Laboratoires en vedette

Liaw Lab
McMaster University
Thrombosis & Atherosclerosis Research Institute (TaARI)

Our Research Program

Research in the Liaw Lab focuses on the biological crosstalk between microbial infection, innate immunity, and blood clotting, a process termed “immunothrombosis”. Our approach is to integrate lab-based studies with translational/clinical research project to better understand how immunothrombosis contributes to morbidity and mortality in critically ill patients. Our integrative research approach includes studies at the levels of cell biology, biochemistry, animal models, and translational studies of ICU patients. We are also engaged in CCCTBG and CCCTG projects to increase biosampling-based translational research capacity in Canada.

Current Projects

Our research is funded by the Canadian Institutes of Health Research (CIHR), the Canadian Venous Thromboembolism Research Network (CanVECTOR) and the Canadian Network of COVID-19 Clinical Trials Networks. Current research projects include:

• Phase 1 clinical trial of intravenous DNaseI in ICU patients with sepsis
• Translational studies of heparin in sepsis-associated immunothrombosis
• Mechanisms of immunothrombosis in COVID-19 patients
• Impact of blood clotting capacity on the host response to infection
• Increasing translational research capacity in academic and community sites in Canada

► The Liaw Lab on PubMed (offsite link)