PRACTICAL (Platform of Randomized Adaptive Clinical Trials in Critical Illness) is a Bayesian adaptive platform randomized clinical trial studying novel interventions to improve outcomes for patients with acute hypoxemic respiratory failure.

The PRACTICAL platform is designed to function as a research “pipeline” to facilitate seamless and efficient evaluation of interventions for hypoxemic respiratory failure, from preliminary trials focused on mechanistic endpoints to full-scale definitive clinical trials.

Interventions will be studied at various phases of investigation, including pilot and feasibility trials, preliminary trials of physiological and biological effect, and definitive trials evaluating treatment effect on patient-centered outcomes.

To learn about PRACTICAL and all its domains, visit www.practicalplatform.org