Publications

Choong K, Bohn D, Fraser DD, Gaboury I, Hutchison JS, Joffe AR, Litalien C, Menon K, McNamara P, Ward RB with the Canadian Critical Care Trials Group. Vasopressin in Pediatric Vasodilatory Shock - A Multi-center Randomized Controlled Trial. Am J Respir Crit Care Med 2009;180(7)632-9. PMID: 19608718

Burns KEA, Meade MO, Lessard M, Keenan SP, Lelouche F for the Canadian Critical Care Trials Group. Wean Earlier and Automatically with New Technology: The WEAN Study: a protocol of a multicenter randomized controlled trial. Trials 2009;10:81. PMCID: PMC2749823 Learn More

Henderson W, Dhingra V, Chittock D, Foster D, Hebert P, Cook DJ, Heyland D, Dodek P, Schulzer M, Ronco R in association with the Canadian Critical Care Trials Group. The efficacy and Safety of Glucose Control Algorithms in Intensive Care: A Pilot Study of the Survival using Glucose Algorithm Regulation Trial (SUGAR). Pol Arch Med Wewn 2009 Jul-Aug;119(7-8):439-46. PMID: 19776683

Doherty DR, Parshuram CS, Aparna Hoskote A, Lacroix J, Tucci M, Joffe A, Choong K, Gaboury I, Farrell R, Bohn DJ, Hutchison J, on behalf of the Canadian Critical Care Trials Group. Hypothermia Therapy after Pediatric Cardio-respiratory Arrest. Circulation 2009;119:1492-1500. PMID: 19273725

Scales DC, Orla M. Smith OM, Pinto R, Barrett KA, Friedrich JO, Lazar NM, Cook DJ, Ferguson ND for the Canadian Critical Care Trials Group.  Patients’ Preferences For Enrolment into Critical Care Trials. Intensive Care Med. 2009 Oct;35(10):1703-12. Epub 2009 Jun 24. PMID: 19551372

NICE SUGAR Study Investigators for the Australian and New Zealand Intensive Care Society, the George Institute for International Health, for the Canadian Critical Care Trials Group, and the Vancouver Coastal Health Research Institute . Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360(13):1283-1297. PMID: 19318384

Marshall JC, Cook DJ for the Canadian Critical Care Trials Group. Investigator-led clinical research consortia: The Canadian Critical Care Trials Group. Crit Care Med 2009; 36(7):S165-S172. PMID: 19104219

Cook D, Sinuff T, Zytaruk N, Rabbat C, Lee A, O'Donnell M, Thabane L, Linkins L, Treleaven D, Patel R, Meade M, Crowther M, Marshall JC, Douketis J; DIRECT Investigators and Canadian Critical Care Trials Group. Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis.J Crit Care. 2009;24(2):168-75. PMID: 19327956

Scales DC, Riva-Cambrin J, Le TL, Pinto R, Cook DJ, Granton JT; Canadian Critical Care Trials Group.J  Prophylaxis against venous thromboembolism in neurointensive care patients: survey of Canadian practice. Crit Care. 2009 Jun;24(2):176-84. PMID: 19501306

Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion. 2009;49(11):2326-34. PMID: 19624600

Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA, Canadian Critical Care Trials Group H1N1 Collaborative Collaborators. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009 Nov 4;302(17):1872-9.  doi: 10.1001/jama.2009.1496.  PMID: 19822627  DOI: 10.1001/jama.2009.1496

McIntyre LA, Fergusson D, Cook DJ, Rankin N, Dhingra V, Granton J, Magder S, Taljjard M, Hebert PC for the Canadian Critical Care Trials Group. Fluid Resuscitation in the Management of Early Septic Shock (FINESS): A pilot randomized controlled feasibility study Can J Anesth 2008, 55: 12; 819-826. PMID: 19050085

Douketis J, Cook D, Meade M, Guyatt G, Geerts W, Skrobik Y, Albert M, Granton J, Hebert PC, Pagliarello G, Marshall JC, Fowler R, Freitag A, Rabbat C, Anderson D, Zytaruk N, Heels-Ansdell D, Crowther MA for the Canadian Critical Care Trials Group. Renal Insufficiency with the Low-molecular-weight Heparin Dalteparin: An Assessment of Safety and Pharmacodynamics. The DIRECT (Dalteparin’s Influence on REnally Compromised anti-Ten-A) Study. Arch Intern Med 2008;168(16):1805-1812. PMID: 18779469

Mehta S, Burry L, Martinez-Motta C, Stewart TE, Hallett D, McDonald E, Clarke F, MacDonald R, Granton J, Matte A, Wong C, Suri A, Cook D for the Canadian Critical Care Trials Group.  A randomized trial of daily awakening in critically ill patients managed with a sedation protocol – A pilot study. Crit Care Med 2008;36(7):2092-2099. PMID: 18552687

Cook DJ, Blythe D, Rischbieth A, Hebert PC, Zytaruk N, Menon K, Erikson S, Fowler R, Heels-Ansdell D, Meade MO for the Canadian Critical Care Trials Group. Enrolment of ICU Patients into Clinical Studies: A Tri-national Survey. Crit Care Med 2008; 36(7):2100-2105. PMID: 18552686

Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Ferguson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW, for the Hypothermia Pediatric Head Injury Trial investigators and for the Canadian Critical Care Trials Group. Hypothermia Therapy Following Traumatic Brain Injury in Children. N Engl J Med. 2008 Jun 5;358(23):2447-56. PMID: 18525042

Cheung CZ, Alibhai SMH, Robinson M, Tomlinson G, Chittock D, Drover J, Skrobik Y for the Canadian Critical Care Trials Group. Recognition and labeling of delirium symptoms by intensivists: Does it matter? Intensive Care Medicine 2008;34:437-446. PMID: 18087692

Heyland DK, Dodek P, Muscedere J, Day A, Cook DJ for the Canadian Critical Care Trials Group. A Randomized Trial of Combination Versus Monotherapy for the Empiric Treatment of Suspected Ventilator-Associated Pneumonia. Crit Care Med 2008; 36: 737-744. PMID: 18091545

Muscedere J, Dodek PE, Keenan S, Fowler R, Cook DJ, Heyland DK for the VAP Guidelines Committee and for the Canadian Critical Care Trials Group.Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Diagnosis and Treatment. J Crit Care 2008; 23: 138-147. PMID: 18359431

Muscedere J, Dodek PE, Keenan S, Fowler R, Cook DJ, Heyland D for the VAP Guidelines Committee and for the Canadian Critical Care Trials Group. Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Prevention.  J Crit Care 2008; 23: 126-137. PMID: 18359430

Sinuff T, Muscedere J, Cook D, Dodek P, Heyland D for the Canadian Critical Care Trials Group. Ventilator-associated pneumonia: Improving outcomes through guideline implementation. J Crit Care 2008; 23: 118-125. PMID: 18359429

Joffe AR, Muscedere J, Marshall JC, Su Y, Heyland DK for the Canadian Critical Care Trials Group. The safety of targeted antibiotic therapy for ventilator-associated pneumonia: A multicenter observational study. J Crit Care 2008; 23: 82-90. PMID: 18359425

Albert M, Friedrich JO, Adhikari NKJ, Day AG, Verdant C, Heyland DK for the Canadian Critical Care Trials Group. Utility of gram stain in the clinical management of suspected ventilator-associated pneumonia: Secondary analysis of a multicenter randomized trial. J Crit Care 2008; 23: 74-81. PMID: 18359424

Shorr AF, Cook D, Jiang X, Muscedere J, Heyland D for the Canadian Critical Care Trials Group. Correlates of clinical failure in ventilator-associated pneumonia: Insights from a large, randomized trial. J Crit Care 2008; 23: 64-73. PMID: 18359423