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Optimizing Transfusion Therapy in Critically-ill Children with Anemia (OpTTICCA): a large confirmatory international multicenter pragmatic parallel open-label non-inferiority SMART randomized controlled trial

Principal Investigator(s):

Marisa Tucci (Canada), Geneviève Du Pont-Thibodeau (Canada), Simon Stanworth (UK), Stéphane Leteurtre (Hôpital Jeanne de Flandre, Lille, France), Avishay Sarfatti (Oxford University Hospitals NHS Foundation Trust, Oxford, UK), Samiran Ray (GOSH, London, UK).

Status: In Development

We are planning to submit OpTTICCA to granting agencies in Canada (CIHR), UK and France in years 2023 and 2024.

This RCT is part of the OpTTICCA program of research, see also P-OpTTICCA


Coordinators:

Josée Poirier

Participating Centres:

To be determined. The list of participating centers will include at least the following sites: CHU Sainte-Justine, Montreal Children's Hospital; Hôpital Jeanne de Flandre (Lille, France); Oxford University Hospitals NHS Foundation Trust, (Oxford, UK); Great Ormond Street Hospital (London, UK); Hôpital Reine-Fabiola (Brussels, Belgium). We expect that many other Canadian sites will join this list.

Co-investigators:

François Carrier (CHUM), Fabrizio Chiusolo (Rome, Italy), Laurence Ducharme-Crevier (CHUSJ), Thierry Ducruet (CHUSJ), Patricia Fontela (McGill University), Elaine Gilfoyle (Toronto), Philippe Jouvet (CHUSJ), Laura Butragueño Laiseca (Madrid, Spain), Benoît Mâsse (chef scientifique, Centre de Soutien à la Gestion et Analyse des Données, CHUSJ), Nancy Robitaille (Héma-Québec), Nadia Roumeliotis (CHUSJ), Michaël Sauthier (IT specialist, CHUSJ), Helen Trottier (CHUSJ, ÉSPUM), Ariane Willems (Brussels)