Publications

Burns KEA, Wong J, Rizvi L, Lafreniere-Roula M, Thorpe K, Devlin JW, Cook DJ, Seely A, Dodek PM, Tanios M, Piraino T, Gouskos A, Kiedrowski KC, Kay P, Mitchell S, Merner GW, Mayette M, D'Aragon F, Lamontagne F, Rochwerg B, Turgeon A, Sia YT, Charbonney E, Aslanian P, Criner GJ, Hyzy RC, Beitler JR, Kassis EB, Kutsogiannis DJ, Meade MO, Liebler J, Iyer-Kumar S, Tsang J, Cirone R, Shanholtz C, Hill NS; Canadian Critical Care Trials Group. Frequency of Screening and Spontaneous Breathing Trial Techniques: A Randomized Clinical Trial. JAMA. 2024 Oct 9. doi: 10.1001/jama.2024.20631. Epub ahead of print. PMID: 39382222.

BALANCE Investigators, for the Canadian Critical Care Trials Group, the Association of Medical Microbiology and Infectious Disease Canada Clinical Research Network, the Australian and New Zealand Intensive Care Society Clinical Trials Group, and the Australasian Society for Infectious Diseases Clinical Research Network; Daneman N, Rishu A, Pinto R, Rogers BA, Shehabi Y, Parke R, Cook D, Arabi Y, Muscedere J, Reynolds S, Hall R, Dwivedi DB, McArthur C, McGuinness S, Yahav D, Coburn B, Geagea A, Das P, Shin P, Detsky M, Morris A, Fralick M, Powis JE, Kandel C, Sligl W, Bagshaw SM, Singhal N, Belley-Cote E, Whitlock R, Khwaja K, Morpeth S, Kazemi A, Williams A, MacFadden DR, McIntyre L, Tsang J, Lamontagne F, Carignan A, Marshall J, Friedrich JO, Cirone R, Downing M, Graham C, Davis J, Duan E, Neary J, Evans G, Alraddadi B, Al Johani S, Martin C, Elsayed S, Ball I, Lauzier F, Turgeon A, Stelfox HT, Conly J, McDonald EG, Lee TC, Sullivan R, Grant J, Kagan I, Young P, Lawrence C, O'Callaghan K, Eustace M, Choong K, Aslanian P, Buehner U, Havey T, Binnie A, Prazak J, Reeve B, Litton E, Lother S, Kumar A, Zarychanski R, Hoffman T, Paterson D, Daley P, Commons RJ, Charbonney E, Naud JF, Roberts S, Tiruvoipati R, Gupta S, Wood G, Shum O, Miyakis S, Dodek P, Kwok C, Fowler RA. Antibiotic Treatment for 7 versus 14 Days in Patients with Bloodstream Infections. N Engl J Med. 2024 Nov 20. doi: 10.1056/NEJMoa2404991. Epub ahead of print. PMID: 39565030.  NEJM/ New England Journal of Medicine

Hohl CM, Yeom DS, Yan J, Archambault PM, Brooks SC, Morrison LJ, Perry J, Rosychuk R; CCEDRRN investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Accuracy of the Canadian COVID-19 Mortality Score (CCMS) to predict in-hospital mortality among vaccinated and unvaccinated patients infected with Omicron: a cohort study. BMJ Open. 2024 Nov 19;14(11):e083280. doi: 10.1136/bmjopen-2023-083280. PMID: 39566942.

Yarnell CJ, Paranthaman A, Reardon P, Angriman F, Bassi T, Bellani G, Brochard L, De Grooth HJ, Dragoi L, Gaus S, Glover P, Goligher EC, Lewis K, Li B, Kareemi H, Tirupakuzhi Vijayaraghavan BK, Mehta S, Mellado-Artigas R, Moore J, Morris I, Roman-Sarita G, Pham T, Sereeyotin J, Tomlinson G, Wozniak H, Yoshida T, Fowler R; Canadian Critical Care Trials Group. An International Factorial Vignette-Based Survey of Intubation Decisions in Acute Hypoxemic Respiratory Failure. Crit Care Med. 2024 Nov 22. doi: 10.1097/CCM.0000000000006494. Epub ahead of print. PMID: 39576153.

Foster JR, Ryan MJ, Garros D, Walls M, Slumkoski C, Moghadam N, Ajidahun A, Seabrook JA, Lee LA; RFP-PICU research group for the Canadian Critical Care Trials Group. Family member experience with restricted family presence in Canadian PICUs: an interpretive descriptive study. Eur J Pediatr. 2024 Nov 29;184(1):52. doi: 10.1007/s00431-024-05854-3. PMID: 39609280; PMCID: PMC11604798.

English SW, Delaney A, Fergusson DA, Chassé M, Turgeon AF, Lauzier F, Tuttle A, Sadan O, Griesdale DE, Redekop G, Chapman M, Hannouche M, Kramer A, Seppelt I, Udy A, Kutsogiannis DJ, Zarychanski R, D'Aragon F, Boyd JG, Salt G, Bellapart J, Wood G, Cava L, Pickett G, Koffman L, Watpool I, Bass F, Hammond N, Ramsay T, Mallick R, Scales DC, Andersen CR, Fitzgerald E, Talbot P, Dowlatshahi D, Sinclair J, Acker J, Marshall SC, McIntyre L; SAHARA Trial Investigators on behalf of the Canadian Critical Care Trials Group. Liberal or Restrictive Transfusion Strategy in Aneurysmal Subarachnoid Hemorrhage. N Engl J Med. 2024 Dec 9. doi: 10.1056/NEJMoa2410962. Epub ahead of print. PMID: 39655786. NEJM / New England Journal of Medicine

Takaoka A, Johnstone J, Lauzier F, Heels-Ansdell D, Davis M, Zytaruk N, Duan E, Dionne J, Saunders L, Arabi YM, Marshall J, Thabane L, Clarke F, Hand L, Masse MH, Rochwerg B, McIntyre L, Girard M, Freitag A, Karachi T, Cook DJ; PROSPECT Investigators; Canadian Critical Care Trials Group. Enrolment patterns in a randomized controlled trial of probiotics in critically ill patients: a retrospective analysis of the PROSPECT trial. Trials. 2024 Dec 27;25(1):851. doi: 10.1186/s13063-024-08701-w. PMID: 39731129; PMCID: PMC11673600.

Schlapbach LJ, Ramnarayan P, Gibbons KS, Morrow BM, Napolitano N, Tume LN, Argent AC, Deep A, Lee JH, Peters MJ, Agus MSD, Appiah JA, Armstrong J, Bacha T, Butt W, de Souza DC, Fernández-Sarmiento J, Flori HR, Fontela P, Gelbart B, González-Dambrauskas S, Ikeyama T, Jabornisky R, Jayashree M, Kazzaz YM, Kneyber MCJ, Long D, Njirimmadzi J, Samransamruajkit R, Asperen RMW, Wang Q, O'Hearn K, Menon K; Australian and New Zealand Intensive Care Society Paediatric Study Group; Brazilian Research Network in Pediatric Intensive Care; Canadian Critical Care Trials Group; European Society of Paediatric and Neonatal Intensive Care; Pediatric Collaborative Network of Latin America; Pediatric Acute & Critical Care Medicine Asian Network; Pediatric Acute Lung Injury and Sepsis Investigators; United Kingdom Paediatric Critical Care Society Study Group; Pediatric Intensive Care Latin-American Society; World Federation of Pediatric Intensive & Critical Care Societies. Building global collaborative research networks in paediatric critical care: a roadmap. Lancet Child Adolesc Health. 2024 Dec 20:S2352-4642(24)00303-1. doi: 10.1016/S2352-4642(24)00303-1. Epub ahead of print. PMID: 39718171.

Bosma KJ, Lafreniere-Roula M, Jiang A, Heath A, Ouyang Y, Wade K, Hu P, Burns KEA, Martin CM, Skrobik Y, Mulligan S, Thorpe KE, Brochard L; members of the Canadian Critical Care Trials Group and the REVA Network. Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation (the PROMIZING study): update to the statistical analysis plan for a randomized controlled trial. Trials. 2024 Dec 30;25(1):855. doi: 10.1186/s13063-024-08669-7. PMID: 39736673; PMCID: PMC11684088.

Lin K, Xu K, Daoust R, Taylor J, Rosychuk RJ, Hau JP, Davis P, Clark G, McRae AD, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, the Canadian Critical Care Trials Group. Prognostic association between d-dimer thresholds and 30-day pulmonary embolism diagnosis among emergency department patients with suspected SARS-CoV-2 infection: a Canadian COVID-19 Emergency Department Rapid Response Network study. CJEM. 2023 Jan 10. doi: 10.1007/s43678-022-00440-8. Epub ahead of print. PMID: 36624252.

McIntyre LA, Fergusson DA, McArdle T, Fox-Robichaud A, English SW, Martin C, Marshall J, Cook DJ, Graham ID, Hawken S, McCartney C, Menon K, Saginur R, Seely A, Stiell I, Thavorn K, Weijer C, Iyengar A, Muscedere J, Forster AJ, Taljaard M; Canadian Critical Care Trials Group. FLUID trial: a hospital-wide open-label cluster cross-over pragmatic comparative effectiveness randomised pilot trial comparing normal saline to Ringer's lactate. BMJ Open. 2023 Feb 3;13(2):e067142. doi: 10.1136/bmjopen-2022-067142. PMID: 36737087; PMCID: PMC9900065.

Bosma KJ, Martin CM, Burns KEA, Mancebo Cortes J, Suárez Montero JC, Skrobik Y, Thorpe KE, Amaral ACK, Arabi Y, Basmaji J, Beduneau G, Beloncle F, Carteaux G, Charbonney E, Demoule A, Dres M, Fanelli V, Geagea A, Goligher E, Lellouche F, Maraffi T, Mercat A, Rodriguez PO, Shahin J, Sibley S, Spadaro S, Vaporidi K, Wilcox ME, Brochard L; Canadian Critical Care Trials Group and; REVA Network. Study protocol for a randomized controlled trial of Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: the PROMIZING study. Trials. 2023 Mar 27;24(1):232. doi: 10.1186/s13063-023-07163-w. PMID: 36973743

Johnstone J, Muscedere J, Dionne J, Duan E, Rochwerg B, Centofanti J, Oczkowski S, Lauzier F, Marshall J, Heels-Ansdell D, Daneman N, Mehta S, Arabi Y, Zytaruk N, Dodek P, Adhikari NK, Karachi T, Charbonney E, Stelfox HT, Kristof AS, Ball I, Hand L, Fowler R, Zarychanski R, Arnaud CS, Takaoka A, Kutsogiannis J, Khwaja K, Sligl W, Loubani O, Tsang J, Lamarche D, Bowdish D, Surette M, Cook D; Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study. J Crit Care. 2023 Mar 2:154284. doi: 10.1016/j.jcrc.2023.154284. Epub ahead of print. PMID: 36870801

Hohl CM, Hau JP, Vaillancourt S, Grant J, Brooks SC, Morrison LJ, Perry JJ, Rosychuk RJ; CCEDRRN investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Sensitivity and Diagnostic Yield of the First SARS-CoV-2 Nucleic Acid Amplification Test Performed for Patients Presenting to the Hospital. JAMA Netw Open. 2022 Oct 3;5(10):e2236288. doi: 10.1001/jamanetworkopen.2022.36288. PMID: 36223119; PMCID: PMC9557877

Li Y, Fiest K, Burns KEA, O'Hearn K, Maratta C, Menon K, Rochwerg B, Murthy S, Fowler R, Mehta S; Canadian Critical Care Trials Group. Addressing health care inequities in Canadian critical care through inclusive science: a pilot tool for standardized data collection. Can J Anaesth. 2023 May 10. English. doi: 10.1007/s12630-023-02450-1. Epub ahead of print. PMID: 37165123.

Sarti AJ, Sutherland S, Meade M, Hornby L, Wilson LC, Landriault A, Vanderspank-Wright B, Valiani S, Keenan S, Weiss MJ, Werestiuk K, Beed S, Kramer AH, Kawchuk J, Cardinal P, Dhanani S, Lotherington K, Pagliarello G, Chassé M, Gatien M, Parsons K, Chandler JA, Nickerson P, Shemie SD; Canadian Critical Care Trials Group (CCCTG). Death determination by neurologic criteria-what do families understand? Can J Anaesth. 2023 Apr;70(4):637-650. doi: 10.1007/s12630-023-02416-3. Epub 2023 May 2. Erratum in: Can J Anaesth. 2023 May 30;: PMID: 37131029; PMCID: PMC10203015.

Full article: https://pubmed.ncbi.nlm.nih.gov/37131029/

Correction: https://pubmed.ncbi.nlm.nih.gov/37253861/

Martin SM, Tucci M, Spinella PC, Ducruet T, Fergusson DA, Freed DH,
Lacroix J, Poirier N, Ben Sivarajan V, Steiner ME, Willems A, Guerra GG, on behalf of the ABC-PICU
Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis
Investigators (PALISI) Network, the BloodNet Pediatric Critical Care Blood Research Network, and the
Groupe Francophone de Réanimation et Urgences Pédiatriques, Effect of red blood cell storage time in
pediatric cardiac surgical patients: a subgroup analysis of a randomized controlled trial, JTCVS Open
(2023), doi: https://doi.org/10.1016/j.xjon.2023.04.022.

Burns KEA, Heels-Ansdell D, Thabane L, Kahn SR, Lauzier F, Mehta S, Ostermann M, Bhuptani P, Crowther MA, Finfer S, Cook DJ; PROTECT Investigators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Sex differences in thromboprophylaxis of the critically ill: a secondary analysis of a randomized trial. Can J Anaesth. 2023 Jun 13. English. doi: 10.1007/s12630-023-02457-8. Epub ahead of print. PMID: 37310606.

Kho ME, Reid J, Molloy AJ, Herridge MS, Seely AJ, Rudkowski JC, Buckingham L, Heels-Ansdell D, Karachi T, Fox-Robichaud A, Ball IM, Burns KEA, Pellizzari JR, Farley C, Berney S, Pastva AM, Rochwerg B, D'Aragon F, Lamontagne F, Duan EH, Tsang JLY, Archambault P, English SW, Muscedere J, Serri K, Tarride JE, Mehta S, Verceles AC, Reeve B, O'Grady H, Kelly L, Strong G, Hurd AH, Thabane L, Cook DJ; CYCLE Investigators and the Canadian Critical Care Trials Group. Critical Care Cycling to Improve Lower Extremity Strength (CYCLE): protocol for an international, multicentre randomised clinical trial of early in-bed cycling for mechanically ventilated patients. BMJ Open. 2023 Jun 23;13(6):e075685. doi: 10.1136/bmjopen-2023-075685. PMID: 37355270.

Archambault PM, Rosychuk RJ, Audet M, Bola R, Vatanpour S, Brooks SC, Daoust R, Clark G, Grant L, Vaillancourt S, Welsford M, Morrison LJ, Hohl CM; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators; Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Accuracy of Self-Reported COVID-19 Vaccination Status Compared With a Public Health Vaccination Registry in Québec: Observational Diagnostic Study. JMIR Public Health Surveill. 2023 Jun 16;9:e44465. doi: 10.2196/44465. PMID: 37327046; PMCID: PMC10278735.

Teo K, Fowler RA, Adhikari NKJ, Rishu A, Tsang JLY, Binnie A, Murthy S; Canadian Critical Care Trials Group. Time required to initiate a clinical trial in Canada at the onset of the COVID-19 pandemic: an observational research-in-motion study. CMAJ Open. 2023 Jul 4;11(4):E615-E620. doi: 10.9778/cmajo.20220129. PMID: 37402556.

O'Hearn K, Menon K, Weiler HA, Amrein K, Fergusson D, Gunz A, Bustos R, Campos R, Catalan V, Roedl S, Tsampalieros A, Barrowman N, Geier P, Henderson M, Khamessan A, Lawson ML, McIntyre L, Redpath S, Jones G, Kaufmann M, McNally D; Canadian Critical Care Trials Group. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study). BMC Pediatr. 2023 Aug 14;23(1):397. doi: 10.1186/s12887-023-04205-9. PMID: 37580663; PMCID: PMC10424361.

Foster JR, Lee LA, Seabrook JA, Ryan M, Slumkoski C, Walls M, Betts LJ, Burgess SA, Moghadam N, Garros D; Canadian Critical Care Trials Group. A survey of pediatric intensive care unit clinician experience with restricted family presence during COVID-19. Can J Anaesth. 2023 Aug 23. English. doi: 10.1007/s12630-023-02547-7. Epub ahead of print. PMID: 37610552.

Dennis BB, Thabane L, Heels-Ansdell D, Dionne JC, Binnie A, Tsang J, Guyatt G, Ahmed A, Lauzier F, Deane A, Arabi Y, Marshall J, Zytaruk N, Saunders L, Finfer S, Myburgh J, Muscedere J, English S, Ostermann M, Hardie M, Knowles S, Cook D; REVISE Investigators the Canadian Critical Care Trials Group. Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial. Trials. 2023 Aug 30;24(1):561. doi: 10.1186/s13063-023-07589-2. PMID: 37644556; PMCID: PMC10466724.