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Sabri  Soussi
Profession:
Anesthesiologist and Intensivist
Institution:
University Health Network
City:
Toronto
Research Focus:
Critical care ultrasonography, Hemodynamic monitoring, Biomarkers discovery, Machine learning, Circulatory shock phenotyping, Personalized medicine in critical care

Sabri Soussi

Translational Biology Group (CCCTBG)

Dr. Sabri Soussi graduated from El Manar University, Tunis, Tunisia in 2007 (MD) and completed his specialty training in Anesthesiology and Critical Care in 2010. In 2011, he obtained his French MD equivalency and began a clinical activity in anesthesiology and critical care as an attending physician in La Pitié-Salpétrière and Lariboisière-Saint Louis University Hospitals in Paris, France. In 2015, Dr. Soussi received his certification in critical care ultrasonography (transthoracic and transesophageal echocardiography and lung ultrasonography) from Paris Descartes University. In 2022, he obtained a PhD in Genes, Omics, Bioinformatics and Systems biology from the University of Paris Cité. His research has mainly focused on identifying hemodynamic patterns and host response biomarkers to improve risk stratification in circulatory shock patients (sepsis, cardiogenic shock, severe burn injury). He set up a transatlantic collaborative research project with the St. Michael's Hospital Academic group to identify different subphenotypes/endotypes of critically ill patients in a large international cohort with a biobank (the FROG-ICU cohort) using unsupervised machine learning tools and a multiomics approach. Dr Soussi was awarded in 2022 the prestigious Doctoral Foreign Study Award (DFSA) from the Canadian Institutes of Health Research (CIHR) for his international research project in Toronto. He has been appointed in the Department of Anesthesiology and Pain Medicine (University Health Network) with an academic position of Assistant Professor at the Temerty Faculty of Medicine, University of Toronto.

Recent work

Soussi S, Sharma D, Jüni P, Lebovic G, Brochard L, Marshall JC, Lawler PR, Herridge M, Ferguson N, Del Sorbo L, Feliot E, Mebazaa A, Acton E, Kennedy JN, Xu W, Gayat E, Dos Santos CC; FROG-ICU; CCCTBG trans-trial group study for InFACT - the International Forum for Acute Care Trialists. Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort. Crit Care. 2022;26(1):114.

Jentzer JC, Soussi S, Lawler PR, Kennedy JN, Kashani KB. Validation of cardiogenic shock phenotypes in a mixed cardiac intensive care unit population. Catheter Cardiovasc Interv. 2022;99(4):1006-1014. 

Soussi S, Collins GS, Jüni P, Mebazaa A, Gayat E, Le Manach Y. Evaluation of Biomarkers in Critical Care and Perioperative Medicine: A Clinician’s Overview of Traditional Statistical Methods and Machine Learning Algorithms. Anesthesiology. 2021;134(1):15-25. 

Soussi S, Berger MM, Colpaert K, Dünser MW, Guttormsen AB, Juffermans NP, Knape P, Koksal G, Lavrentieva A, Leclerc T, Lorente JA, Martin-Loeches I, Metnitz P, Pantet O, Pelosi P, Rousseau AF, Sjöberg F, Legrand M; ESICM Burn ICU working group. Hemodynamic management of critically ill burn patients: an international survey. Crit Care. 2018;22(1):194. 

Soussi S, Dépret F, Benyamina M, Legrand M. Early Hemodynamic Management of Critically Ill Burn Patients. Anesthesiology. 2018;129(3):583-589. 

Soussi S, Gallais P, Kachatryan L, Benyamina M, Ferry A, Cupaciu A, Chaussard M, Maurel V, Chaouat M, Mimoun M, Mebazza A, Legrand M; PRONOBURN Group. Extracorporeal membrane oxygenation in burn patients with refractory acute respiratory distress syndrome leads to 28 % 90-day survival. Intensive Care Med. 2016;42(11):1826-1827.