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Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study

First Author:

Murthy, S

Journal:

CMAJ

Year:

2021

Group:

,

S Murthy, PM Archambault, A Atique, FM Carrier, MP Cheng, C Codan, N Daneman, W Dechert, S Douglas, KM Fiest, R Fowler, G Goco, Y Gu, A Guerguerian, R Hall, JM Hsu, A Joffe, P Jouvet, L Kelly, ME Kho, RJ Kruisselbrink, D Kumar, DJ Kutsogiannis, F Lamontagne, TC Lee, KMenon, H O'Grady, K O'Hearn, DH Ovakim, SG Pharand, T Pitre, R Reel, B Reeve, O Rewa, D Richardson, A Rishu, G Sandhu, S Sarfo-Mensah, E Shadowitz, W Sligl, J Solomon, HT Stelfox, A Swanson, H Tessier-Grenier, JLY Tsang, G Wood, SPRINT-SARI Canada Investigators and the Canadian Critical Care Trials Group. Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study. CMAJ 2021 Mar 8;9(1):E181-E188. PMID: 33688026

Importance of nationally coordinated data collection and quality improvement networks

First Author:

Seely AJE

Journal:

Can J Resp, Crit, Sleep Med

Year:

2021

Group:

Seely, Andrew JE and Robert Fowler. Importance of nationally coordinated data collection and quality improvement networks. Canadian Journal of Respiratory, Critical Care and Sleep Medicine. Published online 17 August, 2021.

Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients A Randomized Clinical Trial

First Author:

Johnstone J

Journal:

JAMA

Year:

2021

Group:

Johnstone J, Meade M, Lauzier F, Marshall J, Duan E, Dionne J, Arabi YM, Heels-Ansdell D, Thabane L, Lamarche D; Surette M, Zytaruk N, Mehta S, Dodek P, McIntyre L, English S, Rochwerg B, Karachi T, Henderson S; Wood G, Ovakim D, Herridge M, Granton J, Wilcox E; Goffi A, Stelfox HT, Niven D, Muscedere J, Lamontagne F, D’Aragon F, St.-Arnaud C, Ball I, Nagpal D, Girard M, Aslanian P, Charbonney E, Williamson D, Sligl W, Friedrich J, Adhikari NK, Marquis F, Archambault P, Khwaja K, Kristof A, Kutsogiannis J, Zarychanski R, Paunovic B, Reeve B, Lellouche F, Hosek P, Tsang J, Binnie A, Trop S, Loubani O, Hall R, Cirone R, Reynolds S, Lysecki P, Golan E, Cartin-Ceba R, Taylor R, Cook D; for the Prevention of Severe Pneumonia and Endotracheal Colonization Trial (PROSPECT) Investigators and the Canadian Critical Care Trials Group. Effect of Probiotics on Incident Ventilator-Associated Pneumonia in Critically Ill Patients: A Randomized Clinical Trial. JAMA 2021; 326(11):1024-1033. doi:10.1001/jama.2021.13355

Consent models in Canadian critical care randomized controlled trials: a scoping review

First Author:

O'Hearn, K

Journal:

Can J Anaesth

Year:

2021

Group:

, ,

O'Hearn K, Gibson J, Krewulak K, Porteous R, Saigle V, Sampson M, Tsampalieros A, Barrowman N, Cameron S; Canadian Critical Care Trials Group. Consent models in Canadian critical care randomized controlled trials: a scoping review. Can J Anaesth. 2022 Apr;69(4):513-526. English. doi: 10.1007/s12630-021-02176-y. Epub 2021 Dec 14. PMID: 34907503.

Impact of Restricted Visitation Policies During the First Wave of the COVID-19 Pandemic on Communication Between Critically Ill Patients, Families and Clinicians: A Qualitative Interview Study

First Author:

Krewulak K

Journal:

Ann Am Thorac Soc

Year:

2021

Group:

Krewulak KD, Jaworska  N, Spence KL, Mizen SJ, Kupsch  S, Stelfox HT, Parsons Leigh J, Fiest KM, and Canadian Critical Care Trials Group. Impact of Restricted Visitation Policies During the First Wave of the COVID-19 Pandemic on Communication Between Critically Ill Patients, Families and Clinicians: A Qualitative Interview Study. Dec. 16, 2021 DOI: 10.1513/AnnalsATS.202107-877OC PMID: 34914537

CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emergency department with suspected COVID-19

First Author:

McRae AD

Journal:

BMJ Open

Year:

2021

Group:

McRae AD, Hohl CM, Rosychuk R, Vatanpour S, Ghaderi G, Archambault PM, Brooks SC, Cheng I, Davis P, Hayward J, Lang E, Ohle R, Rowe B, Welsford M, Yadav K, Morrison LJ, Perry J, Canadian COVID-19 Emergency Department Rapid Response Network (CCEDRRN) investigators for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. CCEDRRN COVID-19 Infection Score (CCIS): development and validation in a Canadian cohort of a clinical risk score to predict SARS-CoV-2 infection in patients presenting to the emergency department with suspected COVID-19 PMID: 34857584  PMCID: PMC8640195  DOI: 10.1136/bmjopen-2021-055832 2021 Dec 2;11 (12):e055832

Clinical evaluation and ancillary testing for the diagnosis of death by neurologic criteria: a cross-sectional survey of Canadian intensivists

First Author:

Chassé M

Journal:

Can J Anaesth

Year:

2021

Group:

,

Chassé M, Neves Briard J, Yu M, P Carvalho L, W English S, D'Aragon F, Lauzier F, F Turgeon A, Dhanani S, McIntyre L, D Shemie S, Knoll G, Fergusson DA, Anthony SJ, Weiss MJ; Canadian Critical Care Trials Group. Clinical evaluation and ancillary testing for the diagnosis of death by neurologic criteria: a cross-sectional survey of Canadian intensivists. Can J Anaesth. 2022 Mar;69(3):353-363. English. doi: 10.1007/s12630-021-02166-0. Epub 2021 Dec 20. PMID: 34931292.

Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial

First Author:

Garcia Guerra G

Journal:

J Intensive Care

Year:

2021

Group:

,

Garcia Guerra G, Joffe AR, Sheppard C, Hewson K, Dinu IA, Hajihosseini M, deCaen A, Jou H, Hartling L, Vohra S; Canadian Critical Care Trials Group. Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial. J Intensive Care. 2021 Jan 12;9(1):7. doi: 10.1186/s40560-020-00523-7. PMID: 33431051; PMCID: PMC7802123.

CardiO Cycle: a pilot feasibility study of in-bed cycling in critically ill patients post cardiac surgery

First Author:

Newman ANL

Journal:

Pilot Feasibility Stud

Year:

2021

Group:

,

Newman ANL, Kho ME, Harris JE, Zamir N, McDonald E, Fox-Robichaud A, Solomon P; Canadian Critical Care Trials Group. CardiO Cycle: a pilot feasibility study of in-bed cycling in critically ill patients post cardiac surgery. Pilot Feasibility Stud. 2021 Jan 7;7(1):13. doi: 10.1186/s40814-020-00760-5. PMID: 33407923; PMCID: PMC7788703.

Utilization and effect of neuromuscular blockade in a randomized trial of high-frequency oscillation

First Author:

Mehta S

Journal:

J Crit Care

Year:

2021

Group:

Mehta S, Zhou Q, Pinto R, Friedrich JO, Lamontagne F, Ferguson ND, Meade MO, Adhikari NKJ; OSCILLATE Investigators and the Canadian Critical Care Trials Group. Utilization and effect of neuromuscular blockade in a randomized trial of high-frequency oscillation. J Crit Care. 2021 Dec;66:86-92. PMID: 34474282

Feasibility of implementing Extubation Advisor, a clinical decision support tool to improve extubation decision-making in the ICU: a mixed-methods observational study

First Author:

Sarti, AJ

Journal:

BMJ Open

Year:

2021

Group:

Sarti AJ, Zheng K, Herry CL, Sutherland S, Scales NB, Watpool I, Porteous R, Hickey M, Anstee C, Fazekas A, Ramsay T, Burns KE, Seely AJ; Canadian Critical Care Trials Group. Feasibility of implementing Extubation Advisor, a clinical decision support tool to improve extubation decision-making in the ICU: a mixed-methods observational study. BMJ Open. 2021 Aug 12;11(8):e045674. PMID: 34385234

Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study

First Author:

Hohl, CM

Journal:

CMAJ Open

Year:

2021

Group:

Hohl CM, Rosychuk RJ, McRae AD, Brooks SC, Archambault P, Fok PT, Davis P, Jelic T, Turner JP, Rowe BH, Mercier É, Cheng I, Taylor J, Daoust R, Ohle R, Andolfatto G, Atzema C, Hayward J, Khangura JK, Landes M, Lang E, Martin I, Mohindra R, Ting DK, Vaillancourt S, Welsford M, Brar B, Dahn T, Wiemer H, Yadav K, Yan JW, Stachura M, McGavin C, Perry JJ, Morrison LJ; Canadian COVID-19 Emergency Department Rapid Response Network investigators and for the Network of Canadian Emergency Researchers and the Canadian Critical Care Trials Group. Development of the Canadian COVID-19 Emergency Department Rapid Response Network population-based registry: a methodology study. CMAJ Open. 2021 Mar 17;9(1):E261-E270. PMID: 33731427

Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians

First Author:

McGinn, R

Journal:

Crit Care Med

Year:

2021

Group:

McGinn R, Fergusson DA, Stewart DJ, Kristof AS, Barron CC, Thebaud B, McIntyre L, Stacey D, Liepmann M, Dodelet-Devillers A, Zhang H, Renlund R, Lilley E, Downey GP, Brown EG, Côté L, Dos Santos CC, Fox-Robichaud AE, Hussain SNA, Laffey JG, Liu M, MacNeil J, Orlando H, Qureshi ST, Turner PV, Winston BW, Lalu MM; Canadian Critical Care Translational Biology Group.. Surrogate Humane Endpoints in Small Animal Models of Acute Lung Injury: A Modified Delphi Consensus Study of Researchers and Laboratory Animal Veterinarians. Crit Care Med. 2021 Feb 1;49(2):311-323. PMID: 33332817

Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study

First Author:

Mendelson AA

Journal:

J Clin Monit Comput

Year:

2021

Group:

Mendelson AA, Rajaram A, Bainbridge D, Lawrence KS, Bentall T, Sharpe M, Diop M, Ellis CG; Canadian Critical Care Translational Biology Group. Dynamic tracking of microvascular hemoglobin content for continuous perfusion monitoring in the intensive care unit: pilot feasibility study. J Clin Monit Comput. 2021 Dec;35(6):1453-1465. PMID: 33104968

Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians

First Author:

Dodek PM

Journal:

Ann Am Thorac Soc

Year:

2021

Group:

,

Dodek PM, Cheung EO, Burns KEA, Martin CM, Archambault PM, Lauzier F, Sarti AJ, Mehta S, Fox-Robichaud AE, Seely AJE, Parshuram C, Garros D, Withington DE, Cook DJ, Piquette D, Carnevale FA, Boyd JG, Downar J, Kutsogiannis DJ, Chassé M, Fontela P, Fowler RA, Bagshaw S, Dhanani S, Murthy S, Gehrke P, Fujii T. Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians. Ann Am Thorac Soc. 2021 Aug;18(8):1343-1351. PMID: 33356972

Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled trial

First Author:

Masse MH

Journal:

Trials

Year:

2020

Group:

,

Masse MH, Ménard J, Sprague S, Battista MC, Cook DJ, Guyatt GH, Heyland DK, Kanji S, Pinto R, Day AG, Cohen D, Annane D, McGuinness S, Parke R, Carr A, Arabi Y, Vijayaraghavan BKT, D'Aragon F, Carbonneau É, Maslove D, Hunt M, Rochwerg B, Millen T, Chassé M, Lebrasseur M, Archambault P, Deblois E, Drouin C, Lellouche F, Lizotte P, Watpool I, Porteous R, Clarke F, Marinoff N, Belley-Côté É, Bolduc B, Walker S, Iazzetta J, Adhikari NKJ, Lamontagne F; Canadian Critical Care Trials Group. Lessening Organ dysfunction with VITamin C (LOVIT): protocol for a randomized controlled  trial. Trials. 2020 Jan 8;21(1):42. PMID: 31915072

A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards

First Author:

Daneman N

Journal:

Trials

Year:

2020

Group:

Daneman N, Rishu AH, Pinto R, Arabi Y, Belley-Cote EP, Cirone R, Downing M, Cook DJ, Hall R, McGuinness S, McIntyre L, Muscedere J, Parke R, Reynolds S, Rogers BA, Shehabi Y, Shin P, Whitlock R, Fowler RA; Canadian Critical Care Trials Group. A pilot randomized controlled trial of 7 versus 14 days of antibiotic treatment for bloodstream infection on non-intensive care versus intensive care wards. Trials. 2020 Jan 15;21(1):92. PMID: 31941546

Motivators and Stressors for Canadian Research Coordinators in Critical Care: The MOTIVATE Survey

First Author:

McDonald E

Journal:

Am J Crit Care

Year:

2020

Group:

,

McDonald E, Zytaruk N, Heels-Ansdell D, Smith O, Borges D, Hand L, Clarke F, Nassar A, Bennardo M, Cook D; Canadian Critical Care Research Coordinators’ Group. Motivators and Stressors for Canadian Research Coordinators in Critical Care: The MOTIVATE Survey.Am J Crit Care. 2020 Jan 1;29(1):41-48. PMID: 31968081

Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial

First Author:

Lamontagne F

Journal:

JAMA

Year:

2020

Group:

Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial. Lamontagne F, Richards-Belle A, Thomas K, Harrison DA, Sadique MZ, Grieve RD, Camsooksai J, Darnell R, Gordon AC, Henry D, Hudson N, Mason AJ, Saull M, Whitman C, Young JD, Rowan KM, Mouncey PR; 65 trial investigators. JAMA. 2020 Feb 12. doi: 10.1001/jama.2020.0930. PMID: 32049269

Music Use for Sedation in Critically ill Children (MUSiCC trial): study protocol for a pilot randomized controlled trial

First Author:

Garcia Guerra G

Journal:

Pilot Feasibility Stud.

Year:

2020

Group:

,

Garcia Guerra G, Joffe A, Sheppard C, Hewson K, Dinu IA, de Caen A, Jou H, Hartling L, Vohra S; Canadian Critical Care Trials Group. Music Use for Sedation in Critically ill Children (MUSiCC trial): study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud. 2020 Feb 25;6:31. doi: 10.1186/s40814-020-0563-x. eCollection 2020.. PMID: 32128249

Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury

First Author:

STARRT-AKI Investigators

Journal:

N Engl J Med.

Year:

2020

Group:

STARRT-AKI Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group; United Kingdom Critical Care Research Group; Canadian Nephrology Trials Network; Irish Critical Care Trials Group, Bagshaw SM, Wald R, Adhikari NKJ, Bellomo R, da Costa BR, Dreyfuss D, Du B, Gallagher MP, Gaudry S, Hoste EA, Lamontagne F, Joannidis M, Landoni G, Liu KD, McAuley DF, McGuinness SP, Neyra JA, Nichol AD, Ostermann M, Palevsky PM, Pettilä V, Quenot JP, Qiu H, Rochwerg B, Schneider AG, Smith OM, Thomé F, Thorpe KE, Vaara S, Weir M, Wang AY, Young P, Zarbock A.Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury. N Engl J Med. 2020 Jul 16;383(3):240-251. 

Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review

First Author:

Chornenki JN

Journal:

Can J Anaesth.

Year:

2020

Chornenki JN, Liaw P, Bagshaw S, Burns K, Dodek P, English S, Fan E, Ferrari N, Fowler R, Fox-Robichaud A, Garland A, Green R, Hebert P, Kho M, Martin C, Maslove D, McDonald E, Menon K, Murthy S, Muscedere J, Scales D, Stelfox HT, Wang HT, Weiss M; Canadian Critical Care Trials Group (CCCTG) and Canadian Critical Care Translational Biology Group (CCCTBG). Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Can J Anaesth. 2020 Apr;67(4):475-484.

Survey of Canadian critical care physicians' knowledge and attitudes towards legislative aspects of the deceased organ donation system

First Author:

Weiss MJ

Journal:

Can J Anaesth.

Year:

2020

Group:

,

Weiss MJ, English SW, D'Aragon F, Lauzier F, Turgeon AF, Dhanani S, McIntyre L, Carvalho LP, Yu M, Shemie SD, Knoll G, Fergusson DA, Anthony SJ, Haj-Moustafa A, Hartell D, Mohr J, Chassé M; Canadian Critical Care Trials Group.Survey of Canadian critical care physicians' knowledge and attitudes towards legislative aspects of the deceased organ donation system. Can J Anaesth. 2020 Oct;67(10):1349-1358.

Adapting two American Decision Aids for Mild Traumatic Brain Injury to the Canadian Context Using the Nominal Group Technique

First Author:

Ghandour EK

Journal:

Patient

Year:

2020

Group:

Ghandour EK, Lelaidier Hould L, Fortier FA, Gélinas V, Melnick ER, Hess EP, Lang ES, Gravel J, Perry JJ, Le Sage N, Truchon C, LeBlanc A, Dubrovsky AS, Gagnon MP, Ouellet MC, Gagnon I, McKenna S, Légaré F, Sauvé L, van de Belt TH, Kavanagh É, Paquette L, Verrette AC, Plante P, Riopelle RJ, Archambault PM; Canadian Critical Care Trials Group, the Canadian Traumatic Brain Injury Research Consortium and the Network of Canadian Emergency Researchers. Adapting two American Decision Aids for Mild Traumatic Brain Injury to the Canadian Context Using the Nominal Group Technique. Patient. 2020 Oct 20. doi: 10.1007/s40271-020-00459-y.