• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.


Programs ▼Principal Investigator(s)Coordinator(s)Status 
WAVE - A Multicenter Evaluation of Altered Heart Rate and Respiratory Rate Variability to Predict Extubation FailureAndrew SeelyAnna FazekasCompletedLearn More
VITdAL-PICU - Rapid normalization of vitamin D in critically ill childrenDayre McNallyKatie O’HearnCompletedLearn More
VITdALIZE-KIDS – Rapid correction of vitamin D deficiency in pediatric critical illness: A phase III multicentre randomized controlled trialDayre McNallyKatie O’HearnEnrollingLearn More
TOP UP - A Randomized Trial of Supplemental Parenteral Nutrition in Under and Over Weight Critically Ill PatientsDaren Heyland
Rupinder Dhaliwal (Project Leader) and Maureen Dansereau (Project Assistant)EnrollingLearn More
THRRIVES - Temperature, Heart and Respiratory Rate Investigation along with Variability Evaluation and Serum Biomarkers StudyAndrew Seely, Christopher BredesonKaitlyn Chambers, Anna Fazekas
EnrollingLearn More
The REDOXS© Study  PublishedLearn More
The REALISTIC 80 Study  PublishedLearn More
The CANTREAT Study  PublishedLearn More
Teams 4 KidsElaine GilfoyleDeanna KootEnrollingLearn More
TBI-PrognosisAlexis TurgeonLucy Clayton and Caroline LégerCompletedLearn More
SuDDICU - Selective Decontamination of the Digestive Tract in the ICUBrian CuthbertsonTo be announcedNot Yet Recruiting Learn More
STRIPES — Steroid Use in Pediatric Fluid and Vasoactive Infusion Dependent ShockKusum MenonKatie O’HearnCompletedLearn More
STARRT-AKI – Standard vs. Accelerated Renal Replacement Therapy in Critically Ill Patients with Acute Kidney InjurySean Bagshaw, Ron WaldJanice Jansen-PereiraEnrollingLearn More
SPICE - Adverse drug reactions in the critically ill Yoanna Skrobik EnrollingLearn More
SLEAPSangeeta MehtaLisa BurryPublishedLearn More
SHIPSS - Stress Hydrocortisone in Pediatric Septic ShockKusum Menon

Katie O’HearnEnrollingLearn More
SEVA - Improving Safety of Sedation Practice and Critical Illness PrognosticationAndrew SeelyAnna FazekasEnrollingLearn More
SENIOR Trial- Screening Elderly PatieNts For InclusiOn in a Weaning TrialKaren Burns

 CompletedLearn More
RELEASE TrialKaren Burns

Leena RizviCompletedLearn More
Re-EValuating the Inhibition of Stress Erosions (REVISE) TrialDeborah J Cook, MD
Nicole Zytaruk, RNEnrollingLearn More
RECOVERMargaret Herridge

Program Manager: Priscila Robles

Research Coordinators: UHN (TWH)Andrea Matte, Paulina Farias, Cheryl Geen-Smith; MSH - Cheryl Ethier, Maedean Brown, Brittany Giacomino and Sumesh Shah; SMH - Orla Smith, Yoon Lee, Kerri Porretta, Julia Lee and Melissa Wang; SHSC - Nicole Marinoff, Jane Wang, Derek Parsotam and Ashwati Raghunath; SJH - Andrea Tkaczyk and France Clarke; OHSC - Mary-Jo Lewis, Tracey McArdle and Brigette Gomes; SPH - Lynda Lazosky, Ellen Woo; CHUS - Chantal Langevin, Karine Grondi, Joanie Lacasse-Bedard and Eugenie Pinsonnault; HMR: Joanne Harvey
EnrollingLearn More
PROSPECT — Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization TrialDeborah CookNicole Zytaruk et France ClarkeEnrollingLearn More
PRECISELauralyn McIntyre EnrollingLearn More
Plasma Transfusions in Critically Ill Children - Point Prevalence StudyOliver Karam To come.EnrollingLearn More
PIT-TBIFrançois LauzierLucy ClaytonEnrollingLearn More
OVATION65 - THE OVATION-65: IMPACT OF PERMISSIVE HYPOTENSION ON END-ORGAN DAMAGE IN THE ELDERLYFrançois Lamontagne, Neill Adhikari, Elizabeth WilcoxMarie-Hélène MasseEnrollingLearn More
OSCILLATE — Oscillation for ARDS Treated EarlyMaureen Meade & Niall FergusonLori HandCompletedLearn More
LOVIT : Lessening Organ dysfunction with VITamin CFrançois Lamontagne, Neill AdhikariMarie-Hélène Masse
Julie Ménard
Sheila Sprague
EnrollingLearn More
Knowledge transfer and best practices in emergency medicine and in traumatology: impact of wikisPatrick ArchambaultCarrie Anna McGinnEnrollingLearn More
IOStudy — International Observational StudyKaren Burns
Ms. Leena Rizvi, Ms. Kelly KlouvidakisEnrollingLearn More
Improvement of ventilatory support during pediatric non-invasive ventilationGuillaume EmeriaudNicole PoitrasEnrollingLearn More
IC4UDayre McNally
Katie O'HearnEnrollingLearn More
HEMOTION TrialAlexis Turgeon, François Lauzier, Dean Fergusson

 EnrollingLearn More
HALORyan Zarychanski & Dean A Ferguson

Nicole Marten, Wendy Janz,  Ellen McDonald, Suzy Lavoie, Irene Watpool, Tracy McArdle, Orla SmithEnrollingLearn More
GRASP1 - Global Resource Allocation Survey ProjectMichael ChristianMelanie GuenetteEnrollingLearn More
FAST TrialKaren Burns

Leena RizviCompletedLearn More
EXERCISE - The EXercise and Early Rehabilitation in Critically Ill Children: a Systematic Evaluation Research ProgramKaren Choong
 EnrollingLearn More
DYNAMICSPatricia LiawEllen McDonald, Irene Watpool,  Tracey McArdle, Claude Ferland, Orla Smith, Betty Jean Ashley, Eileen Campbell,  Christine Skinner, Josee WongNot Yet Recruiting Learn More
DDePICt - Determination of Death Practices in Intensive Care Resarch ProgramSonny DhananiAmanda van BeinumEnrollingLearn More
CYCLE - Critical Care Cycling to Improve Lower Extremity StrengthMichelle KhoFrance ClarkeEnrollingLearn More
Canada DONATEFrederick D'Aragon, Maureen Meade

Aemal Akhtar, Erika Arseneau, Lori Hand, Marie-Hélène Masse
EnrollingLearn More
BALANCE — Bacteremia Antibiotic Length Actually Needed for Clinical EffectivenessNick Daneman & Rob FowlerA RishuCompletedLearn More
aC3KTion Net — A Canadian Critical Care Knowledge Translation NetworkJohn Muscedere Nicole O'Callaghan & Nomusa MngomaNot Yet Recruiting Learn More
ABLE - Age of Blood Evaluation Study: a Multicenter Randomized Clinical TrialJacques LacroixPaul Hébert, Dean Fergusson and Alan TinmouthLucy ClaytonPublishedLearn More
ABC PICU — Age of Blood in Children PICUMarisa TucciNicole Poitras & Lucy ClaytonEnrollingLearn More