Sean Gill

Research in my laboratory is currently focused on the resolution of inflammation and repair following lung injury. Current projects include assessing the role of metalloproteinases and their endogenous inhibitors, the tissue inhibitors of metalloproteinases (TIMPs) in regulating three different aspects of recovery following lung injury: 1) microvascular endothelial cell dysfunction; 2) macrophage polarization and apoptosis; and, 3) initiation and resolution of fibrosis. Additional projects include examining the role of caspases and cell death in microvascular endothelial cell dysfunction during septic lung injury, as well as determining the effects of aging and exercise on the pathophysiology of lung injury.