Home / Nos initiatives/ Sous-groupe canadien de soins intensifs pédiatriques

Sous-groupe canadien de soins intensifs pédiatriques (CCCPEDS)

Le sous-groupe pédiatrique du Canadian Critical Care Trials Group est né de la reconnaissance du fait que les enfants gravement malades diffèrent des adultes gravement malades en ce qui concerne la physiologie, les processus pathologiques, le métabolisme des médicaments et les résultats. De plus, la recherche en soins intensifs pédiatriques présente des considérations uniques, notamment les exigences éthiques pour les mineurs, le nombre réduit de patients et le manque de données pour la grande majorité des traitements utilisés chez les enfants.

Qui sommes-nous?

A photo of a doctor holding a babyLa première étude pédiatrique a été officiellement entreprise en 2000, après que Jacques Lacroix, Jamie Hutchison et Haresh Kirpalani aient obtenu une subvention des IRSC pour lancer un "groupe d'intérêt pédiatrique" au sein du CCCTG. Ce groupe initial, maintenant officiellement appelé le Sous-groupe canadien de soins intensifs en pédiatrie (CCCPEDS), s'est considérablement développé au fil des ans. Le CCCPEDS est composé de plus de 80 membres de tout le Canada et comprend des coordinateurs de recherche, des médecins, des infirmières, des pharmaciens et d'autres professionnels de la santé. Nos membres mènent des études de haute qualité sur les soins intensifs pédiatriques dans différents domaines de recherche, notamment biomédical, clinique, santé de la population et systèmes de santé. La présidente actuelle est Patricia Fontela (intensiviste pédiatrique et docteur en épidémiologie, Université McGill).

Devenir membre

Pour devenir membre du CCCPEDS, vous devez être membre du Groupe canadien d'essais en soins intensifs. Si vous souhaitez adhérer, veuillez consulter la page Devenir membre. Toute personne qui adhère au CCCTG et qui indique la pédiatrie comme intérêt deviendra automatiquement membre de CCCPEDS. L'adhésion à la CCCPEDS est également ouverte à tout membre actuel du CCCTG qui s'intéresse à la recherche en soins intensifs pédiatriques. Pour plus d'informations et pour vous assurer que vous êtes sur la liste des membres de CCCPEDS, veuillez contacter Mary-Ellen Rayner.

Objectifs

Les objectifs du CCCPEDS sont :

  • Diriger, collaborer et promouvoir des études de recherche novatrices en soins intensifs pédiatriques.
  • Établir des collaborations nationales et internationales de recherche en soins intensifs pédiatriques.
  • Développer et mettre en œuvre des initiatives pour accroître l'efficacité de la recherche en soins intensifs pédiatriques.

Initiatives

CanPICC vise à développer et à mettre en œuvre une base de données canadienne sur les soins intensifs pédiatriques qui sera utilisée pour une variété de projets de recherche multicentriques et locaux qui mèneront à des améliorations majeures de la qualité des soins fournis aux enfants gravement malades dans notre pays.

POPCORN est une initiative nationale qui rassemble des chercheurs en santé pédiatrique de 16 sites de recherche à travers le Canada. Elle vise à établir une plateforme de recherche intégrée et complète pour répondre aux questions clés - rapidement et de manière cohérente - nécessaires pour informer les politiques de santé des enfants, en utilisant COVID-19 comme modèle de preuve de concept.

Vous trouverez plus de détails sur POPCORN à l'adresse https://popcornpediatrics.ca/.

 

L'objectif de cette initiative est de développer une approche commune de la collecte, de l'analyse et de la communication des données pour les études sur les soins intensifs pédiatriques. Plus précisément, cette initiative vise à normaliser les éléments de données et l'organisation des formulaires de rapport de cas et à fournir des définitions et du matériel de soutien pour la collecte de données (outils de gravité, PRO). Tout le matériel produit par ce groupe est librement disponible pour les membres du CCCTG et leurs collaborateurs. Nous encourageons également le partage avec des chercheurs externes.

Pour plus d'informations ou pour contribuer à cette initiative, veuillez contacter Shauna O'Donnell.

Les coordonnateurs de recherche au sein du CCCPEDS se réunissent mensuellement le premier jeudi de chaque mois de 13h00 à 14h00 HNE afin de fournir des mises à jour sur les essais et les études en cours, et de partager les connaissances. Ces téléconférences sont ouvertes à tous les membres du CCCPEDS.

Si vous souhaitez vous y joindre, veuillez contacter Katie O'Hearn.

L'objectif de cette initiative est d'accélérer le processus conventionnel d'examen systématique en "crowdsourcing" les étapes les plus chronophages. Le Dr Dayre McNally, en collaboration avec le laboratoire SLiDE du Collège Algonquin, a développé une plateforme en ligne pour soutenir cette approche de revue systématique en grande équipe appelée insightScope. insightScope a été utilisé pour compléter rapidement plusieurs revues systématiques et de portée tout en favorisant la collaboration nationale et internationale et l'application des connaissances.

 Pour en savoir plus, visitez https://insightscope.ca.

L'objectif de la plateforme d'engagement des patients de la CCCPEDS est de créer une grande communauté en ligne de patients de l'USIP, de leurs familles et de leurs soignants, de cliniciens et de chercheurs afin de faciliter l'engagement des patients et des familles dans la recherche sur les soins intensifs pédiatriques.

Pour en savoir plus, voir IC4U.

Réalisations

Subventions

Les membres du CCCPEDS ont collectivement reçu plus de 30 millions de dollars d'organismes de financement, y compris, mais sans s'y limiter, des IRSC, du FRSQ, de l'ISP, de la Thrasher Foundation, de la NFRF, du Hospital for Sick Children, de la Fondation des maladies du cœur et des NIH, pour mener des recherches pertinentes aux enfants gravement malades.

Publications

Les membres du CCCPEDS mènent des recherches innovantes et centrées sur le patient, ancrées dans des méthodes rigoureuses et une collaboration multidisciplinaire aux niveaux national et international. Grâce à leurs programmes de recherche, ils ont modifié la pratique des soins intensifs pédiatriques dans le monde entier en utilisant des méthodes de haute qualité pour évaluer une variété d'interventions, notamment les transfusions sanguines, l'utilisation de l'hypothermie après une lésion cérébrale traumatique, l'utilisation de la vasopressine dans le choc septique pédiatrique et les systèmes d'alerte précoce.

Au fil des ans, la portée des recherches effectuées par les membres du CCCPEDS s'est élargie. Collectivement, nous possédons une expertise dans une multitude de domaines et de méthodes de recherche, y compris la recherche biomédicale, clinique, sur les populations et les systèmes de santé, ainsi que les méthodes quantitatives et qualitatives.

  1. Foster JR, Lee LA, Seabrook JA, Ryan M, Betts LJ, Burgess SA, Slumkoski C, Walls M, Garros D; Canadian Critical Care Trials Group. Family presence in Canadian PICUs during the COVID-19 pandemic: a mixed-methods environmental scan of policy and practice. CMAJ Open. 2022 Jul 5;10(3):E622-E632. PMID: 35790228.
  2. Pong S, Fowler RA, Murthy S, Pernica JM, Gilfoyle E, Fontela P, Rishu AH, Mitsakakis N, Hutchison JS, Science M, Seto W, Jouvet P, Daneman N; Canadian Critical Care Trials Group. Antimicrobial treatment duration for uncomplicated bloodstream infections in critically ill children: a multicentre observational study. BMC Pediatr. 2022 Apr 5;22(1):179. PMID: 35382774.
  3. Fontela PS, Gaudreault J, Dagenais M, Noël KC, Déragon A, Lacroix J, Razack S, Rennick J, Quach C, McNally JD, Carnevale FA; Canadian Critical Care Trials Group. Clinical reasoning behind antibiotic use in PICUs: a qualitative study. Pediatr Crit Care Med 2022;23(3):e126-e135. PMID: 35013080
  4. Ista E, Redivo J, Kananur P, Choong K, Colleti J Jr, Needham DM, Awojoodu R, Kudchadkar SR; International PARK-PICU Investigators. ABCDEF Bundle Practices for Critically Ill Children: An International Survey of 161 PICUs in 18 Countries. Crit Care Med. 2022 Jan 1;50(1):114-125. PMID: 34259659.
  5. Garcia Guerra G, Joffe AR, Sheppard C, Hewson K, Dinu IA, Hajihosseini M, deCaen A, Jou H, Hartling L, Vohra S; Canadian Critical Care Trials Group. Music Use for Sedation in Critically ill Children (MUSiCC trial): a pilot randomized controlled trial. J Intensive Care. 2021 Jan 12;9(1):7. PMID: 33431051.
  6. Noël KC, Papenburg J, Lacroix J, Quach C, O'Donnell S, Gonzales M, Willson DF, Gilfoyle E, McNally JD, Reynolds S, Kazzaz Y, Kawaguchi A, Sato M, Kongkiattikul L, Leteurtre S, Dubos F, Karaca Y, Chiusolo F, Piva J, Dendukuri N, Fontela PS; Canadian Critical Care Trials Group (CCCTG) and the Pediatric Lung Injury and Sepsis Investigators (PALISI) Network. International Survey on Determinants of Antibiotic Duration and Discontinuation in Pediatric Critically Ill Patients. Pediatr Crit Care Med. 2020 Sep;21(9):e696-e706. PMID: 32639469.
  7. Mack J, Kahn SR, Tinmouth A, Fergusson D, Hébert PC, Lacroix J; Canadian Critical Care Trials Group. Volume-dependent effect of stored red blood cells: A secondary analysis of the Age of Blood Evaluation trial. Transfusion. 2020 Sep;60(9):1929-1939. Epub 2020 Aug 28. PMID: 32856734
  8. Garcia Guerra G, Joffe A, Sheppard C, Hewson K, Dinu IA, de Caen A, Jou H, Hartling L, Vohra S; Canadian Critical Care Trials Group. Music Use for Sedation in Critically ill Children (MUSiCC trial): study protocol for a pilot randomized controlled trial. Pilot Feasibility Stud. 2020 Feb 25;6:31. PMID: 32128249; PMCID: PMC7043021.
  9. Spinella PC, Tucci M, Fergusson DA, Lacroix J, Hébert PC, Leteurtre S, Schechtman KB, Doctor A, Berg RA, Bockelmann T, Caro JJ, Chiusolo F, Clayton L, Cholette JM, Guerra GG, Josephson CD, Menon K, Muszynski JA, Nellis ME, Sarpal A, Schafer S, Steiner ME, Turgeon AF; ABC-PICU Investigators, the Canadian Critical Care Trials Group, the Pediatric Acute Lung Injury and Sepsis Investigators Network, the BloodNet Pediatric Critical Care Blood Research Network, and the Groupe Francophone de Réanimation et Urgences P. Effect of Fresh vs Standard-issue Red Blood Cell Transfusions on Multiple Organ Dysfunction Syndrome in Critically Ill Pediatric Patients: A Randomized Clinical Trial. JAMA. 2019 Dec 10;322(22):2179-2190. PMID: 31821429.
  10. Garcia Guerra G, Almeida L, Zorzela L, King-Jones S, Joffe AR, Hartling L, Jou H, Vohra S; Canadian Critical Care Trials Group. Efficacy of music on sedation, analgesia and delirium in critically ill patients. A systematic review of randomized controlled trials. J Crit Care. 2019 Oct;53:75-80. Epub 2019 Jun 4. PMID: 31202161.
  11. Weiss MJ, Domínguez-Gil B, Lahaie N, Nakagawa TA, Scales A, Hornby L, Green M, Gelbart B, Hawkins K, Dhanani S, Dipchand AI, Shemie SD; Canadian Critical Care Trials Group. Development of a multinational registry of pediatric deceased organ donation activity. Pediatr Transplant. 2019 May;23(3):e13345. Epub 2019 Feb 5. PMID: 30724003.
  12. Menon K, McNally D, Acharya A, O'Hearn K, Choong K, Wong HR, McIntyre L, Lawson M; Canadian Critical Care Trials Group. Random serum free cortisol and total cortisol measurements in pediatric septic shock. J Pediatr Endocrinol Metab. 2018 Jul 26;31(7):757-762. PMID: 29953408.
  13. Tucci M, Lacroix J, Fergusson D, Doctor A, Hébert P, Berg RA, Caro J, Josephson CD, Leteurtre S, Menon K, Schechtman K, Steiner ME, Turgeon AF, Clayton L, Bockelmann T, Spinella PC; Canadian Critical Care Trials Group; Pediatric Critical Care Blood Research Network (BloodNet); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. The age of blood in pediatric intensive care units (ABC PICU): study protocol for a randomized controlled trial. Trials. 2018 Jul 28;19(1):404. PMID: 30055634.
  14. Garcia Guerra G, Joffe AR, Sheppard C, Pugh J, Moez EK, Dinu IA, Jou H, Hartling L, Vohra S; Sedation Withdrawal and Analgesia Team (SWAT); Canadian Critical Care Trials Group (CCCTG). Prospective cohort study on noise levels in a pediatric cardiac intensive care unit. J Crit Care. 2018 Apr;44:318-322. Epub 2017 Dec 14. PMID: 29274594.
  15. Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt EA, Joffe AR, Lacroix J, Moga MA, Nadkarni V, Ninis N, Parkin PC, Wensley D, Willan AR, Tomlinson GA; Canadian Critical Care Trials Group and the EPOCH Investigators. Effect of a Pediatric Early Warning System on All-Cause Mortality in Hospitalized Pediatric Patients: The EPOCH Randomized Clinical Trial. JAMA. 2018 Mar 13;319(10):1002-1012. PMID: 29486493.
  16. McNally D, Amrein K, O'Hearn K, Fergusson D, Geier P, Henderson M, Khamessan A, Lawson ML, McIntyre L, Redpath S, Weiler HA, Menon K; Canadian Critical Care Trials Group. Study protocol for a phase II dose evaluation randomized controlled trial of cholecalciferol in critically ill children with vitamin D deficiency (VITdAL-PICU study). Pilot Feasibility Stud. 2017 Dec 8;3:70. PMID: 29234503.
  17. Choong K, Awladthani S, Khawaji A, Clark H, Borhan A, Cheng J, Laskey S, Neu C, Sarti A, Thabane L, Timmons BW, Zheng K, Al-Harbi S; Canadian Critical Care Trials Group. Early Exercise in Critically Ill Youth and Children, a Preliminary Evaluation: The wEECYCLE Pilot Trial. Pediatr Crit Care Med. 2017 Nov;18(11):e546-e554. PMID: 28922268.
  18. Menon K, O'Hearn K, McNally JD, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K. Comparison of Consent Models in a Randomized Trial of Corticosteroids in Pediatric Septic Shock. Pediatr Crit Care Med. 2017 Nov;18(11):1009-1018. PMID: 28817507.
  19. Wilkinson AA, Dennis M, Taylor MJ, Guerguerian AM, Boutis K, Choong K, Campbell C, Fraser D, Hutchison J, Schachar R; Canadian Critical Care Trials Group (CCCTG). Performance Monitoring in Children Following Traumatic Brain Injury Compared to Typically Developing Children. Child Neurol Open. 2017 Oct 12;4:2329048X17732713. PMID: 29051909.
  20. Peters MJ, Argent A, Festa M, Leteurtre S, Piva J, Thompson A, Willson D, Tissières P, Tucci M, Lacroix J. The intensive care medicine clinical research agenda in paediatrics. Intensive Care Med. 2017 Sep;43(9):1210-1224. Epub 2017 Mar 17. PMID: 28315043.
  21. Fontela PS, Quach C, Karim ME, Willson DF, Gilfoyle E, McNally JD, Gonzales M, Papenburg J, Reynolds S, Lacroix J; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network; Canadian Critical Care Trials Group. Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey. Pediatr Crit Care Med. 2017 Sep;18(9):e395-e405. PMID: 28661973.
  22. Wilkinson AA, Dennis M, Simic N, Taylor MJ, Morgan BR, Frndova H, Choong K, Campbell C, Fraser D, Anderson V, Guerguerian AM, Schachar R, Hutchison J; Canadian Critical Care Trials Group (CCCTG); Canadian Critical Care Translational Biology Group (CCCTBG). Brain biomarkers and pre-injury cognition are associated with long-term cognitive outcome in children with traumatic brain injury. BMC Pediatr. 2017 Jul 24;17(1):173. PMID: 28738850.
  23. Menon K, McNally D, O'Hearn K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K; Canadian Critical Care Trials Group. A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study. Pediatr Crit Care Med. 2017 Jun;18(6):505-512. PMID: 28406862.
  24. Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group. Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial. Pilot Feasibility Stud. 2017 May 19;3:26. PMID: 28533916.
  25. Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, Cook DJ; Canadian Critical Care Trials Group. High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators. Pediatr Crit Care Med. 2017 May;18(5):405-413. PMID:28328786.
  26. Gilfoyle E, Koot DA, Annear JC, Bhanji F, Cheng A, Duff JP, Grant VJ, St George-Hyslop CE, Delaloye NJ, Kotsakis A, McCoy CD, Ramsay CE, Weiss MJ, Gottesman RD; Teams4Kids Investigators and the Canadian Critical Care Trials Group. Improved Clinical Performance and Teamwork of Pediatric Interprofessional Resuscitation Teams With a Simulation-Based Educational Intervention. Pediatr Crit Care Med. 2017 Feb;18(2):e62-e69. PMID:28157808.
  27. Parker MJ, Thabane L, Fox-Robichaud A, Liaw P, Choong K; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Trials. 2016 Nov 22;17(1):556. PMID: 27876084.
  28. Garcia Guerra G, Joffe AR, Cave D, Duff J, Duncan S, Sheppard C, Tawfik G, Hartling L, Jou H, Vohra S; Sedation Withdrawal and Analgesia Team, and the Canadian Critical Care Trials Group. Survey of Sedation and Analgesia Practice Among Canadian Pediatric Critical Care Physicians. Pediatr Crit Care Med. 2016 Sep;17(9):823-30. PMID: 27467012.
  29. O'Hearn K, McNally D, Choong K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Menon K; Canadian Critical Care Trials Group. Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial. Trials. 2016 May 6;17(1):238. PMID: 27153945.
  30. Menon K, McNally JD, Choong K, Lawson ML, Ramsay T, Hutchison JS, Foster J, Wong HR; Canadian Critical Care Trials Group STRIPES Investigators. A Cohort Study of Pediatric Shock: Frequency of Corticosteriod Use and Association with Clinical Outcomes. Shock. 2015 Nov;44(5):402-9. PMID: 25692259.
  31. McNally JD, O'Hearn K, Lawson ML, Maharajh G, Geier P, Weiler H, Redpath S, McIntyre L, Fergusson D, Menon K; Canadian Critical Care Trials Groups. Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial. Trials. 2015 Sep 9;16:402. PMID: 26353829.
  32. Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M; Canadian Critical Care Trials Group (CCCTG); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI); BloodNet; PlasmaTV Investigators. Indications and Effects of Plasma Transfusions in Critically Ill Children. Am J Respir Crit Care 2015 Jun 15;191(12):1395-402. PMID: 25859890.
  33. Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt E, Joffe A, Lacroix J, Nadkarni V, Parkin P, Wensley D, Willan AR; Canadian Critical Care Trials Group. Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial. Trials. 2015 Jun 2;16:245. PMID: 26033094.
  34. Choong K, Al-Harbi S, Siu K, Wong K, Cheng J, Baird B, Pogorzelski D, Timmons B, Gorter JW, Thabane L, Khetani M; Canadian Critical Care Trials Group. Functional recovery following critical illness in children: the "wee-cover" pilot study. Pediatr Crit Care Med. 2015 May;16(4):310-8. PMID: 25651047.
  1. Parshuram CS, Amaral AC, Ferguson ND, Baker GR, Etchells EE, Flintoft V, Granton J, Lingard L, Kirpalani H, Mehta S, Moldofsky H, Scales DC, Stewart TE, Willan AR, Friedrich JO; Canadian Critical Care Trials Group. Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial. CMAJ. 2015 Mar 17;187(5):321-9. Epub 2015 Feb 9. PMID: 25667258
  2. Choong K, Foster G, Fraser DD, Hutchison JS, Joffe AR, Jouvet PA, Menon K, Pullenayegum E, Ward RE; Canadian Critical Care Trials Group. Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med. 2014 Jul;15(6):e270-9 PMID: 24777303.
  3. Karam O, Tucci M, Lacroix J, Rimensberger PC; Canadian Critical Care Trials Group and of the Pediatric Acute Lung Injury and Sepsis Investigator Network. International survey on plasma transfusion practices in critically ill children. Transfusion. 2014 Apr;54(4):1125-32. Epub 2013 Aug 27. PMID: 24032693.
  4. Menon K, Ward R; Canadian Critical Care Trials Group. A study of consent for participation in a non-therapeutic study in the pediatric intensive care population. J Med Ethics. 2014 Feb;40(2):123-6. Epub 2013 Jan 23. PMID: 23345569.
  5. McNally JD, Menon K, Chakraborty P, Fisher L, Williams KA, Al-Dirbashi OY, Doherty DR; Canadian Critical Care Trials Group. The association of vitamin D status with pediatric critical illness. Pediatrics. 2012 Sep;130(3):429-36. Epub 2012 Aug 6. PMID: 22869837.
  6. Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F; Canadian Critical Care Trials Group; PALISI Network. Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med. 2011 Sep;12(5):512-8. PMID: 21057356.
  7. Hutchison JS, Frndova H, Lo TY, Guerguerian AM; Hypothermia Pediatric Head Injury Trial Investigators; Canadian Critical Care Trials Group. Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: a post hoc analysis of the Hypothermia Pediatric Head Injury Trial. Dev Neurosci. 2010;32(5-6):406-12. Epub 2011 Jan 21. PMID: 21252486.
  8. Jouvet P, Hutchison J, Pinto R, Menon K, Rodin R, Choong K, Kesselman M, Veroukis S, André Dugas M, Santschi M, Guerguerian AM, Withington D, Alsaati B, Joffe AR, Drews T, Skippen P, Rolland E, Kumar A, Fowler R; Canadian Critical Care Trials Group H1N1 Collaborative. Critical illness in children with influenza A/pH1N1 2009 infection in Canada. Pediatr Crit Care Med. 2010 Sep;11(5):603-9. PMID: 20308929.
  9. Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M; Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion. 2010 Sep;50(9):1902-13. PMID: 20456697.
  10. Menon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, Hébert PC; Canadian Critical Care Trials Group. A prospective multicenter study of adrenal function in critically ill children. Am J Respir Crit Care Med. 2010 Jul 15;182(2):246-51. Epub 2010 Mar 18. PMID: 20299532.
  11. Rouette J, Trottier H, Ducruet T, Beaunoyer M, Lacroix J, Tucci M; Canadian Critical Care Trials Group; PALISI Network. Red blood cell transfusion threshold in postsurgical pediatric intensive care patients: a randomized clinical trial. Ann Surg. 2010 Mar;251(3):421-7. PMID: 20118780.
  12. Willems A, Harrington K, Lacroix J, Biarent D, Joffe AR, Wensley D, Ducruet T, Hébert PC, Tucci M; TRIPICU investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis. Crit Care Med. 2010 Feb;38(2):649-56. PMID: 19789443.
  13. Choong K, Bohn D, Fraser DD, Gaboury I, Hutchison JS, Joffe AR, Litalien C, Menon K, McNamara P, Ward RE; Canadian Critical Care Trials Group. Vasopressin in pediatric vasodilatory shock: a multicenter randomized controlled trial. Am J Respir Crit Care Med. 2009 Oct 1;180(7):632-9. Epub 2009 Jul 16. PMID: 19608718.
  14. Doherty DR, Parshuram CS, Gaboury I, Hoskote A, Lacroix J, Tucci M, Joffe A, Choong K, Farrell R, Bohn DJ, Hutchison JS; Canadian Critical Care Trials Group. Hypothermia therapy after pediatric cardiac arrest. Circulation. 2009 Mar 24;119(11):1492-500. Epub 2009 Mar 9. PMID: 19273725.
  15. Hutchison JS, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Fergusson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW; Hypothermia Pediatric Head Injury Trial Investigators and the Canadian Critical Care Trials Group. Hypothermia therapy after traumatic brain injury in children. N Engl J Med. 2008 Jun 5;358(23):2447-56. PMID: 18525042.
  16. Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ; TRIPICU Investigators; Canadian Critical Care Trials Group; Pediatric Acute Lung Injury and Sepsis Investigators Network. Transfusion strategies for patients in pediatric intensive care units. N Engl J Med. 2007 Apr 19;356(16):1609-19. PMID: 17442904.
  17. Parshuram CS, Kirpalani H, Mehta S, Granton J, Cook D; Canadian Critical Care Trials Group. In-house, overnight physician staffing: a cross-sectional survey of Canadian adult and pediatric intensive care units. Crit Care Med. 2006 Jun;34(6):1674-8. PMID: 16625115.
  18. Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D; HyP-HIT Investigators; Canadian Critical Care Trials Group. Hypothermia pediatric head injury trial: the value of a pretrial clinical evaluation phase. Dev Neurosci. 2006;28(4-5):291-301. PMID: 16943652.
  19. Kotsakis A, Cook D, Griffith L, Anton N, Massicotte P, MacFarland K, Farrell R, Hutchison J; Canadian Critical Care Trials Group. Clinically important venous thromboembolism in pediatric critical care: a Canadian survey. J Crit Care. 2005 Dec;20(4):373-80. PMID: 16310610.
  20. Survey on transfusion practices of pediatric intensivists. Laverdière C, Gauvin F, Hébert PC, Infante-Rivard C, Hume H, Toledano BJ, Guertin MC, Lacroix J; Canadian Critical Care Trials Group.Pediatr Crit Care Med. 2002 Oct;3(4):335-40. PMID: 12780950
  1. Sarti AJ, Sutherland S, Meade M, Shemie S, Landriault A, Vanderspank-Wright B, Valiani S, Keenan S, Weiss MJ, Werestiuk K, Kramer AH, Kawchuk J, Beed S, Dhanani S, Pagliarello G, Chassé M, Lotherington K, Gatien M, Parsons K, Chandler JA, Nickerson P, Cardinal P; Canadian Critical Care Trials Group. The experiences of family members of deceased organ donors and suggestions to improve the donation process: a qualitative study. CMAJ. 2022 Aug 8;194(30):E1054-E1061. PMID: 35940617.
  2. ISARIC Clinical Characterization Group, Garcia-Gallo E, Merson L, Kennon K, Kelly S, Citarella BW, Fryer DV, Shrapnel S, Lee J, Duque S, Fuentes YV, Balan V, Smith S, Wei J, Gonçalves BP, Russell CD, Sigfrid L, Dagens A, Olliaro PL, Baruch J, Kartsonaki C, Dunning J, Rojek A, Rashan A, Beane A, Murthy S, Reyes LF. ISARIC-COVID-19 dataset: A Prospective, Standardized, Global Dataset of Patients Hospitalized with COVID-19. Sci Data. 2022 Jul 30;9(1):454. PMID: 35908040.
  1. O'Hearn K, Gibson J, Krewulak K, Porteous R, Saigle V, Sampson M, Tsampalieros A, Barrowman N, Cameron S; Canadian Critical Care Trials Group. Consent models in Canadian critical care randomized controlled trials: a scoping review. Can J Anaesth. 2022 Apr;69(4):513-526. English. Epub 2021 Dec 14. PMID: 34907503.
  2. Chassé M, Neves Briard J, Yu M, Carvalho L, English S, D'Aragon F, Lauzier F, Turgeon A, Dhanani S, McIntyre L, Shemie S, Knoll G, Fergusson DA, Anthony SJ, Weiss MJ; Canadian Critical Care Trials Group. Clinical evaluation and ancillary testing for the diagnosis of death by neurologic criteria: a cross-sectional survey of Canadian intensivists. Can J Anaesth. 2022 Mar;69(3):353-363. Epub 2021 Dec 20. PMID: 34931292.
  3. Dodek PM, Cheung EO, Burns KEA, Martin CM, Archambault PM, Lauzier F, Sarti AJ, Mehta S, Fox-Robichaud AE, Seely AJE, Parshuram C, Garros D, Withington DE, Cook DJ, Piquette D, Carnevale FA, Boyd JG, Downar J, Kutsogiannis DJ, Chassé M, Fontela P, Fowler RA, Bagshaw S, Dhanani S, Murthy S, Gehrke P, Fujii T. Moral Distress and Other Wellness Measures in Canadian Critical Care Physicians. Ann Am Thorac Soc. 2021 Aug;18(8):1343-1351. PMID: 33356972.
  4. Murthy S, Archambault PM, Atique A, Carrier FM, Cheng MP, Codan C, Daneman N, Dechert W, Douglas S, Fiest KM, Fowler R, Goco G, Gu Y, Guerguerian AM, Hall R, Hsu JM, Joffe A, Jouvet P, Kelly L, Kho ME, Kruisselbrink RJ, Kumar D, Kutsogiannis DJ, Lamontagne F, Lee TC, Menon K, O'Grady H, O'Hearn K, Ovakim DH, Pharand SG, Pitre T, Reel R, Reeve B, Rewa O, Richardson D, Rishu A, Sandhu G, Sarfo-Mensah S, Shadowitz E, Sligl W, Solomon J, Stelfox HT, Swanson A, Tessier- Grenier H, Tsang JLY, Wood G; SPRINT-SARI Canada Investigators and the Canadian
  5. Critical Care Trials Group. Characteristics and outcomes of patients with COVID-19 admitted to hospital and intensive care in the first phase of the pandemic in Canada: a national cohort study. CMAJ Open. 2021 Mar 8;9(1):E181-E188. PMID: 33688026.
  6. Weiss MJ, English SW, D'Aragon F, Lauzier F, Turgeon AF, Dhanani S, McIntyre L, Carvalho LP, Yu M, Shemie SD, Knoll G, Fergusson DA, Anthony SJ, Haj-Moustafa A, Hartell D, Mohr J, Chassé M; Canadian Critical Care Trials Group. Survey of Canadian critical care physicians' knowledge and attitudes towards legislative aspects of the deceased organ donation system. Can J Anaesth. 2020 Oct;67(10):1349-1358. English. Epub 2020 Jul 21. PMID: 32696225.
  7. Jackson Chornenki N, Liaw P, Bagshaw S, Burns K, Dodek P, English S, Fan E, Ferrari N, Fowler R, Fox-Robichaud A, Garland A, Green R, Hebert P, Kho M, Martin C, Maslove D, McDonald E, Menon K, Murthy S, Muscedere J, Scales D, Stelfox HT, Wang HT, Weiss M; Canadian Critical Care Trials Group (CCCTG) and Canadian Critical Care Translational Biology Group (CCCTBG). Data initiatives supporting critical care research and quality improvement in Canada: an environmental scan and narrative review. Can J Anaesth. 2020 Apr;67(4):475-484. English. Epub 2020 Jan 22. PMID: 31970619.
  8. Weiss MJ, English SW, D'Aragon F, Lauzier F, Turgeon AF, Dhanani S, McIntyre L, Shemie SD, Knoll G, Fergusson DA, Anthony SJ, Haj-Moustafa A, Hartell D, Mohr J, Chassé M; Canadian Critical Care Trials Group. Survey of Canadian intensivists on physician non-referral and family override of deceased organ donation. Can J Anaesth. 2020 Mar;67(3):313-323. English. Epub 2019 Nov 25. PMID: 31768789.
  9. Hutchison JS, Emery C, Gagnon I, Léger C, Riopelle R, Wellington C, Wilson E, Turgeon AF. The Canadian Traumatic Brain Injury Research Consortium: Epitomizing Collaborative Research in Canada. J Neurotrauma. 2018 Aug 15;35(16):1858-1863. PMID: 30074867.
  10. Ball IM, Burry L, Dodek P, Hutchison JS, Leigh JP, McCredie V, Murthy S, Rochwerg B, Cook D; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group. The Young Investigator Retreat of the Canadian Critical Care Trials Group: mentorship and self-discovery. Can J Anaesth. 2018 Mar;65(3):239-245. Epub 2017 Nov 17. PMID: 29150787.
  11. Jung JJ, Pinto R, Zarychanski R, Cook DJ, Jouvet P, Marshall JC, Kumar A, Long J, Rodin R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. 2009-2010 Influenza A(H1N1)-related critical illness among Aboriginal and non-Aboriginal Canadians. PLoS One. 2017 Oct 19;12(10):e0184013. PMID: 29049285.
  12. Jain S, Menon K, Piquette D, Gottesman R, Hutchison J, Gilfoyle E; Canadian Critical Care Trials Group. The Development of a Critical Care Resident Research Curriculum: A Needs Assessment. Can Respir J. 2016:9795739. Epub 2016 Aug 16. PMID: 27610029.
  13. Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care. 2016 Mar 30;20:75. PMID: 27036638.
  14. Dhanani S, Hornby L, Ward R, Baker A, Dodek P, Chamber-Evans J, Fowler R, Friedrich JO, Gow RM, Kutsogiannis DJ, Mcintyre L, Momoli F, Morin K, Ramsay T, Scales D, Writer H, Yildirim S, Young B, Shemie S; Canadian Critical Care Trials Group and in collaboration with the Bertram Loeb Chair and Research Consortium in Organ and Tissue Donation. Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study. Crit Care Med. 2014 Nov;42(11):2358-69. PMID: 24810533.
  15. Dhanani S, Ward R, Hornby L, Barrowman NJ, Hornby K, Shemie SD; Canadian Critical Care Trials Group; Bertram Loeb Research Consortium in Organ and Tissue Donation. Survey of determination of death after cardiac arrest by intensive care physicians. Crit Care Med. 2012 May;40(5):1449-55. PMID: 22430244.
  16. Duffett M, Burns KE, Kho ME, Lauzier F, Meade MO, Arnold DM, Adhikari NKJ, Lamontagne F, Cook DJ; Academy of Critical CAre: Development, Evaluation, and MethodologY (ACCADEMY) and the Canadian Critical Care Trials group. Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers. J Crit Care. 2011 Oct;26(5):533.e11-533.e22. Epub 2011 Mar 3. PMID: 21376518.
  17. Freed DH, Henzler D, White CW, Fowler R, Zarychanski R, Hutchison J, Arora RC, Manji RA, Legare JF, Drews T, Veroukis S, Kesselman M, Guerguerian AM, Kumar A; Canadian Critical Care Trials Group. Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth. 2010 Mar;57(3):240-7. Epub 2010 Jan 16. PMID: 20082167.
  18. Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon AF, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet P, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. Critically ill patients with 2009 influenza A(H1N1) infection in Canada. JAMA. 2009 Nov 4;302(17):1872-9. Epub 2009 Oct 12. PMID: 19822627.
  19. Cook DJ, Blythe D, Rischbieth A, Hebert PC, Zytaruk N, Menon K, Erikson S, Fowler R, Heels-Ansdell D, Meade MO. Enrollment of intensive care unit patients into clinical studies: a trinational survey of researchers' experiences, beliefs, and practices. Crit Care Med. 2008 Jul;36(7):2100-5. PMID: 18552686.

 

  1. Ali K, Azher T, Baqi M, Binnie A, Borgia S, Carrier FM, Cavayas YA, Chagnon N, Cheng MP, Conly J, Costiniuk C, Daley P, Daneman N, Douglas J, Downey C, Duan E, Duceppe E, Durand M, English S, Farjou G, Fera E, Fontela P, Fowler R, Fralick M, Geagea A, Grant J, Harrison LB, Havey T, Hoang H, Kelly LE, Keynan Y, Khwaja K, Klein G, Klein M, Kolan C, Kronfli N, Lamontagne F, Lau R, Fralick M, Lee TC, Lee N, Lim R, Longo S, Lostun A, MacIntyre E, Malhamé I, Mangof K, McGuinty M, Mergler S, Munan MP, Murthy S, O'Neil C, Ovakim D, Papenburg J, Parhar K, Parvathy SN, Patel C, Perez-Patrigeon S, Pinto R, Rajakumaran S, Rishu A, Roba-Oshin M, Rushton M, Saleem M, Salvadori M, Scherr K, Schwartz K, Semret M, Silverman M, Singh A, Sligl W, Smith S, Somayaji R, Tan DHS, Tobin S, Todd M, Tran TV, Tremblay A, Tsang J, Turgeon A, Vakil E, Weatherald J, Yansouni C, Zarychanski R; Canadian Treatments for COVID-19 (CATCO); Association of Medical Microbiology and Infectious Disease Canada (AMMI) Clinical Research Network and the Canadian Critical Care Trials Group. Remdesivir for the treatment of patients in hospital with COVID-19 in Canada: a randomized controlled trial. CMAJ. 2022 Feb 22;194(7):E242-E251. Epub 2022 Jan 19. PMID: 35045989.
  2. Dhanani S, Hornby L, van Beinum A, Scales NB, Hogue M, Baker A, Beed S, Boyd JG, Chandler JA, Chassé M, D'Aragon F, Dezfulian C, Doig CJ, Duska F, Friedrich JO, Gardiner D, Gofton T, Harvey D, Herry C, Isac G, Kramer AH, Kutsogiannis DJ, Maslove DM, Meade M, Mehta S, Munshi L, Norton L, Pagliarello G, Ramsay T, Rusinova K, Scales D, Schmidt M, Seely A, Shahin J, Slessarev M, So D, Talbot H, van Mook WNKA, Waldauf P, Weiss M, Wind JT, Shemie SD; Canadian Critical Care Trials Group; Canadian Donation and Transplantation Research Program. Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures. N Engl J Med. 2021 Jan 28;384(4):345-352. PMID: 33503343.
  3. Mack J, Kahn SR, Tinmouth A, Fergusson D, Hébert PC, Lacroix J; Canadian Critical Care Trials Group. Volume-dependent effect of stored red blood cells: A secondary analysis of the Age of Blood Evaluation trial. Transfusion. 2020 Sep;60(9):1929-1939. Epub 2020 Aug 28. PMID: 32856734.
  4. Effect of age of transfused red blood cells on neurologic outcome following traumatic brain injury (ABLE-tbi Study): a nested study of the Age of Blood Evaluation (ABLE) trial. Ruel-Laliberté J, Lessard Bonaventure P, Fergusson D, Lacroix J, Zarychanski R, Lauzier F, Tinmouth A, Hébert PC, Green R, Griesdale D, Fowler R, Kramer A, McIntyre LA, Zygun D, Walsh T, Stanworth S, Capellier G, Pili-Floury S, Samain E, Clayton L, Marshall J, Pagliarello G, Sabri E, Neveu X, Léger C, Turgeon AF; Canadian Critical Care Trials Group. Can J Anaesth. 2019 Jun;66(6):696-705. doi: 10.1007/s12630-019-01326-7. Epub 2019 Feb 26. PMID: 30809776. 
  1. Age of transfused blood in critically ill adult trauma patients: a prespecified nested analysis of the Age of Blood Evaluation randomized trial. Green RS, Erdogan M, Lacroix JHébert PC, Tinmouth AT, Sabri E, Zhang T, Fergusson DA, Turgeon AF; ABLE Investigators and the Canadian Critical Care Trials Group. 2018 Aug;58(8):1846-1854. Epub 2018 Apr 19. PMID: 29672869.
  2. D'Aragon F, Dhanani S, Lamontagne F, Cook DJ, Burns K, Akhtar A, Chassé M, Frenette AJ, Keenan S, Lize JF, Kutsogiannis DJ, Kramer A, Hand LE, Arseneau E, Masse MH, Ribic C, Ball I, Baker A, Boyd G, Rochwerg B, Healey A, Hanna S, Guyatt GH, Meade MO; Canadian Critical Care Trials Group and the Canadian National Transplant Research Program. Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors. BMJ Open. 2017 Sep 28;7(9):e018858. PMID: 28963316.
  3. Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial. Lamontagne F, Meade MO, Hébert PC, Asfar P, Lauzier F, Seely AJE, Day AG, Mehta S, Muscedere J, Bagshaw SM, Ferguson ND, Cook DJ, Kanji S, Turgeon AF, Herridge MS, Subramanian S, Lacroix J, Adhikari NKJ, Scales DC, Fox-Robichaud A, Skrobik Y, Whitlock RP, Green RS, Koo KKY, Tanguay T, Magder S, Heyland DK; Canadian Critical Care Trials Group. Intensive Care Med. 2016 Apr;42(4):542-550. Epub 2016 Feb 18. PMID: 26891677.
  4. The ABLE study: A randomized controlled trial on the efficacy of fresh red cell units to improve the outcome of transfused critically ill adults. Lacroix JHébert PC, Fergusson D, Tinmouth A, Capellier G, Tiberghien P, Bardiaux L; Canadian Critical Care Trials Group. Transfus Clin Biol. 2015 Aug;22(3):107-11. Epub 2015 Jun 3. PMID: 26049675.
  5. Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon AF, Lamontagne F, Kumar A, Zarychanski R, Green R, Bagshaw SM, Stelfox HT, Foster R, Dodek P, Shaw S, Granton J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC, Martin C, Jouvet P; Canadian Critical Care Trials Group; Canadian ICU Capacity Group. Critical care capacity in Canada: results of a national cross-sectional study. Crit Care. 2015 Apr 1;19(1):133. PMID: 25888116.
  6. Age of transfused blood in critically ill adults. Lacroix JHébert PC, Fergusson DA, Tinmouth A, Cook DJ, Marshall JC, Clayton L, McIntyre L, Callum J, Turgeon AF, Blajchman MA, Walsh TS, Stanworth SJ, Campbell H, Capellier G, Tiberghien P, Bardiaux L, van de Watering L, van der Meer NJ, Sabri E, Vo D; ABLE Investigators; Canadian Critical Care Trials Group. N Engl J Med. 2015 Apr 9;372(15):1410-8. Epub 2015 Mar 17. PMID: 25853745

Collaborations

Cet ECR sur l'hydrocortisone d'effort dans le choc septique pédiatrique comprend 75 sites et 12 pays en Amérique du Nord et du Sud et en Asie.

Pour plus d'informations, visitez le site Web de SHIPSS.

Cet ECR sur les seuils de transfusion chez les enfants gravement malades a recruté des patients de 19 sites et de 4 pays en Amérique du Nord et en Europe.

Pour plus de détails, voir Transfusion strategies for patients in pediatric intensive care units.