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Prospective cohort study on the evolution of procalcitonin and other infection markers in children with severe bacterial infections treated with antimicrobials

Principal Investigator(s):

Patricia Fontela

Status: Enrolling

This is a multicenter prospective cohort study whose aims are the following:

Primary aim: to describe the temporal course of procalcitonin, CRP, temperature, and WBC/neutrophil counts in children with severe bacterial infections appropriately treated with antimicrobials who had an uncomplicated infection course (i.e., no infection relapse or superimposed infection).

Secondary aims: a) to describe the course of procalcitonin, CRP, temperature, and WBC/neutrophil counts in infected children receiving inappropriate antimicrobial treatment and also in patients who developed a complicated infection course, b) to explore the association of the trajectory of procalcitonin, CRP, temperature, and WBC/neutrophil counts with inappropriate empiric antimicrobial treatment, as well as with complicated infectious course, c) to compare the temporal evolution of procalcitonin, CRP,  temperature, and WBC/neutrophil counts and PELOD-2 score, and d) to explore the association between different procalcitonin and CRP  cut-offs for antimicrobial stopping and uncomplicated infection course in critically ill children.

Study population: 400 patients between 1 month and <18 years of age with suspected or proven severe bacterial infection for whom ≥1 antimicrobial was initiated in the previous 24 hours to treat the infectious process.

This study is part of the Antibiotic Tailoring at Bedside in PICUs (ATB PICU) program of research. 

 


Participating Centres:

The Montreal Children's Hospital
CHU Sainte Justine
CHEO
Alberta Children's Hospital
BC Children's
McMaster