Brent Winston

Member of both the Trials Group (CCCTG) and the Translational Biology Group (CCCTBG)

Dr. Brent Winston received his M.D. from the University of Alberta. He trained as a Respirologist (University of Toronto) and a Critical Care Physician (University of Manitoba). He also undertook post doctoral training in molecular biology at National Jewish (Denver, CO). He is a Professor in the Critical Care Medicine, Medicine and Biochemistry and Molecular Biology department at the Cumming School of Medicine. From 2004-2011 he served as an Executive Member of the Canadian Critical Care Trials Group (CCCTG) and from 2003-2011 he served as the Organizer and Chair, Canadian Critical Care Translational Biology Group (CCCTBG). In 2021, Dr. Winston received The Michael Ward Award from the Canadian Critical Care Forum for the best basic or translational science study.

His research has focused in three areas:

1)  Metabolomics in human diseases in Critical Care. He has continued to study metabolomics in sepsis, lung injury and head injury.

2)  Gene regulation in sepsis.  He has examined gene regulation in macrophages in sepsis with a focus on the alternative complement cascade Factor B and have examined IGF-I gene regulation in lungs with an interest in acute and chronic lung fibroproliferation.

3)  Clinical/Translational studies on sepsis and ARDS. He has participated in a number of clinical studies.  To this end, he has created a Critical Care Tissue bank (CCE{PTR) to conduct translational research on clinically important problems in the ICU and has also created a wet lab within the ICU to manage samples.

His laboratory is particularly interested in conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.