Fluids in Sepsis and Septic Shock RCT (FISSH)

Research question: In patients with septic shock, what is the impact of administering 0.9% Normal Saline versus Ringer’s Lactate on 30-day mortality and other patient important outcomes including acute kidney injury, need for advanced life support, and ICU/hospital length of stay?

This is a multi-centre stratified concealed and blinded RCT with a primary outcome of 30-day mortality with a plan to enrol 1096 patients.

See publication Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial