Brent Winston
Member of both the Trials Group (CCCTG) and the Translational Biology Group (CCCTBG)
Dr. Brent Winston received his M.D. from the University of Alberta. He trained as a Respirologist (University of Toronto) and a Critical Care Physician (University of Manitoba). He also undertook post doctoral training in molecular biology at National Jewish (Denver, CO). He is a Professor in the Critical Care Medicine, Medicine and Biochemistry and Molecular Biology department at the Cumming School of Medicine. From 2004-2011 he served as an Executive Member of the Canadian Critical Care Trials Group (CCCTG) and from 2003-2011 he served as the Organizer and Chair, Canadian Critical Care Translational Biology Group (CCCTBG). In 2021, Dr. Winston received The Michael Ward Award from the Canadian Critical Care Forum for the best basic or translational science study.
His research has focused in three areas:
1) Metabolomics in human diseases in Critical Care. He has continued to study metabolomics in sepsis, lung injury and head injury.
2) Gene regulation in sepsis. He has examined gene regulation in macrophages in sepsis with a focus on the alternative complement cascade Factor B and have examined IGF-I gene regulation in lungs with an interest in acute and chronic lung fibroproliferation.
3) Clinical/Translational studies on sepsis and ARDS. He has participated in a number of clinical studies. To this end, he has created a Critical Care Tissue bank (CCE{PTR) to conduct translational research on clinically important problems in the ICU and has also created a wet lab within the ICU to manage samples.
His laboratory is particularly interested in conducting translational research on clinically relevant Critical Care and Pulmonary disease processes.
Recent work
1) Beata Mickiewicz, Patrick Tam, Craig N. Jenne, Caroline Leger, Josee Wong, Brent W. Winston, Christopher Doig, Paul Kubes and Hans J. Vogel for the Alberta Sepsis Network (ASN). Integration of metabolic and inflammatory mediator profiles as a potential prognostic approach for septic shock in the intensive care unit. Critical Care 2015, 19 :11 (15 January 2015). doi:10.1186/s13054-014-0729-0.
2) Mohammad M. Banoei, Colin Casault, Sayed Metlwaly, and Brent W. Winston. Metabolomics and biomarker discovery in Traumatic Brain Injury. Journal of Neurotrauma, Volume: 35 Issue 16: August 15, 2018; [Epub ahead of print] Mar 27. doi: 10.1089/neu.2017.5326.
3) Sayed Metwaly, Sarah J. Donnelly, Mohammad M. Banoei, Ahmed I. Mourad, Hans J. Vogel, Oliver Fiehn, Brent W. Winston on behalf of the Canadian Critical Care Translational Biology Group (CCCTBG). “ARDS Metabolic Fingerprints: Characterization, Benchmarking and Potential Mechanistic Interpretation.” Am J Physiol Lung Cell Mol Physiol. 2021 May 5, 321: L79–L90. doi, 10.1152/ajplung.00077.2021.
4) Mohammad M. Banoei, Chel Hee Lee, James Hutchison , William Panenka, David A Wishart, Brent W. Winston, on behalf of the Canadian Biobank and Database for Traumatic Brain Injury (CanTBI) investigators, the Canadian Critical Care Translational Biology Group (CCCTBG) and the Canadian Traumatic Brain Injury Research and Clinical Network (CTRC). Metabolomic profiles in serum predict global functional neurological outcome and death at 3 and 12 months following severe traumatic brain injury. Critical Care, 2023, 27:295. https://doi.org/10.1186/s13054-023-04573-9.