Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT)

Please see publication: Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial

Among critically ill patients requiring mechanical ventilation, administration of the probiotic L rhamnosus GG compared with placebo, resulted in no significant difference in the development of ventilator-associated pneumonia. These findings do not support the use of L rhamnosus GG in critically ill patients.

See also

- Microbial dysbiosis and mortality during mechanical ventilation: a prospective observational study

- Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial

- Definitions, rates and associated mortality of ICU-acquired pneumonia: A multicenter cohort study

- Academic and Community ICUs Participating in a Critical Care Randomized Trial: A Comparison of Patient Characteristics and Trial Metrics

- Health economic evaluation alongside the Probiotics to Prevent Severe Pneumonia and Endotracheal Colonization Trial (E-PROSPECT): a cost-effectiveness analysis

Visual abstract

Source: JAMA

Diagram: Probiotics in ICU Research Program (click to expand)

View trial on ClinicalTrials.gov