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Midodrine for the Early Liberation of Vasopressor Support in the ICU (LIBERATE)

Principal Investigator(s):

Oleksa Rewa

Status: Enrolling

Resuscitation and hemodynamic support with intravenous (IV) vasopressors is a prime indication of treatment in intensive care unit (ICU) settings. Oral vasopressors, such as midodrine, have been historically used for hemodynamic support in non-critically ill patients, but their study in patients as a potential IV vasopressor sparing therapy has been limited. Previous studies evaluating the use of midodrine have been small in scale and limited to septic patients. The LIBERATE study will evaluate the expanded role of midodrine for any vasoplegic patient supported in ICU settings.

More information can be found here. 

See also: Protocol for a randomized control trial (LIBERATE)


Participating Centres:

Grey Nuns Hospital, Edmonton, AB
Misericordia Hospital, Edmonton, AB
University of Alberta Hospital, Edmonton, AB
Sturgeon Community Hospital, St Albert, AB

Co-investigators:

Janek Senaratne
Erika MacIntyre
Jocelyn Slemko
Wendy Sligl
Vince Lau
Constantine Karvellas
Sean Bagshaw