Canadian biobank and database for Traumatic Brain Injury (CanTBI)
This Platform included animal models and a prospective clinical study.
Aims
(1) to discover and begin to validate molecular and neuroimaging biomarkers of traumatic brain injury (TBI)
(2) to develop regional biobanks linked to a national database for patients with TBI. Results from this study will lead to improved prognostic models to deliver tailored management strategies and to allow early risk stratification in future clinical trials. The ultimate goal is to improve the quality of care and quality of life outcomes for patients with TBI and their families.
Attention and Traumatic Brain Injury (ATBI) (published)
The identification of children with traumatic brain injury (TBI) who are at risk of death or poor global neu- rological functional outcome remains a challenge. Magnetic resonance imaging (MRI) can detect several brain pathologies that are a result of TBI; however, the types and locations of pathology that are the most predictive remain to be determined.
Coordinator: Judith Van Huyse
View Publication: Magnetic Resonance Imaging Findings Are Associated with Long-Term Global Neurological Function or Death after Traumatic Brain Injury in Critically Ill Children
Biomarkers and Quality of Life in TBI (published)
Investigators: Jamie Hutchison, Cheryl Wellington
Traumatic brain injury (TBI) is a major health problem in children. Blood-based biomarkers interpreted by use of normative values might improve the accuracy of diagnosis. Ultrasensitive assays can quantify serum concentrations of the neuronal microtubule-associated protein tau, which is increased in adult brains following TBI.
Conclusion: Serum total tau might help to differentiate between patients with mild TBI (GCS 13–14 vs GCS 15), but larger studies are needed to validate these results before this biomarker can be used for diagnosis and prognosis.
View Publication: Characterisation of serum total tau following paediatric traumatic brain injury: a case-control study
Proteomics in Pediatric Traumatic Brain Injury
For more information about this study, click here.
Kirsten Hutchison
1. Neuroscience and Mental Health Research Program, The Hospital for Sick Children, Toronto, Ontario
2. Italy
3. Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada
4. Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON
5. Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia,
6. Division of Intensive Care, Department of Pediatrics, Saint Justine’s Hospital and The University of Montreal, Montreal, Quebec, Canada
7. Institute of Medical Sciences, University of Toronto, Toronto, ON, Canada
8. Department of Rehabilitation Sciences, University of Toronto
9. Department of Psychology, University of Toronto
10. Department of Physiology, University of Toronto
11. Department of Critical Care, University of Calgary
12. Department of Psychology, University of Calgary
13. Department of Pathology and Laboratory Medicine and Djavad Mawafaghian Centre for Brain Health, University of British Columbia.
14. Department of Psychology, University of British Columbia
15. Division of Neurology, Department of Medicine and Department of Psychiatry, University of British Colombia.
Atefeh Mohammadi, Nicole McKinnon, Nelofar Kureshi, Jacques Lacroix, Anne-Marie Guerguerian, Angela Colantonio, Robin Green, Anne Wheeler, Brent Winston, Keith Yeates, Cheryl Wellington, Noah Silverberg, David Clark, William Panenka