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Lorenzo  Del Sorbo
Associate Professor
Toronto General Hospital, UHN
Research Focus:
Extra Corporeal Life Support, Mechanisms of organ injury and therapeutic approaches in cells and animal models of critical illness

Lorenzo Del Sorbo

Translational Biology Group (CCCTBG)

Lorenzo Del Sorbo is an intensive care attending at Toronto General Hospital, since appointment in 2016. He graduated in Medicine at the University of Torino, Italy. He trained in Internal Medicine at the University of Torino, and in adult Critical Care Medicine at the University of Toronto. He was appointed and worked as an Assistant Professor of Intensive Care Medicine at the University of Torino, Italy. Lorenzo’s main academic interests focus on the application of innovative strategies to prevent the injury induced by invasive mechanical ventilation.

These include investigations in extra-corporeal life support strategies in patients with ARDS and COPD exacerbation and in non-invasive ventilation. His work also extends into the translational research defining the mechanisms of organ injury and developing novel therapeutic approaches in cell and animal models of critical illness.

Recent work

Del Sorbo L, Tisminetzky M, Chen L, Brochard L, Arellano D, Brito R, Diaz JC, Cornejo R. Association of lung recruitment and change in recruitment-to-inflation ratio from supine to prone position in acute respiratory distress syndrome. Crit Care. 2023 Apr 13;27(1):140.

Di Nardo M, Tikkanen J, Husain S, Singer LG, Cypel M, Ferguson ND, Keshavjee S, Del Sorbo L. Postoperative Management of Lung Transplant Recipients in the Intensive Care Unit. Anesthesiology. 2021 Dec 15;136(3):482-499.

Al-Fares AA, Ferguson ND, Ma J, Cypel M, Keshavjee S, Fan E, Del Sorbo L. Achieving Safe Liberation During Weaning from VV-ECMO in Patients with Severe ARDS: The role of Tidal Volume and Inspiratory Effort. Chest. 2021Jun 16.

Rosas IO, Br.u N, Waters M, Go RC, Hunter BD, Bhagani S, Skiest D, Aziz MS, Cooper N, Douglas IS, Savic S,Youngstein T, Del Sorbo L, Cubillo Gracian A, De La Zerda DJ, Ustianowski A, Bao M, Dimonaco S, Graham E, Matharu B, Spotswood H, Tsai L, Malhotra A. Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia. N Engl J Med. 2021 Feb 25.

Del Sorbo L, Goffi A, Tomlinson G, Pettenuzzo T, Facchin F, Vendramin A, Goligher EC, Cypel M, Slutsky AS,Keshavjee S, Ferguson ND, Fan E, International ECMO Network (ECMONet). Effect of Driving Pressure Change During Extracorporeal Membrane Oxygenation in Adults With Acute Respiratory Distress Syndrome: A Randomized Crossover Physiologic Study. Crit Care Med. 2020 Dec 1;48(12):1771-1778.

Teijeiro-Paradis R, Grenier J, Urner M, Douflé G, Steel A, Cypel M, Keshavjee S, Herridge M, Goligher E, Granton J, Ferguson N, Fan E, Del Sorbo L. Outcomes of patients with respiratory failure declined for extracorporeal membrane oxygenation: a prospective observational study. Can J Anaesth. 2023 Jul;70(7):1226-1233.