Identifying clinical subphenotypes in sepsis survivors with different epigenetic signatures and one-year outcomes
Principal Investigator(s):
Status:
Enrolment Complete
Late mortality risk in sepsis-survivors persists for years with high readmission rates and low quality of life. The present study seeks to link the clinical sepsis-survivors heterogeneity with distinct biological profiles at ICU discharge and late adverse events using an unsupervised analysis.
This work is part of a broader research program on critically ill patients endotyping using biomarker data.
For more information see: Identifying clinical subtypes in sepsis-survivors with different one-year outcomes: a secondary latent class analysis of the FROG-ICU cohort.
Participating Centres:
St. Michael's Hospital (Toronto, Canada), Lariboisière Hospital (Paris, France)
Co-investigators:
Claudio dos Santos, John Marshall, Alexandre Mebazaa, Etienne Gayat