Publications

Takaoka A, Zytaruk N, Davis M, Matte A, Johnstone J, Lauzier F, Marshall J, Adhikari N, Clarke FJ, Rochwerg B, Lamontagne F,  Hand L, Watpool I, Porteous RK, Masse M, D'Aragon F, Niven D, Heels-Ansdell D, Duan E, Dionne J, English S, St-Arnaud C, Millen T, Cook DJ, PROSPECT Investigators and the Canadian Critical Care Trials Group. Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study. J Crit Care 2022 Jun 17;71:154094. PMID: 35724443

Hohl CM, Rosychuk RJ, Hau JP, Hayward  J, Landes M, Yan JW, Ting DK, Welsford M, Archambault PM, Mercier E, Chandra K, Davis P, Vaillancourt S, Leeies M, Small S, Morrison LJ, Canadian COVID-19 Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, for the Canadian Critical Care Trials Group. Treatments, resource utilization, and outcomes of COVID-19 patients presenting to emergency departments across pandemic waves: an observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN). CJEM 2022 Jun;24(4):397-407. PMID: 35362857

Foster JR, Lee LA, Seabrook JA, Ryan M Betts LJ, Burgess SA, Slumkoski C, Walls M, Garros D, and Canadian Critical Care Trials Group. Family presence in Canadian PICUs during the COVID-19 pandemic: a mixed-methods environmental scan of policy and practice. CMAJ Jul-Sep 2022. PMID: 35790228

F. Lamontagne, M.-H. Masse, J. Menard, S. Sprague, R. Pinto, D.K. Heyland, D.J Cook, M.-C. Battista, A.G. Day, G.H. Guyatt, S. Kanji, R. Parke, S.P. McGuinness, B.-K. Tirupakuzhi Vijayaraghavan, D. Annane, D. Cohen, Y.M. Arabi, B. Bolduc, N. Marinoff, B. Rochwerg, T. Millen, M.O. Meade, L. Hand, I. Watpool, R. Porteous, P.J. Young, F. D’Aragon, E.P. Belley-Cote, E. Carbonneau, F. Clarke, D.M. Maslove, M. Hunt, M. Chassé, M. Lebrasseur, F. Lauzier, S. Mehta, H. Quiroz-Martinez, O.G. Rewa, E. Charbonney, A.J.E. Seely, D.J. Kutsogiannis, R. LeBlanc, A. Mekontso-Dessap, T.S. Mele, A.F. Turgeon, G. Wood, S.S. Kohli, J. Shahin, P. Twardowski, and N.K.J. Adhikari, for the LOVIT Investigators and the Canadian Critical Care Trials Group. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. NEJM. June 15, 2022
DOI: 10.1056/NEJMoa2200644 

Sarti AJ, Sutherland S, Meade M, Shemie S, Landriault A, Vanderspank-Wright B, Valiani S, Keenan S, Weiss MJ, Werestiuk K, Kramer AH, Kawchuk J, Beed S, Dhanani S, Pagliarello G, Chassé M, Lotherington K, Gatien M, Parsons K,  Chandler JA, Nickerson P, Cardinal P
CMAJ Aug 2022, 194 (30) E1054-E1061; DOI: 10.1503/cmaj.220508

Davis P, Rosychuk R, Hau JP, Cheng I, McRae AD, Daoust R, Lang E, Turner J, Khangura J, Fok PT, Stachura M, Brar B, Hohl CM; CCEDRRN investigators, and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group.BMJ Open. 2022 Aug 10;12(8):e057852. doi: 10.1136/bmjopen-2021-057852.PMID: 35948378

Pong S, Fowler RA, Murthy S, Pernica JM, Gilfoyle E, Fontela P, Rishu AH, Mitsakakis N, Hutchison JS, Science M, Seto W, Jouvet P, Daneman N; Canadian Critical Care Trials Group. Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study. BMC Pediatr. 2022 Apr 5;22(1):179. PMID: 35382774

Ista E, Redivo J, Kananur P, Choong K, Colleti J Jr, Needham DM, Awojoodu R, Kudchadkar SR; International PARK-PICU Investigators. ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries. Crit Care Med. 2022 Jan 1;50(1):114-125. PMID: 34259659

ISARIC Clinical Characterization Group, Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Sci Data. 2022 Jul 30;9(1):454. PMID: 35908040

Turgeon AF, Fergusson DA, Clayton L, Patton M-P, Zarychanski R, English S, Docherty A, Walsh T, Griesdale D, Kramer AH, Scales D, Burns KEA, Boyd JG, Marshall JC, Kutsogiannis DJ, Ball I, Hébert PC, Lamontagne F, Costerousse O, St-Onge M, Lessard Bonaventure P, Moore L, Neveu X, Rigamonti A, Khwaja K, Green RS, Laroche V, Fox-Robichaud A, Lauzier F for the HEMOTION Trial Team, the Canadian Critical Care Trials Group, the Canadian Perioperative Anesthesia Clinical Trials Group and the Canadian Traumatic Brain Injury Research Consortium. Haemoglobin transfusion threshold in traumatic brain injury optimisation (HEMOTION): a multicentre, randomised, clinical trial protocol.  BMJ Open
2022;12:e067117. doi:10.1136/bmjopen-2022-067117

Lau VI, Fowler R, Pinto R, Tremblay A, Borgia S, Carrier FM, Cheng MP, Conly J, Costiniuk CT, Daley P, Duan E, Durand M, Fontela PS, Farjou G, Fralick M, Geagea A, Grant J, Keynan Y, Khwaja K, Lee N, Lee TC, Lim R, O’Neil CR, Papenburg J, Semret M, Silverman M, Sligl W, Somayaji R, Tan DHS, Tsang JLY, Weatherald J, Yansouni CP, Zarychanski R and Murthy S for the E-CATCO authors, AMMI Clinical Research Network and Canadian Critical Care Trials Group. Cost-effectiveness of remdesivir plus usual care versus usual care alone for hospitalized patients with COVID-19: an economic evaluation as part of the Canadian Treatments for COVID-19 (CATCO) randomized clinical trial. September 06, 2022 10 (3) E807-E817; DOI: https://doi.org/10.9778/cmajo.20220077

Burns KEA, McDonald E, Debigaré S, Zamir N, Vasquez M, Piche-Ayotte M, Oczkowski S; Canadian Critical Care Trials Group. Patient and family engagement in patient care and research in Canadian intensive care units: a national survey. Can J Anaesth. 2022 Dec;69(12):1527-1536. doi: 10.1007/s12630-022-02342-w. Epub 2022 Nov 7. PMID: 36344874; PMCID: PMC9640777.

O'Hearn K, Cayouette F, Cameron S, Martin DA, Tsampalieros A, Menon K; Canadian Critical Care Trials Group. Assent in Pediatric Critical Care Research: A Cross-Sectional Stakeholder Survey of Canadian Research Ethics Boards, Research Coordinators, Pediatric Critical Care Researchers, and Nurses. Pediatr Crit Care Med. 2022 Oct 13. doi: 10.1097/PCC.0000000000003135. Epub ahead of print. PMID: 36511694.

Brooks SC, Rosychuk RJ, Perry JJ, Morrison LJ, Wiemer H, Fok P, Rowe BH, Daoust R, Vatanpour S, Turner J, Landes M, Ohle R, Hayward J, Scheuermeyer F, Welsford M, Hohl C; Canadian COVID‐19 Rapid Response Network (CCEDRRN) for the Network of Canadian Emergency Researchers (NCER) and the Canadian Critical Care Trials Group (CCCTG). Derivation and validation of a clinical decision rule to risk-stratify COVID-19 patients discharged from the emergency department: The CCEDRRN COVID discharge score. J Am Coll Emerg Physicians Open. 2022 Dec 22;3(6):e12868. doi: 10.1002/emp2.12868. PMID: 36579029; PMCID: PMC9780419.

Fiest KM, Krewulak KD, Jaworska N, Spence KL, Mizen SJ, Bagshaw SM, Burns KEA, Cook DJ, Fowler RA, Olafson K, Patten SB, Rewa OG, Rochwerg B, Spence S, West A, Stelfox HT, Parsons Leigh J; Canadian Critical Care Trials Group. Impact of restricted visitation policies during COVID-19 on critically ill adults, their families, critical care clinicians, and decision-makers: a qualitative interview study. Can J Anaesth. 2022 Oct;69(10):1248-1259. doi: 10.1007/s12630-022-02301-5. Epub 2022 Aug 17. PMID: 35978160; PMCID: PMC9385091

Hohl CM, Rosychuk RJ, Archambault PM, O'Sullivan F, Leeies M, Mercier É, Clark G, Innes GD, Brooks SC, Hayward J, Ho V, Jelic T, Welsford M, Sivilotti MLA, Morrison LJ, Perry JJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. The CCEDRRN COVID-19 Mortality Score to predict death among nonpalliative patients with COVID-19 presenting to emergency departments: a derivation and validation study. CMAJ Open. 2022 Feb 8;10(1):E90-E99. doi: 10.9778/cmajo.20210243. PMID: 35135824; PMCID: PMC9259439

Dhanani S, Hornby L, van Beinum A, Scales NB, Hogue M, Baker A, Beed S, Boyd JG, Chandler JA, Chassé M, D'Aragon F, Dezfulian C, Doig CJ, Duska F, Friedrich JO, Gardiner D, Gofton T, Harvey D, Herry C, Isac G, Kramer AH, Kutsogiannis DJ, Maslove DM, Meade M, Mehta S, Munshi L, Norton L, Pagliarello G, Ramsay T, Rusinova K, Scales D, Schmidt M, Seely A, Shahin J, Slessarev M, So D, Talbot H, van Mook WNKA, Waldauf P, Weiss M, Wind JT, Shemie SD; Canadian Critical Care Trials Group and the Canadian Donation and Transplantation Research Program.  Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures. N Engl J Med. 2021 Jan 28;384(4):345-352. PMID: 33503343 

Burns KEA, Rizvi L, Cook DJ, Lebovic G, Dodek P, Villar J, Slutsky AS, Jones A, Kapadia FN, Gattas DJ, Epstein SK, Pelosi P, Kefala K, Meade MO; Canadian Critical Care Trials Group. Ventilator Weaning and Discontinuation Practices for Critically Ill Patients.JAMA. 2021 Mar 23;325(12):1173-1184. PMID: 33755077

Fiest KM, Krewulak KD, Hiploylee C, Bagshaw SM, Burns KEA, Cook DJ, Fowler RA, Kredentser MS, Niven DJ, Olafson K, Parhar KKS, Patten SB, Fox-Robichaud AE, Rewa OG, Rochwerg B, Spence KL, Straus SE, Spence S, West A, Stelfox HT, Parsons Leigh J; Canadian Critical Care Trials Group. An environmental scan of visitation policies in Canadian intensive care units during the first wave of the COVID-19 pandemic. Can J Anaesth. 2021 Oct;68(10):1474-1484. doi: 10.1007/s12630-021-02049-4. Epub 2021 Jun 30. PMID: 34195922; PMCID: PMC8244673.

S Murthy, PM Archambault, A Atique, FM Carrier, MP Cheng, C Codan, N Daneman, W Dechert, S Douglas, KM Fiest, R Fowler, G Goco, Y Gu, A Guerguerian, R Hall, JM Hsu, A Joffe, P Jouvet, L Kelly, ME Kho, RJ Kruisselbrink, D Kumar, DJ Kutsogiannis, F Lamontagne, TC Lee, KMenon, H O'Grady, K O'Hearn, DH Ovakim, SG Pharand, T Pitre, R Reel, B Reeve, O Rewa, D Richardson, A Rishu, G Sandhu, S Sarfo-Mensah, E Shadowitz, W Sligl, J Solomon, HT Stelfox, A Swanson, H Tessier-Grenier, JLY Tsang, G Wood, SPRINT-SARI Canada Investigators and the Canadian Critical Care Trials Group. Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study. CMAJ 2021 Mar 8;9(1):E181-E188. PMID: 33688026

Seely, Andrew JE and Robert Fowler. Importance of nationally coordinated data collection and quality improvement networks. Canadian Journal of Respiratory, Critical Care and Sleep Medicine. Published online 17 August, 2021.

Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi YM, Heels-Ansdell D, Thabane L, Lamarche D; Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English S, Rochwerg B, Karachi T, Henderson S; Wood G, Ovakim D, Herridge M, Granton J, Wilcox E; Goffi A, Stelfox HT, Niven D, Muscedere J, Lamontagne F, D’Aragon F, St.-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari NK, Marquis F, Archambault P, Khwaja K, Kristof A, Kutsogiannis J, Zarychanski R, Paunovic B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Cartin-Ceba R, Taylor R, Cook D; for the Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. JAMA 2021; 326(11):1024-1033. doi:10.1001/jama.2021.13355

O'Hearn K, Gibson J, Krewulak K, Porteous R, Saigle V, Sampson M, Tsampalieros A, Barrowman N, Cameron S; Canadian Critical Care Trials Group. Consent models in Canadian critical care randomized controlled trials: a scoping review. Can J Anaesth. 2022 Apr;69(4):513-526. English. doi: 10.1007/s12630-021-02176-y. Epub 2021 Dec 14. PMID: 34907503.

Krewulak KD, Jaworska  N, Spence KL, Mizen SJ, Kupsch  S, Stelfox HT, Parsons Leigh J, Fiest KM, and Canadian Critical Care Trials Group. Impact of Restricted Visitation Policies During the First Wave of the COVID-19 Pandemic on Communication Between Critically Ill Patients, Families and Clinicians: A Qualitative Interview Study. Dec. 16, 2021 DOI: 10.1513/AnnalsATS.202107-877OC PMID: 34914537