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A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study)

First Author:

O'Hearn K

Journal:

BMC Pediatr

Year:

2023

Group:

O'Hearn K, Menon K, Weiler HA, Amrein K, Fergusson D, Gunz A, Bustos R, Campos R, Catalan V, Roedl S, Tsampalieros A, Barrowman N, Geier P, Henderson M, Khamessan A, Lawson ML, McIntyre L, Redpath S, Jones G, Kaufmann M, McNally D; Canadian Critical Care Trials Group. A phase II dose evaluation pilot feasibility randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study). BMC Pediatr. 2023 Aug 14;23(1):397. doi: 10.1186/s12887-023-04205-9. PMID: 37580663; PMCID: PMC10424361.

A survey of pediatric intensive care unit clinician experience with restricted family presence during COVID-19

First Author:

Foster JR

Journal:

Can J Anaesth

Year:

2023

Group:

Foster JR, Lee LA, Seabrook JA, Ryan M, Slumkoski C, Walls M, Betts LJ, Burgess SA, Moghadam N, Garros D; Canadian Critical Care Trials Group. A survey of pediatric intensive care unit clinician experience with restricted family presence during COVID-19. Can J Anaesth. 2023 Aug 23. English. doi: 10.1007/s12630-023-02547-7. Epub ahead of print. PMID: 37610552.

Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial

First Author:

Dennis BB

Journal:

Trials

Year:

2023

Group:

Dennis BB, Thabane L, Heels-Ansdell D, Dionne JC, Binnie A, Tsang J, Guyatt G, Ahmed A, Lauzier F, Deane A, Arabi Y, Marshall J, Zytaruk N, Saunders L, Finfer S, Myburgh J, Muscedere J, English S, Ostermann M, Hardie M, Knowles S, Cook D; REVISE Investigators the Canadian Critical Care Trials Group. Proton pump inhibitors in critically ill mechanically ventilated patients with COVID-19: protocol for a substudy of the Re-EValuating the Inhibition of Stress Erosions (REVISE) Trial. Trials. 2023 Aug 30;24(1):561. doi: 10.1186/s13063-023-07589-2. PMID: 37644556; PMCID: PMC10466724.

Differences in directives to limit treatment and discontinue mechanical ventilation between elderly and very elderly patients: a substudy of a multinational observational study

First Author:

Burns KEA

Journal:

Intensive Care Med

Year:

2023

Group:

Burns KEA, Cook DJ, Xu K, Dodek P, Villar J, Jones A, Kapadia FN, Gattas DJ, Epstein SK, Pelosi P, Kefala K, Meade MO, Rizvi L; Canadian Critical Care Trials Group. Differences in directives to limit treatment and discontinue mechanical ventilation between elderly and very elderly patients: a substudy of a multinational observational study. Intensive Care Med. 2023 Sep 22. doi: 10.1007/s00134-023-07188-4. Epub ahead of print. PMID: 37736783.

Comparing methods to classify admitted patients with SARS-CoV-2 as admitted for COVID-19 versus with incidental SARS-CoV-2: A cohort study

First Author:

Hohl CM

Journal:

PLoS One

Year:

2023

Group:

Hohl CM, Cragg A, Purssel E, McAlister FA, Ting DK, Scheuermeyer F, Stachura M, Grant L, Taylor J, Kanu J, Hau JP, Cheng I, Atzema CL, Bola R, Morrison LJ, Landes M, Perry JJ, Rosychuk RJ; Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers; Canadian Critical Care Trials Group. Comparing methods to classify admitted patients with SARS-CoV-2 as admitted for COVID-19 versus with incidental SARS-CoV-2: A cohort study. PLoS One. 2023 Sep 26;18(9):e0291580. doi: 10.1371/journal.pone.0291580. PMID: 37751455; PMCID: PMC10522023.

Frequency of screening and SBT Technique Trial-North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan

First Author:

Burns KEA

Journal:

Trials

Year:

2023

Group:

Burns KEA, Lafrienier-Roula M, Hill NS, Cook DJ, Seely AJE, Rochwerg B, Mayette M, D'Aragon F, Devlin JW, Dodek P, Tanios M, Gouskos A, Turgeon AF, Aslanian P, Sia YT, Beitler JR, Hyzy R, Criner GJ, Kassis EB, Tsang JLY, Meade MO, Liebler JM, Wong JTY, Thorpe KE; Canadian Critical Care Trials Group. Frequency of screening and SBT Technique Trial-North American Weaning Collaboration (FAST-NAWC): an update to the protocol and statistical analysis plan. Trials. 2023 Oct 2;24(1):626. doi: 10.1186/s13063-023-07079-5. PMID: 37784109; PMCID: PMC10544476.

A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer's Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial

First Author:

Shaw JF

Journal:

JMIR Res Protoc

Year:

2023

Group:

Shaw JF, Ouyang Y, Fergusson DA, McArdle T, Martin C, Cook D, Graham ID, Hawken S, McCartney CJL, Menon K, Saginur R, Seely A, Stiell I, Fox-Robichaud A, English S, Marshall J, Thavorn K, Taljaard M, McIntyre LA; Canadian Critical Care Trials Group. A Hospital-Wide Open-Label Cluster Crossover Pragmatic Comparative Effectiveness Randomized Trial Comparing Normal Saline to Ringer's Lactate: Protocol and Statistical Analysis Plan of The FLUID Trial. JMIR Res Protoc. 2023 Oct 6;12:e51783. doi: 10.2196/51783. PMID: 37801356.

Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial

First Author:

Martin SM

Journal:

JTCVS Open

Year:

2023

Group:

Martin SM, Tucci M, Spinella PC, Ducruet T, Fergusson DA, Freed DH, Lacroix J, Poirier N, Sivarajan VB, Steiner ME, Willems A, Garcia Guerra G; Age of Blood in Children in Pediatric Intensive Care Unit Trial Investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators Network; BloodNet Pediatric Critical Care Blood Research Network; Groupe Francophone de Réanimation et Urgences Pédiatriques. Effect of red blood cell storage time in pediatric cardiac surgery patients: A subgroup analysis of a randomized controlled trial. JTCVS Open. 2023 May 31;15:454-467. doi: 10.1016/j.xjon.2023.04.022. PMID: 37808065; PMCID: PMC10556812.

Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials

First Author:

LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group

Journal:

JAMA

Year:

2023

Group:

LOVIT-COVID Investigators, on behalf of the Canadian Critical Care Trials Group, and the REMAP-CAP Investigators; Adhikari NKJ, Hashmi M, Tirupakuzhi Vijayaraghavan BK, Haniffa R, Beane A, Webb SA, Angus DC, Gordon AC, Cook DJ, Guyatt GH, Berry LR, Lorenzi E, Mouncey PR, Au C, Pinto R, Ménard J, Sprague S, Masse MH, Huang DT, Heyland DK, Nichol AD, McArthur CJ, de Man A, Al-Beidh F, Annane D, Anstey M, Arabi YM, Battista MC, Berry S, Bhimani Z, Bonten MJM, Bradbury CA, Brant EB, Brunkhorst FM, Burrell A, Buxton M, Cecconi M, Cheng AC, Cohen D, Cove ME, Day AG, Derde LPG, Detry MA, Estcourt LJ, Fagbodun EO, Fitzgerald M, Goossens H, Green C, Higgins AM, Hills TE, Ichihara N, Jayakumar D, Kanji S, Khoso MN, Lawler PR, Lewis RJ, Litton E, Marshall JC, McAuley DF, McGlothlin A, McGuinness SP, McQuilten ZK, McVerry BJ, Murthy S, Parke RL, Parker JC, Reyes LF, Rowan KM, Saito H, Salahuddin N, Santos MS, Saunders CT, Seymour CW, Shankar-Hari M, Tolppa T, Trapani T, Turgeon AF, Turner AM, Udy AA, van de Veerdonk FL, Zarychanski R, Lamontagne F. Intravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials. JAMA. 2023 Oct 25:e2321407. doi: 10.1001/jama.2023.21407. Epub ahead of print. PMID: 37877585; PMCID: PMC10600726.

REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol

First Author:

Deane AM

Journal:

BMJ Open

Year:

2023

Group:

Deane AM, Alhazzani W, Guyatt G, Finfer S, Marshall JC, Myburgh J, Zytaruk N, Hardie M, Saunders L, Knowles S, Lauzier F, Chapman MJ, English S, Muscedere J, Arabi Y, Ostermann M, Venkatesh B, Young P, Thabane L, Billot L, Heels-Ansdell D, Al-Fares AA, Hammond NE, Hall R, Rajbhandari D, Poole A, Johnson D, Iqbal M, Reis G, Xie F, Cook DJ; Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. REVISE: Re-Evaluating the Inhibition of Stress Erosions in the ICU: a randomised trial protocol. BMJ Open. 2023 Nov 15;13(11):e075588. doi: 10.1136/bmjopen-2023-075588. PMID: 37968012

Clinical Reasoning Behind Antibiotic Use in PICUs: A Qualitative Study

First Author:

Fontela PS

Journal:

Pediatr Crit Care Med.

Year:

2022

Group:

Fontela PS, Gaudreault J, Dagenais M, Noël KC, Déragon A, Lacroix J, Razack S, Rennick J, Quach C, McNally JD, Carnevale FA; Canadian Critical Care Trials Group. Clinical Reasoning Behind Antibiotic Use in PICUs: A Qualitative Study. Pediatr Crit Care Med. 2022 Jan 11. doi: 10.1097/PCC.0000000000002886 

Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial

First Author:

Ali K

Journal:

CMAJ

Year:

2022

Group:

,

Ali K, Azher T, Baqi M, Binnie A, Borgia S, Carrier FM, Cavayas YA, Chagnon N, Cheng MP, Conly J, Costiniuk C, Daley P, Daneman N, Douglas J, Downey C, Duan E, Duceppe E, Durand M, English S, Farjou G, Fera E, Fontela P, Fowler R, Fralick M, Geagea A, Grant J, Harrison LB, Havey T, Hoang H, Kelly LE, Keynan Y, Khwaja K, Klein G, Klein M, Kolan C, Kronfli N, Lamontagne F, Lau R, Fralick M, Lee TC, Lee N, Lim R, Longo S, Lostun A, MacIntyre E, Malhamé I, Mangof K, McGuinty M, Mergler S, Munan MP, Murthy S, O'Neil C, Ovakim D, Papenburg J, Parhar K, Parvathy SN, Patel C, Perez-Patrigeon S, Pinto R, Rajakumaran S, Rishu A, Roba-Oshin M, Rushton M, Saleem M, Salvadori M, Scherr K, Schwartz K, Semret M, Silverman M, Singh A, Sligl W, Smith S, Somayaji R, Tan DHS, Tobin S, Todd M, Tran TV, Tremblay A, Tsang J, Turgeon A, Vakil E, Weatherald J, Yansouni C, Zarychanski R; Canadian Treatments for COVID-19 (CATCO); Association of Medical Microbiology and Infectious Disease Canada (AMMI) Clinical Research Network and the Canadian Critical Care Trials Group.  CMAJ. 2022 Jan 19:cmaj.211698. doi: 10.1503/cmaj.211698.

Diversity of Authors of Publications From the Canadian Critical Care Trials Group

First Author:

Mehta S

Journal:

Crit Care Med

Year:

2022

Group:

Mehta S, Ahluwalia N, Heybati K, Burns KEA, Owais S, Cook DJ, Canadian Critical Care Trials Group. Diversity of Authors of Publications From the Canadian Critical Care Trials Group. Crit Care Med. 2022 Apr 1;50(4):535-542PMID: 34473658

The impact of the COVID-19 pandemic on intensive care unit workers: a nationwide survey

First Author:

Mehta S

Journal:

Can J Anaesth

Year:

2022

Group:

Mehta S, Yarnell C, Shah S, Dodek P, Parsons-Leigh J, Maunder R, Kayitesi J, Eta-Ndu C, Priestap F, LeBlanc D, Chen J, Honarmand K; Canadian Critical Care Trials Group. The impact of the COVID-19 pandemic on intensive care unit workers: a nationwide survey.Can J Anaesth. 2021 Dec 23:1-13. PMID: 34940952

Evidence-informed consensus statements to guide COVID-19 patient visitation policies: results from a national stakeholder meeting

First Author:

Fiest KM

Journal:

Can J Anaesth

Year:

2022

Group:

Fiest KM, Krewulak KD, Hernández LC, Jaworska N, Makuk K, Schalm E, Bagshaw SM, Bernet X, Burns KEA, Couillard P, Doig CJ, Fowler R, Kho ME, Kupsch S, Lauzier F, Niven DJ, Oggy T, Rewa OG, Rochwerg B, Spence S, West A, Stelfox HT, Parsons Leigh J, Canadian Critical Care Trials Group. Evidence-informed consensus statements to guide COVID-19 patient visitation policies: results from a national stakeholder meeting. Can J Anaesth 2022; Jul;69(7):868-879. PMID: 35359262 Read the full article

Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study

First Author:

Takaoka A

Journal:

J Crit Care

Year:

2022

Group:

Takaoka A, Zytaruk N, Davis M, Matte A, Johnstone J, Lauzier F, Marshall J, Adhikari N, Clarke FJ, Rochwerg B, Lamontagne F,  Hand L, Watpool I, Porteous RK, Masse M, D'Aragon F, Niven D, Heels-Ansdell D, Duan E, Dionne J, English S, St-Arnaud C, Millen T, Cook DJ, PROSPECT Investigators and the Canadian Critical Care Trials Group. Monitoring and auditing protocol adherence, data integrity and ethical conduct of a randomized clinical trial: A case study. J Crit Care 2022 Jun 17;71:154094. PMID: 35724443

Treatments, resource utilization, and outcomes of COVID-19 patients presenting to emergency departments across pandemic waves: an observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN)

First Author:

Cohl CM

Journal:

CJEM

Year:

2022

Group:

Hohl CM, Rosychuk RJ, Hau JP, Hayward  J, Landes M, Yan JW, Ting DK, Welsford M, Archambault PM, Mercier E, Chandra K, Davis P, Vaillancourt S, Leeies M, Small S, Morrison LJ, Canadian COVID-19 Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers, for the Canadian Critical Care Trials Group. Treatments, resource utilization, and outcomes of COVID-19 patients presenting to emergency departments across pandemic waves: an observational study by the Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN). CJEM 2022 Jun;24(4):397-407. PMID: 35362857

Family presence in Canadian PICUs during the COVID-19 pandemic: a mixed-methods environmental scan of policy and practice

First Author:

Foster JR

Journal:

CMAJ

Year:

2022

Group:

,

Foster JR, Lee LA, Seabrook JA, Ryan M Betts LJ, Burgess SA, Slumkoski C, Walls M, Garros D, and Canadian Critical Care Trials Group. Family presence in Canadian PICUs during the COVID-19 pandemic: a mixed-methods environmental scan of policy and practice. CMAJ Jul-Sep 2022. PMID: 35790228

Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit

First Author:

Lamontagne F

Journal:

N Engl J Med

Year:

2022

Group:

F. Lamontagne, M.-H. Masse, J. Menard, S. Sprague, R. Pinto, D.K. Heyland, D.J Cook, M.-C. Battista, A.G. Day, G.H. Guyatt, S. Kanji, R. Parke, S.P. McGuinness, B.-K. Tirupakuzhi Vijayaraghavan, D. Annane, D. Cohen, Y.M. Arabi, B. Bolduc, N. Marinoff, B. Rochwerg, T. Millen, M.O. Meade, L. Hand, I. Watpool, R. Porteous, P.J. Young, F. D’Aragon, E.P. Belley-Cote, E. Carbonneau, F. Clarke, D.M. Maslove, M. Hunt, M. Chassé, M. Lebrasseur, F. Lauzier, S. Mehta, H. Quiroz-Martinez, O.G. Rewa, E. Charbonney, A.J.E. Seely, D.J. Kutsogiannis, R. LeBlanc, A. Mekontso-Dessap, T.S. Mele, A.F. Turgeon, G. Wood, S.S. Kohli, J. Shahin, P. Twardowski, and N.K.J. Adhikari, for the LOVIT Investigators and the Canadian Critical Care Trials Group. Intravenous Vitamin C in Adults with Sepsis in the Intensive Care Unit. NEJM. June 15, 2022
DOI: 10.1056/NEJMoa2200644 

The experiences of family members of deceased organ donors and suggestions to improve the donation process: a qualitative study

First Author:

Sarti AJ

Journal:

CMAJ

Year:

2022

Group:

,

Sarti AJ, Sutherland S, Meade M, Shemie S, Landriault A, Vanderspank-Wright B, Valiani S, Keenan S, Weiss MJ, Werestiuk K, Kramer AH, Kawchuk J, Beed S, Dhanani S, Pagliarello G, Chassé M, Lotherington K, Gatien M, Parsons K,  Chandler JA, Nickerson P, Cardinal P
CMAJ Aug 2022, 194 (30) E1054-E1061; DOI: 10.1503/cmaj.220508

Diagnostic yield of screening for SARS-CoV-2 among patients admitted to hospital for alternate diagnoses: an observational cohort study

First Author:

Davis P

Journal:

BMJ Open

Year:

2022

Group:

Davis P, Rosychuk R, Hau JP, Cheng I, McRae AD, Daoust R, Lang E, Turner J, Khangura J, Fok PT, Stachura M, Brar B, Hohl CM; CCEDRRN investigators, and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group.BMJ Open. 2022 Aug 10;12(8):e057852. doi: 10.1136/bmjopen-2021-057852.PMID: 35948378

Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study

First Author:

Pong S

Journal:

BMC Pediatr

Year:

2022

Group:

,

Pong S, Fowler RA, Murthy S, Pernica JM, Gilfoyle E, Fontela P, Rishu AH, Mitsakakis N, Hutchison JS, Science M, Seto W, Jouvet P, Daneman N; Canadian Critical Care Trials Group. Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study. BMC Pediatr. 2022 Apr 5;22(1):179. PMID: 35382774

ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries

First Author:

Ista E

Journal:

Crit Care Med

Year:

2022

Group:

,

Ista E, Redivo J, Kananur P, Choong K, Colleti J Jr, Needham DM, Awojoodu R, Kudchadkar SR; International PARK-PICU Investigators. ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries. Crit Care Med. 2022 Jan 1;50(1):114-125. PMID: 34259659

ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19

First Author:

ISARIC Clinical Characterization Group

Journal:

Sci Data

Year:

2022

Group:

,

ISARIC Clinical Characterization Group, Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Sci Data. 2022 Jul 30;9(1):454. PMID: 35908040