, Sabri E, Neveu X, Léger C, Turgeon AF; Canadian Critical Care Trials Group.Effect of age of transfused red blood cells on neurologic outcome following traumatic brain injury (ABLE-tbi Study): a nested study of the Age of Blood Evaluation (ABLE) trial. Can J Anaesth. 2019 Feb 26. doi: 10.1007/s12630-019-01326-7. [Epub ahead of print] PMID: 30809776

Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials

First Author:

Burns KEA

Journal:

Crit Care Med.

Year:

2019

Group:

Burns KEA, Wong JTY, Dodek P, Cook DJ, Lamontagne F, Cohen A, Mehta S, Kho ME, Hebert PC, Aslanian P, Friedrich JO, Brochard L, Rizvi L, Hand L, Meade MO, Amaral AC, Seely AJ; Canadian Critical Care Trials Group. Frequency of Screening for Weaning From Mechanical Ventilation: Two Contemporaneous Proof-of-Principle Randomized Controlled Trials. Crit Care Med. 2019 Jun;47(6):817-825. PMID: 30920411

Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes

First Author:

Lessard Bonaventure P

Journal:

Can J Anaesth.

Year:

2019

Group:

Lessard Bonaventure P, Lauzier F, Zarychanski R, Boutin A, Shemilt M, Saxena M, Zolfagari P, Griesdale D, Menon DK, Stanworth S, English S, Chassé M, Fergusson DA, Moore L, Kramer A, Robitaille A, Myburgh J, Cooper J, Hutchinson P, Turgeon AF; Canadian Critical Care Trials Group and the Canadian Traumatic Brain Injury Research Consortium. Red blood cell transfusion in critically ill patients with traumatic brain injury: an international survey of physicians' attitudes. Can J Anaesth. 2019 Sep;66(9):1038-1048. PMID: 31012052

Determinants of Depressive Symptoms at One Year after Intensive Care Unit Discharge in Survivors of ≥7 Days of Mechanical Ventilation: Results from the RECOVER Program - a Secondary Analysis of a Prospective Multi-Centre Cohort Study

First Author:

Hamilton M

Journal:

Chest

Year:

2019

Group:

Hamilton M, Tomlinson G, Chu L, Robles P, Matte A, Burns S, Thomas C, Lamontagne F, Adhikari NK, Ferguson N, Friedrich JO, Rudkowski JC, Skrobik Y, Meggison H, Cameron J, Herridge M; RECOVER Program Investigators and the Canadian Critical Care Trials Group. Determinants of Depressive Symptoms at One Year after Intensive Care Unit Discharge in Survivors of ≥7 Days of Mechanical Ventilation: Results from the RECOVER Program - a Secondary Analysis of a Prospective Multi-Centre Cohort Study. Chest. 2019 May 15. pii: S0012-3692(19)31046-3. doi: 10.1016/j.chest.2019.04.104. [Epub ahead of print]. PMID: 31102611

Body Mass Index and Mortality in Subjects With ARDS: Post-hoc Analysis of the OSCILLATE Trial

First Author:

Tlayjeh H

Journal:

Respir Care

Year:

2019

Group:

Tlayjeh H, Arabi YM, Ferguson ND, Zhou Q, Lamontagne F, Arroliga A, Danesh V, Dominguez-Cherit G, Jimenez E, Mullaly A, Staub B, Meade MO; Canadian Critical Care Trials Group.Body Mass Index and Mortality in Subjects With ARDS: Post-hoc Analysis of the OSCILLATE Trial. Respir Care. 2019 May 28. pii: respcare.06675. doi: 10.4187/respcare.06675. [Epub ahead of print]. PMID: 31138733

Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials.

First Author:

Garcia Guerra G

Journal:

J Crit Care

Year:

2019

Group:

,

Garcia Guerra G, Almeida L, Zorzela L, King-Jones S, Joffe AR, Hartling L, Jou H, Vohra S; Canadian Critical Care Trials Group. Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials. J Crit Care. 2019 Jun 4;53:75-80. PMID: 31202161

Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury

First Author:

Turgeon AF

Journal:

CMAJ

Year:

2019

Group:

Turgeon AF, Dorrance K, Archambault P, Lauzier F, Lamontagne F, Zarychanski R, Fowler R, Moore L, Lacroix J, English S, Boutin A, Muscedere J, Burns KEA, Griesdale D, McIntyre LA, Scales D, Bernard F, Yamada J, Squires JE; Canadian Traumatic Brain Injury Research Consortium and the Canadian Critical Care Trials Group. Factors influencing decisions by critical care physicians to withdraw life-sustaining treatments in critically ill adult patients with severe traumatic brain injury. CMAJ. 2019 Jun 17;191(24):E652-E663. PMID: 31209132 

Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT.

First Author:

Johnstone J

Journal:

BMJ Open

Year:

2019

Group:

,

Johnstone J, Heels-Ansdell D, Thabane L, Meade M, Marshall J, Lauzier F, Duan EH, Zytaruk N, Lamarche D, Surette M, Cook DJ; PROSPECT Investigators and the Canadian Critical Care Trials Group.Evaluating probiotics for the prevention of ventilator-associated pneumonia: a randomised placebo-controlled multicentre trial protocol and statistical analysis plan for PROSPECT. BMJ Open. 2019 Jun 20;9(6):e025228. PMID: 31227528

Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group.

First Author:

Wood MD

Journal:

BMJ Open

Year:

2019

Group:

,

Wood MD, Khan J, Lee KFH, Maslove DM, Muscedere J, Hunt M, Scott SH, Day A, Jacobson JA, Ball I, Slessarev M, O'Regan N, English SW, McCredie V, Chasse M, Griesdale D, Boyd JG. Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group. BMJ Open. 2019 Jun 25;9(6):e029189. PMID: 31243036

Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study.

First Author:

Burns KEA

Journal:

BMJ Open

Year:

2019

Group:

Burns KEA, Rizvi L, Cook DJ, Dodek P, Slutsky AS, Jones A, Villar J, Kapadia FN, Gattas DJ, Epstein SK, Meade MO; Canadian Critical Care Trials Group. Variation in the practice of discontinuing mechanical ventilation in critically ill adults: study protocol for an international prospective observational study. BMJ Open. 2019 Sep 8;9(9):e031775. PMID: 31501132

Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial.

First Author:

Burns KEA

Journal:

Trials

Year:

2019

Group:

Burns KEA, Rizvi L, Cook DJ, Seely AJE, Rochwerg B, Lamontagne F, Devlin JW, Dodek P, Mayette M, Tanios M, Gouskos A, Kay P, Mitchell S, Kiedrowski KC, Hill NS; Canadian Critical Care Trials Group. Frequency of Screening and SBT Technique Trial - North American Weaning Collaboration (FAST-NAWC): a protocol for a multicenter, factorial randomized trial Trials. 2019 Oct 11;20(1):587. PMID: 31604480

Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial.

First Author:

Spinella PC

Journal:

JAMA

Year:

2019

Group:

,

Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF; ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10;322(22):2179-2190. PMID: 31821429

Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol.

First Author:

Crawshaw J

Journal:

BMJ Open

Year:

2019

Group:

Crawshaw J, Presseau J, van Allen Z, Pinheiro Carvalho L, Jordison K, English S, Fergusson DA, Lauzier F, Turgeon AF, Sarti AJ, Martin C, D'Aragon F, Li AH, Knoll G, Ball I, Brehaut J, Burns KEA, Fortin MC, Weiss M, Meade M, Marsolais P, Shemie S, Zaabat S, Dhanani S, Kitto SC, Chassé M; Canadian Donation and Transplantation Research Program and the Canadian Critical Care Trials Group. Exploring the experiences and perspectives of substitute decision-makers involved in decisions about deceased organ donation: a qualitative study protocol. BMJ Open. 2019 Dec 23;9(12):e034594. PMID: 31874899

Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial.

First Author:

McIntyre LA

Journal:

Am J Respir Crit Care Med.

Year:

2018

Group:

, ,

McIntyre LA, Stewart DJ, Mei SHJ, Courtman D, Watpool I, Granton J, Marshall J, Dos Santos C, Walley KR, Winston BW, Schlosser K, Fergusson DA; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. Cellular Immunotherapy for Septic Shock (CISS): A Phase I Clinical Trial. Am J Respir Crit Care Med. 2018 Feb 1;197(3):337-347. PMID: 28960096

The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery.

First Author:

Ball IM

Journal:

Can J Anaesth.

Year:

2018

Group:

, ,

Ball IM, Burry L, Dodek P, Hutchison JS, Leigh JP, McCredie V, Murthy S, Rochwerg B, Cook D; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery. Can J Anaesth. 2018 Mar;65(3):239-245. PMID: 29150787

Chloride and Other Electrolyte Concentrations in Commonly Available 5% Albumin Products.

First Author:

Lai AT

Journal:

Crit Care Med

Year:

2018

Group:

Lai AT, Zeller MP, Millen T, Kavsak P, Szczeklik W, Elahie A, Alhazzani W, D'Aragon F, Jaeschke R, Lamontagne F, Karachi T, Cook D, Meade M, Rochwerg B; Canadian Critical Care Trials Group. Chloride and Other Electrolyte Concentrations in Commonly Available 5% Albumin Products. Crit Care Med. 2018 Apr;46(4):e326-e329. PMID: 29293151

Prospective cohort study on noise levels in a pediatric cardiac intensive care unit.

First Author:

Garcia Guerra G

Journal:

J Crit Care

Year:

2018

Group:

, ,

Garcia Guerra G, Joffe AR, Sheppard C, Pugh J, Moez EK, Dinu IA, Jou H, Hartling L, Vohra S; Sedation Withdrawal and Analgesia Team (SWAT); Canadian Critical Care Trials Group (CCCTG). Prospective cohort study on noise levels in a pediatric cardiac intensive care unit.  J Crit Care. 2018 Apr;44:318-322. PMID: 29274594

Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial.

First Author:

Parshuram CS

Journal:

JAMA

Year:

2018

Group:

,

Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt EA, Joffe AR, Lacroix J, Moga MA, Nadkarni V, Ninis N, Parkin PC, Wensley D, Willan AR, Tomlinson GA; Canadian Critical Care Trials Group and the EPOCH Investigators. Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial. JAMA. 2018 Mar 13;319(10):1002-1012. PMID: 29486493

Assessing frailty in the intensive care unit: A reliability and validity study

First Author:

Shears, M

Journal:

J Crit Care

Year:

2018

Group:

Shears M, Takaoka A, Rochwerg B, Bagshaw SM, Johnstone J, Holding A, Tharmalingam S, Millen T, Clarke F, Rockwood K, Li G, Thabane L, Muscedere J, Stelfox HT, Cook DJ; Canadian Critical Care Trials Group. Assessing frailty in the intensive care unit: A reliability and validity study. J Crit Care. 2018 Feb 8;45:197-203. PMID: 29574340

Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials.

First Author:

Alhazzani W

Journal:

Intensive Care Med.

Year:

2018

Group:

Alhazzani W, Alshamsi F, Belley-Cote E, Heels-Ansdell D, Brignardello-Petersen R, Alquraini M, Perner A, Møller MH, Krag M, Almenawer S, Rochwerg B, Dionne J, Jaeschke R, Alshahrani M, Deane A, Perri D, Thebane L, Al-Omari A, Finfer S, Cook D, Guyatt G. Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials. Intensive Care Med. 2018 Jan;44(1):1-11. PMID: 29199388

Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial.

First Author:

Green RS

Journal:

Transfusion

Year:

2018

Group:

,

Green RS, Erdogan M, Lacroix J, Hébert PC, Tinmouth AT, Sabri E, Zhang T, Fergusson DA, Turgeon AF; ABLE Investigators and the Canadian Critical Care Trials Group. Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial. Transfusion. 2018 Aug;58(8):1846-1854. PMID: 29672869