• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.

Curriculum

 First Author ▲JournalYearTitleTitre
Adhikari NKCrit Care Med2011High frequency oscillation in adults: a utilization review21765359Adhikari NK, Bashir A, Lamontagne F, Mehta S, Ferguson ND, Zhou Q, Hand L, Czarnecka K, Cook DJ, Granton JT, Friedrich JO, Freitag A, Watpool I, Meade MO for the Canadian Critical Care Trials Group. High frequency oscillation in adults: a utilization review. Crit Care Med. 2011 Dec;39(12):2631-44. PMID: 21765359
Albert MJ Crit Care2008Utility of gram stain in the clinical management of suspected ventilator-associated pneumonia: Secondary analysis of a multicenter randomized trial18359424Albert M, Friedrich JO, Adhikari NKJ, Day AG, Verdant C, Heyland DK for the Canadian Critical Care Trials Group. Utility of gram stain in the clinical management of suspected ventilator-associated pneumonia: Secondary analysis of a multicenter randomized trial. J Crit Care 2008; 23: 74-81. PMID: 18359424
Albert MIntensive Care Med2014Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Efficacy of Antifungal Treatment: a randomized placebo controlled trial (CANTREAT Study)24981955Albert, M, Williamson, D, Muscedere, J, Lauzier, F, Rotstein, C, Kanji, S, Jiang, X, Hall, M, Heyland, DK.
Candida in the Respiratory Tract Secretions of Critically Ill Patients and The Efficacy of Antifungal Treatment: a randomized placebo controlled trial (CANTREAT Study) Intensive Care Medecine 2014; 40: 1313–1322. PMID: 24981955
Alhazzani WCrit Care Med.2017Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis.28459708Alhazzani W, Guyatt G, Alshahrani M, Deane AM, Marshall JC, Hall R, Muscedere J, English SW, Lauzier F, Thabane L, Arabi YM, Karachi T, Rochwerg B, Finfer S, Daneman N, Alshamsi F, Zytaruk N, Heel-Ansdell D, Cook D; Canadian Critical Care Trials Group.Withholding Pantoprazole for Stress Ulcer Prophylaxis in Critically Ill Patients: A Pilot Randomized Clinical Trial and Meta-Analysis. Crit Care Med. 2017 Jul;45(7):1121-1129. PMID: 28459708
Amrein KIntensive Care Med.2015Understanding vitamin D deficiency in intensive care patients.26142054Amrein K, Christopher KB, McNally JD.Understanding vitamin D deficiency in intensive care patients. Intensive Care Med. 2015 Jul 4. [Epub ahead of print] PMID: 26142054
Arabi YMAm J Respir Crit Care Med2015Characteristics and Outcomes of Eligible Non-Enrolled Patients in a Mechanical Ventilation Trial of Acute Respiratory Distress Syndrome.26192398Arabi YM, Cook DJ, Zhou Q, Smith O, Hand L, Turgeon AF, Matte A, Mehta S, Graham R, Brierley K, Adhikari NK, Meade MO, Ferguson ND; Canadian Critical Care Trials Group. Characteristics and Outcomes of Eligible Non-Enrolled Patients in a Mechanical Ventilation Trial of Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2015 Jul 20. [Epub ahead of print] PMID: 26192398
Archambault PJMIR Res Protoc2015Implementation and Evaluation of a Wiki Involving Multiple Stakeholders Including Patients in the Promotion of Best Practices in Trauma Care:The WikiTrauma Interrupted Time Series Protocol. Archambault PM, Turgeon AF, Witteman HO, Lauzier F, Moore L, Lamontagne F, Horsley T, Gagnon M-P, Droit A, Weiss M, Tremblay S, Lachaine J, Le Sage N, Émond M, Berthelot S, Plaisance A, Lapointe J, Razek T, van de Belt TH, Brand K, Bérubé M, Clément J, Grajales FJ, Eysenbach G, Kuziemsky  G, Friedman D, Lang E, Muscedere J, Rizoli S, Roberts DJ, Scales DC, Sinuff T, Stelfox HT, Gagnon I, Chabot C, Grenier R, Légaré F, Canadian Critical Care Trials Group. Implementation and Evaluation of a Wiki Involving Multiple Stakeholders Including Patients in the Promotion of Best Practices in Trauma Care:The WikiTrauma Interrupted Time Series Protocol. JMIR Res Protoc 2015,4(1): e21p.2.
Archambault, PMJMIR Res Protoc2014Development and validation of questionnaires exploring health care professionals' intention to use wiki-based reminders to promote best practices in trauma25281856 Archambault PM, Gagnon S, Gagnon MP, Turcotte S, Lapointe J, Fleet R, Côté M, Beaupré P, Le Sage N, Emond M, Légaré F., Canadian Critical Care Trials Group. Development and validation of questionnaires exploring health care professionals' intention to use wiki-based reminders to promote best practices in trauma. JMIR Res Protoc., 2014;3(3):e50. PMID: 25281856 
Arnold DMThromb Res. 2013 Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness.23317632Arnold DM, Lauzier F, Rabbat C, Zytaruk N, Barlow Cash B, Clarke F, Heels-Ansdell D, Guyatt G, Walter SD, Davies A, Cook DJ; PROTECT Investigators, on behalf of the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group.Adjudication of bleeding outcomes in an international thromboprophylaxis trial in critical illness.Thromb Res. 2013 Mar;131(3):204-9. PMID: 23317632
Bagshaw SMBMC Nephrol.2013Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study.23763900Bagshaw SM,Sood MM, Long J, Fowler RA, Adhikari NK; Canadian Critical Care Trials Group H1N1 Collaborative. Acute kidney injury among critically ill patients with pandemic H1N1 influenza A in Canada: cohort study. BMC Nephrol. 2013;14:123. PMID:23763900
Bagshaw SMJ Crit Care2012Clinical factors associated with initiation of renal replacement therapy in critically ill patients with acute kidney injury-a prospective multicenter observational stud21798709Bagshaw SM, Wald R, Barton J, Burns KE, Friedrich JO, House AA, James MT, Levin A, Moist L, Pannu N, Stollery DE, Walsh MW. Clinical factors associated with initiation of renal replacement therapy in critically ill patients with acute kidney injury-a prospective multicenter observational study.
J Crit Care. 2012 Jun;27(3):268-75. PMID: 21798709
Boutin ATransfus Med Rev2016Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis.26409622Boutin A, Chassé M, Shemilt M, Lauzier F, Moore L, Zarychanski R, Griesdale D, Desjardins P, Lacroix J, Fergusson D, Turgeon AF. Red Blood Cell Transfusion in Patients With Traumatic Brain Injury: A Systematic Review and Meta-Analysis. Transfus Med Rev. 2016 Jan;30(1):15-24. PMID: 26409622
Burns KCrit Care Med.2013 Participation of Ontario Intensive Care Units in Critical Care Pandemic Research. Burns K, Rizvi L, Tan W, Marshall JC, Pope K. Participation of Ontario Intensive Care Units in Critical Care Pandemic Research. Crit Care Med. 2013 Apr;41(4):1009-1016.  
Burns KCan Respir J2014Evaluation of an internal review process for grants and manuscripts in the Canadian Critical Care Trials Group.24712017Burns KE, Caon E, Dodek PM. Evaluation of an internal review process for grants and manuscripts in the Canadian Critical Care Trials Group. Can Respir J. 2014 21(5):283-6. PMID: 24712017
Burns KETrials2011A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial21388549Burns KE, Chant C, Smith O, Cuthbertson B, Fowler R, Cook DJ, Kruger P, Webb S, Alhashemi J, Dominguez-Cherit G, Zala C, Rubenfeld GD, Marshall JC for the Canadian Critical Care Trials Group. A Canadian Critical Care Trials Group project in collaboration with the international forum for acute care trialists - Collaborative H1N1 Adjuvant Treatment pilot trial (CHAT): study protocol and design of a randomized controlled trial. Trials. 2011 Mar 9;12:70. PMID: 21388549
Burns KECritical Care Medicine2013Participation of Intensive Care Units in Critical Care Pandemic Research: A Province Wide, Cross-Sectional Survey23385105Burns KEA, Rizvi L, Tan W, Marshall JC, Pope K for the Canadian Critical Care Trials Group. Participation of Intensive Care Units in Critical Care Pandemic Research: A Province Wide, Cross-Sectional Survey. Crit Care Med. 2013;41(4):1009-16. PMID:23385105
Burns KETrials2009The WEAN Study: a protocol of a multicenter randomized controlled trial2749823Burns KE, Meade MO, Lessard M, Keenan SP, Lelouche F for the Canadian Critical Care Trials Group. Wean Earlier and Automatically with New Technology: The WEAN Study: a protocol of a multicenter randomized controlled trial. Trials 2009;10:81. PMCID: PMC2749823
Burns KEAm J Respir Crit Care Med.2013Wean Earlier and Automatically with New Technology (The WEAN Study): A Multicentre Pilot RCT. Burns KE, Meade MO, Lessard MR, Hand L, Zhou Q, Keenan SP, Lellouche F. Wean Earlier and Automatically with New Technology (The WEAN Study): A Multicentre Pilot RCT. Am J Respir Crit Care Med. 2013 Jun 1;187(11):1203-11.
Burns KEAm J Respir Crit Care Med.2013Research Recruitment Practices of Critically Ill Patients: A Multicenter, Cross-Sectional Study (The Consent Study)23525935Burns KE, Zubrinich C, Tan W, Raptis S, Xiong W, Smith O, McDonald E, Marshall JC, Saginur R, Heslegrave R, Rubenfeld G, Cook DJ; for the Canadian Critical Care Trials Group.  Research Recruitment Practices of Critically Ill Patients: A Multicenter, Cross-Sectional Study (The Consent Study).    Am J Respir Crit Care Med. 2013 Jun 1;187(11):1212-8.  [Epub ahead of print].  PMID: 23525935  
Burns KEIntensive Care Med2015 Is There a Role for Physician Involvement in Introducing Research to Surrogate Decision Makers in the Intensive Care Unit? (The Approach Trial: A Mixed Methods Study)25491659Burns KEA, Rizvi L, Smith O, Lee Y, Lee J, Wang M, Brown M, Parker M, Premji A, Leung D, Hammond Mobilio M, Gotlib-Conn L, Nisenbaum R, Santos M, Li Y,  Mehta S.  Is There a Role for Physician Involvement in Introducing Research to Surrogate Decision Makers in the Intensive Care Unit? (The Approach Trial: A Mixed Methods Study) Intensive Care Med 2015;41:58-67. PMID: 25491659
Burns KECochrane Database of Systematic Reviews2014Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults25203308Burns KEA, Lellouche F, Nisenbaum R, Lessard MR, Friedrich JO. Automated weaning and SBT systems versus non-automated weaning strategies for weaning time in invasively ventilated critically ill adults. Cochrane Database of Systematic Reviews 2014, Sep 9;9:CD008638. PMID: 25203308
Burns KEJ Clin Trials2014The Approach Trial: A Mixed Methods Pilot RCT Comparing Alternative Strategies for Approaching Substitute Decision Makers for Proxy Consent for Research Participation. Burns KEA, Rizvi L, Smith OM, Mehta S. The Approach Trial: A Mixed Methods Pilot RCT Comparing Alternative Strategies for Approaching Substitute Decision Makers for Proxy Consent for Research Participation. J Clin Trials 2014, 4:164. DOI:10.4172/2167-0870.1000164.
Burns KECochrane Database of Systematic Review2014SmartCare™ versus non-automated mechanical ventilation strategies on discontinuation time for adults in the postoperative period 24526330Burns KEA, Lellouche F, Nisenbaum R, Lessard M, Friedrich J, Blackwood B. SmartCare™ versus non-automated mechanical ventilation strategies on discontinuation time for adults in the postoperative period. Cochrane Database of Systematic Reviews 2014. Issue 2. Art. No.: CD008639. DOI: 10.1002/14651858.CD008639.pub2).PMID: 24526330
Burns KEAnn Am Thorac Soc.2017A Multicenter Study of Surrogate Decision-Makers Experiences in Being Approached for Consent for Patient Participation in Research.27849142Burns KE, Juando Prats C, Maione M, Lanceta M, Zubrinich C Md, Jeffs L PhD, Smith OM; Canadian Critical Care Trials Group. A Multicenter Study of Surrogate Decision-Makers Experiences in Being Approached for Consent for Patient Participation in Research. Ann Am Thorac Soc. 2017 Feb;14(2):238-245. PMID: 27849142
Burry LCrit Care Med2015Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption.26181221Burry L, Cook D, Herridge M, Devlin JW, Fergusson D, Meade M, Steinberg M, Skrobik Y, Olafson K, Burns K, Dodek P, Granton J, Ferguson N, Jacka M, Tanios M, Fowler R, Reynolds S, Keenan S, Mallick R, Mehta S; SLEAP Investigators and the Canadian Critical Care Trials Group. Recall of ICU Stay in Patients Managed With a Sedation Protocol or a Sedation Protocol With Daily Interruption. Crit Care Med. 2015 Oct;43(10):2180-90. PMID: 26181221
Cahill NEJ Crit Care2012Barriers to feeding critically ill patients: a multicenter survey of critical care nurses22981532Cahill NE, Murch L, Cook D, Heyland DK; Canadian Critical Care Trials Group. Barriers to feeding critically ill patients: a multicenter survey of critical care nurses. J Crit Care. 2012 Dec;27(6):727-34. PMID: 22981532
Cahill NECrit Care2014Implementing a multifaceted tailored intervention to improve nutrition adequacy in critically ill patients: results of a multicenter feasibility study24887445Cahill NE, Murch L, Cook D, Heyland DK; Canadian Critical Care Trials Group. Implementing a multifaceted tailored intervention to improve nutrition adequacy in critically ill patients: results of a multicenter feasibility study.Crit Care. 2014 May 11;18(3):R96. PMID: 24887445 
Cahill NENutr Clin Pract.2014Improving the provision of enteral nutrition in the intensive care unit: a description of a multifaceted intervention tailored to overcome local barriers.24344255Cahill NE, Murch L, Cook D, Heyland DK; Canadian Critical Care Trials Group.Improving the provision of enteral nutrition in the intensive care unit: a description of a multifaceted intervention tailored to overcome local barriers.Nutr Clin Pract. 2014 Feb;29(1):110-7. PMID: 24344255
Cahill NEImplement Sci2013Development and psychometric properties of a questionnaire to assess barriers to feeding critically ill patients.24305039mplement Sci. 2013 Dec 4;8:140. doi: 10.1186/1748-5908-8-140.
Development and psychometric properties of a questionnaire to assess barriers to feeding critically ill patients.
Cahill NE, Day AG, Cook D, Heyland DK; Canadian Critical Care Trials Group.Development and psychometric properties of a questionnaire to assess barriers to feeding critically ill patients.Implement Sci. 2013 Dec 4;8:140. PMID: 24305039
Cameron JIN Engl J Med2016One-Year Outcomes in Caregivers of Critically Ill Patients27168433Cameron JI, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, dos Santos C, Abbey SE, Tan A, Lo V, Mathur S, Parotto M, Morris D, Flockhart L, Fan E, Lee CM, Wilcox ME, Ayas N, Choong K, Fowler R, Scales DC, Sinuff T, Cuthbertson BH, Rose L, Robles P, Burns S, Cypel M, Singer L, Chaparro C, Chow CW, Keshavjee S, Brochard L, Hébert P, Slutsky AS, Marshall JC, Cook D, Herridge MS; RECOVER Program Investigators (Phase 1: towards RECOVER); Canadian Critical Care Trials Group. One-Year Outcomes in Caregivers of Critically Ill Patients.
N Engl J Med. 2016 May 12;374(19):1831-41. PMID: 27168433
Canter RRBr J Anaesth2014Observational study of current use of selective decontamination of the digestive tract in UK critical care units.24829442Canter RR, Harvey SE, Harrison DA, Campbell MK, Rowan KM, Cuthbertson BH; Selective Decontamination of the Digestive tract in critically ill patients treated in Intensive Care Unit (SuDDICU) Investigators.Observational study of current use of selective decontamination of the digestive tract in UK critical care units. Br J Anaesth. 2014;113(4):610-7. PMID: 24829442
Carson JLJAMA2013Outcomes using lower vs higher hemoglobin thresholds for red blood cell transfusion.23280228Carson JL, Carless PA, Hébert PC.Outcomes using lower vs higher hemoglobin thresholds for red blood cell transfusion. JAMA;309(1):83-4. PMID: 23280228
Carson JLCochrane Database Syst Rev.2012Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion.22513904Carson JL, Carless PA, Hebert PC. Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion. Cochrane Database Syst Rev. 2012;4. PMID: 22513904
Cheung AMAm J Resp Crit Care Med2006Two-year health care utilization, costs and outcomes in survivors of the acute respiratory distress syndrome16763220Cheung AM, Tansey CM, Tomlinson G, Diaz-Granados N, Matte-Martyn A, Mehta S, Mazer D, Guest CB, Stewart TE, Al-Saidi F, Cooper AB, Cook DJ, Slutsky AS, Herridge MS for The Canadian Critical Care Trials Group. Two-year health care utilization, costs and outcomes in survivors of the acute respiratory distress syndrome. Am J Resp Crit Care Med 2006; 174:538-544. PMID: 16763220
Cheung CZIntensive Care Medicine2008Recognition and labeling of delirium symptoms by intensivists: Does it matter?18087692Cheung CZ, Alibhai SMH, Robinson M, Tomlinson G, Chittock D, Drover J, Skrobik Y for the Canadian Critical Care Trials Group. Recognition and labeling of delirium symptoms by intensivists: Does it matter? Intensive Care Medicine 2008;34:437-446. PMID: 18087692
Choong KAm J Respir Crit Care Med2009Vasopressin in Pediatric Vasodilatory Shock - A Multi-center Randomized Controlled Trial19608718Choong K, Bohn D, Fraser DD, Gaboury I, Hutchison JS, Joffe AR, Litalien C, Menon K, McNamara P, Ward RB with the Canadian Critical Care Trials Group. Vasopressin in Pediatric Vasodilatory Shock - A Multi-center Randomized Controlled Trial. Am J Respir Crit Care Med 2009;180(7)632-9. PMID: 19608718
Choong KPediatr Crit Care Med2014Acute rehabilitation practices in critically ill children: a multicenter study24777303Choong K1, Foster G, Fraser DD, Hutchison JS, Joffe AR, Jouvet PA, Menon K, Pullenayegum E, Ward RE. Canadian Critical Care Trials Group. Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med. 2014;15(6):e270-9. PMID:24777303
Choong KPediatr Crit Care Med2015Functional Recovery Following Critical Illness in Children: The "Wee-Cover" Pilot Study.25651047Choong K, Al-Harbi S, Siu K, Wong K, Cheng J, Baird B, Pogorzelski D, Timmons B, Gorter JW, Thabane L, Khetani M; on behalf of the Canadian Critical Care Trials Group.Functional Recovery Following Critical Illness in Children: The "Wee-Cover" Pilot Study. Pediatr Crit Care Med. 2015 May;16(4):310-8. PMID: 25651047
Clark ECan J Anaesth.2012Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study.22752716Clark E, Wald R, Levin A, Bouchard J, Adhikari NK, Hladunewich M, Richardson RM, James MT, Walsh MW, House AA, Moist L, Stollery DE, Burns KE, Friedrich JO, Barton J, Lafrance JP, Pannu N, Bagshaw SM; Canadian Acute Kidney Injury (CANAKI) Investigators. Timing the initiation of renal replacement therapy for acute kidney injury in Canadian intensive care units: a multicentre observational study.
Can J Anaesth. 2012 Sep;59(9):861-70. PMID: 22752716
Clark ENephrol Dial Transplant.2012Timing of initiation of renal replacement therapy for acute kidney injury: a survey of nephrologists and intensivists in Canada.22207332 Clark E, Wald R, Walsh M, Bagshaw SM; Canadian Acute Kidney Injury (CANAKI) Investigators. Timing of initiation of renal replacement therapy for acute kidney injury: a survey of nephrologists and intensivists in Canada.
Nephrol Dial Transplant. 2012 Jul;27(7):2761-7. PMID: 22207332 
Clarke FCrit Care Med2013Knowledge Translation for Thromboprophylaxis (CONECCKT-T) Clarke F, Foster D, Laberge A, O'Callaghan N, Thompson P, Meade L, Julien L, Watpool I, Ashley BJ,  Marinoff N, Cook D, for the Co-operative Network of Critical Care Knowledge Translation for Thromboprophylaxis (CONECCKT-T) Investigators and the CCCTG REB and Contract Approval Times for a Multicenter Audit. Crit Care Med 2013 (in press).
Cook DIntensive Care Med2013Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis24022796Cook D, Arabi Y, Ferguson N, Heels-Ansdell D, Freitag A, McDonald E, Clarke F, Keenan S, Pagliarello G, Plaxton W, Herridge M, Karachi T, Vallance S, Cade J, Crozier T, Alves da Silva S, Costa Filho R, Brandao N, Watpool I, McArdle T, Hollinger G, Mandourah Y, Al-Hazmi M, Zytaruk N, Adhikari NK; PROTECT Research Coordinators; PROTECT Investigators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group. Physicians declining patient enrollment in a critical care trial: a case study in thromboprophylaxis. Intensive Care Med. 2013;39(12):2115-25. PMID:24022796
Cook DJ Crit Care2014Barriers and facilitators of thromboprophylaxis for medical-surgical intensive care unit patients: a multicenter survey.24629574 Cook D, Duffett M2, Lauzier F3, Ye C4, Dodek P5, Paunovic B6, Fowler R7, Kho ME8, Foster D9, Stelfox T10, Sinuff T7, Zytaruk N4, Clarke F4, Wood G11, Cox M12, Kutsiogiannis J13, Jacka M13, Roussos M14, Kumar H15, Guyatt G16; CONECCKT-T (Co-operative Network of Critical Care Knowledge Translation for Thromboprophylaxis) Investigators; Canadian Critical Care Trials Group.Barriers and facilitators of thromboprophylaxis for medical-surgical intensive care unit patients: a multicenter survey.
J Crit Care. 2014;29(3):471. PMID: 24629574 

Cook DJ Crit Care2009Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis.19327956Cook D, Sinuff T, Zytaruk N, Rabbat C, Lee A, O'Donnell M, Thabane L, Linkins L, Treleaven D, Patel R, Meade M, Crowther M, Marshall JC, Douketis J; DIRECT Investigators and Canadian Critical Care Trials Group. Event adjudication and data monitoring in an intensive care unit observational study of thromboprophylaxis.J Crit Care. 2009;24(2):168-75. PMID: 19327956
Cook DCrit Care Med2008Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors.18315876 Cook D, Douketis J, Meade M, Guyatt G, Zytaruk N, Granton J, Skrobik Y, Albert M, Fowler R, Hebert P, Pagliarello G, Friedrich J, Freitag A, Karachi T, Rabbat C, Heels-Ansdell D, Geerts W, Crowther M; Canadian Critical Care Trials Group.Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors.Crit Care. 2008;12(2):R32. PMID: 18315876 
Cook DJLancet2001Cardiopulmonary resuscitation directives on admission to the Intensive Care Unit: an international observational study11747918Cook DJ, Guyatt GH, Rocker G, Sjokvist P, Weaver B, Dodek P, Marshall J, Leasa D, Levy M, Varon J, Fisher M, Cook DJ, for The Canadian Critical Care Trials Group. Cardiopulmonary resuscitation directives on admission to the Intensive Care Unit: an international observational study. Lancet 2001;358:1941-1945. PMID: 11747918
Cook DJntensive Care Med2001On the need for observational studies to design and interpret randomized trials in ICU patients: a case study in stress ulcer prophylaxis11396278Cook DJ, Heyland D, Marshall J, for The Canadian Critical Care Trials Group. On the need for observational studies to design and interpret randomized trials in ICU patients: a case study in stress ulcer prophylaxis. Intensive Care Med. 2001 Feb;27(2):347-54. PMID: 11396278
Cook DJCrit Care Med1999Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation10628631Cook DJ, Heyland D, Griffith LE, Cook RJ, Marshall JC, Pagliarello G, for The Canadian Critical Care Trials Group. Risk factors for clinically important upper gastrointestinal bleeding in patients requiring mechanical ventilation. Crit Care Med 1999;27(12):2812-2817. PMID: 10628631
Cook DJCMAJ1999Life support in the intensive care unit: a qualitative investigation of technological purposes10569086Cook DJ, Giacomini M, Johnson N, Willms D, for The Canadian Critical Care Trials Group. Life support in the intensive care unit: a qualitative investigation of technological purposes. CMAJ 1999 Nov 2;161(9):1109-13. PMID: 10569086
Cook DJJ Crit Care1998Lessons from adjudicating pneumonia in a randomized trial of critically ill patients9869541Cook DJ, Walter SD, Freitag A, Guyatt GH, Devitt H, Meade MO, Griffith LE, Sarabia A, Fuller, H, Turner M, Gough K, for The Canadian Critical Care Trials Group. Lessons from adjudicating pneumonia in a randomized trial of critically ill patients. J Crit Care 1998;13(4):159-163. PMID: 9869541
Cook DJAnn Intern Med1998Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients9735080Cook DJ, Walter S, Cook RJ, Griffith LE, Guyatt GH, Leasa D, Jaeschke R, Brun-Buisson C, for The Canadian Critical Care Trials Group. Incidence of and risk factors for ventilator-associated pneumonia in critically ill patients. Ann Intern Med 1998 Sep 15;129(6):433-40. PMID: 9735080
Cook DJN Engl J Med1998A comparison of sucralfate and ranitidine for prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation9504939Cook DJ, Guyatt GH, Marshall J, Leasa D, Fuller H, Hall R, Peters S, Rutledge F, Griffith L, McLellan PA, Wood G, Kirby A, Tweeddale M, Pagliarello J, Johnston R, for The Canadian Critical Care Trials Group. A comparison of sucralfate and ranitidine for prevention of upper gastrointestinal bleeding in patients requiring mechanical ventilation. N Engl J Med 1998;338(12):791-797. PMID: 9504939
Cook DJIntensive Care World1997The Canadian Critical Care Trials Group: A collaborative, educational organization for the advancement of adult ICU researchNo PMID foundCook DJ, Todd TRJ. The Canadian Critical Care Trials Group: A collaborative, educational organization for the advancement of adult ICU research. Intensive Care World 1997;14(2):68-70. No PMID found.
Cook DJJAMA1995Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill7853627Cook DJ, Guyatt GH, Jaeschke R, Reeve J, Spanier A, King D, Molloy DW, Willan A, Streiner D, for The Canadian Critical Care Trials Group. Determinants in Canadian health care workers of the decision to withdraw life support from the critically ill. JAMA 1995;273(9):703-708. PMID: 7853627
Cook DJN Engl J Med1994Risk factors for gastrointestinal bleeding in critically ill patients8284001Cook DJ, Fuller H, Guyatt GH, Marshall JC, Leasa D, Hall R, Winton TL, Rutledge F, Todd TRJ, Roy P, Lacroix J, Griffith LE, Willan A, for The Canadian Critical Care Trials Group. Risk factors for gastrointestinal bleeding in critically ill patients. N Engl J Med 1994;330:377-381. PMID: 8284001
Cook DJJ Crit Care2011PROTECT (Prophylaxis for ThromboEmbolism in Critical Care Trial) Protocol and Analysis Plan21482348Cook DJ, Meade M, Guyatt G, Walter SD, Heels-Ansdell D, Geerts W, Warkentin T, Cooper DJ, Zytaruk N, Vallance S, Berwanger O, Rocha M, Qushmaq I, Crowther MA for the PROTECT Investigators, for the Canadian Critical Care Trials Group and the Australian and New Zealand Intensive Care Society Clinical Trials Group. PROTECT (Prophylaxis for ThromboEmbolism in Critical Care Trial) Protocol and Analysis Plan.  J Crit Care 2011;26(2); e223.e9 & doi:10.1016/j.jcrc.2011.02.010) PMID: 21482348
Cook DJCrit Care Med2008Enrolment of ICU Patients into Clinical Studies: A Tri-national Survey18552686Cook DJ, Blythe D, Rischbieth A, Hebert PC, Zytaruk N, Menon K, Erikson S, Fowler R, Heels-Ansdell D, Meade MO for the Canadian Critical Care Trials Group. Enrolment of ICU Patients into Clinical Studies: A Tri-national Survey. Crit Care Med 2008; 36(7):2100-2105. PMID: 18552686
Cook DJAm J Crit Care2006Levels of Care in the Intensive Care Unit: A Research Program16632769Cook DJ, Rocker G, Marshall J, Griffith L, McDonald E, Guyatt GH for the Level of Care Study Investigators and the Canadian Critical Care Trials Group. Levels of Care in the Intensive Care Unit: A Research Program. Am J Crit Care 2006 May;15(3):269-79. PMID: 16632769
Cook DJJ Crit Care2005Prophylaxis of ThromboEmbolism in Critical Care Trial: (PROTECT): A Pilot Study16310609Cook DJ, Rocker G, Meade MO, Guyatt GH, Geerts W, Anderson D, Skrobik Y, Hébert P, Albert M, Cooper DJ, Bates S, Caco C, Finfer S, Freitag A, Granton J, Jones G, Langevin S, Mehta G, Pagliarello G, Poirier G, Rabbat C, Schiff D, Griffith LE, Crowther MA, for the PROTECT Investigators and the Canadian Critical Care Trials Group. Prophylaxis of ThromboEmbolism in Critical Care Trial: (PROTECT): A Pilot Study.  J Crit Care 2005;20:364-372. PMID: 16310609
Cook DJCrit Care2004Clinically important deep vein thrombosis in the ICU: A survey of intensivists15153243Cook DJ, Meade MO, Guyatt GH, Griffith LE, Granton J, Geerts W, Crowther M for the Canadian Critical Care Trials Group. Clinically important deep vein thrombosis in the ICU: A survey of intensivists. Crit Care 2004;8:R145-R152. PMID: 15153243
Cook DJN Engl J Med2003Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit13679526Cook DJ, Rocker G, Marshall J, Sjokvist P, Dodek P, Griffith L, Freitag A, Varon J, Bradley C, Levy M, Finfer S, Walter, S Guyatt GH, for the Level of Care Study Investigators and The Canadian Critical Care Trials Group. Withdrawal of mechanical ventilation in anticipation of death in the intensive care unit. N Engl J Med 2003;349:1123-1132. PMID: 13679526
Cook DJCrit Care2013Coenrolment of Critically Ill Patients into Multiple Studies: Patterns, Predictors and Consequences. Cook DJ, McDonald E, Smith O, Zytaruk N, Heels-Ansdell D, Watpool I, McArdle T, Matte A, Clarke F, Vallance S, Finfer S, Galt P, Crozier T, Fowler R, Arabi Y, Woolfe C, Orford N, Hall R, Adhikari N, Ferland MC, Marshall JD, Meade M for the PROTECT Investigators, CCCTG and ANZICS-CTG. Coenrolment of Critically Ill Patients into Multiple Studies: Patterns, Predictors and Consequences. Crit Care 2013;17:R1-R8.
Cook DJCrit Care2001The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients.11737927Cook DJ, Griffith LE, Walter SD, Guyatt GH, Meade MO, Heyland DK, Kirby A, Tryba M; Canadian Critical Care Trials Group.The attributable mortality and length of intensive care unit stay of clinically important gastrointestinal bleeding in critically ill patients. Crit Care. 2001;5(6):368-75. PMID: 11737927
Cook DJCrit Care Med2015Coenrollment in a Randomized Trial of High-Frequency Oscillation: Prevalence, Patterns, Predictors, and Outcomes.25393702Cook DJ, Ferguson ND, Hand L, Austin P, Zhou Q, Adhikari NK, Danesh V, Arabi Y, Matte AL, Clarke FE, Mehta S, Smith O, Wise MP, Friedrich JO, Keenan SP, Hanna S, Meade MO; for the OSCILLation for ARDS Treated Early Investigators and the Canadian Critical Care Trials Group.Coenrollment in a Randomized Trial of High-Frequency Oscillation: Prevalence, Patterns, Predictors, and Outcomes. Crit Care Med. 2015 Feb;43(2):328-38 PMID: 25393702

Cook DJTrials2016Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial.27480757 Cook DJ, Johnstone J, Marshall JC, Lauzier F, Thabane L, Mehta S, Dodek PM, McIntyre L, Pagliarello J, Henderson W, Taylor RW, Cartin-Ceba R, Golan E, Herridge M, Wood G, Ovakim D, Karachi T, Surette MG, Bowdish DM, Lamarche D, Verschoor CP, Duan EH, Heels-Ansdell D, Arabi Y, Meade M; PROSPECT Investigators and the Canadian Critical Care Trials Group. Probiotics: Prevention of Severe Pneumonia and Endotracheal Colonization Trial-PROSPECT: a pilot trial. Trials. 2016 Aug 2;17:377. PMID: 27480757 
Cook RCrit Care Med2001Multiple organ dysfunction: Baseline and serial component scores11700393Cook R, Cook DJ, Tilley J, Lee KA, Marshall J, for The Canadian Critical Care Trials Group. Multiple organ dysfunction: Baseline and serial component scores. Crit Care Med 2001;29(11):2046-2050. PMID: 11700393
Côte NNeurocrit Care2012Factors Associated with the Withdrawal of Life-Sustaining Therapies in Patients with Severe Traumatic Brain Injury: A Multicenter Cohort Study23099846Côte N, Turgeon AF, Lauzier F, Moore L, Scales DC, Bernard F, Zarychanski R, Burns KE, Meade MO, Zygun D, Simard JF, Boutin A, Brochu JG, Fergusson DA for the Canadian Critical Care Trials Group. Factors Associated with the Withdrawal of Life-Sustaining Therapies in Patients with Severe Traumatic Brain Injury: A Multicenter Cohort Study. Neurocrit Care. 2012 Oct 26. [Epub ahead of print] PMID: 23099846
Crowther MJ Crit Care2014Heparin-induced thrombocytopenia in the critically ill: interpreting the 4Ts test in a randomized trial.24726205Crowther M, Cook D, Guyatt G, Zytaruk N, McDonald E, Williamson D, Albert M, Dodek P, Finfer S, Vallance S, Heels-Ansdell D, McIntyre L, Mehta S, Lamontagne F, Muscedere J, Jacka M, Lesur O, Kutsiogiannis J, Friedrich J1, Klinger JR, Qushmaq I, Burry L, Khwaja K, Sheppard JA, Warkentin TE; PROTECT collaborators; Canadian Critical Care Trials Group; Australian and New Zealand Intensive Care Society Clinical Trials Group.Heparin-induced thrombocytopenia in the critically ill: interpreting the 4Ts test in a randomized trial. J Crit Care. 2014 Jun;29(3):470.e7-15. PMID:24726205
Crowther MAJ Crit Care2010The 4Ts scoring system for heparin induced thrombocytopenia in medical-surgical ICU patients20149589Crowther MA, Cook DJ, Albert M, Williamson D, Meade M, Granton J, Skrobik Y, Langevin S, Mehta S, Hebert PC, Guyatt GH, Geerts W, Rabbat C, Douketis J, Zytaruk N, Sheppard J, Greinacher A, Warkentin TE for the Canadian Critical Care Trials Group. The 4Ts scoring system for heparin induced thrombocytopenia in medical-surgical ICU patients. J Crit Care 2010; 25(2):287-293. doi:10.1016/j.jcrc.2009.12.006 PMID: 20149589
Cuthbertson BHCritical care2013Clinical stakeholders' opinions on the use of selective decontamination of the digestive tract in critically ill patients in intensive care units: an international Delphi study24207137Cuthbertson BH, Campbell MK, Maclennan G, Duncan EM, Marshall AP, Wells EC, Prior ME, Todd
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Czerwonka AIJ Crit Care2015Changing support needs of survivors of complex critical illness and their family caregivers across the care continuum: A qualitative pilot study of Towards RECOVER25466314Czerwonka AI, Herridge MS, Chan L, Chu LM, Matte A, Cameron JI. Changing support needs of survivors of complex critical illness and their family caregivers across the care continuum: A qualitative pilot study of Towards RECOVER. J Crit Care. 2015;30(2):242-9. PMID: 25466314

Daneman NLancet Infect Dis.2013Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Daneman N, Sarwar S, Fowler RA, Cuthbertson BH. Effect of selective decontamination on antimicrobial resistance in intensive care units: a systematic review and meta-analysis. Lancet Infect Dis. 2013 Apr;13(4):328-41.
Daneman NTrials2015Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial.25903783 Daneman N, Rishu AH, Xiong W, Bagshaw SM, Cook DJ, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall JC, Martin CM, McIntyre L, Muscedere J, Reynolds S, Stelfox HT, Fowler RA; Canadian Critical Care Trials Group. Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness (BALANCE): study protocol for a pilot randomized controlled trial. Trials. 2015 Apr 18;16(1):173. PMID: 25903783 
Daneman NCrit Care Med.2016Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients.26496448Daneman N, Rishu AH, Xiong W, Bagshaw SM, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall J, Martin CM, McIntyre L, Muscedere J, Reynolds S, Stelfox HT, Cook DJ, Fowler RA; Canadian Critical Care Trials Group. Duration of Antimicrobial Treatment for Bacteremia in Canadian Critically Ill Patients. Crit Care Med.2016 Feb;44(2):256-64. PMID: 26496448
Daneman NInt J Antimicrob Agents2011Antibiotic treatment duration for bloodstream infections in critically ill patients: a national survey of Canadian infectious diseases and critical care specialists.21982833Daneman N, Shore K, Pinto R, Fowler R.. Antibiotic treatment duration for bloodstream infections in critically ill patients: a national survey of Canadian infectious diseases and critical care specialists.Int J Antimicrob Agents. 2011 Dec;38(6):480-5. PMID: 21982833 

D'Aragon FShock2015Blood pressure targets for vasopressor therapy: a systematic review.25895147D'Aragon F, Belley-Cote EP, Meade MO, Lauzier F, Adhikari NK, Briel M, Lalu M, Kanji S, Asfar P, Turgeon AF, Fox-Robichaud A, Marshall JC, Lamontagne F; Canadian Critical Care Trials Group. Blood pressure targets for vasopressor therapy: a systematic review. Shock. 2015 Jun;43(6):530-9. PMID: 25895147
Delaloye NJJ Patient Saf. 2017Errors During Resuscitation: The Impact of Perceived Authority on Delivery of Care.28671912Delaloye NJ, Tobler K, OʼNeill T, Kotsakis A, Cooper J, Bank I, Gilfoyle E; Teams4Kids Investigators and the Canadian Critical Care Trials Group. Errors During Resuscitation: The Impact of Perceived Authority on Delivery of Care. J Patient Saf. 2017 Jun 30. doi: 10.1097/PTS.0000000000000359. [Epub ahead of print] PMID: 28671912
Delaney JWCrit Care2016The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness27036638 Delaney JW, Pinto R, Long J, Lamontagne F, Adhikari NK, Kumar A, Marshall JC, Cook DJ, Jouvet P, Ferguson ND, Griesdale D, Burry LD, Burns KE, Hutchison J, Mehta S, Menon K, Fowler RA; Canadian Critical Care Trials Group H1N1 Collaborative. The influence of corticosteroid treatment on the outcome of influenza A(H1N1pdm09)-related critical illness. Crit Care. 2016 Mar 30;20(1):75. PMID: 27036638 
DELIRIUM-CS InvestigatorsCMAJ Open2017Incidence of delirium after cardiac surgery: protocol for the DELIRIUM-CS Canada cross-sectional cohort study.28743102 DELIRIUM-CS Investigators*; Canadian Cardiovascular Critical Care Society Investigator Group and the Canadian Critical Care Trials Group. Incidence of delirium after cardiac surgery: protocol for the DELIRIUM-CS Canada cross-sectional cohort study. CMAJ Open. 2017 Jul 13;5(3):E565-E569. PMID: 28743102 
Delisle MSJ Crit Care2008The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients18359416Delisle MS, Williamson DR, Perreault MM, Albert M, Jiang X, Heyland DK. The clinical significance of Candida colonization of respiratory tract secretions in critically ill patients. J Crit Care 2008; 23: 11-17. PMID: 18359416
Delisle MSCan Respir J2011Impact of Candida species on clinical outcomes in patients with suspected ventilator-associated pneumonia.21766075Delisle MS, Williamson DR, Albert M, Perreault MM, Jiang X, Day AG, Heyland DK. Impact of Candida species on clinical outcomes in patients with suspected ventilator-associated pneumonia. Can Respir J. 2011;18(3):131-6. PMID: 21766075
Demaret PTransfusion2014Red blood cell transfusion in critically ill children (CME)24517132Demaret P, Tucci M, Ducruet T, Trottier H, Lacroix J. Red blood cell transfusion in critically ill children (CME). Transfusion. 2014 Feb;54(2):365-75. PMID: 24517132
Desjardins DCrit Care 2012Hemoglobin levels and transfusion in neurocritically ill patients: a systematic review of comparative studies22471943 Desjardins *, Turgeon AF, Tremblay MH, Lauzier F, Zarychanski R, Moore L, McIntyre L, English S, Boutin A, Lacroix J, Fergusson DA. Hemoglobin levels and transfusion in neurocritically ill patients: a systematic review of comparative studies. Crit Care 2012;Apr 2;16(2):R54. PMID: 22471943 
Dhanani SJ Intensive Care Med2012Variability in the determination of death after cardiac arrest: a review of guidelines and statements21841147Dhanani S, Hornby L, Ward R, Shemie S for the Canadian Critical Care Trials Group. Variability in the determination of death after cardiac arrest: a review of guidelines and statements. J Intensive Care Med 2012;27:238-52. PMID: 21841147
Dhanani SCrit Care Med2012 Survey of determination of death after cardiac arrest by intensive care physicians22430244Dhanani S, Ward R, Hornby L, Barrowman NJ, Hornby K, Shemie SD for the Canadian Critical Care Trials Group. Survey of determination of death after cardiac arrest by intensive care physicians. Crit Care Med 2012;40:1449-55. PMID: 22430244
Dhanani SCrit Care Med2014Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study24810533Dhanani S, Hornby L, Ward R, Baker A, Dodek P, Chamber-Evans J, Fowler R, Friedrich JO, Gow RM, Kutsogiannis DJ, Mcintyre L, Momoli F, Morin K, Ramsay T, Scales D, Writer H, Yildirim S, Young B, Shemie S; Canadian Critical Care Trials Group and in collaboration with the Bertram Loeb Chair and Research Consortium in Organ and Tissue Donation.Vital signs after cardiac arrest following withdrawal of life-sustaining therapy: a multicenter prospective observational study*. Crit Care Med. 2014 Nov;42(11):2358-69. PMID: 24810533
Dodek PMAm J Respir Crit Care Med 1852012Evaluation of an Internal Review Process for Grants and Manuscripts at the Canadian Critical Care Trials Group Dodek PM, Caon E, Burns K, On behalf of the Canadian Critical Care Trials Group.  Evaluation of an Internal Review Process for Grants and Manuscripts at the Canadian Critical Care Trials Group. Am J Respir Crit Care Med 185;2012:A2542.
Dodek PMAnn Intern Med2004Evidence based clinical practice guideline for the prevention of ventilator-associated pneumonia15313747Dodek PM, Cook DJ, Keenan S, Heyland DK, Brun-Buisson C, Hall R, Jacka M, Foster D, Hand L, Mehta N, Muscedere J, for The Canadian Critical Care Trials Group. Evidence based clinical practice guideline for the prevention of ventilator-associated pneumonia. Ann Intern Med. 2004 Aug 17;141(4):305-13. PMID: 15313747
Doherty DR Circulation2009Hypothermia Therapy after Pediatric Cardio-respiratory Arres19273725Doherty DR, Parshuram CS, Aparna Hoskote A, Lacroix J, Tucci M, Joffe A, Choong K, Gaboury I, Farrell R, Bohn DJ, Hutchison J, on behalf of the Canadian Critical Care Trials Group. Hypothermia Therapy after Pediatric Cardio-respiratory Arrest. Circulation 2009;119:1492-1500. PMID: 19273725
Dombrowski SUAust Crit Care.2013Clinical components and associated behavioural aspects of a complex healthcare intervention: Multi-methods study of selective decontamination of the digestive tract in critical care. 23680533Dombrowski SU, Prior ME, Duncan E, Cuthbertson BH, Bellingan G, Campbell MK, Rose L, Binning AR, Gordon AC, Wilson P, Shulman R, Francis JJ; the SuDDICU UK Study Group. Clinical components and associated behavioural aspects of a complex healthcare intervention: Multi-methods study of selective decontamination of the digestive tract in critical care. Aust Crit Care. 2013;26(4):173-9. PMID: 23680533
Douketis JArch Intern Med2008Renal Insufficiency with the Low-molecular-weight Heparin Dalteparin: An Assessment of Safety and Pharmacodynamics. The DIRECT (Dalteparin’s Influence on REnally Compromised anti-Ten-A) Study18779469Douketis J, Cook D, Meade M, Guyatt G, Geerts W, Skrobik Y, Albert M, Granton J, Hebert PC, Pagliarello G, Marshall JC, Fowler R, Freitag A, Rabbat C, Anderson D, Zytaruk N, Heels-Ansdell D, Crowther MA for the Canadian Critical Care Trials Group. Renal Insufficiency with the Low-molecular-weight Heparin Dalteparin: An Assessment of Safety and Pharmacodynamics. The DIRECT (Dalteparin’s Influence on REnally Compromised anti-Ten-A) Study. Arch Intern Med 2008;168(16):1805-1812. PMID: 18779469
Downar JCrit Care Med2015Nonbeneficial Treatment Canada: Definitions, Causes, and Potential Solutions From the Perspective of Healthcare Practitioners.25377017Downar J, You JJ, Bagshaw SM, Golan E, Lamontagne F, Burns K, Sridhar SK, Seely A, Meade MO, Fox-Robichaud A, Cook D, Turgeon AF, Dodek P, Xiong W, Fowler R; on behalf of the Canadian Critical Care Trials Group.Nonbeneficial Treatment Canada: Definitions, Causes, and Potential Solutions From the Perspective of Healthcare Practitioners.Crit Care Med. 2015 43(2):270-81. PMID: 25377017
Du Pont-Thibodeau GPediatr Crit Care Med2014Survey on stated transfusion practices in PICUs 24732292 Du Pont-Thibodeau G1, Tucci M, Ducruet T, Lacroix J. Survey on stated transfusion practices in PICUs. Pediatr Crit Care Med. 2014 Jun;15(5):409-16. PMID: 24732292 


Duan EHIntensive Care Med Exp2015Contemporary Ventilation Strategies And Adjunctive Therapies For Acute Respiratory Distress Syndrome (Ards).27290167Duan EH, Adhikari NK, Hand L, D'Aragon F, Austin P, Zhou Q, Alhazzani W, Cook DJ, Ferguson ND, Meade MO; Canadian Critical Care Trials Group. Contemporary Ventilation Strategies And Adjunctive Therapies For Acute Respiratory Distress Syndrome (Ards). Intensive Care Med Exp. 2015 Dec;3(Suppl 1):A6. PMID: 27290167
Duffett MJ Crit Care2011Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers21376518Duffett M, Burns KEA, Kho M, Lauzier L, Meade M,, Arnold D, Adhikari N,  Lamontagne L, Cook DJ for ACCADEMY and for the Canadian Critical Care Trials Group. Consent in critical care trials: a survey of Canadian research ethics boards and critical care researchers. J Crit Care. 2011;26(5):533. PMID: 21376518
Duffett MPediatr Crit Care Med.2017High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators.28328786Duffett M, Choong K, Foster J, Meade M, Menon K, Parker M, Cook DJ; Canadian Critical Care Trials Group. High-Quality Randomized Controlled Trials in Pediatric Critical Care: A Survey of Barriers and Facilitators. Pediatr Crit Care Med. 2017 Mar 21. [Epub ahead of print] PMID: 28328786
Duffett MPilot Feasibility Stud2017Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial.28533916 Duffett M, Choong K, Foster J, Gilfoyle E, Lacroix J, Pai N, Thabane L, Cook DJ; Canadian Critical Care Trials Group. Pediatric intensive care stress ulcer prevention (PIC-UP): a protocol for a pilot randomized trial. Pilot Feasibility Stud. 2017 May 19;3:26. PMID: 28533916 
Duncan EMJ Crit Care.2014For the SuDDICU International Study Group. The views of health care professionals about selective decontamination of the digestive tract: An international, theoretically informed interview study24747038Duncan EM, Cuthbertson BH, Prior ME, Marshall AP, Wells EC, Todd LE, Bolsover D, Newlands RS, Webster F, Rose L, Campbell MK, Bellingan G, Seppelt IM, Francis JJ; For the SuDDICU International Study Group. The views of health care professionals about selective decontamination of the digestive tract: An international, theoretically informed interview study. J Crit Care. 2014;29(4):634-10.PMID: 24747038
English SWJ Clin Epidemiol.2016Enriched Administrative Data Can Be Used To Retrospectively Identify All Known Cases of Primary Subarachnoid Hemorrhage.26399902English SW, McIntyre L, Fergusson D, Turgeon A, Sun C, Dos Santos MP, Lum C, Sinclair J, Forster A, van Walraven C. Enriched Administrative Data Can Be Used To Retrospectively Identify All Known Cases of Primary Subarachnoid Hemorrhage. J Clin Epidemiol. 2016 Feb;70:146-54. PMID: 26399902
English SWSyst Rev.2015Red blood cell transfusion and mortality effect in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis protocol.25927348 English SW, Chassé M, Turgeon AF, Tinmouth A, Boutin A, Pagliarello G, Fergusson D, McIntyre L. Red blood cell transfusion and mortality effect in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis protocol. Syst Rev. 2015 Apr 3;4:41. PMID: 25927348 
English SWBMJ Open 2016Aneurysmal SubArachnoid Hemorrhage-Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol.27927658English SW, Fergusson D, Chassé M, Turgeon AF, Lauzier F, Griesdale D, Algird A, Kramer A, Tinmouth A, Lum C, Sinclair J, Marshall S, Dowlatshahi D, Boutin A, Pagliarello G, McIntyre LA; Canadian Critical Care Trials Group. Aneurysmal SubArachnoid Hemorrhage-Red Blood Cell Transfusion And Outcome (SAHaRA): a pilot randomised controlled trial protocol. BMJ Open. 2016 Dec 7;6(12):e012623. PMID: 27927658
Ethier CJ of Crit Care2011Recall of ICU stay in patients managed with a Sedation Protocol or a Sedation Protocol with Daily Sedative Interruption: A Pilot Study20889289Ethier C, Burry L, Martinez-Motta C, Tirgari S, Jiang D, McDonald E, Granton J, Cook D, Mehta S, for the Canadian Critical Care Trials Group. Recall of ICU stay in patients managed with a Sedation Protocol or a Sedation Protocol with Daily Sedative Interruption: A Pilot Study. J of Crit Care 2011;26:127-132. Epub Oct 1, 2010. PMID: 20889289
Feguson NDAm J Respir Crit Care Med2013Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials.23204250Ferguson ND, Scales DC, Pinto R, Wilcox ME, Cook DJ, Guyatt GH, Schünemann HJ, Marshall JC, Herridge MS, Meade MO; Canadian Critical Care Trials Group. Integrating mortality and morbidity outcomes: using quality-adjusted life years in critical care trials. Am J Respir Crit Care Med. 2013;187(3):256-61. PMID:23204250
Ferguson NDN Engl J Med2013High-frequency oscillation in early acute respiratory distress syndrome.23339639Ferguson ND, Cook DJ, Guyatt GH, Mehta S, Hand L, Austin P, Zhou Q, Matte A, Walter SD, Lamontagne F, Granton JT, Arabi YM, Arroliga AC, Stewart TE, Slutsky AS, Meade MO; OSCILLATE Trial Investigators; Canadian Critical Care Trials Group.High-frequency oscillation in early acute respiratory distress syndrome.N Engl J Med. 2013 Feb 28;368(9):795-805. PMID: 23339639
Fléchelles, OWorld J Clin Pediatr 2016Pandemic influenza 2009: Impact of vaccination coverage on critical illness in children, a Canada and France observational study Fléchelles, O, Brissaud, O, Fowler, R, Ducruet, T, Jouvet, P. The Pediatric Canadian
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Fontela PSPediatr Crit Care Med.2017Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey.28661973Fontela PS, Quach C, Karim ME, Willson DF, Gilfoyle E, McNally JD, Gonzales M, Papenburg J, Reynolds S, Lacroix J; Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network; on behalf of the Canadian Critical Care Trials Group. Determinants of Antibiotic Tailoring in Pediatric Intensive Care: A National Survey.
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Foster DCrit Care Med2000Use of a screen log to audit patient recruitment into multiple randomized trials in the ICU10752843Foster D, Cook DJ, Granton J, Steinberg M, Marshall J. for The Canadian Critical Care Trials Group. Use of a screen log to audit patient recruitment into multiple randomized trials in the ICU. Crit Care Med 2000;28(3):867-871. PMID: 10752843
Fowler RAJAMA2014Cost-effectiveness of Dalteparin vs Unfractionated Heparin for the Prevention of Venous Thromboembolism in Critically Ill Patients.25362228Fowler RA, Mittmann N, Geerts W, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D; for the Canadian Critical Care Trials Group and the Australia and New Zealand Intensive Care Society Clinical Trials Group.Cost-effectiveness of Dalteparin vs Unfractionated Heparin for the Prevention of Venous Thromboembolism in Critically Ill Patients.JAMA. 2014 312(20):2135-45.PMID:25362228
Fowler RATrials2014Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial.25528663Fowler RA, Mittmann N, Geerts WH, Heels-Ansdell D, Gould MK, Guyatt G, Krahn M, Finfer S, Pinto R, Chan B, Ormanidhi O, Arabi Y, Qushmaq I, Rocha MG, Dodek P, McIntyre L, Hall R, Ferguson ND, Mehta S, Marshall JC, Doig CJ, Muscedere J, Jacka MJ, Klinger JR, Vlahakis N, Orford N, Seppelt I, Skrobik YK, Sud S, Cade JF, Cooper J, Cook D.Economic evaluation of the prophylaxis for thromboembolism in critical care trial (E-PROTECT): study protocol for a randomized controlled trial. Trials. 2014;15(1):502. PMID: 25528663
Fowler RACrit Care2015Critical Care capacity in Canada: results of a national cross-sectional study.25888116Fowler RA, Abdelmalik P, Wood G, Foster D, Gibney N, Bandrauk N, Turgeon AF, Lamontagne F, Kumar A, Zarychanski R, Green R, Bagshaw SM, Stelfox HT, Foster R, Dodek P, Shaw S, Granton J, Lawless B, Hill A, Rose L, Adhikari NK, Scales DC, Cook DJ, Marshall JC, Martin C, Jouvet P; Canadian Critical Care Trials Group and The Canadian ICU Capacity Group. Critical Care capacity in Canada: results of a national cross-sectional study. Crit Care. 2015 Apr 1;19(1):133. PMID: 25888116
Francis JJHealth Technol Assess2014Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study).24775071Francis JJ, Duncan EM, Prior ME, Maclennan GS, Dombrowski S, Bellingan GU, Campbell MK, Eccles MP, Rose L, Rowan KM, Shulman R, Peter R Wilson A, Cuthbertson BH. Selective decontamination of the digestive tract in critically ill patients treated in intensive care units: a mixed-methods feasibility study (the SuDDICU study). Health Technol Assess. 2014;18(25):1-170.PMID: 24775071
Francis JJBr J Health Psychol.2014Comparison of four methods for assessing the importance of attitudinal beliefs: An international Delphi study in intensive care settings.24112280Francis JJ, Duncan EM, Prior ME, Maclennan G, Marshall AP, Wells EC, Todd L, Rose L, Campbell MK, Webster F, Eccles MP, Bellingan G, Seppelt IM, Grimshaw JM, Cuthbertson BH; for the SuDDICU study groups. Comparison of four methods for assessing the importance of attitudinal beliefs: An international Delphi study in intensive care settings. Br J Health Psychol. 2014;19(2):274-91. PMID: 24112280
Fraser DDPediatr Crit Care Med2011Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum20625342Fraser DD, Close TE, Rose KL, Ward R, Mehl M, Farrell C, Lacroix J, Creery D, Kesselman M, Stanimirovic D, Hutchison JS, for the Canadian Critical Care Translational Biology Group. Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med 2011;12:319-24. PMID: 20625342
Freed DHCan J Anaesth2010Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada20082167Freed DH, Henzler D, White CW, Fowler R, Zarychanski R, Hutchison J, Arora RC, Manji RA, Legare JF, Drews T, Veroukis S, Kesselman M, Guerguerian AM, Kumar A; for the Canadian Critical Care Trials Group. Extracorporeal lung support for patients who had severe respiratory failure secondary to influenza A (H1N1) 2009 infection in Canada. Can J Anaesth 2010;57(3):240-7. PMID: 20082167
Friedrich JOCrit Care2012Hemofiltration compared to hemodialysis for acute kidney injury: systematic review and meta-analysis22867021Friedrich JO, Wald R, Bagshaw SM, Burns KE, Adhikari NK for the Canadian Critical Care Trials Group. Hemofiltration compared to hemodialysis for acute kidney injury: systematic review and meta-analysis. Crit Care. 2012 Aug 6;16(4):R146. [Epub ahead of print] PMID: 22867021
Gauvin FTransfusion2010Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients20456697Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M, on behalf of the Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.  Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion. 2010 Sep;50(9):1902-13 PMID: 20456697
Gilfoyle EPediatr Crit Care Med2017Improved Clinical Performance and Teamwork of Pediatric Interprofessional Resuscitation Teams With a Simulation-Based Educational Intervention.28157808Gilfoyle E, Koot DA, Annear JC, Bhanji F, Cheng A, Duff JP, Grant VJ, St George-Hyslop CE, Delaloye NJ, Kotsakis A, McCoy CD, Ramsay CE, Weiss MJ, Gottesman RD; Teams4Kids Investigators and the Canadian Critical Care Trials Group. Improved Clinical Performance and Teamwork of Pediatric Interprofessional Resuscitation Teams With a Simulation-Based Educational Intervention. Pediatr Crit Care Med. 2017 Feb;18(2):e62-e69. PMID: 28157808
Green RSJ Crit Care2015Postintubation hypotension in intensive care unit patients: A multicenter cohort study.26117220Green RS, Turgeon AF, McIntyre LA, Fox-Robichaud AE, Fergusson DA, Doucette S, Butler MB, Erdogan M; Canadian Critical Care Trials Group (CCCTG). Postintubation hypotension in intensive care unit patients: A multicenter cohort study. J Crit Care. 2015 Oct;30(5):1055-60. PMID: 26117220
Griffith LIntensive Care Med2004Predictors of clinician discomfort with daily life support plans for mechanically ventilated patients15221128Griffith L, Cook D, Hanna S, Rocker G, Sjokvist P, Dodek P, Marshall JC, Levy M, Varon J, Finfer S, Jaeschke R, Buckingham L, Guyatt G for The Canadian Critical Care Trials Group. Predictors of clinician discomfort with daily life support plans for mechanically ventilated patients. Intensive Care Med 2004;30:1783-1790. PMID: 15221128
Guerra GGPediatr Crit Care Med.2016Survey of Sedation and Analgesia Practice Among Canadian Pediatric Critical Care Physicians27467012Guerra GG, Joffe AR, Cave D, Duff J, Duncan S, Sheppard C, Tawfik G, Hartling L, Jou H, Vohra S; Sedation Withdrawal and Analgesia Team, and the Canadian Critical Care Trials Group. Survey of Sedation and Analgesia Practice Among Canadian Pediatric Critical Care Physicians. Pediatr Crit Care Med. 2016 Sep;17(9):823-30. PMID: 27467012
Guyatt GJ Crit Care2003The influence of perceived functional and employment status on cardiopulmonary resuscitation directives.14595566Guyatt G, Cook D, Weaver B, Rocker G, Dodek P, Sjokvist P, Hamielec C, Puksa S, Marshall J, Foster D, Levy M, Varon J, Thorpe K, Fisher M, Walter S for the Level of Care Investigators and The Canadian Critical Care Trials Group.  The influence of perceived functional and employment status on cardiopulmonary resuscitation directives.  J Crit Care 2003;18(3):133-141. PMID: 14595566
Havey TCCan J. of ID & MM2013Duration of Antibiotic Therapy for Critically Ill Patients with Bloodstream Infections: A Retrospective Cohort Study.24421823Havey TC, Fowler RA, Pinto R, Elligsen M, Daneman N. Duration of Antibiotic Therapy for Critically Ill Patients with Bloodstream Infections: A Retrospective Cohort Study. Can J Infect Dis Med Microbiol. 2013;24(3):129-37. PMID:24421823
Havey TCCrit Care2011Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis.22085732 Havey TC, Fowler RA, Daneman N.Duration of antibiotic therapy for bacteremia: a systematic review and meta-analysis. Crit Care. 2011;15(6):R267. PMID: 22085732 
Hebert PCAnesth Analg2005A pilot trial evaluating the clinical effects of prolonged storage of red cell15845701Hebert PC, Chin-Yee I, Fergusson D, Blajchman M, Martineau R, Clinch J, Olberg B for the Canadian Critical Care Trials Group.  A pilot trial evaluating the clinical effects of prolonged storage of red cell.  Anesth Analg 2005 May;100(5):1433-8. PMID: 15845701
Hébert PCChest2001Do blood transfusions improve outcomes from mechanical ventilation?11399714Hébert PC, Blajchman MA, Cook DJ, Yetisir E, Wells G, Marshall J, Schweitzer I, and the Transfusion Requirements in Critical Care Investigators for The Canadian Critical Care Trials Group. Do blood transfusions improve outcomes from mechanical ventilation? Chest 2001;119(6):1850-1857. PMID: 11399714
Hébert PCCrit Care Med2001Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?11246298Hébert PC, Yetisir E, Martin C, Blajchman MA, Wells G, Marshall J, Tweeddale M, Pagliarello G, Schweitzer I, and the Transfusion Requirements in Critical Care Investigators for The Canadian Critical Care Trials Group. Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases? Crit Care Med 2001;29(2):227-234. PMID: 11246298
Hébert PCCrit Care Med1999Variation in red cell transfusion practice in the intensive care unit11056725Hébert PC, Wells G, Martin C, Tweeddale M, Marshall J, Blajchman M, Pagliarello G, Sandham D, Schweitzer I, Boisvert D, Calder L, for the Transfusion Requirements in Critical Care (TRICC) Investigators and The Canadian Critical Care Trials Group. Variation in red cell transfusion practice in the intensive care unit. Crit Care 1999;3(2):57-63. PMID: 11056725
Hébert PCN Engl J Med1999Transfusion requirements in critical care: a multicenter randomized controlled clinical trial9971864Hébert PC, Wells G, Blajchman MA, Marshall J, Martin C, Pagliarello G, Tweeddale M, Schweitzer I, Yetisier E and the Transfusion Requirements in Critical Care Investigators, for The Canadian Critical Care Trials Group. Transfusion requirements in critical care: a multicenter randomized controlled clinical trial. N Engl J Med 1999;340(6):409-417. PMID: 9971864
Hébert PCBr J Anaesth1998Transfusion requirements in critical care: a multicentre randomized controlled clinical study10318985Hébert PC for the Transfusion Requirements in Critical Care Investigators and The Canadian Critical Care Trials Group. Transfusion requirements in critical care: a multicentre randomized controlled clinical study. Br J Anaesth 1998 Dec;81 Suppl 1:25-33. PMID: 10318985
Hébert PCAm J Respir Crit Care Med1997Does transfusion practice affect mortality in critically ill patients?9154866Hébert PC, Wells G, Tweeddale M, Martin C, Marshall JC, Pham B, Blajchman M, Schweitzer I, Pagliarello G for the Canadian Critical Care Trials Group. Does transfusion practice affect mortality in critically ill patients? Am J Respir Crit Care Med. 1997 May;155(5):1618-23. PMID: 9154866
Hébert PCCrit Care Med1998A Canadian survey of transfusion practices in critically ill patients9504576Hébert PC, Wells G, Martin C, Tweeddale M, Marshall J, Blajchman M, Pagliarello G, Schweitzer I, Calder L, for the Transfusion Requirements in Critical Care Investigators and The Canadian Critical Care Trials Group. A Canadian survey of transfusion practices in critically ill patients. Crit Care Med 1998;26(3):482-487. PMID: 9504576
Hébert PCJAMA1995ransfusion requirements in critical care: A pilot study7723158Hébert PC, Wells G, Marshall JC, Martin C, Tweeddale M, Pagliarello G, Blajchman M, for The Canadian Critical Care Trials Group. Transfusion requirements in critical care: A pilot study. JAMA 1995;273:1439-1444. PMID: 7723158
Hébert PCCrit Care Clin.2004Clinical consequences of anemia and red cell transfusion in the critically ill.15135462Hébert PC, McDonald BJ, Tinmouth A.Clinical consequences of anemia and red cell transfusion in the critically ill. Crit Care Clin. 2004;20(2):225-35. PMID: 15135462
Hébert PCCrit Care Med.2005Revisiting transfusion practices in critically ill patients.15644642Hébert PC, Fergusson DA, Stather D, McIntyre L, Martin C, Doucette S, Blajchman M, Graham ID; Canadian Critical Care Trials Group. Revisiting transfusion practices in critically ill patients. Crit Care Med. 2005;33(1):7-12. PMID: 15644642
Henderson WPol Arch Med Wewn2009The efficacy and Safety of Glucose Control Algorithms in Intensive Care: A Pilot Study of the Survival using Glucose Algorithm Regulation Trial (SUGAR)19776683Henderson W, Dhingra V, Chittock D, Foster D, Hebert P, Cook DJ, Heyland D, Dodek P, Schulzer M, Ronco R in association with the Canadian Critical Care Trials Group. The efficacy and Safety of Glucose Control Algorithms in Intensive Care: A Pilot Study of the Survival using Glucose Algorithm Regulation Trial (SUGAR). Pol Arch Med Wewn 2009 Jul-Aug;119(7-8):439-46. PMID: 19776683
Herridge MSN Engl J Med2003One year outcomes in survivors of the acute respiratory distress syndrome12594312Herridge MS, Cheung AM, Tansey CM, Matte-Martyn A, Diaz-Granados N, Al-Saidi F, Cooper A, Guest C, Mazer D, Mehta S, Stewart T, Barr A, Cook DJ, Slutsky A, for The Canadian Critical Care Trials Group. One year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med. 2003 Feb 20;348(8):683-93. PMID: 12594312
Herridge MSN Engl J Med2011Functional disability 5 years after acute respiratory distress syndrome21470008Herridge MS, Tansey CM, Matté A, Tomlinson G, Diaz-Granados N, Cooper A, Guest CB, Mazer CD, Mehta S, Stewart TE, Kudlow P, Cook D, Slutsky AS, Cheung AM; for the Canadian Critical Care Trials Group. Functional disability 5 years after acute respiratory distress syndrome. N Engl J Med. 2011 Apr 7;364(14):1293-304. PMID: 21470008
Herridge MSAm J Respir Crit Care Med2016The RECOVER Program: Disability Risk Groups & One Year Outcome after ≥ 7 Days of Mechanical Ventilation.26974173Herridge MS, Chu LM, Matte A, Tomlinson G, Chan L, Thomas C, Friedrich JO, Mehta S, Lamontagne F, Levasseur M, Ferguson ND, Adhikari NK, Rudkowski JC, Meggison H, Skrobik Y, Flannery J, Bayley M, Batt J, Dos Santos C, Abbey SE, Tan A, Lo V, Mathur S, Parotto M, Morris D, Flockhart L, Fan E, Lee CM, Wilcox ME, Ayas N, Choong K, Fowler R, Scales DC, Sinuff T, Cuthbertson BH, Rose L, Robles P, Burns S, Cypel M, Singer L, Chaparro C, Chow CW, Keshavjee S, Brochard L, Hebert P, Slutsky AS, Marshall JC, Cook D, Cameron JI; RECOVER Program Investigators (Phase 1: towards RECOVER) and the Canadian Critical Care Trials Group. The RECOVER Program: Disability Risk Groups & One Year Outcome after ≥ 7 Days of Mechanical Ventilation. Am J Respir Crit Care Med. 2016 Mar 14. [Epub ahead of print] PMID: 26974173
Herridge MSIntensive Care Med.2016Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers.27025938Herridge MS, Moss M, Hough CL, Hopkins RO, Rice TW, Bienvenu OJ, Azoulay E.Recovery and outcomes after the acute respiratory distress syndrome (ARDS) in patients and their family caregivers. Intensive Care Med. 2016 May;42(5):725-38. PMID: 27025938
Heyland DK  Is the stomach an important source of tracheal contamination and subsequent pneumonia? Heyland DK, Wood G, Cook DJ, for The Canadian Critical Care Trials Group. Is the stomach an important source of tracheal contamination and subsequent pneumonia?
Heyland DKCrit Care Med1999The effect of acidified enteral feeds on gastric colonization in critically ill patients: Results of a multicenter randomized trial10579255Heyland DK, Cook DJ, Schoenfeld PS, Freitag A, Varon J, Wood G, for The Canadian Critical Care Trials Group. The effect of acidified enteral feeds on gastric colonization in critically ill patients: Results of a multicenter randomized trial. Crit Care Med 1999;27(11):2399-1406. PMID: 10579255
Heyland DKChest1999The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia10208211Heyland DK, Cook DJ, Marshall J, Heule M, Guslits B, Lang J, Jaeschke R, for The Canadian Critical Care Trials Group. The clinical utility of invasive diagnostic techniques in the setting of ventilator-associated pneumonia. Chest 1999;115(4):1076-1084. PMID: 10208211
Heyland DK Am J Respir Crit Care Med1999The attributable morbidity and mortality of ventilator-associated pneumonia10194173Heyland DK, Cook DJ, Griffith LE, Keenan SP, Brun-Buisson C, for The Canadian Critical Care Trials Group. The attributable morbidity and mortality of ventilator-associated pneumonia. Am J Respir Crit Care Med 1999;159(4):1249-1256. PMID: 10194173
Heyland DKClin Intens Care1996The clinical and economic consequence of clinically important gastrointestinal bleeding in critically ill patientsNo PMID foundHeyland DK, Gafni A, Griffith L, Cook DJ, Marshall JC, Fuller HD, Todd TRJ, Guslits B, Heule M, Hewson JR, Lacroix J, Noseworthy T, Powles ACP, for The Canadian Critical Care Trials Group. The clinical and economic consequence of clinically important gastrointestinal bleeding in critically ill patients. Clin Intens Care 1996;7(3):121-125. No PMID found
Heyland DKCrit Care2011Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials21418560Heyland DK, Muscedere J, Drover J, Jiang X, Day AG for the Canadian Critical Care Trials Group. Persistent organ dysfunction plus death: a novel, composite outcome measure for critical care trials. Crit Care. 2011;15(2):R98. Epub 2011 Mar 18. PMID: 21418560
Heyland DKCrit Care Med2008A Randomized Trial of Combination Versus Monotherapy for the Empiric Treatment of Suspected Ventilator-Associated Pneumonia18091545Heyland DK, Dodek P, Muscedere J, Day A, Cook DJ for the Canadian Critical Care Trials Group. A Randomized Trial of Combination Versus Monotherapy for the Empiric Treatment of Suspected Ventilator-Associated Pneumonia. Crit Care Med 2008; 36: 737-744. PMID: 18091545
Heyland DKN Engl J Med2006A randomized trial of diagnostic techniques and empiric broad-spectrum antibiotics for suspected ventilator-associated pneumonia17182987Heyland DK, Cook D, Dodek P, Muscedere J, Day A. The Canadian Critical Care Trials Group. A randomized trial of diagnostic techniques and empiric broad-spectrum antibiotics for suspected ventilator-associated pneumonia. N Engl J Med 2006;355(25):2619-2630. PMID: 17182987
Heyland DKProc Nutr Soc2006REducing Deaths due to OXidative Stress: The REDOXS© Study: Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically ill patients16923310Heyland DK, Dhaliwal R, Day A, Muscedere J, Drover J, Suchner U, Cook DJ, For the Canadian Critical Care Trials Group.  REducing Deaths due to OXidative Stress: The REDOXS© Study: Rationale and study design for a randomized trial of glutamine and antioxidant supplementation in critically ill patients.  Proc Nutr Soc 2006;65(3):250-263. PMID: 16923310
Heyland DKJ Parenter Enteral Nutr2014Glutamine and Antioxidants in the Critically Ill Patient: A Post Hoc Analysis of a Large-Scale Randomized Trial.24803474Heyland DK, Elke G, Cook D, Berger MM, Wischmeyer PE, Albert M, Muscedere J, Jones G, Day AG on behalf of the Canadian Critical Care Trials Group.Glutamine and Antioxidants in the Critically Ill Patient: A Post Hoc Analysis of a Large-Scale Randomized Trial. JPEN J Parenter Enteral Nutr. 2014 May 5. PMID: 24803474
Heyland DKN Engl J Med2013A randomized trial of glutamine and antioxidants in critically ill patients23594003Heyland D, Muscedere J, Wischmeyer PE, Cook D, Jones G, Albert M, Elke G, Berger MM, Day AG; Canadian Critical Care Trials Group. A randomized trial of glutamine and antioxidants in critically ill patients.N Engl J Med. 2013;368(16):1489-97. PMID: 23594003
Heyland DKJ Crit Care2002Prevention of ventilator-associated pneumonia: current practice in Canadian intensive care units.12297991Heyland DK, Cook DJ, Dodek PM.Prevention of ventilator-associated pneumonia: current practice in Canadian intensive care units.J Crit Care. 2002 Sep;17(3):161-7. PMID: 12297991
Heyland DKPalliat Med.2015Admission of the very elderly to the intensive care unit: Family members' perspectives on clinical decision-making from a multicenter cohort study.25645668Heyland DK, Dodek P, Mehta S, Cook D, Garland A, Stelfox HT, Bagshaw SM, Kutsogiannis DJ, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; on behalf of the Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network (CARENET).Admission of the very elderly to the intensive care unit: Family members' perspectives on clinical decision-making from a multicenter cohort study. Palliat Med. 2015 Apr;29(4):324-35. PMID: 25645668
Heyland DKCrit Care Med2015The Very Elderly Admitted to ICU: A Quality Finish?25901550Heyland DK, Cook D, Bagshaw SM, Garland A, Stelfox HT, Mehta S, Dodek P, Kutsogiannis J, Burns K, Muscedere J, Turgeon AF, Fowler R, Jiang X, Day AG; Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network. The Very Elderly Admitted to ICU: A Quality Finish?
Crit Care Med. 2015Jul;43(7):1352-60. PMID: 25901550
Heyland DKIntensive Care Med.2015Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study.26306719Heyland DK, Garland A, Bagshaw SM, Cook D, Rockwood K, Stelfox HT, Dodek P, Fowler RA, Turgeon AF, Burns K, Muscedere J, Kutsogiannis J, Albert M, Mehta S, Jiang X, Day AG. Recovery after critical illness in patients aged 80 years or older: a multi-center prospective observational cohort study.
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Heyland DKJPEN J Parenter Enteral Nutr.2015Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial.24803474Heyland DK, Elke G, Cook D, Berger MM, Wischmeyer PE, Albert M, Muscedere J, Jones G, Day AG; Canadian Critical Care Trials Group. Glutamine and antioxidants in the critically ill patient: a post hoc analysis of a large-scale randomized trial. JPEN J Parenter Enteral Nutr. 2015 May;39(4):401-9. PMID: 24803474
Heyland DKCrit Care Med2016Predicting Performance Status 1 Year After Critical Illness in Patients 80 Years or Older: Development of a Multivariable Clinical Prediction Model.27075141Heyland DK, Stelfox HT, Garland A, Cook D, Dodek P, Kutsogiannis J, Jiang X, Turgeon AF, Day AG; Canadian Critical Care Trials Group and the Canadian Researchers at the End of Life Network. Predicting Performance Status 1 Year After Critical Illness in Patients 80 Years or Older: Development of a Multivariable Clinical Prediction Model. Crit Care Med. 2016 Sep;44(9):1718-26. PMID: 27075141
Hosein FSCrit Care2014A meta-analysis to derive literature-based benchmarks for readmission and hospital mortality after patient discharge from intensive care.25551448Hosein FS, Roberts DJ, Turin TC, Zygun D, Ghali WA, Stelfox HT. A meta-analysis to derive literature-based benchmarks for readmission and hospital mortality after patient discharge from intensive care. Crit Care. 2014;18(6):2558.PMID: 25551448
Howes DResuscitation2016Canadian Guidelines for the Use of Targeted Temperature Management (Therapeutic Hypothermia) After Cardiac Arrest: A joint statement from The Canadian Association of Emergency Physicians (CAEP), the Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG)26417702Howes D, Gray SH, Brooks SC, Boyd JG, Djogovic D, Golan E, Green RS, Jacka MJ, Sinuff T, Chaplin T, Smith OM, Owen J, Szulewski A, Murphy L, Irvine S, Jichici D, Muscedere J. Canadian Guidelines for the Use of Targeted Temperature Management (Therapeutic Hypothermia) After Cardiac Arrest: A joint statement from The Canadian Association of Emergency Physicians (CAEP), the Canadian Critical Care Society (CCCS), Canadian Neurocritical Care Society (CNCCS), and the Canadian Critical Care Trials Group (CCCTG). Resuscitation. 2016 Jan;98:48-63. PMID: 26417702
Hutchison JDevelopmental Neuroscience2006Hypothermia Pediatric Head Injury Trial (HyP-HIT): The value of a pre-trial clinical evaluation phase16943652Hutchison J, Ward R, Lacroix J, Hébert P, Skippen P, Barnes M, Meyer P, Morris K, Kirpalani H, Singh R, Dirks P, Bohn D, Moher D, for the HyP-HIT investigators and the Canadian Critical Care Trials Group. Hypothermia Pediatric Head Injury Trial (HyP-HIT): The value of a pre-trial clinical evaluation phase. Developmental Neuroscience 2006;28:291-301. PMID: 16943652
Hutchison JSDev Neurosci2010Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: A post hoc analysis of the hypothermia pediatric head injury trial21252486Hutchison JS, Frndova H, Lo TY, Guerguerian AM for the Hypothermia Pediatric Head Injury Trial Investigators and for the Canadian Critical Care Trials Group. Impact of hypotension and low cerebral perfusion pressure on outcomes in children treated with hypothermia therapy following severe traumatic brain injury: A post hoc analysis of the hypothermia pediatric head injury trial. Dev Neurosci 2010;32:406-412. PMID: 21252486
Hutchison SJN Engl J Med2008Hypothermia Therapy Following Traumatic Brain Injury in Children18525042Hutchison SJ, Ward RE, Lacroix J, Hébert PC, Barnes MA, Bohn DJ, Dirks PB, Doucette S, Ferguson D, Gottesman R, Joffe AR, Kirpalani HM, Meyer PG, Morris KP, Moher D, Singh RN, Skippen PW, for the Hypothermia Pediatric Head Injury Trial investigators and for the Canadian Critical Care Trials Group. Hypothermia Therapy Following Traumatic Brain Injury in Children. N Engl J Med. 2008 Jun 5;358(23):2447-56. PMID: 18525042
Hutton BCan J Anaesth.2005Transfusion rates vary significantly amongst Canadian medical centres.15983142Hutton B, Fergusson D, Tinmouth A, McIntyre L, Kmetic A, Hébert PC. Transfusion rates vary significantly amongst Canadian medical centres. Can J Anaesth. 2005;52(6):581-90. PMID: 15983142
Jain SCan Respir J.2016The Development of a Critical Care Resident Research Curriculum: A Needs Assessment.27610029 Jain S, Menon K, Piquette D, Gottesman R, Hutchison J, Gilfoyle E, Group CC. The Development of a Critical Care Resident Research Curriculum: A Needs Assessment. Can Respir J. 2016; Epub 2016 Aug 16. PMID: 27610029 
Joffe ARJ Crit Care2008The safety of targeted antibiotic therapy for ventilator-associated pneumonia: A multicenter observational study18359425Joffe AR, Muscedere J, Marshall JC, Su Y, Heyland DK for the Canadian Critical Care Trials Group. The safety of targeted antibiotic therapy for ventilator-associated pneumonia: A multicenter observational study. J Crit Care 2008; 23: 82-90. PMID: 18359425
Jouvet PPediatr Crit Care Med2010Critical illness in children with influenza A/pH1N1 2009 infection in Canada20308929Jouvet P, Hutchison J, Pinto R, Menon K, Rodin R, Choong K, Kesselman M, Veroukis S, André Dugas M, Santschi M, Guerguerian AM, Withington D, Alsaati B, Joffe AR, Drews T, Skippen P, Rolland E, Kumar A, Fowler RA, for the Canadian Critical Care Trials Group H1N1 Collaborative. Critical illness in children with influenza A/pH1N1 2009 infection in Canada. Pediatr Crit Care Med. 2010 Sep;11(5):603-9. PMID: 20308929
Kanji SJ Crit Care2012Epidemiology and management of atrial fibrillation in medical and noncardiac surgical adult intensive care unit patients22226423Kanji S, Williamson DR, Yaghchi BM, Albert M, McIntyre L, On behalf of the Canadian Critical Care Trials Group. J Epidemiology and management of atrial fibrillation in medical and noncardiac surgical adult intensive care unit patients. J Crit Care. 2012 Jun;27(3):326.e1-8. Epub 2012 Jan 4. PMID: 22226423
Karam OPediatr Crit Care Med2011Red blood cell transfusion thresholds in pediatric patients with sepsis21057356Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F; for the Canadian Critical Care Trials Group and the PALISI Network. Red blood cell transfusion thresholds in pediatric patients with sepsis. Pediatr Crit Care Med. 2011 Sep;12(5):512-518. PMID: 21057356
Karam OTransfusion2009Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells19624600Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion. 2009;49(11):2326-34. PMID: 19624600

Karam OCochrane Database Syst Rev2013Plasma transfusion strategies for critically ill patients.24374651Karam O, Tucci M, Combescure C, Lacroix J, Rimensberger PC. Plasma transfusion strategies for critically ill patients. Cochrane Database Syst Rev. 2013 Dec 28;12:CD010654. PMID: 24374651

Karam OVox Sang2013Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study.23294337 Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sang. 2013 May;104(4):342-9. PMID: 23294337 
Karam OTransfusion2014International survey on plasma transfusion practices in critically ill children.24032693Karam O, Tucci M, Lacroix J, Rimensberger PC; Canadian Critical Care Trials Group and of the Pediatric Acute Lung Injury and Sepsis Investigator Network.. International survey on plasma transfusion practices in critically ill children. Transfusion. 2014 Apr;54(4):1125-32. PMID: 24032693
Karam OAm J Respir Crit Care Med2015Indications and Effects of Plasma Transfusions in Critically Ill Children.25859890Karam O, Demaret P, Shefler A, Leteurtre S, Spinella P, Stanworth S, Tucci M; Canadian Critical Care Trials Group (CCCTG), Pediatric Acute Lung Injury and Sepsis Investigators (PALISI), BloodNet, and the PlasmaTV investigators. Indications and Effects of Plasma Transfusions in Critically Ill Children. Am J Respir Crit Care Med. 2015 Jun 15;191(12):1395-402. PMID: 25859890
Karvellas CJCrit Care2011A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis.21352532 Karvellas CJ, Farhat MR, Sajjad I, Mogensen SS, Leung AA, Wald R, Bagshaw SM. A comparison of early versus late initiation of renal replacement therapy in critically ill patients with acute kidney injury: a systematic review and meta-analysis. Crit Care. 2011;15(1):R72. PMID: 21352532 
Katsios CCrit Care2011Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical-surgical critically ill patients: a prospective observational cohort study22044745Katsios C, Griffith L, Spinella P, Lacroix J, Crowther M, Hebert P, Meade M, Geerts W, Rabbat C, Cook D for the Canadian Critical Care Trials Group. Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical-surgical critically ill patients: a prospective observational cohort study. Crit Care 2011; 15:R263. PMID: 22044745
Keenan SPCan Med Assoc J2011Clinical practice guidelines for noninvasive positive pressure ventilation (NPPV) and noninvasive continuous positive airway pressure (nCPAP) in the acute care setting21324867Keenan SP, Sinuff T, Burns K, Muscedere J, Kutsogiannis J, Sangeeta M, Dodek P, Cook DJ, Ayas N, Adhikari N, Hand L, Scales D, Pagnotta R, Lazosky L, Rocker G, Dial S, Laupland K, Sanders K for the Canadian Critical Care Trials Group and Canadian Critical Care Society. Noninvasive Ventilation Guidelines Group. Clinical practice guidelines for noninvasive positive pressure ventilation (NPPV) and noninvasive continuous positive airway pressure (nCPAP) in the acute care setting. Can Med Assoc J 2011 Feb 22;183(3):E195-214. Epub 2011 Feb 14. PMID: 21324867
Kho MEBMJ Open 2016CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients27059469Kho, ME,  Molloy,AJ, Clarke, F, Herridge, MS, Koo, KKY, Rudkowski, J, Seely, AJE, Pellizzari, JR, Tarride, JE, Mourtzakis, M, Karachi, T, Cook, DJ, the Canadian Critical Care Trials Group. CYCLE pilot: a protocol for a pilot randomised study of early cycle ergometry versus routine physiotherapy in mechanically ventilated patients. BMJ Open. 2016 Apr 8;6(4):e011659. PMID: 27059469
Kho MEPLoS One2016Ventilated Patients.28030555 Kho ME, Molloy AJ, Clarke FJ, Ajami D, McCaughan M, Obrovac K, Murphy C, Camposilvan L, Herridge MS, Koo KK, Rudkowski J, Seely AJ, Zanni JM, Mourtzakis M, Piraino T, Cook DJ; Canadian Critical Care Trials Group.TryCYCLE: A Prospective Study of the Safety and Feasibility of Early In-Bed Cycling in Mechanically Ventilated Patients. PLoS One. 2016 Dec 28;11(12). PMID: 28030555 
Koo KKAm J Respir Crit Care Med (in press)2013Inter-rater Reliability of Observed, Stated and Documented Acute Rehabilitation in Canadian Intensive Care Units. Koo KK, Cook DJ, Lamontagne F, Campbell E, Hand L, Clarke F, Zytaruk N, McLeod A, Soucy I, Boutin M, Priestap F, Meade MO on behalf of the Canadian Critical Care Trials Group.  Inter-rater Reliability of Observed, Stated and Documented Acute Rehabilitation in Canadian Intensive Care Units.  Am J Respir Crit Care Med 2013  (in press)
Koo KKCMAJ Open2016Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists.27730109 Koo KK, Choong K, Cook DJ, Herridge M, Newman A, Lo V, Guyatt G, Priestap F, Campbell E, Burns KE, Lamontagne F, Meade MO; Canadian Critical Care Trials Group. Early mobilization of critically ill adults: a survey of knowledge, perceptions and practices of Canadian physicians and physiotherapists. CMAJ Open. 2016 Aug 18;4(3):E448-E454. PMID: 27730109 
Kotsakis AJ Crit Care2005Clinically Important Venous Thromboembolism in Pediatric Critical Care: A Canadian Survey16310610Kotsakis A, Cook DJ, Griffith LE, Anton N, Massicotte P, MacFarland K, Farrell R, Hutchison J, for the Canadian Critical Care Trials Group.  Clinically Important Venous Thromboembolism in Pediatric Critical Care: A Canadian Survey.  J Crit Care 2005;20:373-380. PMID: 16310610
Kumar AJAMA2009Critically Ill Patients with Novel Swine Origin Influenza Virus A/H1N1 Infection in Canada19822627Kumar A, Zarychanski R, Pinto R, Cook DJ, Marshall J, Lacroix J, Stelfox T, Bagshaw S, Choong K, Lamontagne F, Turgeon A, Lapinsky S, Ahern SP, Smith O, Siddiqui F, Jouvet J, Khwaja K, McIntyre L, Menon K, Hutchison J, Hornstein D, Joffe A, Lauzier F, Singh J, Karachi T, Wiebe K, Olafson K, Ramsey C, Sharma S, Dodek P, Meade M, Hall R, Fowler R for the Canadian Critical Care Trials Group H1N1 Collaborative. Critically Ill Patients with Novel Swine Origin Influenza Virus A/H1N1 Infection in Canada JAMA 2009; 302(17):1872-1879. PMID: 19822627
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Lacroix JTransfusion Medicine Reviews2011The age of blood evaluation (ABLE) randomized controlled trial: Study design21550205Lacroix J, Hébert PC, Fergusson D, Tinmouth A, Blajchman MA, Callum J, Cook D, Marshall J, McIntyre L, Turgeon A, for the ABLE study group, and for the Canadian Critical Care Trials Group. The age of blood evaluation (ABLE) randomized controlled trial: Study design. Transfusion Medicine Reviews 2011;25:197-205. PMID: 21550205
Lacroix JN Engl J Med2007Transfusion Requirements In Pediatric Intensive Care Units: A Noninferiority Tria17442904Lacroix J, Hébert PC, Hutchison JS, Hume HA, Tucci M, Ducruet T, Gauvin F, Collet JP, Toledano BJ, Robillard P, Joffe A, Biarent D, Meert K, Peters MJ on behalf of the TRIPICU investigators, for the Canadian Critical Care Trials Group and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Transfusion Requirements In Pediatric Intensive Care Units: A Noninferiority Trial. N Engl J Med 2007;356(16):1609-1619. PMID: 17442904
Lacroix JN Engl J Med2015Age of Transfused Blood in Critically Ill Adults25776801Lacroix, J, Hébert, PC, Fergusson, DA, Tinmouth, A, Cook, DJ, Marshall, JC, Clayton, L, McIntyre, L, Callum, J, Turgeon, AF, Blajchman, MA, Walsh, TS, Stanworth, SJ, Campbell, H, Capellier, G, Tiberghien, P, Bardiaux, L, van de Watering, L, van der Meer, NJ, Sabri, E, Vo, D for the ABLE Investigators and the Canadian Critical Care Trials Group. Age of Transfused Blood in Critically Ill Adults.N Engl J Med. 2015, 372(15):1410-8. PMID: 25776801
Lacroix JTransfus Clin Biol2015The ABLE study: A randomized controlled trial on the efficacy of fresh red cell units to improve the outcome of transfused critically ill adult26049675Lacroix J, Hébert PC, Fergusson D, Tinmouth A, Capellier G, Tiberghien P, Bardiaux L; Canadian Critical Care Trials Group. The ABLE study: A randomized controlled trial on the efficacy of fresh red cell units to improve the outcome of transfused critically ill adults. Transfus Clin Biol. 2015 Aug;22(3):107-11. French. PMID: 26049675
Lamontagne FJ Crit Care2011Vasopressor administration and sepsis: a survey of Canadian intensivists21454040Lamontagne F, Cook DJ, Adhikari NK, Briel M, Duffett M, Kho ME, Burns KE, Guyatt G, Turgeon AF, Zhou Q, Meade MO for the Canadian Critical Care Trials Group. Vasopressor administration and sepsis: a survey of Canadian intensivists. J Crit Care. 2011 Oct;26(5):532.e1-7. Epub 2011 Mar 30. PMID: 21454040
Lamontagne FCan J Anaesth.2013Corticosteroid in the Intensive Care Unit: A Survey of Intensivists. Lamontagne F, Martinez HQ, Adhikari N, Cook D, Koo K, Lauzier F, Turgeon A, Kho M,  Burns KEA, Chant C, Fowler R, Douglas I, Poulin Y, Choong K, Ferguson ND, Meade MO. Corticosteroid in the Intensive Care Unit: A Survey of Intensivists. Can J Anaesth. 2013 Apr 19. [Epub ahead of print]
Lamontagne FJAMA Intern Med.2014Non-leg venous thrombi during critical illness: a nested prospective cohort study.24638843Lamontagne F, Heels-Ansdell D, McIntyre L, Dodek P, Meade M, Skrobik Y, McDonald E, Vallance S, Zytaruk N, Cook D, for the PROTECT Investigators, on behalf of the CCCTG and the ANZICS-CTG.  Non-leg venous thrombi during critical illness: a nested prospective cohort study.  JAMA Intern Med. 2014;174(5):689-96. PMID:24638843
Lamontagne FIntensive Care Med2016Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial.26891677Lamontagne F, Meade MO, Hébert PC, Asfar P, Lauzier F, Seely AJ, Day AG, Mehta S, Muscedere J, Bagshaw SM, Ferguson ND, Cook DJ, Kanji S, Turgeon AF, Herridge MS, Subramanian S, Lacroix J, Adhikari NK, Scales DC, Fox-Robichaud A, Skrobik Y, Whitlock RP, Green RS, Koo KK, Tanguay T, Magder S, Heyland DK; Canadian Critical Care Trials Group. Higher versus lower blood pressure targets for vasopressor therapy in shock: a multicentre pilot randomized controlled trial.
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Lauzier FJ Crit Care2008The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia18359421Lauzier F, Ruest A, Cook D, Dodek P, Albert M, Shorr AF, Day A, Jiang X, Heyland D for the Canadian Critical Care Trials Group. The value of pretest probability and modified clinical pulmonary infection score to diagnose ventilator-associated pneumonia. J Crit Care 2008; 23: 50-57. PMID: 18359421
Lauzier FCrit Care2014Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit.24766968Lauzier F, Muscedere J, Deland E, Kutsogiannis DJ, Jacka M, Heels-Ansdell D, Crowther M, Cartin-Ceba R, Cox MJ, Zytaruk N, Foster D, Sinuff T, Clarke F, Thompson P, Hanna S, Cook D; Co-operative Network of Critical Care Knowledge Translation for Thromboprophylaxis (CONECCKT-T) Investigators; Canadian Critical Care Trials Group. Thromboprophylaxis patterns and determinants in critically ill patients: a multicenter audit. Crit Care. 2014;18(2):R82. PMID:24766968
Lauzier FIntensive Care Med2013Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis.23942857Lauzier F, Arnold DM, Rabbat C, Heels-Ansdell D, Zarychanski R, Dodek P, Ashley BJ, Albert M, Khwaja K, Ostermann M, Skrobik Y, Fowler R, McIntyre L, Nates JL, Karachi T, Lopes RD, Zytaruk N, Finfer S, Crowther M, Cook D. Risk factors and impact of major bleeding in critically ill patients receiving heparin thromboprophylaxis. Intensive Care Med. 2013;39(12):2135-43. PMID: 23942857
Laverdiere CPediatr Crit Care Med2002Survey on transfusion practices of pediatric intensivists12780950Laverdiere C, Gauvin F, Hébert PC, Infante-Rivard C, Hume H, Toledano BJ, Guertin M-C, Lacroix J, for The Canadian Critical Care Trials Group. Survey on transfusion practices of pediatric intensivists. Pediatr Crit Care Med. 2002 Oct;3(4):335-40. PMID: 12780950
Lee ZYNutr Clin Pract.2016Enhanced Protein-Energy Provision via the Enteral Route in Critically Ill Patients (PEP uP Protocol): A Review of Evidence.26385874Lee ZY, Barakatun-Nisak MY, Airini IN, Heyland DK. Enhanced Protein-Energy Provision via the Enteral Route in Critically Ill Patients (PEP uP Protocol): A Review of Evidence.Nutr Clin Pract. 2016 Feb;31(1):68-79. PMID: 26385874
Li GMedicine2015Competing Risk Analysis for Evaluation of Dalteparin Versus Unfractionated Heparin for Venous Thromboembolism in Medical-Surgical Critically Ill Patients.26356708Li G, Cook DJ, Levine MA, Guyatt G, Crowther M, Heels-Ansdell D, Holbrook A, Lamontagne F, Walter SD, Ferguson ND, Finfer S, Arabi YM, Bellomo R, Cooper DJ, Thabane L; PROTECT Investigators for the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Competing Risk Analysis for Evaluation of Dalteparin Versus Unfractionated Heparin for Venous Thromboembolism in Medical-Surgical Critically Ill Patients. Medicine (Baltimore). 2015 Sep;94(36):e1479. PMID: 26356708
Li GRespir Res.2016Risk factors for mortality in patients admitted to intensive care units with pneumonia.27401184Li G, Cook DJ, Thabane L, Friedrich JO, Crozier TM, Muscedere J, Granton J, Mehta S, Reynolds SC, Lopes RD, Francois L, Freitag AP, Levine MA; PROTECT Investigators for the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Risk factors for mortality in patients admitted to intensive care units with pneumonia. Respir Res. 2016 Jul 11;17(1):80. PMID: 27401184
Li PCan Respir J.2015Stakeholder Views regarding Patient Discharge from Intensive Care: Suboptimal Quality and Opportunities for Improvement.25522304Li P, Boyd JM, Ghali WA, Stelfox HT. Stakeholder Views regarding Patient Discharge from Intensive Care: Suboptimal Quality and Opportunities for Improvement. Can Respir J. 2015, 22(2):115-4. PMID: 25522304
Liet JMJ Pediatrics2005Non-invasive therapy with helium-oxygen for severe RSV bronchiolitis: A multicenter randomized controlled trial16356437Liet JM, Millotte B, Tucci M, LaFlamme S, Hutchison J, Creery D, Ducruet T, Lacroix J, for The Canadian Critical Care Trials Group. Non-invasive therapy with helium-oxygen for severe RSV bronchiolitis: A multicenter randomized controlled trial. J Pediatrics 2005;147:812-817. PMID: 16356437
Lim WCrit Care Med2015Failure of Anticoagulant Thromboprophylaxis: Risk Factors in Medical-Surgical Critically Ill Patients.25474533Lim W, Meade M, Lauzier F, Zarychanski R, Mehta S, Lamontagne F, Dodek P, McIntyre L, Hall R, Heels-Ansdell D, Fowler R, Pai M, Guyatt G, Crowther MA, Warkentin TE, Devereaux PJ, Walter SD, Muscedere J, Herridge M, Turgeon AF, Geerts W, Finfer S, Jacka M, Berwanger O, Ostermann M, Qushmaq I, Friedrich JO, Cook DJ; for the PROphylaxis for ThromboEmbolism in Critical Care Trial Investigators, the Canadian Critical Care Trials Group, and the Australian and New Zealand Intensive Care Society Clinical Trials Group. Failure of Anticoagulant Thromboprophylaxis: Risk Factors in Medical-Surgical Critically Ill Patients.Crit Care Med. 2015; 43(2):401-10. PMID: 25474533
Lutz KJ Crit Care2012Research Ethics Board Approval. For An International Thromboprophylaxis Trial22305662Lutz K, Wilton K, Zytaruk N, Julien L, Hall R, Harvey J, Skrobik Y, Vlahakis N, Meade L, Matte A, Meade M, Burns KB, Albert M, Barlow Cash B, Vallance S, Klinger J, Heels-Ansdell D, Cook D, for the PROTECT Investigators in collaboration with the Canadian Critical Care Trials Group and ANZICS-CTG. Research Ethics Board Approval. For An International Thromboprophylaxis Trial. J Crit Care. 2012;27(3):225-31. PMID:22305662
Marshall APHeart Lung. 2014Implementing selective digestive tract decontamination in the intensive care unit: A qualitative analysis of nurse-identified consideration24239299 Marshall AP, Weisbrodt L, Rose L, Duncan E, Prior M, Todd L, Wells E, Seppelt I, Cuthbertson B, Francis J. Implementing selective digestive tract decontamination in the intensive care unit: A qualitative analysis of nurse-identified considerations. Heart Lung. 2014;43(1):13-8. PMID: 24239299 
Marshall JCCrit Care Med2009Investigator-led clinical research consortia: The Canadian Critical Care Trials Group19104219Marshall JC, Cook DJ for the Canadian Critical Care Trials Group. Investigator-led clinical research consortia: The Canadian Critical Care Trials Group. Crit Care Med 2009; 36(7):S165-S172. PMID: 19104219
Marshall JCCrit Care Med.2016Determinants of Citation Impact in Large Clinical Trials in Critical Care: The Role of Investigator-led Clinical Trials Groups.26571189Marshall JC, Kwong W, Kommaraju K, Burns KE. Determinants of Citation Impact in Large Clinical Trials in Critical Care: The Role of Investigator-Led Clinical Trials Groups. Crit Care Med. 2016 Apr;44(4):663-70. PMID: 26571189
McCredie VAAnn Am Thorac Soc2017Airway Management Strategies for Brain-injured Patients Meeting Standard Criteria to Consider Extubation. A Prospective Cohort Study.27870576McCredie VA, Ferguson ND, Pinto RL, Adhikari NK, Fowler RA, Chapman MG, Burrell A, Baker AJ, Cook DJ, Meade MO, Scales DC; Canadian Critical Care Trials Group.Airway Management Strategies for Brain-injured Patients Meeting Standard Criteria to Consider Extubation. A Prospective Cohort Study.
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McIntyre L Transfus Med Rev2012The PRECISE RCT: Evolution of an early septic shock fluid resuscitation tria22222146McIntyre L, Fergusson DA, Rowe B, Cook DJ, Arabi Y, Bagshaw S, Emond M, Finfer S Fox-Robichaud A, Gray A, Green R, Hebert P, Lang E, Marshall J, Stiell I, Tinmouth A, Pagliarello J, Turgeon A, Walsh T, Worster A, Zarychanski R for the Canadian Critical Care Trials Group: The PRECISE RCT: Evolution of an early septic shock fluid resuscitation trial. Transfus Med Rev. 2012 Oct;26(4):333-341. Epub 2012 Jan 4. PMID: 22222146
McIntyre LJ Neuro Critical Care2006Effect of a liberal versus restrictive transfusion strategies on mortality in patients with moderate to severe head injury?16960287McIntyre L, Fergusson D, Hutchinson J, Pagliarello G, Marshall J, Yetisir E, Hare GMT, Blajchman MJ, Hebert PC for The Canadian Care Trials Group. Effect of a liberal versus restrictive transfusion strategies on mortality in patients with moderate to severe head injury? J Neuro Critical Care 2006;5:4-9. PMID: 16960287
McIntyre LJ. Trauma2004Is a restrictive transfusion strategy safe in resuscitated and critically ill trauma victims?15454803McIntyre L, Hébert PC, Wells G, Fergusson D, Marshall J, Yetisir E, Blajchman MJ, for The Canadian Critical Care Trials Group. Is a restrictive transfusion strategy safe in resuscitated and critically ill trauma victims? J. Trauma 2004;57(3):563-568. PMID: 15454803
McIntyre LACan J Anesth2008Fluid Resuscitation in the Management of Early Septic Shock (FINESS): A pilot randomized controlled feasibility study19050085McIntyre LA, Fergusson D, Cook DJ, Rankin N, Dhingra V, Granton J, Magder S, Taljjard M, Hebert PC for the Canadian Critical Care Trials Group. Fluid Resuscitation in the Management of Early Septic Shock (FINESS): A pilot randomized controlled feasibility study Can J Anesth 2008, 55: 12; 819-826. PMID: 19050085
McIntyre LACrit Care2007A Survey of Canadian Intensivists Resuscitation Practices in Early Septic Shock17623059McIntyre LA, Hebert PC, Fergusson D, Cook DJ, Aziz A for the Canadian Critical Care Trials Group. A Survey of Canadian Intensivists Resuscitation Practices in Early Septic Shock. Crit Care. 2007;11(4):R74. PMID: 17623059
McIntyre LLJ Crit Care2012Fluid Resuscitation with 5% Albumin versus Normal Saline in Early Septic Shock (PRECISE): A Pilot Randomized Controlled Tria22176806McIntyre LL, Fergusson DA, Cook DJ, Rowe B, Bagshaw S, Easton D, Edmond M, Finfer S, Fox-Robichaud A, Green R, Hebert P, Marshall J, Rankin N, Stiell I, Tinmouth A, Pagliarello J, Turgeon A, Worster A, Zarychanski R for the Canadian Critical Care Trials Group. Fluid Resuscitation with 5% Albumin versus Normal Saline in Early Septic Shock (PRECISE): A Pilot Randomized Controlled Trial. J Crit Care. 2012 Jun;27(3):317.e1-6. Epub 2011 Dec 15. PMID: 22176806
McIntyre LLCan J Anaesth2007Resuscitating patients with early severe sepsis: A Canadian multicenter observational study17934160McIntyre LL, Fergusson D, Cook DJ, Nair RC, Bell D, Dhingra V, Hutton B, Magder S, Hébert PC for the Canadian Critical Care Trials Group. Resuscitating patients with early severe sepsis: A Canadian multicenter observational study. Can J Anaesth. 2007 Oct;54(10):790-8. PMID: 17934160
McIntyre LLBMJ Open2016Multicountry survey of emergency and critical care medicine physicians' fluid resuscitation practices for adult patients with early septic shock.27388345McIntyre L, Rowe BH, Walsh TS, Gray A, Arabi Y, Perner A, Gordon A, Marshall J, Cook D, Fox-Robichaud A, Bagshaw SM, Green R, Schweitzer I, Turgeon A, Zarychanski R, English S, Chassé M, Stiell I, Fergusson D; Canadian Critical Care Trials Group. Multicountry survey of emergency and critical care medicine physicians' fluid resuscitation practices for adult patients with early septic shock. BMJ Open. 2016 Jul 7;6(7). PMID: 27388345
McMullen SPLoS ONE2012Partial Ventilatory Support Modalities in Acute Lung Injury and Acute Respiratory Distress Syndrome – A systematic review22916094McMullen S, Meade M, Rose L, Mehta S, Burns K, Doyle R and Henzler D for the Canadian Critical Care Trials Group. Partial Ventilatory Support Modalities in Acute Lung Injury and Acute Respiratory Distress Syndrome – A systematic review. PLoS ONE 2012, 7(8): e40190. PMID: 22916094.
McNally DPediatrics2012The Association of Vitamin D Status with Pediatric Critical Illness22869837McNally D, Menon K, Williams K, Chakraborty P, Doherty D for the Canadian Critical Care Trials Group. Vitamin D Status in Pediatric Critical Illness. Pediatrics. 2012;130(3):429-36. PMID:22869837
McNally DJAnesthesiology2013Impact of Anesthesia and Surgery for Congenital Heart Disease on the Vitamin D Status of Infants and Children A Prospective Longitudinal Study23470437McNally DJ, Menon K, Chakraborty P, Fisher L,  Williams KA,  Al-Dirbashi  OY, Girolamo T,  Maharajh T, Doherty DR. Impact of Anesthesia and Surgery for Congenital Heart Disease on the Vitamin D Status of Infants and Children A Prospective Longitudinal Study. Anesthesiology 2013;119(1):71-80. PMID:23470437
McNally JDTrials2015Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial.26353829 McNally JD, O'Hearn K, Lawson ML, Maharajh G, Geier P, Weiler H, Redpath S, McIntyre L, Fergusson D, Menon K; Canadian Critical Care Trials Groups. Prevention of vitamin D deficiency in children following cardiac surgery: study protocol for a randomized controlled trial. Trials. 2015 Sep 9;16(1):402. PMID: 26353829 
McNally JDJ Clin Endocrinol Metab20151,25-Dihydroxyvitamin D Levels in Pediatric Intensive Care Units: Risk Factors and Association With Clinical Course.26052726McNally JD, Menon K, Lawson ML, Williams K, Doherty DR.1,25-Dihydroxyvitamin D Levels in Pediatric Intensive Care Units: Risk Factors and Association With Clinical Course. J Clin Endocrinol Metab. 2015 Aug;100(8):2942-5.PMID: 26052726
McNally JDPediatrics2015Rapid normalization of vitamin D levels: a meta-analysis.25511115McNally JD, Iliriani K, Pojsupap S, Sampson M, O'Hearn K, McIntyre L, Fergusson D, Menon K. Rapid normalization of vitamin D levels: a meta-analysis. Pediatrics. 2015 Jan;135(1):e152-66. PMID: 25511115
Meade MOCrit Care Med2004Survey of interventions for the prevention and treatment of acute respiratory distress syndrome15071383Meade MO, Jacka MJ, Cook DJ, Dodek P, Griffith L, Guyatt GH, for The Canadian Critical Care Trials Group. Survey of interventions for the prevention and treatment of acute respiratory distress syndrome. Crit Care Med 2004;32(4):946-954. PMID: 15071383
Mehta SCrit Care Med 2008A randomized trial of daily awakening in critically ill patients managed with a sedation protocol – A pilot study18552687Mehta S, Burry L, Martinez-Motta C, Stewart TE, Hallett D, McDonald E, Clarke F, MacDonald R, Granton J, Matte A, Wong C, Suri A, Cook D for the Canadian Critical Care Trials Group.  A randomized trial of daily awakening in critically ill patients managed with a sedation protocol – A pilot study. Crit Care Med 2008;36(7):2092-2099. PMID: 18552687
Mehta SJAMA2012A randomized trial of daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol23180503Mehta S, Burry L, Cook D, Fergusson D, Steinberg M, Granton J, Herridge M, Ferguson N, Devlin J, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Skrobik Y, Hebert P, Sabri E, and Meade M, for the SLEAP Investigators and the Canadian Critical Care Trials Group. A randomized trial of daily sedation interruption in mechanically ventilated critically ill patients cared for with a sedation protocol. JAMA. 2012;308(19):1985-92. PMID: 23180503
Mehta SCrit Care Med2006A Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients16424717Mehta S, Burry L, Fischer S, Martinez-Motta JC, Hallett D, Bowman D, Wong C, Meade MO, Stewart TE, Cook DJ for The Canadian Critical Care Trials Group. A Canadian survey of the use of sedatives, analgesics, and neuromuscular blocking agents in critically ill patients. Crit Care Med 2006; 34:374-380. PMID: 16424717
Mehta SCrit Care Med2015Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults.25493968 Mehta S, Cook D, Devlin JW, Skrobik Y, Meade M, Fergusson D, Herridge M, Steinberg M, Granton J, Ferguson N, Tanios M, Dodek P, Fowler R, Burns K, Jacka M, Olafson K, Mallick R, Reynolds S, Keenan S, Burry L; for the SLEAP Investigators and the Canadian Critical Care Trials Group. Prevalence, Risk Factors, and Outcomes of Delirium in Mechanically Ventilated Adults.Crit Care Med. 2015, 43(3):557-66. PMID: 25493968 
Mehta SAnn Intensive Care2014A ventilator strategy combining low tidal volume ventilation, recruitment maneuvers, and high positive end-expiratory pressure does not increase sedative, opioid, or neuromuscular blocker use in adults with acute respiratory distress syndrome and may improve patient comfort.25593749Mehta S, Cook DJ, Skrobik Y, Muscedere J, Martin CM, Stewart TE, Burry LD, Zhou Q, Meade M.A ventilator strategy combining low tidal volume ventilation, recruitment maneuvers, and high positive end-expiratory pressure does not increase sedative, opioid, or neuromuscular blocker use in adults with acute respiratory distress syndrome and may improve patient comfort.Ann Intensive Care. 2014;4:33. PMID: 25593749 
Mehta SCrit Care2016Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption.27480314 Mehta S, Meade M, Burry L, Mallick R, Katsios C, Fergusson D, Dodek P, Burns K, Herridge M, Devlin JW, Tanios M, Fowler R, Jacka M, Skrobik Y, Olafson K, Cook D; SLEAP Investigators and the Canadian Critical Care Trials Group. Variation in diurnal sedation in mechanically ventilated patients who are managed with a sedation protocol alone or a sedation protocol and daily interruption.
Crit Care. 2016 Aug 1;20(1):233. PMID: 27480314 
Menon KPediatr Crit Care Med2013A Survey of Physician Practices and Beliefs on the Use of Steroids in Pediatric Shock23628832Menon K, McNally D, Choong K, Lawson M, Ward R, Ramsay T, Wong H for the Canadian Critical Care Trials Group. A Survey of Physician Practices and Beliefs on the Use of Steroids in Pediatric Shock. Pediatric Critical Care Medicine. Pediatr Crit Care Med. 2013;14(5):462-6. PMID:23628832
Menon KAm J Respir Crit Care Med2010A Prospective Multi-Center Study of Adrenal Function in Critically Ill Children20299532Menon K, Ward RE, Lawson ML, Gaboury I, Hutchison JS, Hébert PC, and for the Canadian Critical Care Trials Group. A Prospective Multi-Center Study of Adrenal Function in Critically Ill Children.  Am J Respir Crit Care Med. 2010 Jul 15;182(2):246-51. Epub 2010 Mar 18. PMID: 20299532
Menon KInt Care Med2012Understanding the Consent Process in Pediatric Critical Care Research Menon K, Ward R, Gaboury I, Thomas M, Joffe A, Burns K, Cook D for the Canadian Critical Care Trials Group. Understanding the Consent Process in Pediatric Critical Care Research. Int Care Med. Volume 38, Issue 1 (2012), Page 153-159.
Menon KJ Med Ethics2014A Study of Consent for Participation in a Non-Therapeutic Study in the Pediatric Intensive Care Population.23345569Menon K, Ward R. A Study of Consent for Participation in a Non-Therapeutic Study in the Pediatric Intensive Care Population. J Med Ethics 2014;40(2):123-6. PMID: 23345569
Menon KPediatr Crit Care Med.2017A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.28406862Menon K, McNally D, O'Hearn K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Choong K; Canadian Critical Care Trials Group. A Randomized Controlled Trial of Corticosteroids in Pediatric Septic Shock: A Pilot Feasibility Study.
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Munshi LIntensive Care Med2015Predicting time to death after withdrawal of life-sustaining therapy.25944573Munshi L, Dhanani S, Shemie SD, Hornby L, Gore G, Shahin J. Predicting time to death after withdrawal of life-sustaining therapy. Intensive Care Med. 2015 Jun;41(6):1014-28. PMID: 25944573
Muscedere JJ Crit Care2012The adequacy of timely empiric antibiotic therapy for ventilator-associated pneumonia: an important determinant of outcome22137378Muscedere J., Shorr A.F., Jiang X., Day A., Heyland DK on behalf of the Canadian Critical Care Trials Group. The adequacy of timely empiric antibiotic therapy for ventilator-associated pneumonia: an important determinant of outcome. J Crit Care. 2012 Jun;27(3):322.e7-14. Epub 2011 Dec 1. PMID: 22137378
Muscedere JJ Crit Care2008Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Diagnosis and Treatment18359431Muscedere J, Dodek PE, Keenan S, Fowler R, Cook DJ, Heyland DK for the VAP Guidelines Committee and for the Canadian Critical Care Trials Group.Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Diagnosis and Treatment. J Crit Care 2008; 23: 138-147. PMID: 18359431
Muscedere JJ Crit Care2008Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Prevention18359430Muscedere J, Dodek PE, Keenan S, Fowler R, Cook DJ, Heyland D for the VAP Guidelines Committee and for the Canadian Critical Care Trials Group. Comprehensive Evidence-Based Clinical Practice Guidelines for Ventilator-Associated Pneumonia: Prevention.  J Crit Care 2008; 23: 126-137. PMID: 18359430
Muscedere JChest2013The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection.23392627Muscedere J, Ofner M, Kumar A, Long J, Lamontagne F, Cook D, McGeer A, Chant C, Marshall J, Jouvet P, Fowler R; ICU-FLU Group; Canadian Critical Care Trials Group. The occurrence and impact of bacterial organisms complicating critical care illness associated with 2009 influenza A(H1N1) infection. Chest. 2013 Jul;144(1):39-47. PMID:23392627
Muscedere JChest2013The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated24030318Muscedere J, Sinuff T, Heyland DK, Dodek PM, Keenan SP, Wood G, Jiang X, Day AG, Laporta D, Klompas M; Canadian Critical Care Trials Group. The clinical impact and preventability of ventilator-associated conditions in critically ill patients who are mechanically ventilated. Chest. 2013 Nov;144(5):1453-60. PMID: 24030318
Muscedere JGJ Crit Care2008Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia18359420Muscedere JG, McColl C, Shorr A, Jiang X, Marshall J, Heyland DK for the Canadian Critical Care Trials Group. Determinants of outcome in patients with a clinical suspicion of ventilator-associated pneumonia. J Crit Care 2008; 23: 41-49. PMID: 18359420
Muscedere JGJ Crit Care2008The impact of ventilator-associated pneumonia on the Canadian health care system18359415Muscedere JG, Martin CM, Heyland DK. The impact of ventilator-associated pneumonia on the Canadian health care system. J Crit Care 2008; 23: 5-10. PMID: 18359415
NICE-SUGAR Study InvestigatorsIntensive Care Med2015Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study26088909NICE-SUGAR Study Investigators for the Australian and New Zealand Intensive Care Society Clinical Trials Group and the Canadian Critical Care Trials Group. Intensive versus conventional glucose control in critically ill patients with traumatic brain injury: long-term follow-up of a subgroup of patients from the NICE-SUGAR study.
Intensive Care Med. 2015 Jun;41(6):1037-47. PMID: 26088909
O'Hearn KTrials2016Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial.27153945O'Hearn K, McNally D, Choong K, Acharya A, Wong HR, Lawson M, Ramsay T, McIntyre L, Gilfoyle E, Tucci M, Wensley D, Gottesman R, Morrison G, Menon K; Canadian Critical Care Trials Group. Steroids in fluid and/or vasoactive infusion dependent pediatric shock: study protocol for a randomized controlled trial.
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Parker CMJ Crit Care2008Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: Prevalence, incidence, risk factors, and outcomes18359417Parker CM, Kutsogiannis J, Muscedere J, Cook D, Dodek P, Day AG, Heyland DK for the Canadian Critical Care Trials Group. Ventilator-associated pneumonia caused by multidrug-resistant organisms or Pseudomonas aeruginosa: Prevalence, incidence, risk factors, and outcomes. J Crit Care 2008;23: 18-26. PMID: 18359417
Parker MJTrials2016A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial.27876084Parker MJ, Thabane L, Fox-Robichaud A, Liaw P, Choong K; Canadian Critical Care Trials Group and the Canadian Critical Care Translational Biology Group.A trial to determine whether septic shock-reversal is quicker in pediatric patients randomized to an early goal-directed fluid-sparing strategy versus usual care (SQUEEZE): study protocol for a pilot randomized controlled trial. Trials. 2016 Nov 22;17(1):556. PMID: 27876084
Parshuram CCritical Care2011Multi-centre validation of the Bedside Paediatric Early Warning System Score: A severity of illness score to detect evolving critical illness in hospitalized children21812993Parshuram C, Duncan H, Joffe A, Farrell C, Lacroix J, Middaugh K, Hutchison JS, Wensley D, Beyene J, Parkin P, for the Canadian Critical Care Trials Group. Multi-centre validation of the Bedside Paediatric Early Warning System Score: A severity of illness score to detect evolving critical illness in hospitalized children. Critical Care 2011 Aug 3;15(4):R184. PMID: 21812993
Parshuram CSCrit Care Med2006In-house, overnight physician staffing: A cross-sectional survey of Canadian adult and paediatric ICUs16625115Parshuram CS, Mehta G, Kirpalani H, Granton J, Cook DJ, for The Canadian Critical Care Trials Group. In-house, overnight physician staffing: A cross-sectional survey of Canadian adult and paediatric ICUs. Crit Care Med 2006;34(6):1674-1678. PMID: 16625115
Parshuram CSCMAJ2015Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial.25667258Parshuram CS, Amaral AC, Ferguson ND, Baker GR, Etchells EE, Flintoft V, Granton J, Lingard L, Kirpalani H, Mehta S, Moldofsky H, Scales DC, Stewart TE, Willan AR, Friedrich JO; Canadian Critical Care Trials Group. Patient safety, resident well-being and continuity of care with different resident duty schedules in the intensive care unit: a randomized trial. CMAJ. 2015 Mar 17;187(5):321-9. PMID: 25667258
Parshuram CSTrials2015Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial.26033094 Parshuram CS, Dryden-Palmer K, Farrell C, Gottesman R, Gray M, Hutchison JS, Helfaer M, Hunt E, Joffe A, Lacroix J, Nadkarni V, Parkin P, Wensley D, Willan AR; Canadian Critical Care Trials Group .Evaluating processes of care and outcomes of children in hospital (EPOCH): study protocol for a randomized controlled trial. Trials. 2015;16(1):245. PMID: 26033094 
Patel RJ Crit Care2005Burden of illness: Thrombo-embolism in critical care (BITEC) study16310605Patel R, Cook DJ, Meade MO, Griffith L, Mehta S, Rocker G, Marshall J, Hodder R, Martin C, Heyland D, Peters S, Muscadere J, Soth M, Campbell N, Guyatt GH, for The Canadian Critical Care Trials Group. Burden of illness: Thrombo-embolism in critical care (BITEC) study. J Crit Care 2005;20:341-347. PMID: 16310605
Peters MJIntensive Care Med2017The intensive care medicine clinical research agenda in paediatrics.28315043Peters MJ, Argent A, Festa M, Leteurtre S, Piva J, Thompson A, Willson D, Tissières P, Tucci M, Lacroix J. The intensive care medicine clinical research agenda in paediatrics. Intensive Care Med. 2017 Mar 17. doi: 10.1007/s00134-017-4729-9. [Epub ahead of print] PMID: 28315043
Potter BJJ Crit Care2012Cardiac output responses in a flow-driven protocol of resuscitation following cardiac surgery.23159133Potter BJ, Deverenne B, Doucette S, Fergusson D, Magder S; for the Canadian Critical Care Trials Group.  Cardiac output responses in a flow-driven protocol of resuscitation following cardiac surgery.  J Crit Care. 2013 Jun;28(3):265-9. Epub 2012 Nov 14. PMID: 23159133.
Rewa OJ Crit Care2015Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study.26421697Rewa O, Wald R, Adhikari NK, Hladunewich M, Lapinsky S, Muscedere J, Bagshaw SM, Smith OM, Lebovic G, Kuint R, Klein DJ. Whole-blood neutrophil gelatinase-associated lipocalin to predict adverse events in acute kidney injury: A prospective observational cohort study. J Crit Care. 2015 Dec;30(6):1359-64. PMID: 26421697
Rishu AHJ Crit Care2017Time required to initiate outbreak and pandemic observational research.28288355Rishu AH, Marinoff N, Julien L, Dumitrascu M, Marten N, Eggertson S, Willems S, Ruddell S, Lane D, Light B, Stelfox HT, Jouvet P, Hall R, Reynolds S, Daneman N, Fowler RA; Canadian Critical Care Trials Group. Time required to initiate outbreak and pandemic observational research. J Crit Care. 2017 Mar 1;40:7-10. PMID: 28288355
Rochwerg BBMJ Open2017Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial.28729329 Rochwerg B, Millen T, Austin P, Zeller M, D'Aragon F, Jaeschke R, Masse MH, Mehta S, Lamontagne F, Meade M, Guyatt G, Cook DJ; Canadian Critical Care Trials Group. Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial. BMJ Open. 2017 Jul 20;7(7):e017602. PMID: 28729329 
Rocker GCrit Care Med2004Clinician predictions of mortality in the intensive care unit15190965Rocker G, Cook D, Sjokvist P, Weaver B, Finfer S, McDonald E, Marshall J, Kirby A, Levy M, Dodek P, Heyland D, Guyatt G, for the Canadian Critical Care Trials Group. Clinician predictions of mortality in the intensive care unit. Crit Care Med 2004;32(5):1149-1154. PMID: 15190965
Rose LJ Crit Care2015Clinician perspectives on protocols designed to minimize sedation.25466317 Rose L, Fitzgerald E, Cook D, Kim S, Steinberg M, Devlin JW, Ashley BJ, Dodek P, Smith O, Poretta K, Lee Y, Burns K, Harvey J, Skrobik Y, Fergusson D, Meade M, Kraguljac A, Burry L, Mehta S; SLEAP Investigators and the Canadian Critical Care Trials Group.Clinician perspectives on protocols designed to minimize sedation.J Crit Care. 30(2):348-52. PMID: 25466317 
Rouette J Annals of Surgery2010Red blood cell transfusion threshold in post-surgical pediatric intensive care patients: a randomized clinical trial20118780Rouette J, Trottier H, Ducruet T, Beaunoyer M, Lacroix J, Tucci M for the Canadian Critical Care Trials Group and PALISI.  Red blood cell transfusion threshold in post-surgical pediatric intensive care patients: a randomized clinical trial.  Annals of Surgery 2010; 251:421-7. PMID: 20118780
Sanders KMJ Crit Care2008Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: Secondary analysis from a randomized trial18359422Sanders KM, Adhikari N, Friedrich JO, Day A, Jiang S, Heyland D for the Canadian Critical Care Trials Group. Previous cultures are not clinically useful for guiding empiric antibiotics in suspected ventilator-associated pneumonia: Secondary analysis from a randomized trial. J Crit Care 2008; 23: 58-63. PMID: 18359422
Sandham JDN Engl J Med2003A randomised controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients12510037Sandham JD, Hull RD, Brant RF, Knox L, Pineo GF, Doig CJ, Laporta DP, Viner S, Passerini L, Devitt H, Kirby A, Jacka M, for The Canadian Critical Care Trials Group. A randomised controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med. 2003 Jan 2;348(1):5-14. PMID: 12510037
Savage RDPLoS One2016The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study.27152615Savage RD, Fowler RA, Rishu AH, Bagshaw SM, Cook D, Dodek P, Hall R, Kumar A, Lamontagne F, Lauzier F, Marshall J, Martin CM, McIntyre L, Muscedere J, Reynolds S, Stelfox HT, Daneman N. The Effect of Inadequate Initial Empiric Antimicrobial Treatment on Mortality in Critically Ill Patients with Bloodstream Infections: A Multi-Centre Retrospective Cohort Study. PLoS One. 2016 May 6;11(5):e0154944. PMID:27152615
Scales DCIntensive Care Med2009Patients’ Preferences For Enrolment into Critical Care Trials19551372Scales DC, Orla M. Smith OM, Pinto R, Barrett KA, Friedrich JO, Lazar NM, Cook DJ, Ferguson ND for the Canadian Critical Care Trials Group.  Patients’ Preferences For Enrolment into Critical Care Trials. Intensive Care Med. 2009 Oct;35(10):1703-12. Epub 2009 Jun 24. PMID: 19551372
Scales DCJ Crit Care2009Prophylaxis against venous thromboembolism in neurointensive care patients: survey of Canadian practice. 19501306Scales DC, Riva-Cambrin J, Le TL, Pinto R, Cook DJ, Granton JT; Canadian Critical Care Trials Group.J 
Prophylaxis against venous thromboembolism in neurointensive care patients: survey of Canadian practice. Crit Care. 2009 Jun;24(2):176-84. PMID: 19501306
Seely ACrit Care2014Do heart and respiratory rate variability improve prediction of extubation outcomes in critically ill patients?24713049Seely A, Bravi A, Herry C, Green G, Longtin A, Ramsay T, Fergusson D, McIntyre L, Kubelik D, Maziak DE, Ferguson N, Brown SM, Mehta S, Martin C, Rubenfeld G, Jacono FJ, Clifford G, Fazekas A, Marshall J; The Canadian Critical Care Trials Group (CCCTG); The Canadian Critical Care Trials Group CCCTG. Do heart and respiratory rate variability improve prediction of extubation outcomes in critically ill patients?Crit Care. 2014 Dec 2;18(6):620. PMID: 24713049
Shears MCan J Anaesth.2016Stress ulcer prophylaxis in critical illness: a Canadian survey.26911559Shears M, Alhazzani W, Marshall JC, Muscedere J, Hall R, English SW, Dodek PM, Lauzier F, Kanji S, Duffett M, Barletta J, Alshahrani M, Arabi Y, Deane A, Cook DJ. Stress ulcer prophylaxis in critical illness: a Canadian survey. Can J Anaesth. 2016 Feb 24. [Epub ahead of print] PMID: 26911559
Shemie SIntensive Care Med2014International guideline development for the determination of death.24664151 Shemie SD, Hornby L, Baker A, Teitelbaum J, Torrance S, Young K, Capron AM, Bernat JL, Noel L; The International Guidelines for Determination of Death phase 1 participants, in collaboration with the World Health Organization. International guideline development for the determination of death. Intensive Care Med. 2014;40(6):788-97. PMID: 24664151 
Shorr AFJ Crit Care2008Correlates of clinical failure in ventilator-associated pneumonia: Insights from a large, randomized trial18359423Shorr AF, Cook D, Jiang X, Muscedere J, Heyland D for the Canadian Critical Care Trials Group. Correlates of clinical failure in ventilator-associated pneumonia: Insights from a large, randomized trial. J Crit Care 2008; 23: 64-73. PMID: 18359423
Sinuff TJ Crit Care2008Ventilator-associated pneumonia: Improving outcomes through guideline implementation18359429Sinuff T, Muscedere J, Cook D, Dodek P, Heyland D for the Canadian Critical Care Trials Group. Ventilator-associated pneumonia: Improving outcomes through guideline implementation. J Crit Care 2008; 23: 118-125. PMID: 18359429
Sinuff TCan J Anesth2004Resuscitation directives in the intensive care unit15574557Sinuff T, Cook DJ, Rocker GM, Griffith L, Walter SD, Fisher M, Dodek P, Sjokvist P, McDonald E, Marshall J, Levy M, Guyatt G, and The Canadian Critical Care Trials Group. Resuscitation directives in the intensive care unit. Can J Anesth 2004;51(10):1034-1041. PMID: 15574557
Sinuff TCrit Care Med2013Knowledge translation interventions for critically ill patients: a systematic review23939356Sinuff T, Muscedere J, Adhikari NK, Stelfox HT, Dodek P, Heyland DK, Rubenfeld GD, Cook DJ, Pinto R, Manoharan V, Currie J, Cahill N, Friedrich JO, Amaral A, Piquette D, Scales DC, Dhanani S, Garland A; KRITICAL Working Group, the Canadian Critical Care Trials Group, and the Canadian Critical Care Society. Knowledge translation interventions for critically ill patients: a systematic review. Crit Care Med. 2013;41(11):2627-4. PMID: 23939356
Sinuff T.Critical Care Medicine2013Clinical Practice Guidelines for Ventilator Associated Pneumonia: A Multicentre Prospective Study23222254T. Sinuff, J. Muscedere, D.J. Cook, P. M. Dodek, W. Anderson, S. P. Keenan, G. Wood, R. Tan, M.T. Haupt, M. Miletin, R. Bouali, X. Jiang, Day A.G., Overvelde J, D.K. Heyland for the Canadian Critical Care Trials Group. Implementation of clinical practice guidelines for ventilator-associated pneumonia: a multicenter prospective study. Crit Care Med. 2013;41(1):15-23. PMID:23222254
Smith OMJ Crit Care2013Rates and determinants of informed consent: A case study of an international thromboprophylaxis trial.23089679Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Meade L, O’Callaghan N, Vallance S, Galt P, Rajbhandari D, Rocha M, Mehta S, Ferguson ND, Hall R, Fowler R, Burns K, Qushmaq I, Ostermann M, Heels-Ansdell, Cook DJ for the PROTECT Research Coordinators, PROTECT Investigators, Canadian Critical Care Trials Group, and the Australian, New Zealand Intensive Care Society Clinical Trials Group. Rates and determinants of informed consent: A case study of an international thromboprophylaxis trial. J Crit Care 2013;28: 28-39. PMID: 23089679
Smith OMTrials2013Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial.24093950Smith OM, Wald R, Adhikari NK, Pope K, Weir MA, Bagshaw SM; Canadian Critical Care Trials Group. Standard versus accelerated initiation of renal replacement therapy in acute kidney injury (STARRT-AKI): study protocol for a randomized controlled trial. Trials. 2013;14:320. PMID: 24093950
Smith OMIntensive Crit Care Nurs2013Enhancing the informed consent process for critical care research: strategies from a thromboprophylaxis trial.23871290 Smith OM, McDonald E, Zytaruk N, Foster D, Matte A, Clarke F, Fleury S, Krause K, McArdle T, Skrobik Y, Cook DJ.Enhancing the informed consent process for critical care research: strategies from a thromboprophylaxis trial. Intensive Crit Care Nurs. 2013;29(6):300-9. PMID: 23871290 
Smith OMCrit Care Med.2016Nurse Research Experiences and Attitudes Toward the Conduct of Intensive Care Research: A Questionnaire Study26672924Smith, OM, Dale, C, Mehta, S, Pinto, R, Rose, LN. Nurse Research Experiences and Attitudes Toward the Conduct of Intensive Care Research: A Questionnaire Study. Crit Care Med. 2016 Jan;44(1):153-61. PMID: 26672924
Steinberg MJ Intensive Care Med2014A National Survey of Critical Care Physicians' Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs.25005699Steinberg M, Dresser LD, Daneman N, Smith OM, Matte A, Marinoff N, Bell CM, Morris AM.A National Survey of Critical Care Physicians' Knowledge, Attitudes, and Perceptions of Antimicrobial Stewardship Programs.J Intensive Care Med. 2014 Jul 8. [Epub ahead of print]. PMID: 25005699
Stelfox HChest2015A Scoping Review of Patient Discharge from Intensive Care: Opportunities and Tools to Improve Care25210942Stelfox H, Lane D, Boyd J, Taylor S, Perrier L, Straus S, Zygun D, Zuege D. A Scoping Review of Patient Discharge from Intensive Care: Opportunities and Tools to Improve Care. Chest. 2015;147(2):317-27. PMID: 25210942
Stiff DPediatr Crit Care Med2011Potential pediatric intensive care unit demand/capacity mismatch due to novel pH1N1 in Canada.20473239Stiff D1, Kumar A, Kissoon N, Fowler R, Jouvet P, Skippen P, Smetanin P, Kesselman M, Veroukis S. Potential pediatric intensive care unit demand/capacity mismatch due to novel pH1N1 in Canada. Pediatr Crit Care Med. 2011 Mar;12(2):e51-7. PMID: 20473239


Sud SAm J Respir Crit Care Med2011Screening and Prevention of Venous Thromboembolism in Critically Ill Patients: A Decision Analysis and Economic Evaluation21868500Sud S, Mittmann N, Cook DJ, Geerts W, Chan B, Dodek P, Gould MK, Guyatt G, Arabi Y, Fowler RA; On Behalf of the E-PROTECT Investigators and for the Canadian Critical Care Trials Group. Screening and Prevention of Venous Thromboembolism in Critically Ill Patients: A Decision Analysis and Economic Evaluation. Am J Respir Crit Care Med. 2011 Aug 25. [Epub ahead of print] PMID: 21868500
The NICE SUGAR Study InvestigatorsN Engl J Med2009Intensive versus conventional glucose control in critically ill patients19318384The NICE SUGAR Study Investigators for the Australian and New Zealand Intensive Care Society, the George Institute for International Health, for the Canadian Critical Care Trials Group, and the Vancouver Coastal Health Research Institute . Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360(13):1283-1297. PMID: 19318384
The NICE-SUGAR Study InvestigatorsN Engl J Med2012Hypoglycemia and risk of death in critically ill patients.22992074NICE-SUGAR Study Investigators, Finfer S, Liu B, Chittock DR, Norton R, Myburgh JA, McArthur C, Mitchell I, Foster D, Dhingra V, Henderson WR, Ronco JJ, Bellomo R, Cook D, McDonald E, Dodek P, Hébert PC, Heyland DK, Robinson BG.Hypoglycemia and risk of death in critically ill patients.N Engl J Med. 2012 Sep 20;367(12):1108-18. PMID: 22992074
The PROTECTN Engl J Med2011A Randomized Trial of Dalteparin versus Unfractionated Heparin in Critically Ill Patients21417952The PROTECT Investigators for the Canadian Critical Care Trials Group & the Australian and New Zealand Intensive Care Society Clinical Trials Group.  A Randomized Trial of Dalteparin versus Unfractionated Heparin in Critically Ill Patients.  N Engl J Med 2011;364(14):1305-1314. PMID: 21417952
Thomas MDynamics2013Consenting to Pediatric Research: Understanding the Parent’s Perspective.24288878Thomas M, Menon K for the Canadian Critical Care Trials Group. Consenting to Pediatric Research: Understanding the Parent’s Perspective. Dynamics 2013;24(3):18-24. PMID:24288878
Tinmouth ATransfusion2006Clinical consequences of red cell storage in the critically ill.17076859 Tinmouth A, Fergusson D, Yee IC, Hébert PC; ABLE Investigators; Canadian Critical Care Trials Group. Clinical consequences of red cell storage in the critically ill. Transfusion. 2006;46(11):2014-27. PMID: 17076859 
Tinmouth AArch Intern Med. 2005Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians' transfusion practices.15851633Tinmouth A, Macdougall L, Fergusson D, Amin M, Graham ID, Hebert PC, Wilson K. Reducing the amount of blood transfused: a systematic review of behavioral interventions to change physicians' transfusion practices. Arch Intern Med. 2005;165(8):845-52. PMID: 15851633
Turgeon AFCMAJ2011Mortality associated with withdrawal of life-sustaining therapy for patients with severe traumatic brain injury: a Canadian multicentre cohort study21876014Turgeon AF, Lauzier F, Simard JF, Scales DC, Burns KEA, Moore L, Zygun DA, Bernard F, Meade MO, Dung TC, Ratnapalan M, Todd S, Harlock J, Fergusson DA for the Canadian Critical Care Trials Group. Mortality associated with withdrawal of life-sustaining therapy for patients with severe traumatic brain injury: a Canadian multicentre cohort study. CMAJ October 4, 2011 vol. 183 no. 14 First published August 29, 2011. PMID: 21876014
Turgeon AFCrit Care Med2012Determination of neurological prognosis in adult patients with severe traumatic brain injury: a survey of Canadian intensivists, neurosurgeons and neurologists Turgeon AF, Lauzier F, Burns K, Fergusson DA, Zygun D, Meade M, Scales D, Zarychanski R, McIntyre L, Kanji S, Pagliarello J, Hébert P for the Canadian Critical Care Trials Group. Determination of neurological prognosis in adult patients with severe traumatic brain injury: a survey of Canadian intensivists, neurosurgeons and neurologists. Crit Care Med 2012; (in press).
Turgeon AFCrit Care Med.2013Determination of neurologic prognosis and clinical decision making in adult patients with severe traumatic brain injury: a survey of Canadian intensivists, neurosurgeons, and neurologists.23385104Turgeon AF, Lauzier F, Burns KE, Meade MO, Scales DC, Zarychanski R, Moore L, Zygun DA, McIntyre LA, Kanji S, Hébert PC, Murat V, Pagliarello G, Fergusson DA; for the Canadian Critical Care Trials Group.   Determination of neurologic prognosis and clinical decision making in adult patients with severe traumatic brain injury: a survey of Canadian intensivists, neurosurgeons, and neurologists. Crit Care Med. 2013 Apr;41(4):1086-93. PMID: 23385104
Turgeon AFCan J Anaesth.2006Red blood cell transfusion practices amongst Canadian anesthesiologists: a survey.16575031Turgeon AF, Fergusson DA, Doucette S, Khanna MP, Tinmouth A, Aziz A, Hébert PC. Red blood cell transfusion practices amongst Canadian anesthesiologists: a survey. Can J Anaesth. 2006;53(4):344-52. PMID: 16575031
Turgeon AFBMJ Open.2017Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study.28416497 Turgeon AF, Lauzier F, Zarychanski R, Fergusson DA, Léger C, McIntyre LA, Bernard F, Rigamonti A, Burns K, Griesdale DE, Green R, Scales DC, Meade MO, Savard M, Shemilt M, Paquet J, Gariépy JL, Lavoie A, Reddy K, Jichici D, Pagliarello G, Zygun D, Moore L; TBI-Prognosis Study Team and the Canadian Critical Care Trials Group. Prognostication in critically ill patients with severe traumatic brain injury: the TBI-Prognosis multicentre feasibility study. BMJ Open. 2017 Apr 17;7(4):e013779. PMID: 28416497 
van Beinum AJ Intensive Care Med2015Exploration of Withdrawal of Life-Sustaining Therapy in Canadian Intensive Care Units.25680980van Beinum A, Hornby L, Ramsay T, Ward R, Shemie SD, Dhanani S. Exploration of Withdrawal of Life-Sustaining Therapy in Canadian Intensive Care Units. J Intensive Care Med. 2015 Feb 12. [Epub ahead of print] PMID: 25680980
van Beinum ACrit Care Med2015Variations in the Operational Process of Withdrawal of Life-Sustaining Therapy.26121072van Beinum A, Hornby L, Ward R, Ramsay T, Dhanani S. Variations in the Operational Process of Withdrawal of Life-Sustaining Therapy. Crit Care Med. 2015 Oct;43(10):e450-7. PMID: 26121072
van Zanten ARCrit Care2015Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis.26283217 van Zanten AR, Dhaliwal R, Garrel D, Heyland DK. Enteral glutamine supplementation in critically ill patients: a systematic review and meta-analysis. Crit Care. 2015 Aug 18;19:294. PMID: 26283217 
Wald RCrit Care2012Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysist23095370Wald R, Friedrich JO, Bagshaw SM, Burns KE, Garg AX, Hladunewich MA, House AA, Lapinsky S, Klein D, Pannu NI, Pope K, Richardson RM, Thorpe K, Adhikari NK for the Canadian Critical Care Trials Group. Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI) - a pilot randomized controlled trial of hemofiltration versus hemodialysist. Crit Care. 2012 Oct 24;16(5):R205. [Epub ahead of print] PMID: 23095370.
Wald RAm J Kidney Dis2014Changing Incidence and Outcomes Following Dialysis-Requiring Acute Kidney Injury Among Critically Ill Adults: A Population-Based Cohort Study.25533599Wald R, McArthur E, Adhikari NK, Bagshaw SM, Burns KE, Garg AX, Harel Z, Kitchlu A, Mazer CD, Nash DM, Scales DC, Silver SA, Ray JG, Friedrich JO. Changing Incidence and Outcomes Following Dialysis-Requiring Acute Kidney Injury Among Critically Ill Adults: A Population-Based Cohort Study. Am J Kidney Dis. 2015 Jun;65(6):870-7. PMID: 25533599
Wald RKidney Int2015Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury26154928Wald, R, Adhikari, NKJ, Smith, OM, Weir, MA, Pope, K, Cohen, A, Thorpe, K, McIntyre, L, Lamontagne, F, Soth, M, Herridge, M, Lapinsky, S, Clark, E, Garg, AX, Hiremath, S, Klein, D, Mazer, CD, Richardson, RMA, Wilcox, EM, Friedrich, JO, Burns, KEA and Bagshaw, SM on behalf of the Canadian Critical Care Trials Group. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney Int. 2015 Oct;88(4):897-904. PMID: 26154928
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