Publications

Muscedere J, Dodek PE, Keenan S, Fowler R, Cook DJ, Heyland D for the VAP Guidelines Committee and for the Canadian Critical Care Trials Group. Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Prevention.  J Crit Care 2008; 23: 126-137. PMID: 18359430

Sinuff T, Muscedere J, Cook D, Dodek P, Heyland D for the Canadian Critical Care Trials Group. Ventilator-associated pneumonia: Improving outcomes through guideline implementation. J Crit Care 2008; 23: 118-125. PMID: 18359429

Joffe AR, Muscedere J, Marshall JC, Su Y, Heyland DK for the Canadian Critical Care Trials Group. The safety of targeted antibiotic therapy for ventilator-associated pneumonia: A multicenter observational study. J Crit Care 2008; 23: 82-90. PMID: 18359425

Albert M, Friedrich JO, Adhikari NKJ, Day AG, Verdant C, Heyland DK for the Canadian Critical Care Trials Group. Utility of gram stain in the clinical management of suspected ventilator-associated pneumonia: Secondary analysis of a multicenter randomized trial. J Crit Care 2008; 23: 74-81. PMID: 18359424

Shorr AF, Cook D, Jiang X, Muscedere J, Heyland D for the Canadian Critical Care Trials Group. Correlates of clinical failure in ventilator-associated pneumonia: Insights from a large, randomized trial. J Crit Care 2008; 23: 64-73. PMID: 18359423

Sanders KM, Adhikari N, Friedrich JO, Day A, Jiang S, Heyland D for the Canadian Critical Care Trials Group. Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: Secondary analysis from a randomized trial. J Crit Care 2008; 23: 58-63. PMID: 18359422

Lauzier F, Ruest A, Cook D, Dodek P, Albert M, Shorr AF, Day A, Jiang X, Heyland D for the Canadian Critical Care Trials Group. The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia. J Crit Care 2008; 23: 50-57. PMID: 18359421

Muscedere JG, McColl C, Shorr A, Jiang X, Marshall J, Heyland DK for the Canadian Critical Care Trials Group. Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia. J Crit Care 2008; 23: 41-49. PMID: 18359420

Parker CM, Kutsogiannis J, Muscedere J, Cook D, Dodek P, Day AG, Heyland DK for the Canadian Critical Care Trials Group. Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: Prevalence, incidence, risk factors, and outcomes. J Crit Care 2008;23: 18-26. PMID: 18359417

Delisle MS, Williamson DR, Perreault MM, Albert M, Jiang X, Heyland DK. The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients. J Crit Care 2008; 23: 11-17. PMID: 18359416

Muscedere JG, Martin CM, Heyland DK. The impact of ventilator-associated pneumonia on the Canadian health care system. J Crit Care 2008; 23: 5-10. PMID: 18359415

Cook D, Douketis J, Meade M, Guyatt G, Zytaruk N, Granton J, Skrobik Y, Albert M, Fowler R, Hebert P, Pagliarello G, Friedrich J, Freitag A, Karachi T, Rabbat C, Heels-Ansdell D, Geerts W, Crowther M; Canadian Critical Care Trials Group.Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors.Crit Care. 2008;12(2):R32. PMID: 18315876

McIntyre LA, Fergusson D, Cook DJ, Nair RC, Bell D, Dhingra V, Hutton B, Magder S, Hébert PC for the Canadian Critical Care Trials Group. Resuscitating patients with early severe sepsis: A Canadian multicenter observational study. Can J Anaesth. 2007 Oct;54(10):790-8. PMID: 17934160

McIntyre LA, Hebert PC, Fergusson D, Cook DJ, Aziz A for the Canadian Critical Care Trials Group. A Survey of Canadian Intensivists Resuscitation Practices in Early Septic Shock. Crit Care. 2007;11(4):R74. PMID: 17623059

Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ on behalf of the TRIPICU investigators, for the Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Transfusion Requirements In Pediatric Intensive Care Units: A Noninferiority Trial. N Engl J Med 2007;356(16):1609-1619. PMID: 17442904

Menon K, Lawson M.Identification of adrenal insufficiency in pediatric critical illness. Pediatr Crit Care Med. 2007 May;8(3):276-8. PMID: 17417118

Heyland DK, Cook D, Dodek P, Muscedere J, Day A. The Canadian Critical Care Trials Group. A randomized trial of diagnostic techniques and empiric broad-spectrum antibiotics for suspected ventilator-associated pneumonia. N Engl J Med 2006;355(25):2619-2630. PMID: 17182987

Cook DJ, Rocker G, Marshall J, Griffith L, McDonald E, Guyatt GH for the Level of Care Study Investigators and the Canadian Critical Care Trials Group. Levels of Care in the Intensive Care Unit: A Research Program. Am J Crit Care 2006 May;15(3):269-79. PMID: 16632769

McIntyre LA, Fergusson D, Hutchinson J, Pagliarello G, Marshall J, Yetisir E, Hare GMT, Blajchman MJ, Hebert PC for The Canadian Care Trials Group. Effect of a liberal versus restrictive transfusion strategies on mortality in patients with moderate to severe head injury? J Neuro Critical Care 2006;5:4-9. PMID: 16960287

Hutchison JS, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D, for the HyP-HIT investigators and the Canadian Critical Care Trials Group. Hypothermia Pediatric Head Injury Trial (HyP-HIT): The value of a pre-trial clinical evaluation phase. Developmental Neuroscience 2006;28:291-301. PMID: 16943652

Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matte-Martyn A, Mehta S, Mazer D, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook DJ, Slutsky AS, Herridge MS for The Canadian Critical Care Trials Group. Two-year health care utilization, costs and outcomes in survivors of the acute respiratory distress syndrome. Am J Resp Crit Care Med 2006; 174:538-544. PMID: 16763220

Heyland DK, Dhaliwal R, Day A, Muscedere J, Drover J, Suchner U, Cook DJ, For the Canadian Critical Care Trials Group.  REducing Deaths due to OXidative Stress: The REDOXS© Study: Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically ill patients.  Proc Nutr Soc 2006;65(3):250-263. PMID: 16923310

Parshuram CS, Mehta G, Kirpalani H, Granton J, Cook DJ, for The Canadian Critical Care Trials Group. In-house, overnight physician staffing: A cross-sectional survey of Canadian adult and paediatric ICUs. Crit Care Med 2006;34(6):1674-1678. PMID: 16625115

Mehta S, Burry L, Fischer S, Martinez-Motta JC, Hallett D, Bowman D, Wong C, Meade MO, Stewart TE, Cook DJ for The Canadian Critical Care Trials Group. A Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med 2006; 34:374-380. PMID: 16424717