Paediatric intensive care stress ulcer prevention pilot trial (PIC-UP)

View publication Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial

There are many uncertainties about the risks and benefits of stress ulcer prophylaxis. In an era of widespread use—where clinicians prescribe prophylaxis to the more severely ill—a large, rigorous RCT is required. A trial to determine if a strategy of withholding stress ulcer prophylaxis is not inferior to a strategy of routine stress ulcer prophylaxis will be challenging. A carefully designed and implemented pilot trial is essential.