• Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a highly collegial group that is dedicated to the pursuit of excellence and advancement of critical care research in Canada.
  • Canadian Critical Care Trials Group
    The CCCTG has are more than 30 research programs underway and over 100 peer-reviewed publications to its credit, with direct impact on clinical practice in critical care.
  • Canadian Critical Care Trials Group
    The Canadian Critical Care Trials Group (CCCTG) is a national organization of more than 300 individuals with research interests in the management of the critically ill patient.
  • Canadian Critical Care Trials Group
    Endorsement by the CCCTG communicates our full commitment to ensure that the work is undertaken in a rigorous and ethical manner, and communicated in a timely and effective way.


Clinical research is key to the future of improved clinical care in the ICU. Reducing the morbidity and mortality of critical illness requires a broad clinical research agenda to understand how to reduce organ dysfunction, improve survival, restore health and maximize quality of life. However, the conduct of clinical research in the ICU setting involves unique challenges.

Clinical practice guidelines for the use of noninvasive positive-pressure ventilation (NIV) and noninvasive continuous positive airway pressure in the acute care setting 

These guidelines were developed to answer the following questions: What evidence is available in the literature to support recommendations for the use of noninvasive positive-pressure venti lation and continuous positive airway pressure for patients who are at risk of or who have acute respiratory distress or failure, patients who have undergone surgery and patients who are being weaned from mechanical ventilation or have recently undergone extubation? How can these two modes of noninvasive ventilation be optimally applied in these settings?

TO LEARN MORE, download the NIV Guidelines published in the Canadian Medical Association Journal.

Co-enrolment Guidelines

Since co-enrolment is ongoing in many disciplines today, and little is known about it, and since there is great REB variability, we developed draft guidelines. The following guidelines refer primarily to co-enrolment of 1 patient into 2 RCTs of established interventions (not to co-enrolment in industry-initiated RCTs or into trials of new drugs or devices).

TO LEARN MORE, download the Co-enrolment Guidelines.

OR download the Critical Care Medicine article.

OR download the Co-enrolment Algorithm.

Critical Care Nutrition

Critical Care Nutrition, at the Clinical Evaluation Research Unit (CERU), is dedicated to improving nutrition therapies in the critically ill through knowledge generation, synthesis, and translation. We engage in a broad range of research activities and promote a culture of best practices in critical care nutrition. Ultimately, this will result in improved clinical outcomes for critically ill patients and increased efficiencies to our health care systems.

TO LEARN MORE, visit the Critical Care Nutrition website.

Canadian Clinical Practice Guidelines for Nutrition Support in Mechanically Ventilated, Critically ill PatientsCare Nutrition

The Canadian Critical Care Practice Guidelines (CCPGs) were first published in  2003 and are among the most regularly updated evidence-based guidelines, with updates in 2005, 2007, 2009 and 2013. The 2013 CCPGs summarize the evidence from approximately 300 randomized controlled trials in the area of critical care nutrition since 1980. The 2013 guideline updates and implementation strategies are published in Nutrition in Clinical Practice and available on the Critical Care Nutrition website.

The included studies have undergone a formal review process by a multidisciplinary Canadian Clinical Practice Guidelines Committee and provide the latest and best evidence for clinical practice in the various areas of critical care nutrition.

These guidelines have been developed in collaboration with the Canadian Critical Care Society (CCCS) and the CCCTG.

TO LEARN MORE, download the Canadian Critical Care Nutrition Guidelines.

OR read them on the Critical Care Nutrition website.